J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H693_LEIBR

TriTrypDb:

LbrM.10.1150 , LBRM2903_100020500

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H693

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H693

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.569
CLV_NRD_NRD_1	212	214	PF00675	0.479
CLV_PCSK_FUR_1	172	176	PF00082	0.508
CLV_PCSK_KEX2_1	174	176	PF00082	0.508
CLV_PCSK_KEX2_1	207	209	PF00082	0.567
CLV_PCSK_KEX2_1	212	214	PF00082	0.456
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.593
CLV_PCSK_PC7_1	208	214	PF00082	0.582
CLV_PCSK_SKI1_1	129	133	PF00082	0.655
CLV_PCSK_SKI1_1	53	57	PF00082	0.578
CLV_PCSK_SKI1_1	70	74	PF00082	0.533
DEG_APCC_KENBOX_2	40	44	PF00400	0.345
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DOC_ANK_TNKS_1	8	15	PF00023	0.428
DOC_MAPK_gen_1	150	158	PF00069	0.434
DOC_MAPK_gen_1	33	39	PF00069	0.465
DOC_MAPK_MEF2A_6	150	158	PF00069	0.467
DOC_PP1_RVXF_1	16	23	PF00149	0.521
DOC_PP4_FxxP_1	119	122	PF00568	0.549
DOC_PP4_FxxP_1	22	25	PF00568	0.436
DOC_USP7_MATH_1	122	126	PF00917	0.685
DOC_USP7_MATH_1	154	158	PF00917	0.566
DOC_USP7_MATH_1	65	69	PF00917	0.409
DOC_USP7_UBL2_3	170	174	PF12436	0.466
DOC_USP7_UBL2_3	29	33	PF12436	0.353
LIG_14-3-3_CanoR_1	129	134	PF00244	0.619
LIG_14-3-3_CanoR_1	3	7	PF00244	0.494
LIG_BRCT_BRCA1_1	154	158	PF00533	0.427
LIG_deltaCOP1_diTrp_1	109	119	PF00928	0.658
LIG_LIR_Apic_2	117	122	PF02991	0.570
LIG_LIR_Apic_2	19	25	PF02991	0.434
LIG_LIR_Gen_1	109	119	PF02991	0.602
LIG_LIR_Gen_1	155	165	PF02991	0.470
LIG_LIR_Gen_1	195	205	PF02991	0.595
LIG_LIR_Gen_1	63	73	PF02991	0.516
LIG_LIR_Nem_3	109	115	PF02991	0.660
LIG_LIR_Nem_3	155	161	PF02991	0.414
LIG_LIR_Nem_3	195	200	PF02991	0.498
LIG_LIR_Nem_3	242	247	PF02991	0.463
LIG_LIR_Nem_3	63	69	PF02991	0.410
LIG_NRBOX	68	74	PF00104	0.469
LIG_SH2_CRK	66	70	PF00017	0.382
LIG_SH2_PTP2	249	252	PF00017	0.466
LIG_SH2_STAP1	164	168	PF00017	0.480
LIG_SH2_STAT5	196	199	PF00017	0.531
LIG_SH2_STAT5	249	252	PF00017	0.422
LIG_SH2_STAT5	66	69	PF00017	0.452
LIG_SH3_3	128	134	PF00018	0.420
LIG_TYR_ITIM	247	252	PF00017	0.464
MOD_CK1_1	124	130	PF00069	0.653
MOD_CK1_1	146	152	PF00069	0.542
MOD_CK2_1	142	148	PF00069	0.594
MOD_CK2_1	154	160	PF00069	0.354
MOD_GlcNHglycan	100	103	PF01048	0.658
MOD_GlcNHglycan	93	96	PF01048	0.677
MOD_GSK3_1	139	146	PF00069	0.573
MOD_GSK3_1	182	189	PF00069	0.494
MOD_GSK3_1	239	246	PF00069	0.478
MOD_GSK3_1	60	67	PF00069	0.523
MOD_GSK3_1	96	103	PF00069	0.641
MOD_NEK2_1	2	7	PF00069	0.598
MOD_NEK2_2	154	159	PF00069	0.355
MOD_NEK2_2	243	248	PF00069	0.490
MOD_NEK2_2	65	70	PF00069	0.490
MOD_PK_1	152	158	PF00069	0.336
MOD_PKA_1	207	213	PF00069	0.685
MOD_PKA_2	2	8	PF00069	0.430
MOD_PKA_2	207	213	PF00069	0.685
MOD_Plk_4	139	145	PF00069	0.556
MOD_Plk_4	2	8	PF00069	0.577
MOD_SUMO_rev_2	145	151	PF00179	0.495
MOD_SUMO_rev_2	46	55	PF00179	0.479
TRG_ENDOCYTIC_2	249	252	PF00928	0.422
TRG_ENDOCYTIC_2	66	69	PF00928	0.376
TRG_ER_diArg_1	230	233	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRV7	Leptomonas seymouri	60%	100%
A0A0S4JQU3	Bodo saltans	30%	100%
A0A1X0NRW0	Trypanosomatidae	36%	100%
A0A3Q8IB40	Leishmania donovani	75%	92%
A0A3R7ND09	Trypanosoma rangeli	33%	100%
A4HUL6	Leishmania infantum	75%	92%
C9ZVP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ANB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QHA9	Leishmania major	76%	100%