Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H694_LEIBR

TriTrypDb:

LbrM.10.1160 , LBRM2903_100020600

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H694

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H694

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.629
CLV_C14_Caspase3-7	81	85	PF00656	0.620
CLV_NRD_NRD_1	143	145	PF00675	0.587
CLV_PCSK_KEX2_1	143	145	PF00082	0.596
CLV_PCSK_KEX2_1	225	227	PF00082	0.538
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.538
CLV_PCSK_SKI1_1	211	215	PF00082	0.552
DEG_Nend_UBRbox_1	1	4	PF02207	0.522
DOC_MAPK_gen_1	192	201	PF00069	0.514
DOC_MAPK_RevD_3	212	226	PF00069	0.542
DOC_USP7_MATH_1	12	16	PF00917	0.594
DOC_USP7_MATH_1	83	87	PF00917	0.621
DOC_WW_Pin1_4	20	25	PF00397	0.764
DOC_WW_Pin1_4	54	59	PF00397	0.516
LIG_14-3-3_CanoR_1	226	232	PF00244	0.591
LIG_Actin_WH2_2	212	227	PF00022	0.509
LIG_APCC_ABBA_1	157	162	PF00400	0.315
LIG_Clathr_ClatBox_1	169	173	PF01394	0.296
LIG_Clathr_ClatBox_1	312	316	PF01394	0.444
LIG_EH1_1	312	320	PF00400	0.539
LIG_FHA_1	152	158	PF00498	0.456
LIG_FHA_1	164	170	PF00498	0.238
LIG_FHA_1	194	200	PF00498	0.594
LIG_FHA_1	228	234	PF00498	0.620
LIG_FHA_1	55	61	PF00498	0.572
LIG_FHA_1	89	95	PF00498	0.575
LIG_FHA_2	235	241	PF00498	0.614
LIG_FHA_2	247	253	PF00498	0.680
LIG_LIR_Gen_1	171	179	PF02991	0.394
LIG_LIR_LC3C_4	47	52	PF02991	0.324
LIG_LIR_Nem_3	171	175	PF02991	0.387
LIG_PDZ_Class_1	317	322	PF00595	0.480
LIG_Pex14_2	131	135	PF04695	0.425
LIG_Pex14_2	309	313	PF04695	0.563
LIG_PTB_Apo_2	129	136	PF02174	0.585
LIG_SH2_GRB2like	130	133	PF00017	0.600
LIG_SH2_STAT3	178	181	PF00017	0.532
LIG_SH2_STAT5	130	133	PF00017	0.531
LIG_SH2_STAT5	160	163	PF00017	0.385
LIG_SH2_STAT5	174	177	PF00017	0.398
LIG_SH3_3	108	114	PF00018	0.640
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.319
LIG_SUMO_SIM_par_1	47	53	PF11976	0.540
LIG_TRAF2_1	237	240	PF00917	0.667
LIG_WRC_WIRS_1	169	174	PF05994	0.401
MOD_CK1_1	133	139	PF00069	0.491
MOD_CK1_1	227	233	PF00069	0.603
MOD_CK1_1	23	29	PF00069	0.598
MOD_CK1_1	278	284	PF00069	0.746
MOD_CK1_1	294	300	PF00069	0.594
MOD_CK1_1	53	59	PF00069	0.403
MOD_CK1_1	88	94	PF00069	0.507
MOD_CK2_1	13	19	PF00069	0.638
MOD_CK2_1	131	137	PF00069	0.488
MOD_CK2_1	234	240	PF00069	0.550
MOD_CK2_1	83	89	PF00069	0.642
MOD_GlcNHglycan	101	104	PF01048	0.540
MOD_GlcNHglycan	15	18	PF01048	0.788
MOD_GlcNHglycan	151	154	PF01048	0.624
MOD_GlcNHglycan	226	229	PF01048	0.497
MOD_GlcNHglycan	263	266	PF01048	0.801
MOD_GlcNHglycan	277	280	PF01048	0.718
MOD_GlcNHglycan	291	294	PF01048	0.601
MOD_GlcNHglycan	52	55	PF01048	0.396
MOD_GlcNHglycan	74	77	PF01048	0.630
MOD_GSK3_1	164	171	PF00069	0.494
MOD_GSK3_1	19	26	PF00069	0.626
MOD_GSK3_1	261	268	PF00069	0.559
MOD_GSK3_1	278	285	PF00069	0.459
MOD_GSK3_1	50	57	PF00069	0.402
MOD_N-GLC_1	131	136	PF02516	0.567
MOD_N-GLC_1	20	25	PF02516	0.511
MOD_NEK2_1	13	18	PF00069	0.506
MOD_NEK2_1	131	136	PF00069	0.495
MOD_NEK2_1	149	154	PF00069	0.453
MOD_NEK2_1	224	229	PF00069	0.533
MOD_NEK2_1	50	55	PF00069	0.403
MOD_NEK2_2	138	143	PF00069	0.515
MOD_NEK2_2	37	42	PF00069	0.417
MOD_PIKK_1	25	31	PF00454	0.602
MOD_PKA_2	193	199	PF00069	0.622
MOD_Plk_1	131	137	PF00069	0.495
MOD_Plk_1	138	144	PF00069	0.427
MOD_Plk_1	83	89	PF00069	0.689
MOD_Plk_2-3	168	174	PF00069	0.441
MOD_Plk_4	294	300	PF00069	0.613
MOD_ProDKin_1	20	26	PF00069	0.750
MOD_ProDKin_1	54	60	PF00069	0.524
MOD_SUMO_rev_2	239	245	PF00179	0.679
TRG_DiLeu_BaEn_4	240	246	PF01217	0.457
TRG_ENDOCYTIC_2	128	131	PF00928	0.420
TRG_ENDOCYTIC_2	160	163	PF00928	0.389
TRG_ER_diArg_1	142	144	PF00400	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X0	Leptomonas seymouri	50%	95%
A0A1X0NS26	Trypanosomatidae	30%	100%
A0A3S7WRA2	Leishmania donovani	81%	100%
A0A422NGN0	Trypanosoma rangeli	35%	100%
A4HUL7	Leishmania infantum	82%	100%
C9ZVP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ANB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QHA8	Leishmania major	85%	99%
V5DKP6	Trypanosoma cruzi	36%	100%