Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H698_LEIBR

TriTrypDb:

LbrM.10.1210 , LBRM2903_100021300

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H698

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H698

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.371
CLV_NRD_NRD_1	146	148	PF00675	0.611
CLV_NRD_NRD_1	206	208	PF00675	0.446
CLV_NRD_NRD_1	332	334	PF00675	0.453
CLV_NRD_NRD_1	349	351	PF00675	0.571
CLV_NRD_NRD_1	409	411	PF00675	0.455
CLV_NRD_NRD_1	497	499	PF00675	0.577
CLV_PCSK_KEX2_1	146	148	PF00082	0.536
CLV_PCSK_KEX2_1	206	208	PF00082	0.522
CLV_PCSK_KEX2_1	275	277	PF00082	0.447
CLV_PCSK_KEX2_1	332	334	PF00082	0.453
CLV_PCSK_KEX2_1	497	499	PF00082	0.577
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.417
CLV_PCSK_PC7_1	271	277	PF00082	0.435
CLV_PCSK_SKI1_1	298	302	PF00082	0.536
CLV_PCSK_SKI1_1	485	489	PF00082	0.524
DEG_APCC_DBOX_1	179	187	PF00400	0.422
DEG_APCC_DBOX_1	270	278	PF00400	0.550
DEG_APCC_DBOX_1	332	340	PF00400	0.473
DEG_Nend_UBRbox_4	1	3	PF02207	0.486
DOC_CDC14_PxL_1	382	390	PF14671	0.481
DOC_CKS1_1	27	32	PF01111	0.538
DOC_CKS1_1	355	360	PF01111	0.565
DOC_CYCLIN_RxL_1	127	138	PF00134	0.370
DOC_CYCLIN_yCln2_LP_2	277	283	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	63	69	PF00134	0.510
DOC_MAPK_DCC_7	32	40	PF00069	0.544
DOC_MAPK_gen_1	275	281	PF00069	0.435
DOC_MAPK_gen_1	32	40	PF00069	0.525
DOC_MAPK_gen_1	332	338	PF00069	0.475
DOC_MAPK_MEF2A_6	115	123	PF00069	0.668
DOC_MAPK_MEF2A_6	448	457	PF00069	0.562
DOC_MAPK_MEF2A_6	7	15	PF00069	0.463
DOC_PP1_RVXF_1	131	138	PF00149	0.363
DOC_PP2B_LxvP_1	277	280	PF13499	0.539
DOC_PP2B_LxvP_1	300	303	PF13499	0.534
DOC_PP2B_LxvP_1	514	517	PF13499	0.751
DOC_PP2B_LxvP_1	63	66	PF13499	0.520
DOC_PP4_FxxP_1	40	43	PF00568	0.494
DOC_PP4_FxxP_1	52	55	PF00568	0.476
DOC_USP7_MATH_1	103	107	PF00917	0.527
DOC_USP7_MATH_1	421	425	PF00917	0.567
DOC_USP7_MATH_1	75	79	PF00917	0.517
DOC_USP7_MATH_2	335	341	PF00917	0.589
DOC_WW_Pin1_4	237	242	PF00397	0.426
DOC_WW_Pin1_4	259	264	PF00397	0.465
DOC_WW_Pin1_4	26	31	PF00397	0.538
DOC_WW_Pin1_4	351	356	PF00397	0.606
DOC_WW_Pin1_4	360	365	PF00397	0.566
DOC_WW_Pin1_4	446	451	PF00397	0.699
DOC_WW_Pin1_4	519	524	PF00397	0.706
LIG_14-3-3_CanoR_1	170	178	PF00244	0.384
LIG_14-3-3_CanoR_1	207	216	PF00244	0.578
LIG_14-3-3_CanoR_1	284	292	PF00244	0.633
LIG_14-3-3_CanoR_1	506	514	PF00244	0.599
LIG_14-3-3_CterR_2	527	529	PF00244	0.577
LIG_Actin_WH2_2	224	240	PF00022	0.445
LIG_CtBP_PxDLS_1	24	28	PF00389	0.534
LIG_deltaCOP1_diTrp_1	124	131	PF00928	0.384
LIG_FHA_1	118	124	PF00498	0.654
LIG_FHA_1	159	165	PF00498	0.540
LIG_FHA_1	18	24	PF00498	0.547
LIG_FHA_1	222	228	PF00498	0.578
LIG_FHA_1	438	444	PF00498	0.744
LIG_FHA_1	54	60	PF00498	0.504
LIG_FHA_1	85	91	PF00498	0.549
LIG_FHA_2	447	453	PF00498	0.574
LIG_FHA_2	481	487	PF00498	0.488
LIG_LIR_Apic_2	49	55	PF02991	0.504
LIG_LIR_Gen_1	124	131	PF02991	0.384
LIG_LIR_Gen_1	136	143	PF02991	0.322
LIG_LIR_Gen_1	193	202	PF02991	0.366
LIG_LIR_Gen_1	478	488	PF02991	0.528
LIG_LIR_Nem_3	124	129	PF02991	0.386
LIG_LIR_Nem_3	136	140	PF02991	0.333
LIG_LIR_Nem_3	161	165	PF02991	0.425
LIG_LIR_Nem_3	193	197	PF02991	0.488
LIG_LIR_Nem_3	392	397	PF02991	0.601
LIG_LYPXL_yS_3	379	382	PF13949	0.509
LIG_LYPXL_yS_3	397	400	PF13949	0.535
LIG_NRBOX	366	372	PF00104	0.498
LIG_PCNA_yPIPBox_3	448	461	PF02747	0.408
LIG_Pex14_1	330	334	PF04695	0.459
LIG_Pex14_2	36	40	PF04695	0.563
LIG_PTB_Apo_2	156	163	PF02174	0.660
LIG_RPA_C_Fungi	414	426	PF08784	0.695
LIG_SH2_CRK	194	198	PF00017	0.366
LIG_SH2_STAT3	202	205	PF00017	0.371
LIG_SH2_STAT3	346	349	PF00017	0.378
LIG_SH3_3	116	122	PF00018	0.405
LIG_SH3_3	349	355	PF00018	0.490
LIG_SH3_3	395	401	PF00018	0.531
LIG_SH3_3	447	453	PF00018	0.683
LIG_SH3_3	513	519	PF00018	0.716
LIG_SH3_3	68	74	PF00018	0.525
LIG_SUMO_SIM_par_1	233	240	PF11976	0.558
LIG_SUMO_SIM_par_1	247	254	PF11976	0.389
LIG_SUMO_SIM_par_1	334	340	PF11976	0.580
LIG_TRAF2_1	308	311	PF00917	0.572
LIG_TRAF2_1	401	404	PF00917	0.501
LIG_TRAF2_2	221	226	PF00917	0.536
LIG_TYR_ITIM	192	197	PF00017	0.366
LIG_TYR_ITIM	377	382	PF00017	0.625
LIG_WRC_WIRS_1	342	347	PF05994	0.599
LIG_WRC_WIRS_1	457	462	PF05994	0.651
MOD_CDK_SPxK_1	26	32	PF00069	0.539
MOD_CDK_SPxxK_3	259	266	PF00069	0.441
MOD_CDK_SPxxK_3	354	361	PF00069	0.512
MOD_CK1_1	253	259	PF00069	0.629
MOD_CK1_1	26	32	PF00069	0.539
MOD_CK1_1	354	360	PF00069	0.718
MOD_CK1_1	45	51	PF00069	0.493
MOD_CK2_1	170	176	PF00069	0.541
MOD_CK2_1	366	372	PF00069	0.600
MOD_Cter_Amidation	144	147	PF01082	0.447
MOD_GlcNHglycan	143	146	PF01048	0.389
MOD_GlcNHglycan	153	156	PF01048	0.462
MOD_GlcNHglycan	259	262	PF01048	0.717
MOD_GlcNHglycan	303	306	PF01048	0.586
MOD_GlcNHglycan	339	342	PF01048	0.577
MOD_GlcNHglycan	77	80	PF01048	0.534
MOD_GSK3_1	210	217	PF00069	0.509
MOD_GSK3_1	253	260	PF00069	0.468
MOD_GSK3_1	337	344	PF00069	0.586
MOD_GSK3_1	471	478	PF00069	0.632
MOD_GSK3_1	505	512	PF00069	0.565
MOD_GSK3_1	82	89	PF00069	0.564
MOD_LATS_1	212	218	PF00433	0.527
MOD_LATS_1	80	86	PF00433	0.807
MOD_N-GLC_1	158	163	PF02516	0.655
MOD_N-GLC_1	509	514	PF02516	0.572
MOD_NEK2_1	135	140	PF00069	0.381
MOD_NEK2_1	247	252	PF00069	0.637
MOD_NEK2_1	444	449	PF00069	0.728
MOD_NEK2_1	456	461	PF00069	0.440
MOD_NEK2_1	69	74	PF00069	0.507
MOD_NEK2_2	341	346	PF00069	0.595
MOD_NEK2_2	421	426	PF00069	0.476
MOD_PIKK_1	103	109	PF00454	0.524
MOD_PKA_1	82	88	PF00069	0.803
MOD_PKA_2	505	511	PF00069	0.548
MOD_Plk_1	158	164	PF00069	0.551
MOD_Plk_1	509	515	PF00069	0.570
MOD_Plk_4	341	347	PF00069	0.511
MOD_Plk_4	366	372	PF00069	0.600
MOD_Plk_4	463	469	PF00069	0.407
MOD_ProDKin_1	237	243	PF00069	0.418
MOD_ProDKin_1	259	265	PF00069	0.465
MOD_ProDKin_1	26	32	PF00069	0.539
MOD_ProDKin_1	351	357	PF00069	0.610
MOD_ProDKin_1	360	366	PF00069	0.563
MOD_ProDKin_1	446	452	PF00069	0.695
MOD_ProDKin_1	519	525	PF00069	0.707
TRG_DiLeu_BaEn_1	404	409	PF01217	0.511
TRG_DiLeu_BaEn_4	372	378	PF01217	0.612
TRG_DiLeu_LyEn_5	181	186	PF01217	0.386
TRG_ENDOCYTIC_2	194	197	PF00928	0.369
TRG_ENDOCYTIC_2	379	382	PF00928	0.509
TRG_ENDOCYTIC_2	397	400	PF00928	0.535
TRG_ENDOCYTIC_2	481	484	PF00928	0.513
TRG_ER_diArg_1	146	148	PF00400	0.530
TRG_ER_diArg_1	32	35	PF00400	0.534
TRG_ER_diArg_1	332	334	PF00400	0.453
TRG_ER_diArg_1	496	498	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA4	Leptomonas seymouri	49%	100%
A0A3Q8IHA3	Leishmania donovani	70%	100%
A4HUM2	Leishmania infantum	70%	100%
E9ANC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QHA4	Leishmania major	67%	100%