RNA-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4H691_LEIBR

TriTrypDb:

LbrM.10.1130 , LBRM2903_100020300

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H691

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H691

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.511
CLV_NRD_NRD_1	18	20	PF00675	0.564
CLV_NRD_NRD_1	245	247	PF00675	0.494
CLV_NRD_NRD_1	257	259	PF00675	0.419
CLV_NRD_NRD_1	277	279	PF00675	0.490
CLV_NRD_NRD_1	58	60	PF00675	0.674
CLV_PCSK_FUR_1	199	203	PF00082	0.269
CLV_PCSK_KEX2_1	18	20	PF00082	0.564
CLV_PCSK_KEX2_1	201	203	PF00082	0.289
CLV_PCSK_KEX2_1	245	247	PF00082	0.542
CLV_PCSK_KEX2_1	256	258	PF00082	0.396
CLV_PCSK_KEX2_1	277	279	PF00082	0.550
CLV_PCSK_KEX2_1	326	328	PF00082	0.575
CLV_PCSK_KEX2_1	382	384	PF00082	0.560
CLV_PCSK_KEX2_1	78	80	PF00082	0.649
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.564
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.289
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.575
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.518
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.649
CLV_PCSK_SKI1_1	240	244	PF00082	0.452
CLV_PCSK_SKI1_1	257	261	PF00082	0.436
CLV_PCSK_SKI1_1	63	67	PF00082	0.650
CLV_PCSK_SKI1_1	86	90	PF00082	0.584
DEG_SPOP_SBC_1	347	351	PF00917	0.497
DOC_CYCLIN_RxL_1	17	28	PF00134	0.526
DOC_MAPK_DCC_7	216	224	PF00069	0.414
DOC_MAPK_gen_1	18	24	PF00069	0.540
DOC_MAPK_gen_1	205	214	PF00069	0.469
DOC_MAPK_gen_1	277	286	PF00069	0.450
DOC_MAPK_MEF2A_6	216	224	PF00069	0.469
DOC_MAPK_MEF2A_6	277	286	PF00069	0.450
DOC_MAPK_RevD_3	230	246	PF00069	0.501
DOC_PP1_RVXF_1	166	172	PF00149	0.304
DOC_PP1_RVXF_1	18	25	PF00149	0.535
DOC_PP4_FxxP_1	176	179	PF00568	0.474
DOC_USP7_MATH_1	247	251	PF00917	0.370
DOC_USP7_MATH_1	3	7	PF00917	0.676
DOC_USP7_MATH_1	358	362	PF00917	0.558
DOC_USP7_MATH_1	381	385	PF00917	0.568
DOC_USP7_MATH_1	96	100	PF00917	0.618
DOC_USP7_UBL2_3	26	30	PF12436	0.412
DOC_USP7_UBL2_3	378	382	PF12436	0.537
DOC_USP7_UBL2_3	4	8	PF12436	0.665
DOC_USP7_UBL2_3	66	70	PF12436	0.528
DOC_USP7_UBL2_3	86	90	PF12436	0.527
DOC_WW_Pin1_4	146	151	PF00397	0.571
DOC_WW_Pin1_4	266	271	PF00397	0.499
DOC_WW_Pin1_4	368	373	PF00397	0.590
LIG_14-3-3_CanoR_1	168	172	PF00244	0.355
LIG_14-3-3_CanoR_1	19	25	PF00244	0.531
LIG_14-3-3_CanoR_1	199	209	PF00244	0.469
LIG_14-3-3_CanoR_1	240	245	PF00244	0.462
LIG_14-3-3_CterR_2	386	390	PF00244	0.507
LIG_FHA_1	348	354	PF00498	0.677
LIG_FHA_1	36	42	PF00498	0.601
LIG_FHA_2	289	295	PF00498	0.426
LIG_LIR_Apic_2	174	179	PF02991	0.473
LIG_LIR_Nem_3	162	167	PF02991	0.413
LIG_Pex14_2	184	188	PF04695	0.469
LIG_SH2_CRK	164	168	PF00017	0.424
LIG_SH2_STAT5	211	214	PF00017	0.480
LIG_SH2_STAT5	298	301	PF00017	0.487
LIG_SH3_3	354	360	PF00018	0.507
LIG_SH3_3	369	375	PF00018	0.492
LIG_SH3_4	378	385	PF00018	0.519
LIG_SUMO_SIM_par_1	220	226	PF11976	0.498
LIG_TRAF2_1	99	102	PF00917	0.680
MOD_CDK_SPK_2	368	373	PF00069	0.590
MOD_CDK_SPxK_1	266	272	PF00069	0.432
MOD_CDK_SPxxK_3	146	153	PF00069	0.541
MOD_CDK_SPxxK_3	266	273	PF00069	0.437
MOD_CK1_1	200	206	PF00069	0.486
MOD_CK1_1	367	373	PF00069	0.560
MOD_CK1_1	73	79	PF00069	0.513
MOD_CK2_1	288	294	PF00069	0.335
MOD_CK2_1	96	102	PF00069	0.651
MOD_Cter_Amidation	16	19	PF01082	0.571
MOD_GlcNHglycan	130	134	PF01048	0.676
MOD_GlcNHglycan	329	332	PF01048	0.511
MOD_GlcNHglycan	73	76	PF01048	0.682
MOD_GlcNHglycan	79	82	PF01048	0.527
MOD_GSK3_1	167	174	PF00069	0.298
MOD_GSK3_1	20	27	PF00069	0.615
MOD_GSK3_1	310	317	PF00069	0.498
MOD_GSK3_1	347	354	PF00069	0.573
MOD_GSK3_1	363	370	PF00069	0.586
MOD_GSK3_1	66	73	PF00069	0.703
MOD_N-GLC_1	102	107	PF02516	0.623
MOD_N-GLC_1	123	128	PF02516	0.504
MOD_N-GLC_1	351	356	PF02516	0.512
MOD_NEK2_1	188	193	PF00069	0.485
MOD_NEK2_1	24	29	PF00069	0.498
MOD_NEK2_1	310	315	PF00069	0.481
MOD_NEK2_2	25	30	PF00069	0.545
MOD_NEK2_2	3	8	PF00069	0.584
MOD_NEK2_2	381	386	PF00069	0.518
MOD_PIKK_1	183	189	PF00454	0.414
MOD_PIKK_1	310	316	PF00454	0.487
MOD_PKA_1	20	26	PF00069	0.520
MOD_PKA_1	77	83	PF00069	0.589
MOD_PKA_2	154	160	PF00069	0.593
MOD_PKA_2	167	173	PF00069	0.271
MOD_PKA_2	215	221	PF00069	0.414
MOD_PKB_1	238	246	PF00069	0.431
MOD_Plk_1	129	135	PF00069	0.495
MOD_Plk_2-3	102	108	PF00069	0.586
MOD_Plk_4	167	173	PF00069	0.331
MOD_Plk_4	188	194	PF00069	0.561
MOD_Plk_4	215	221	PF00069	0.414
MOD_ProDKin_1	146	152	PF00069	0.570
MOD_ProDKin_1	266	272	PF00069	0.503
MOD_ProDKin_1	368	374	PF00069	0.590
TRG_ENDOCYTIC_2	164	167	PF00928	0.427
TRG_ENDOCYTIC_2	211	214	PF00928	0.469
TRG_ER_diArg_1	152	155	PF00400	0.531
TRG_ER_diArg_1	237	240	PF00400	0.398
TRG_ER_diArg_1	244	246	PF00400	0.457
TRG_ER_diArg_1	256	258	PF00400	0.506
TRG_ER_diArg_1	276	278	PF00400	0.571
TRG_NLS_Bipartite_1	59	81	PF00514	0.557
TRG_NLS_Bipartite_1	8	23	PF00514	0.599
TRG_NLS_MonoCore_2	17	22	PF00514	0.555
TRG_NLS_MonoCore_2	323	328	PF00514	0.616
TRG_NLS_MonoExtC_3	323	328	PF00514	0.609
TRG_NLS_MonoExtC_3	58	63	PF00514	0.536
TRG_NLS_MonoExtN_4	18	23	PF00514	0.542
TRG_NLS_MonoExtN_4	324	329	PF00514	0.633
TRG_NLS_MonoExtN_4	59	64	PF00514	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9B0	Leptomonas seymouri	56%	94%
A0A3Q8I7S8	Leishmania donovani	73%	100%
A4HUL4	Leishmania infantum	73%	100%
E9ANB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QHB1	Leishmania major	73%	100%