MIF4G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4 gamma 5

Species:

Leishmania braziliensis

UniProt:

A4H696_LEIBR

TriTrypDb:

LbrM.10.1180 , LBRM2903_100020800 , LBRM2903_100020900

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H696

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H696

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.648
CLV_C14_Caspase3-7	263	267	PF00656	0.465
CLV_C14_Caspase3-7	84	88	PF00656	0.529
CLV_NRD_NRD_1	113	115	PF00675	0.697
CLV_NRD_NRD_1	166	168	PF00675	0.469
CLV_NRD_NRD_1	328	330	PF00675	0.246
CLV_NRD_NRD_1	403	405	PF00675	0.630
CLV_NRD_NRD_1	706	708	PF00675	0.441
CLV_NRD_NRD_1	740	742	PF00675	0.456
CLV_NRD_NRD_1	780	782	PF00675	0.601
CLV_PCSK_KEX2_1	113	115	PF00082	0.669
CLV_PCSK_KEX2_1	166	168	PF00082	0.473
CLV_PCSK_KEX2_1	272	274	PF00082	0.354
CLV_PCSK_KEX2_1	328	330	PF00082	0.239
CLV_PCSK_KEX2_1	377	379	PF00082	0.252
CLV_PCSK_KEX2_1	403	405	PF00082	0.710
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.291
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.295
CLV_PCSK_SKI1_1	161	165	PF00082	0.628
CLV_PCSK_SKI1_1	189	193	PF00082	0.303
CLV_PCSK_SKI1_1	209	213	PF00082	0.320
CLV_PCSK_SKI1_1	273	277	PF00082	0.315
CLV_PCSK_SKI1_1	519	523	PF00082	0.436
CLV_PCSK_SKI1_1	604	608	PF00082	0.592
CLV_PCSK_SKI1_1	703	707	PF00082	0.435
CLV_PCSK_SKI1_1	708	712	PF00082	0.446
CLV_PCSK_SKI1_1	734	738	PF00082	0.473
CLV_PCSK_SKI1_1	741	745	PF00082	0.411
CLV_Separin_Metazoa	251	255	PF03568	0.539
CLV_Separin_Metazoa	704	708	PF03568	0.479
DEG_APCC_DBOX_1	505	513	PF00400	0.371
DEG_APCC_DBOX_1	740	748	PF00400	0.469
DEG_Nend_UBRbox_3	1	3	PF02207	0.672
DOC_MAPK_gen_1	186	196	PF00069	0.484
DOC_MAPK_gen_1	292	299	PF00069	0.438
DOC_MAPK_MEF2A_6	713	722	PF00069	0.468
DOC_MAPK_MEF2A_6	766	773	PF00069	0.266
DOC_MAPK_RevD_3	769	782	PF00069	0.292
DOC_PP1_RVXF_1	207	213	PF00149	0.504
DOC_PP1_RVXF_1	284	290	PF00149	0.464
DOC_PP1_RVXF_1	375	382	PF00149	0.480
DOC_SPAK_OSR1_1	611	615	PF12202	0.329
DOC_USP7_MATH_1	218	222	PF00917	0.452
DOC_USP7_MATH_1	27	31	PF00917	0.518
DOC_USP7_MATH_1	412	416	PF00917	0.564
DOC_USP7_MATH_1	627	631	PF00917	0.547
DOC_USP7_MATH_1	63	67	PF00917	0.648
DOC_USP7_MATH_1	91	95	PF00917	0.590
DOC_WW_Pin1_4	25	30	PF00397	0.517
DOC_WW_Pin1_4	275	280	PF00397	0.539
DOC_WW_Pin1_4	619	624	PF00397	0.405
DOC_WW_Pin1_4	666	671	PF00397	0.512
DOC_WW_Pin1_4	676	681	PF00397	0.393
LIG_14-3-3_CanoR_1	113	123	PF00244	0.449
LIG_14-3-3_CanoR_1	19	24	PF00244	0.645
LIG_14-3-3_CanoR_1	197	204	PF00244	0.437
LIG_14-3-3_CanoR_1	257	261	PF00244	0.546
LIG_14-3-3_CanoR_1	273	278	PF00244	0.367
LIG_14-3-3_CanoR_1	495	501	PF00244	0.406
LIG_14-3-3_CanoR_1	559	565	PF00244	0.295
LIG_14-3-3_CanoR_1	762	766	PF00244	0.507
LIG_14-3-3_CanoR_1	8	13	PF00244	0.680
LIG_Actin_WH2_2	691	709	PF00022	0.483
LIG_Actin_WH2_2	747	764	PF00022	0.481
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.711
LIG_BRCT_BRCA1_1	27	31	PF00533	0.518
LIG_BRCT_BRCA1_1	684	688	PF00533	0.309
LIG_BRCT_BRCA1_1	731	735	PF00533	0.424
LIG_CaM_IQ_9	284	300	PF13499	0.491
LIG_FHA_1	569	575	PF00498	0.327
LIG_FHA_1	62	68	PF00498	0.530
LIG_FHA_1	715	721	PF00498	0.394
LIG_FHA_2	198	204	PF00498	0.473
LIG_FHA_2	214	220	PF00498	0.546
LIG_FHA_2	364	370	PF00498	0.504
LIG_FHA_2	596	602	PF00498	0.616
LIG_FHA_2	637	643	PF00498	0.599
LIG_FHA_2	657	663	PF00498	0.239
LIG_FHA_2	762	768	PF00498	0.460
LIG_Integrin_isoDGR_2	428	430	PF01839	0.660
LIG_IRF3_LxIS_1	367	373	PF10401	0.379
LIG_LIR_Gen_1	220	231	PF02991	0.480
LIG_LIR_Gen_1	333	343	PF02991	0.442
LIG_LIR_Gen_1	453	461	PF02991	0.422
LIG_LIR_Gen_1	511	521	PF02991	0.377
LIG_LIR_Gen_1	541	552	PF02991	0.392
LIG_LIR_Gen_1	652	661	PF02991	0.398
LIG_LIR_Gen_1	685	695	PF02991	0.335
LIG_LIR_Nem_3	107	112	PF02991	0.533
LIG_LIR_Nem_3	220	226	PF02991	0.448
LIG_LIR_Nem_3	333	338	PF02991	0.442
LIG_LIR_Nem_3	453	457	PF02991	0.553
LIG_LIR_Nem_3	511	516	PF02991	0.360
LIG_LIR_Nem_3	541	547	PF02991	0.409
LIG_LIR_Nem_3	610	615	PF02991	0.371
LIG_LIR_Nem_3	652	657	PF02991	0.383
LIG_LIR_Nem_3	685	691	PF02991	0.315
LIG_LIR_Nem_3	700	705	PF02991	0.378
LIG_MLH1_MIPbox_1	684	688	PF16413	0.388
LIG_NRBOX	317	323	PF00104	0.447
LIG_NRBOX	614	620	PF00104	0.409
LIG_PCNA_PIPBox_1	380	389	PF02747	0.491
LIG_PCNA_yPIPBox_3	305	318	PF02747	0.577
LIG_PCNA_yPIPBox_3	377	387	PF02747	0.539
LIG_Pex14_1	492	496	PF04695	0.455
LIG_Pex14_2	735	739	PF04695	0.374
LIG_REV1ctd_RIR_1	209	217	PF16727	0.504
LIG_RPA_C_Fungi	745	757	PF08784	0.493
LIG_SH2_CRK	223	227	PF00017	0.193
LIG_SH2_CRK	335	339	PF00017	0.417
LIG_SH2_CRK	621	625	PF00017	0.436
LIG_SH2_GRB2like	223	226	PF00017	0.193
LIG_SH2_GRB2like	496	499	PF00017	0.417
LIG_SH2_GRB2like	653	656	PF00017	0.396
LIG_SH2_PTP2	227	230	PF00017	0.274
LIG_SH2_SRC	356	359	PF00017	0.350
LIG_SH2_STAP1	126	130	PF00017	0.638
LIG_SH2_STAP1	223	227	PF00017	0.417
LIG_SH2_STAP1	693	697	PF00017	0.490
LIG_SH2_STAT5	223	226	PF00017	0.350
LIG_SH2_STAT5	227	230	PF00017	0.276
LIG_SH2_STAT5	488	491	PF00017	0.331
LIG_SH2_STAT5	496	499	PF00017	0.341
LIG_SH2_STAT5	502	505	PF00017	0.384
LIG_SH2_STAT5	550	553	PF00017	0.320
LIG_SH2_STAT5	621	624	PF00017	0.433
LIG_SH2_STAT5	653	656	PF00017	0.343
LIG_SH2_STAT5	723	726	PF00017	0.340
LIG_SH3_3	343	349	PF00018	0.417
LIG_SH3_3	435	441	PF00018	0.592
LIG_SH3_3	446	452	PF00018	0.489
LIG_SH3_3	53	59	PF00018	0.683
LIG_SH3_3	64	70	PF00018	0.726
LIG_SH3_3	71	77	PF00018	0.728
LIG_SH3_3	93	99	PF00018	0.664
LIG_SUMO_SIM_anti_2	471	479	PF11976	0.393
LIG_SUMO_SIM_anti_2	483	488	PF11976	0.425
LIG_SUMO_SIM_anti_2	583	588	PF11976	0.287
LIG_SUMO_SIM_anti_2	639	646	PF11976	0.427
LIG_SUMO_SIM_par_1	471	479	PF11976	0.549
LIG_SUMO_SIM_par_1	716	721	PF11976	0.453
LIG_SUMO_SIM_par_1	767	776	PF11976	0.403
LIG_TRAF2_1	200	203	PF00917	0.417
LIG_TRAF2_1	443	446	PF00917	0.644
LIG_TRAF2_1	538	541	PF00917	0.527
LIG_TRAF2_1	77	80	PF00917	0.761
LIG_TRAF2_2	600	605	PF00917	0.637
LIG_TYR_ITSM	331	338	PF00017	0.417
LIG_UBA3_1	512	519	PF00899	0.403
LIG_UBA3_1	543	549	PF00899	0.457
LIG_UBA3_1	736	742	PF00899	0.307
LIG_WRC_WIRS_1	687	692	PF05994	0.317
MOD_CK1_1	157	163	PF00069	0.600
MOD_CK1_1	22	28	PF00069	0.664
MOD_CK1_1	221	227	PF00069	0.436
MOD_CK1_1	37	43	PF00069	0.772
MOD_CK1_1	475	481	PF00069	0.449
MOD_CK1_1	568	574	PF00069	0.339
MOD_CK1_1	94	100	PF00069	0.659
MOD_CK2_1	179	185	PF00069	0.440
MOD_CK2_1	196	202	PF00069	0.292
MOD_CK2_1	213	219	PF00069	0.429
MOD_CK2_1	234	240	PF00069	0.442
MOD_CK2_1	363	369	PF00069	0.424
MOD_CK2_1	466	472	PF00069	0.428
MOD_CK2_1	535	541	PF00069	0.514
MOD_CK2_1	761	767	PF00069	0.449
MOD_CK2_1	769	775	PF00069	0.416
MOD_CK2_1	94	100	PF00069	0.684
MOD_GlcNHglycan	10	13	PF01048	0.633
MOD_GlcNHglycan	25	28	PF01048	0.634
MOD_GlcNHglycan	262	265	PF01048	0.424
MOD_GlcNHglycan	289	292	PF01048	0.422
MOD_GlcNHglycan	36	39	PF01048	0.787
MOD_GlcNHglycan	434	437	PF01048	0.603
MOD_GlcNHglycan	44	47	PF01048	0.628
MOD_GlcNHglycan	537	540	PF01048	0.524
MOD_GlcNHglycan	684	687	PF01048	0.328
MOD_GSK3_1	157	164	PF00069	0.591
MOD_GSK3_1	19	26	PF00069	0.588
MOD_GSK3_1	256	263	PF00069	0.368
MOD_GSK3_1	472	479	PF00069	0.448
MOD_GSK3_1	496	503	PF00069	0.447
MOD_GSK3_1	666	673	PF00069	0.478
MOD_GSK3_1	682	689	PF00069	0.227
MOD_GSK3_1	725	732	PF00069	0.267
MOD_GSK3_1	8	15	PF00069	0.581
MOD_GSK3_1	90	97	PF00069	0.606
MOD_N-GLC_1	142	147	PF02516	0.719
MOD_N-GLC_1	154	159	PF02516	0.697
MOD_N-GLC_1	212	217	PF02516	0.308
MOD_N-GLC_1	413	418	PF02516	0.696
MOD_N-GLC_1	432	437	PF02516	0.647
MOD_NEK2_1	212	217	PF00069	0.329
MOD_NEK2_1	23	28	PF00069	0.694
MOD_NEK2_1	234	239	PF00069	0.358
MOD_NEK2_1	260	265	PF00069	0.417
MOD_NEK2_1	303	308	PF00069	0.308
MOD_NEK2_1	370	375	PF00069	0.295
MOD_NEK2_1	386	391	PF00069	0.308
MOD_NEK2_1	424	429	PF00069	0.555
MOD_NEK2_1	464	469	PF00069	0.413
MOD_NEK2_1	512	517	PF00069	0.437
MOD_NEK2_1	682	687	PF00069	0.383
MOD_NEK2_1	697	702	PF00069	0.359
MOD_NEK2_1	729	734	PF00069	0.495
MOD_NEK2_1	761	766	PF00069	0.490
MOD_NEK2_1	769	774	PF00069	0.481
MOD_NEK2_2	218	223	PF00069	0.291
MOD_PIKK_1	114	120	PF00454	0.425
MOD_PIKK_1	12	18	PF00454	0.545
MOD_PIKK_1	697	703	PF00454	0.483
MOD_PKA_2	196	202	PF00069	0.274
MOD_PKA_2	23	29	PF00069	0.556
MOD_PKA_2	256	262	PF00069	0.427
MOD_PKA_2	363	369	PF00069	0.471
MOD_PKA_2	402	408	PF00069	0.660
MOD_PKA_2	7	13	PF00069	0.681
MOD_PKA_2	761	767	PF00069	0.493
MOD_Plk_1	142	148	PF00069	0.720
MOD_Plk_1	154	160	PF00069	0.698
MOD_Plk_1	218	224	PF00069	0.306
MOD_Plk_1	333	339	PF00069	0.485
MOD_Plk_1	368	374	PF00069	0.193
MOD_Plk_1	432	438	PF00069	0.499
MOD_Plk_1	504	510	PF00069	0.506
MOD_Plk_1	649	655	PF00069	0.466
MOD_Plk_1	94	100	PF00069	0.714
MOD_Plk_2-3	142	148	PF00069	0.720
MOD_Plk_4	256	262	PF00069	0.398
MOD_Plk_4	27	33	PF00069	0.678
MOD_Plk_4	317	323	PF00069	0.417
MOD_Plk_4	333	339	PF00069	0.485
MOD_Plk_4	472	478	PF00069	0.487
MOD_Plk_4	512	518	PF00069	0.507
MOD_Plk_4	553	559	PF00069	0.457
MOD_Plk_4	560	566	PF00069	0.463
MOD_Plk_4	636	642	PF00069	0.579
MOD_Plk_4	649	655	PF00069	0.334
MOD_Plk_4	714	720	PF00069	0.409
MOD_Plk_4	769	775	PF00069	0.423
MOD_ProDKin_1	25	31	PF00069	0.519
MOD_ProDKin_1	275	281	PF00069	0.417
MOD_ProDKin_1	619	625	PF00069	0.422
MOD_ProDKin_1	666	672	PF00069	0.501
MOD_ProDKin_1	676	682	PF00069	0.388
MOD_SUMO_for_1	187	190	PF00179	0.274
MOD_SUMO_for_1	77	80	PF00179	0.692
MOD_SUMO_rev_2	593	600	PF00179	0.537
MOD_SUMO_rev_2	601	608	PF00179	0.514
TRG_DiLeu_BaEn_3	242	248	PF01217	0.350
TRG_ENDOCYTIC_2	223	226	PF00928	0.417
TRG_ENDOCYTIC_2	227	230	PF00928	0.276
TRG_ENDOCYTIC_2	335	338	PF00928	0.289
TRG_ENDOCYTIC_2	454	457	PF00928	0.547
TRG_ENDOCYTIC_2	702	705	PF00928	0.459
TRG_ER_diArg_1	112	114	PF00400	0.663
TRG_ER_diArg_1	166	168	PF00400	0.543
TRG_ER_diArg_1	506	509	PF00400	0.381
TRG_NES_CRM1_1	185	198	PF08389	0.334
TRG_NES_CRM1_1	760	775	PF08389	0.260

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC9	Leptomonas seymouri	70%	100%
A0A0S4J374	Bodo saltans	29%	90%
A0A1X0NQC6	Trypanosomatidae	41%	100%
A0A3R7KDY4	Trypanosoma rangeli	39%	100%
A0A3S7WRD0	Leishmania donovani	91%	100%
A4HUL9	Leishmania infantum	91%	100%
C9ZVP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ANB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHA6	Leishmania major	90%	100%
V5BTU8	Trypanosoma cruzi	39%	100%