Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H695_LEIBR

TriTrypDb:

LbrM.10.1170 , LBRM2903_100020700

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H695

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H695

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.553
CLV_C14_Caspase3-7	497	501	PF00656	0.483
CLV_NRD_NRD_1	124	126	PF00675	0.694
CLV_NRD_NRD_1	267	269	PF00675	0.577
CLV_NRD_NRD_1	327	329	PF00675	0.652
CLV_NRD_NRD_1	42	44	PF00675	0.636
CLV_NRD_NRD_1	422	424	PF00675	0.609
CLV_NRD_NRD_1	469	471	PF00675	0.700
CLV_NRD_NRD_1	52	54	PF00675	0.617
CLV_NRD_NRD_1	552	554	PF00675	0.620
CLV_PCSK_KEX2_1	126	128	PF00082	0.688
CLV_PCSK_KEX2_1	267	269	PF00082	0.577
CLV_PCSK_KEX2_1	326	328	PF00082	0.655
CLV_PCSK_KEX2_1	42	44	PF00082	0.568
CLV_PCSK_KEX2_1	420	422	PF00082	0.597
CLV_PCSK_KEX2_1	468	470	PF00082	0.718
CLV_PCSK_KEX2_1	52	54	PF00082	0.564
CLV_PCSK_KEX2_1	552	554	PF00082	0.620
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.688
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.667
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.718
CLV_PCSK_PC7_1	417	423	PF00082	0.555
CLV_PCSK_SKI1_1	145	149	PF00082	0.668
CLV_PCSK_SKI1_1	194	198	PF00082	0.637
CLV_PCSK_SKI1_1	229	233	PF00082	0.693
CLV_PCSK_SKI1_1	312	316	PF00082	0.405
CLV_PCSK_SKI1_1	357	361	PF00082	0.635
CLV_PCSK_SKI1_1	42	46	PF00082	0.569
CLV_PCSK_SKI1_1	434	438	PF00082	0.540
CLV_PCSK_SKI1_1	555	559	PF00082	0.525
CLV_Separin_Metazoa	195	199	PF03568	0.414
CLV_Separin_Metazoa	512	516	PF03568	0.655
DEG_APCC_DBOX_1	124	132	PF00400	0.587
DEG_APCC_DBOX_1	144	152	PF00400	0.332
DEG_APCC_DBOX_1	304	312	PF00400	0.426
DEG_APCC_DBOX_1	325	333	PF00400	0.612
DEG_APCC_DBOX_1	433	441	PF00400	0.533
DEG_APCC_DBOX_1	537	545	PF00400	0.567
DEG_COP1_1	76	84	PF00400	0.573
DEG_MDM2_SWIB_1	142	149	PF02201	0.664
DEG_Nend_Nbox_1	1	3	PF02207	0.698
DEG_SPOP_SBC_1	19	23	PF00917	0.807
DOC_CKS1_1	81	86	PF01111	0.819
DOC_CYCLIN_RxL_1	152	162	PF00134	0.442
DOC_MAPK_gen_1	172	181	PF00069	0.621
DOC_MAPK_gen_1	267	273	PF00069	0.654
DOC_USP7_MATH_1	103	107	PF00917	0.671
DOC_USP7_MATH_1	19	23	PF00917	0.705
DOC_USP7_MATH_1	254	258	PF00917	0.695
DOC_USP7_MATH_1	436	440	PF00917	0.623
DOC_USP7_MATH_1	6	10	PF00917	0.677
DOC_USP7_MATH_1	62	66	PF00917	0.661
DOC_USP7_MATH_1	97	101	PF00917	0.793
DOC_WW_Pin1_4	167	172	PF00397	0.764
DOC_WW_Pin1_4	23	28	PF00397	0.571
DOC_WW_Pin1_4	484	489	PF00397	0.563
DOC_WW_Pin1_4	561	566	PF00397	0.486
DOC_WW_Pin1_4	65	70	PF00397	0.765
DOC_WW_Pin1_4	80	85	PF00397	0.821
LIG_14-3-3_CanoR_1	178	187	PF00244	0.708
LIG_14-3-3_CanoR_1	53	62	PF00244	0.667
LIG_14-3-3_CanoR_1	552	562	PF00244	0.665
LIG_Actin_WH2_2	523	540	PF00022	0.654
LIG_APCC_ABBA_1	157	162	PF00400	0.457
LIG_BRCT_BRCA1_1	440	444	PF00533	0.378
LIG_FHA_1	105	111	PF00498	0.603
LIG_FHA_1	267	273	PF00498	0.654
LIG_FHA_1	488	494	PF00498	0.754
LIG_FHA_1	8	14	PF00498	0.619
LIG_FHA_1	96	102	PF00498	0.555
LIG_FHA_2	111	117	PF00498	0.664
LIG_FHA_2	296	302	PF00498	0.402
LIG_FHA_2	317	323	PF00498	0.657
LIG_FHA_2	384	390	PF00498	0.423
LIG_FHA_2	457	463	PF00498	0.429
LIG_FHA_2	554	560	PF00498	0.669
LIG_LIR_Gen_1	143	151	PF02991	0.570
LIG_LIR_Gen_1	173	183	PF02991	0.474
LIG_LIR_Gen_1	441	452	PF02991	0.511
LIG_LIR_Gen_1	504	514	PF02991	0.578
LIG_LIR_LC3C_4	269	273	PF02991	0.396
LIG_LIR_Nem_3	143	149	PF02991	0.509
LIG_LIR_Nem_3	173	179	PF02991	0.483
LIG_LIR_Nem_3	441	447	PF02991	0.501
LIG_LIR_Nem_3	504	509	PF02991	0.589
LIG_MYND_3	513	517	PF01753	0.558
LIG_PCNA_TLS_4	555	562	PF02747	0.464
LIG_Pex14_2	142	146	PF04695	0.564
LIG_SH2_CRK	506	510	PF00017	0.681
LIG_SH2_STAP1	395	399	PF00017	0.633
LIG_SH2_STAT5	237	240	PF00017	0.537
LIG_SH2_STAT5	561	564	PF00017	0.509
LIG_SH3_3	163	169	PF00018	0.514
LIG_SH3_3	66	72	PF00018	0.732
LIG_SH3_3	78	84	PF00018	0.673
LIG_TRAF2_1	319	322	PF00917	0.653
LIG_TRAF2_1	377	380	PF00917	0.554
LIG_TRAF2_1	404	407	PF00917	0.643
MOD_CDK_SPK_2	167	172	PF00069	0.648
MOD_CDK_SPK_2	65	70	PF00069	0.765
MOD_CDK_SPxxK_3	167	174	PF00069	0.758
MOD_CK1_1	104	110	PF00069	0.704
MOD_CK1_1	170	176	PF00069	0.684
MOD_CK1_1	23	29	PF00069	0.591
MOD_CK1_1	241	247	PF00069	0.721
MOD_CK1_1	257	263	PF00069	0.515
MOD_CK1_1	481	487	PF00069	0.615
MOD_CK1_1	494	500	PF00069	0.520
MOD_CK1_1	55	61	PF00069	0.758
MOD_CK1_1	65	71	PF00069	0.689
MOD_CK1_1	77	83	PF00069	0.596
MOD_CK2_1	14	20	PF00069	0.557
MOD_CK2_1	189	195	PF00069	0.588
MOD_CK2_1	295	301	PF00069	0.404
MOD_CK2_1	316	322	PF00069	0.556
MOD_CK2_1	498	504	PF00069	0.467
MOD_CK2_1	525	531	PF00069	0.586
MOD_CK2_1	553	559	PF00069	0.665
MOD_Cter_Amidation	40	43	PF01082	0.469
MOD_GlcNHglycan	103	106	PF01048	0.644
MOD_GlcNHglycan	22	25	PF01048	0.637
MOD_GlcNHglycan	27	30	PF01048	0.562
MOD_GlcNHglycan	348	351	PF01048	0.634
MOD_GlcNHglycan	427	430	PF01048	0.395
MOD_GlcNHglycan	484	487	PF01048	0.748
MOD_GlcNHglycan	493	496	PF01048	0.600
MOD_GlcNHglycan	500	503	PF01048	0.552
MOD_GlcNHglycan	526	530	PF01048	0.422
MOD_GlcNHglycan	76	79	PF01048	0.769
MOD_GSK3_1	110	117	PF00069	0.680
MOD_GSK3_1	19	26	PF00069	0.580
MOD_GSK3_1	237	244	PF00069	0.693
MOD_GSK3_1	316	323	PF00069	0.403
MOD_GSK3_1	478	485	PF00069	0.567
MOD_GSK3_1	487	494	PF00069	0.534
MOD_GSK3_1	571	578	PF00069	0.558
MOD_GSK3_1	7	14	PF00069	0.672
MOD_GSK3_1	73	80	PF00069	0.693
MOD_GSK3_1	97	104	PF00069	0.794
MOD_N-GLC_1	346	351	PF02516	0.640
MOD_NEK2_1	101	106	PF00069	0.707
MOD_NEK2_1	179	184	PF00069	0.520
MOD_NEK2_1	18	23	PF00069	0.692
MOD_NEK2_1	232	237	PF00069	0.799
MOD_NEK2_1	493	498	PF00069	0.712
MOD_NEK2_1	537	542	PF00069	0.427
MOD_NEK2_1	74	79	PF00069	0.673
MOD_NEK2_2	114	119	PF00069	0.422
MOD_NEK2_2	189	194	PF00069	0.583
MOD_NEK2_2	254	259	PF00069	0.528
MOD_NEK2_2	97	102	PF00069	0.552
MOD_PKA_1	52	58	PF00069	0.765
MOD_PKA_2	177	183	PF00069	0.704
MOD_PKA_2	266	272	PF00069	0.654
MOD_PKA_2	416	422	PF00069	0.655
MOD_PKA_2	52	58	PF00069	0.680
MOD_PKA_2	537	543	PF00069	0.656
MOD_Plk_1	189	195	PF00069	0.677
MOD_Plk_1	346	352	PF00069	0.643
MOD_Plk_1	456	462	PF00069	0.426
MOD_Plk_1	525	531	PF00069	0.422
MOD_Plk_1	62	68	PF00069	0.627
MOD_Plk_2-3	456	462	PF00069	0.426
MOD_Plk_4	33	39	PF00069	0.436
MOD_Plk_4	456	462	PF00069	0.426
MOD_ProDKin_1	167	173	PF00069	0.761
MOD_ProDKin_1	23	29	PF00069	0.567
MOD_ProDKin_1	484	490	PF00069	0.566
MOD_ProDKin_1	561	567	PF00069	0.492
MOD_ProDKin_1	65	71	PF00069	0.763
MOD_ProDKin_1	80	86	PF00069	0.821
TRG_AP2beta_CARGO_1	442	451	PF09066	0.397
TRG_DiLeu_BaEn_1	456	461	PF01217	0.425
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.678
TRG_ENDOCYTIC_2	506	509	PF00928	0.681
TRG_ER_diArg_1	125	128	PF00400	0.594
TRG_ER_diArg_1	171	174	PF00400	0.639
TRG_ER_diArg_1	266	268	PF00400	0.572
TRG_ER_diArg_1	326	328	PF00400	0.655
TRG_ER_diArg_1	421	423	PF00400	0.669
TRG_ER_diArg_1	469	472	PF00400	0.626
TRG_ER_diArg_1	52	54	PF00400	0.492
TRG_ER_diArg_1	551	553	PF00400	0.619
TRG_NES_CRM1_1	195	210	PF08389	0.421
TRG_NES_CRM1_1	361	375	PF08389	0.385
TRG_NES_CRM1_1	539	554	PF08389	0.398
TRG_NLS_MonoExtC_3	467	472	PF00514	0.721
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL10	Leptomonas seymouri	33%	100%
A0A3S7WRC5	Leishmania donovani	71%	98%
A4HUL8	Leishmania infantum	71%	98%
E9ANB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	98%
Q4QHA7	Leishmania major	69%	100%