RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H6A2_LEIBR

TriTrypDb:

LbrM.10.1250 , LBRM2903_100021800

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6A2

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0005488	binding	1	11
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0061630	ubiquitin protein ligase activity	5	11
GO:0061659	ubiquitin-like protein ligase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.478
CLV_C14_Caspase3-7	292	296	PF00656	0.466
CLV_NRD_NRD_1	227	229	PF00675	0.486
CLV_NRD_NRD_1	76	78	PF00675	0.556
CLV_PCSK_KEX2_1	76	78	PF00082	0.587
CLV_PCSK_SKI1_1	266	270	PF00082	0.439
CLV_PCSK_SKI1_1	351	355	PF00082	0.377
DEG_SCF_FBW7_1	176	183	PF00400	0.424
DOC_CYCLIN_RxL_1	94	102	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.544
DOC_MAPK_gen_1	125	132	PF00069	0.557
DOC_MAPK_gen_1	266	274	PF00069	0.434
DOC_MAPK_gen_1	76	85	PF00069	0.520
DOC_PP2B_LxvP_1	238	241	PF13499	0.385
DOC_PP4_FxxP_1	31	34	PF00568	0.505
DOC_USP7_MATH_1	139	143	PF00917	0.612
DOC_USP7_MATH_1	180	184	PF00917	0.513
DOC_USP7_MATH_1	222	226	PF00917	0.697
DOC_USP7_MATH_1	248	252	PF00917	0.623
DOC_USP7_UBL2_3	226	230	PF12436	0.379
DOC_WW_Pin1_4	176	181	PF00397	0.527
DOC_WW_Pin1_4	86	91	PF00397	0.628
LIG_14-3-3_CanoR_1	131	138	PF00244	0.591
LIG_14-3-3_CterR_2	351	355	PF00244	0.365
LIG_Actin_WH2_2	119	135	PF00022	0.346
LIG_BIR_III_4	295	299	PF00653	0.465
LIG_BRCT_BRCA1_1	208	212	PF00533	0.616
LIG_BRCT_BRCA1_1	34	38	PF00533	0.638
LIG_FHA_1	100	106	PF00498	0.477
LIG_FHA_1	149	155	PF00498	0.539
LIG_FHA_1	157	163	PF00498	0.528
LIG_FHA_1	177	183	PF00498	0.652
LIG_FHA_1	262	268	PF00498	0.505
LIG_FHA_1	315	321	PF00498	0.273
LIG_FHA_1	65	71	PF00498	0.454
LIG_FHA_2	14	20	PF00498	0.581
LIG_FHA_2	147	153	PF00498	0.519
LIG_FHA_2	216	222	PF00498	0.586
LIG_FHA_2	234	240	PF00498	0.367
LIG_GBD_Chelix_1	14	22	PF00786	0.429
LIG_GSK3_LRP6_1	86	91	PF00069	0.521
LIG_HP1_1	161	165	PF01393	0.314
LIG_Integrin_RGD_1	289	291	PF01839	0.434
LIG_NRBOX	163	169	PF00104	0.312
LIG_Pex14_2	27	31	PF04695	0.444
LIG_PTB_Apo_2	273	280	PF02174	0.508
LIG_PTB_Phospho_1	273	279	PF10480	0.503
LIG_SH2_CRK	117	121	PF00017	0.272
LIG_SH2_CRK	190	194	PF00017	0.384
LIG_SH2_NCK_1	173	177	PF00017	0.452
LIG_SH2_SRC	173	176	PF00017	0.472
LIG_SH2_STAP1	173	177	PF00017	0.543
LIG_SH2_STAP1	49	53	PF00017	0.607
LIG_SH2_STAT5	117	120	PF00017	0.302
LIG_SH2_STAT5	235	238	PF00017	0.333
LIG_SH2_STAT5	28	31	PF00017	0.429
LIG_SH3_3	155	161	PF00018	0.481
LIG_SH3_3	40	46	PF00018	0.692
LIG_SH3_3	82	88	PF00018	0.384
LIG_SH3_4	226	233	PF00018	0.343
LIG_SUMO_SIM_par_1	191	196	PF11976	0.328
LIG_SUMO_SIM_par_1	66	71	PF11976	0.470
LIG_TRAF2_1	240	243	PF00917	0.571
LIG_TYR_ITIM	171	176	PF00017	0.371
LIG_TYR_ITIM	188	193	PF00017	0.364
LIG_TYR_ITIM	233	238	PF00017	0.354
LIG_UBA3_1	164	172	PF00899	0.535
MOD_CK1_1	206	212	PF00069	0.477
MOD_CK2_1	13	19	PF00069	0.592
MOD_CK2_1	215	221	PF00069	0.561
MOD_CK2_1	233	239	PF00069	0.455
MOD_GlcNHglycan	134	137	PF01048	0.595
MOD_GSK3_1	148	155	PF00069	0.641
MOD_GSK3_1	176	183	PF00069	0.603
MOD_GSK3_1	199	206	PF00069	0.407
MOD_GSK3_1	64	71	PF00069	0.416
MOD_N-GLC_1	2	7	PF02516	0.658
MOD_N-GLC_2	329	331	PF02516	0.352
MOD_N-GLC_2	340	342	PF02516	0.212
MOD_NEK2_1	132	137	PF00069	0.575
MOD_NEK2_1	247	252	PF00069	0.552
MOD_NEK2_1	327	332	PF00069	0.195
MOD_NEK2_1	335	340	PF00069	0.247
MOD_NEK2_1	68	73	PF00069	0.450
MOD_NEK2_1	99	104	PF00069	0.334
MOD_NMyristoyl	1	7	PF02799	0.612
MOD_OFUCOSY	326	331	PF10250	0.195
MOD_PIKK_1	105	111	PF00454	0.509
MOD_PIKK_1	206	212	PF00454	0.699
MOD_PIKK_1	220	226	PF00454	0.547
MOD_PKA_2	261	267	PF00069	0.463
MOD_PKA_2	335	341	PF00069	0.406
MOD_Plk_1	315	321	PF00069	0.316
MOD_Plk_4	10	16	PF00069	0.470
MOD_Plk_4	153	159	PF00069	0.567
MOD_Plk_4	233	239	PF00069	0.356
MOD_Plk_4	315	321	PF00069	0.275
MOD_ProDKin_1	176	182	PF00069	0.529
MOD_ProDKin_1	86	92	PF00069	0.628
MOD_SUMO_for_1	171	174	PF00179	0.568
TRG_DiLeu_BaEn_4	242	248	PF01217	0.402
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.551
TRG_ENDOCYTIC_2	117	120	PF00928	0.263
TRG_ENDOCYTIC_2	173	176	PF00928	0.389
TRG_ENDOCYTIC_2	190	193	PF00928	0.389
TRG_ENDOCYTIC_2	235	238	PF00928	0.333
TRG_ENDOCYTIC_2	28	31	PF00928	0.538
TRG_ER_diArg_1	124	127	PF00400	0.580
TRG_ER_diArg_1	75	77	PF00400	0.562
TRG_NLS_MonoExtN_4	226	232	PF00514	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A9	Leptomonas seymouri	49%	91%
A0A1X0NRX0	Trypanosomatidae	36%	97%
A0A3R7KAZ9	Trypanosoma rangeli	34%	98%
A0A3S7WRB2	Leishmania donovani	79%	99%
A4HUM6	Leishmania infantum	78%	99%
C9ZVQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ANC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4QHA0	Leishmania major	79%	100%
V5BTV5	Trypanosoma cruzi	35%	98%