LsmAD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PAB1-binding protein , putative

Species:

Leishmania braziliensis

UniProt:

A4H699_LEIBR

TriTrypDb:

LbrM.10.1220 , LBRM2903_100021500

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H699

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H699

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0034063	stress granule assembly	7	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.350
CLV_C14_Caspase3-7	474	478	PF00656	0.826
CLV_C14_Caspase3-7	68	72	PF00656	0.399
CLV_NRD_NRD_1	229	231	PF00675	0.663
CLV_NRD_NRD_1	494	496	PF00675	0.793
CLV_PCSK_KEX2_1	223	225	PF00082	0.749
CLV_PCSK_KEX2_1	494	496	PF00082	0.776
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.749
CLV_PCSK_SKI1_1	179	183	PF00082	0.438
CLV_PCSK_SKI1_1	307	311	PF00082	0.619
CLV_PCSK_SKI1_1	93	97	PF00082	0.613
DEG_Nend_Nbox_1	1	3	PF02207	0.715
DOC_CYCLIN_yClb5_NLxxxL_5	190	196	PF00134	0.438
DOC_MAPK_MEF2A_6	12	20	PF00069	0.377
DOC_PP1_RVXF_1	115	122	PF00149	0.579
DOC_PP2B_LxvP_1	276	279	PF13499	0.711
DOC_PP4_FxxP_1	302	305	PF00568	0.662
DOC_PP4_MxPP_1	421	424	PF00568	0.717
DOC_SPAK_OSR1_1	148	152	PF12202	0.424
DOC_USP7_MATH_1	238	242	PF00917	0.679
DOC_USP7_MATH_1	282	286	PF00917	0.789
DOC_USP7_MATH_1	295	299	PF00917	0.627
DOC_USP7_MATH_1	305	309	PF00917	0.640
DOC_USP7_MATH_1	4	8	PF00917	0.634
DOC_USP7_MATH_1	455	459	PF00917	0.627
DOC_USP7_MATH_1	475	479	PF00917	0.770
DOC_USP7_UBL2_3	515	519	PF12436	0.728
DOC_WW_Pin1_4	291	296	PF00397	0.647
DOC_WW_Pin1_4	297	302	PF00397	0.643
DOC_WW_Pin1_4	431	436	PF00397	0.701
DOC_WW_Pin1_4	98	103	PF00397	0.651
LIG_14-3-3_CanoR_1	442	448	PF00244	0.867
LIG_BIR_III_4	218	222	PF00653	0.711
LIG_deltaCOP1_diTrp_1	329	336	PF00928	0.666
LIG_eIF4E_1	15	21	PF01652	0.344
LIG_EVH1_1	276	280	PF00568	0.709
LIG_FHA_1	159	165	PF00498	0.344
LIG_FHA_1	187	193	PF00498	0.344
LIG_FHA_1	201	207	PF00498	0.344
LIG_FHA_1	22	28	PF00498	0.509
LIG_FHA_1	250	256	PF00498	0.784
LIG_FHA_1	298	304	PF00498	0.672
LIG_FHA_1	454	460	PF00498	0.593
LIG_FHA_2	152	158	PF00498	0.356
LIG_FHA_2	160	166	PF00498	0.328
LIG_FHA_2	178	184	PF00498	0.344
LIG_FHA_2	227	233	PF00498	0.741
LIG_FHA_2	41	47	PF00498	0.344
LIG_LIR_Apic_2	300	305	PF02991	0.668
LIG_LIR_Apic_2	321	327	PF02991	0.610
LIG_LIR_Apic_2	342	347	PF02991	0.711
LIG_LIR_Gen_1	137	145	PF02991	0.565
LIG_LIR_Gen_1	14	25	PF02991	0.344
LIG_LIR_Gen_1	210	219	PF02991	0.317
LIG_LIR_Nem_3	137	143	PF02991	0.576
LIG_LIR_Nem_3	14	20	PF02991	0.344
LIG_LIR_Nem_3	210	215	PF02991	0.317
LIG_PAM2_1	293	305	PF00658	0.586
LIG_RPA_C_Fungi	37	49	PF08784	0.438
LIG_SH2_CRK	324	328	PF00017	0.564
LIG_SH2_CRK	344	348	PF00017	0.512
LIG_SH2_CRK	359	363	PF00017	0.542
LIG_SH2_GRB2like	17	20	PF00017	0.344
LIG_SH2_NCK_1	324	328	PF00017	0.610
LIG_SH2_NCK_1	344	348	PF00017	0.512
LIG_SH2_SRC	84	87	PF00017	0.438
LIG_SH2_STAP1	160	164	PF00017	0.344
LIG_SH2_STAP1	337	341	PF00017	0.659
LIG_SH2_STAP1	84	88	PF00017	0.438
LIG_SH2_STAT5	15	18	PF00017	0.345
LIG_SH2_STAT5	160	163	PF00017	0.344
LIG_SH2_STAT5	205	208	PF00017	0.424
LIG_SH3_1	344	350	PF00018	0.560
LIG_SH3_3	262	268	PF00018	0.751
LIG_SH3_3	271	277	PF00018	0.651
LIG_SH3_3	289	295	PF00018	0.549
LIG_SH3_3	298	304	PF00018	0.658
LIG_SH3_3	344	350	PF00018	0.654
LIG_SH3_3	360	366	PF00018	0.764
LIG_SH3_3	421	427	PF00018	0.687
LIG_SH3_3	445	451	PF00018	0.688
LIG_SUMO_SIM_par_1	23	29	PF11976	0.424
LIG_TRAF2_1	269	272	PF00917	0.709
LIG_TYR_ITIM	13	18	PF00017	0.344
LIG_UBA3_1	87	93	PF00899	0.424
LIG_WRC_WIRS_1	306	311	PF05994	0.625
MOD_CDC14_SPxK_1	434	437	PF00782	0.749
MOD_CDK_SPxK_1	431	437	PF00069	0.742
MOD_CK1_1	134	140	PF00069	0.645
MOD_CK1_1	167	173	PF00069	0.344
MOD_CK1_1	210	216	PF00069	0.400
MOD_CK1_1	342	348	PF00069	0.663
MOD_CK1_1	73	79	PF00069	0.438
MOD_CK2_1	151	157	PF00069	0.344
MOD_CK2_1	177	183	PF00069	0.438
MOD_CK2_1	226	232	PF00069	0.740
MOD_Cter_Amidation	221	224	PF01082	0.546
MOD_GlcNHglycan	185	189	PF01048	0.379
MOD_GlcNHglycan	240	243	PF01048	0.582
MOD_GlcNHglycan	283	287	PF01048	0.809
MOD_GlcNHglycan	297	300	PF01048	0.572
MOD_GlcNHglycan	391	394	PF01048	0.579
MOD_GlcNHglycan	473	476	PF01048	0.801
MOD_GlcNHglycan	477	481	PF01048	0.752
MOD_GlcNHglycan	487	490	PF01048	0.674
MOD_GlcNHglycan	516	519	PF01048	0.638
MOD_GlcNHglycan	67	70	PF01048	0.399
MOD_GSK3_1	196	203	PF00069	0.349
MOD_GSK3_1	244	251	PF00069	0.655
MOD_GSK3_1	291	298	PF00069	0.665
MOD_GSK3_1	451	458	PF00069	0.721
MOD_GSK3_1	471	478	PF00069	0.820
MOD_GSK3_1	61	68	PF00069	0.432
MOD_N-GLC_1	389	394	PF02516	0.639
MOD_N-GLC_1	4	9	PF02516	0.641
MOD_NEK2_1	159	164	PF00069	0.351
MOD_NEK2_1	38	43	PF00069	0.467
MOD_PIKK_1	443	449	PF00454	0.770
MOD_PIKK_1	453	459	PF00454	0.773
MOD_PKA_2	256	262	PF00069	0.588
MOD_Plk_1	282	288	PF00069	0.557
MOD_Plk_1	339	345	PF00069	0.621
MOD_Plk_1	76	82	PF00069	0.351
MOD_Plk_2-3	115	121	PF00069	0.673
MOD_Plk_4	207	213	PF00069	0.317
MOD_Plk_4	21	27	PF00069	0.424
MOD_Plk_4	288	294	PF00069	0.717
MOD_Plk_4	305	311	PF00069	0.576
MOD_Plk_4	61	67	PF00069	0.489
MOD_ProDKin_1	291	297	PF00069	0.646
MOD_ProDKin_1	431	437	PF00069	0.704
MOD_ProDKin_1	98	104	PF00069	0.651
MOD_SUMO_rev_2	109	119	PF00179	0.706
MOD_SUMO_rev_2	165	170	PF00179	0.438
MOD_SUMO_rev_2	85	95	PF00179	0.438
TRG_DiLeu_BaEn_2	50	56	PF01217	0.438
TRG_DiLeu_BaEn_4	271	277	PF01217	0.738
TRG_ENDOCYTIC_2	15	18	PF00928	0.344
TRG_ENDOCYTIC_2	84	87	PF00928	0.344
TRG_ER_diArg_1	493	495	PF00400	0.773
TRG_ER_diLys_1	515	519	PF00400	0.757
TRG_NLS_MonoExtC_3	490	495	PF00514	0.768

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I433	Leptomonas seymouri	68%	100%
A0A3S5H6H2	Leishmania donovani	89%	99%
A0A422NGM0	Trypanosoma rangeli	39%	95%
A4HUM3	Leishmania infantum	89%	99%
E9ANC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4QHA3	Leishmania major	87%	100%
V5DKQ2	Trypanosoma cruzi	37%	94%