Cilia- and flagella-associated protein 45

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tumour suppressor, Mitostatin, putative

Species:

Leishmania braziliensis

UniProt:

A4H6A3_LEIBR

TriTrypDb:

LbrM.10.1260 , LBRM2903_100021900

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4H6A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6A3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.555
CLV_NRD_NRD_1	211	213	PF00675	0.192
CLV_NRD_NRD_1	24	26	PF00675	0.525
CLV_NRD_NRD_1	240	242	PF00675	0.263
CLV_NRD_NRD_1	246	248	PF00675	0.256
CLV_NRD_NRD_1	274	276	PF00675	0.296
CLV_NRD_NRD_1	329	331	PF00675	0.264
CLV_NRD_NRD_1	340	342	PF00675	0.215
CLV_NRD_NRD_1	348	350	PF00675	0.149
CLV_NRD_NRD_1	405	407	PF00675	0.272
CLV_NRD_NRD_1	427	429	PF00675	0.245
CLV_NRD_NRD_1	440	442	PF00675	0.246
CLV_NRD_NRD_1	456	458	PF00675	0.164
CLV_NRD_NRD_1	472	474	PF00675	0.449
CLV_NRD_NRD_1	82	84	PF00675	0.522
CLV_PCSK_FUR_1	209	213	PF00082	0.330
CLV_PCSK_FUR_1	327	331	PF00082	0.256
CLV_PCSK_FUR_1	403	407	PF00082	0.330
CLV_PCSK_FUR_1	425	429	PF00082	0.257
CLV_PCSK_KEX2_1	15	17	PF00082	0.609
CLV_PCSK_KEX2_1	153	155	PF00082	0.267
CLV_PCSK_KEX2_1	211	213	PF00082	0.271
CLV_PCSK_KEX2_1	240	242	PF00082	0.254
CLV_PCSK_KEX2_1	246	248	PF00082	0.240
CLV_PCSK_KEX2_1	329	331	PF00082	0.250
CLV_PCSK_KEX2_1	340	342	PF00082	0.233
CLV_PCSK_KEX2_1	405	407	PF00082	0.330
CLV_PCSK_KEX2_1	425	427	PF00082	0.113
CLV_PCSK_KEX2_1	472	474	PF00082	0.548
CLV_PCSK_KEX2_1	81	83	PF00082	0.532
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.273
CLV_PCSK_SKI1_1	267	271	PF00082	0.265
CLV_PCSK_SKI1_1	472	476	PF00082	0.507
DEG_APCC_DBOX_1	367	375	PF00400	0.465
DEG_APCC_DBOX_1	471	479	PF00400	0.610
DOC_CYCLIN_RxL_1	107	115	PF00134	0.377
DOC_MAPK_gen_1	263	271	PF00069	0.469
DOC_MAPK_gen_1	297	306	PF00069	0.530
DOC_MAPK_gen_1	472	478	PF00069	0.600
DOC_MAPK_MEF2A_6	193	202	PF00069	0.466
DOC_PP2B_LxvP_1	465	468	PF13499	0.456
DOC_USP7_MATH_1	34	38	PF00917	0.536
DOC_USP7_UBL2_3	116	120	PF12436	0.469
DOC_USP7_UBL2_3	372	376	PF12436	0.549
LIG_14-3-3_CanoR_1	16	24	PF00244	0.592
LIG_14-3-3_CanoR_1	308	316	PF00244	0.435
LIG_APCC_ABBAyCdc20_2	350	356	PF00400	0.369
LIG_CaM_IQ_9	197	213	PF13499	0.516
LIG_CaM_IQ_9	227	243	PF13499	0.549
LIG_CaM_IQ_9	386	402	PF13499	0.530
LIG_Clathr_ClatBox_1	229	233	PF01394	0.369
LIG_FHA_1	402	408	PF00498	0.549
LIG_FHA_2	39	45	PF00498	0.486
LIG_FHA_2	98	104	PF00498	0.559
LIG_LIR_Gen_1	122	131	PF02991	0.373
LIG_LIR_Nem_3	122	128	PF02991	0.373
LIG_PCNA_yPIPBox_3	162	175	PF02747	0.465
LIG_PCNA_yPIPBox_3	376	387	PF02747	0.527
LIG_REV1ctd_RIR_1	1	7	PF16727	0.685
LIG_SH2_SRC	125	128	PF00017	0.465
LIG_SH2_STAP1	300	304	PF00017	0.369
LIG_SH2_STAT3	161	164	PF00017	0.505
LIG_SH2_STAT3	280	283	PF00017	0.505
LIG_SH2_STAT5	180	183	PF00017	0.530
LIG_SH2_STAT5	280	283	PF00017	0.456
LIG_SH2_STAT5	335	338	PF00017	0.530
LIG_SH3_3	8	14	PF00018	0.536
LIG_SUMO_SIM_anti_2	412	417	PF11976	0.456
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.480
LIG_TRAF2_1	100	103	PF00917	0.609
LIG_TRAF2_1	76	79	PF00917	0.606
LIG_WW_3	12	16	PF00397	0.521
MOD_CK2_1	38	44	PF00069	0.496
MOD_CK2_1	97	103	PF00069	0.625
MOD_GlcNHglycan	36	39	PF01048	0.617
MOD_GSK3_1	34	41	PF00069	0.516
MOD_GSK3_1	56	63	PF00069	0.597
MOD_GSK3_1	67	74	PF00069	0.569
MOD_NEK2_1	309	314	PF00069	0.369
MOD_NEK2_1	56	61	PF00069	0.609
MOD_PIKK_1	309	315	PF00454	0.490
MOD_PKA_2	309	315	PF00069	0.369
MOD_PKA_2	34	40	PF00069	0.534
MOD_PKB_1	15	23	PF00069	0.653
MOD_Plk_1	409	415	PF00069	0.445
MOD_SUMO_rev_2	122	131	PF00179	0.469
MOD_SUMO_rev_2	228	236	PF00179	0.549
MOD_SUMO_rev_2	268	278	PF00179	0.469
MOD_SUMO_rev_2	343	352	PF00179	0.535
TRG_DiLeu_BaEn_1	266	271	PF01217	0.465
TRG_DiLeu_BaEn_3	381	387	PF01217	0.456
TRG_DiLeu_BaEn_4	366	372	PF01217	0.369
TRG_ENDOCYTIC_2	125	128	PF00928	0.457
TRG_ER_diArg_1	14	17	PF00400	0.612
TRG_ER_diArg_1	185	188	PF00400	0.530
TRG_ER_diArg_1	209	212	PF00400	0.530
TRG_ER_diArg_1	239	241	PF00400	0.465
TRG_ER_diArg_1	246	248	PF00400	0.444
TRG_ER_diArg_1	297	300	PF00400	0.525
TRG_ER_diArg_1	326	329	PF00400	0.474
TRG_ER_diArg_1	368	371	PF00400	0.377
TRG_ER_diArg_1	403	406	PF00400	0.530
TRG_ER_diArg_1	425	428	PF00400	0.445
TRG_ER_diArg_1	454	457	PF00400	0.405
TRG_ER_diArg_1	471	473	PF00400	0.527
TRG_ER_diArg_1	81	83	PF00400	0.557
TRG_NES_CRM1_1	221	234	PF08389	0.554
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	385	390	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.113
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W7	Leptomonas seymouri	78%	100%
A0A0S4INS9	Bodo saltans	48%	98%
A0A1X0NS36	Trypanosomatidae	57%	100%
A0A3S7WRD8	Leishmania donovani	91%	100%
A0A422NGP1	Trypanosoma rangeli	55%	100%
A0A480NP79	Sus scrofa	34%	87%
A4HUM7	Leishmania infantum	91%	100%
A8I9E8	Chlamydomonas reinhardtii	39%	96%
C9ZVQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ANC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q32LN4	Bos taurus	36%	87%
Q4QH99	Leishmania major	91%	100%
Q9D9U9	Mus musculus	37%	87%
Q9UL16	Homo sapiens	32%	87%
V5BJP2	Trypanosoma cruzi	57%	99%