Putative carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carrier protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H690_LEIBR

TriTrypDb:

LbrM.10.1120 , LBRM2903_100020200

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	32
GO:0110165	cellular anatomical entity	1	32
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H690

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H690

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0006862	nucleotide transport	6	5
GO:0009987	cellular process	1	5
GO:0015748	organophosphate ester transport	5	5
GO:0015931	nucleobase-containing compound transport	5	5
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055085	transmembrane transport	2	5
GO:0071702	organic substance transport	4	5
GO:0071705	nitrogen compound transport	4	5
GO:0035352	NAD transmembrane transport	4	1
GO:0043132	NAD transport	7	1
GO:1901679	nucleotide transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0051724	NAD transmembrane transporter activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.588
CLV_NRD_NRD_1	108	110	PF00675	0.323
CLV_NRD_NRD_1	208	210	PF00675	0.181
CLV_NRD_NRD_1	343	345	PF00675	0.268
CLV_PCSK_KEX2_1	208	210	PF00082	0.181
CLV_PCSK_SKI1_1	136	140	PF00082	0.290
CLV_PCSK_SKI1_1	200	204	PF00082	0.245
CLV_PCSK_SKI1_1	226	230	PF00082	0.209
CLV_PCSK_SKI1_1	254	258	PF00082	0.482
CLV_PCSK_SKI1_1	96	100	PF00082	0.293
DEG_APCC_DBOX_1	135	143	PF00400	0.579
DEG_Nend_Nbox_1	1	3	PF02207	0.708
DEG_SCF_FBW7_1	327	334	PF00400	0.469
DEG_SPOP_SBC_1	20	24	PF00917	0.763
DOC_CKS1_1	328	333	PF01111	0.437
DOC_CYCLIN_yCln2_LP_2	316	322	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.528
DOC_MAPK_MEF2A_6	188	196	PF00069	0.426
DOC_USP7_MATH_1	19	23	PF00917	0.613
DOC_USP7_MATH_1	204	208	PF00917	0.490
DOC_USP7_MATH_1	369	373	PF00917	0.280
DOC_WW_Pin1_4	202	207	PF00397	0.509
DOC_WW_Pin1_4	327	332	PF00397	0.443
DOC_WW_Pin1_4	48	53	PF00397	0.713
LIG_14-3-3_CanoR_1	109	119	PF00244	0.534
LIG_14-3-3_CanoR_1	208	214	PF00244	0.457
LIG_14-3-3_CanoR_1	223	229	PF00244	0.500
LIG_Actin_WH2_2	212	228	PF00022	0.526
LIG_APCC_ABBA_1	261	266	PF00400	0.210
LIG_BRCT_BRCA1_1	125	129	PF00533	0.477
LIG_BRCT_BRCA1_1	49	53	PF00533	0.705
LIG_CtBP_PxDLS_1	102	106	PF00389	0.481
LIG_FHA_1	119	125	PF00498	0.520
LIG_FHA_1	232	238	PF00498	0.298
LIG_FHA_1	311	317	PF00498	0.285
LIG_FHA_1	337	343	PF00498	0.437
LIG_FHA_1	381	387	PF00498	0.469
LIG_FHA_1	55	61	PF00498	0.647
LIG_FHA_1	68	74	PF00498	0.608
LIG_FHA_2	22	28	PF00498	0.722
LIG_FHA_2	291	297	PF00498	0.362
LIG_FHA_2	369	375	PF00498	0.253
LIG_FHA_2	402	408	PF00498	0.573
LIG_IBAR_NPY_1	318	320	PF08397	0.437
LIG_LIR_Apic_2	12	18	PF02991	0.565
LIG_LIR_Apic_2	283	289	PF02991	0.473
LIG_LIR_Gen_1	153	160	PF02991	0.446
LIG_LIR_Gen_1	372	380	PF02991	0.265
LIG_LIR_Gen_1	76	85	PF02991	0.518
LIG_LIR_LC3C_4	234	238	PF02991	0.436
LIG_LIR_Nem_3	120	125	PF02991	0.530
LIG_LIR_Nem_3	132	138	PF02991	0.609
LIG_LIR_Nem_3	153	159	PF02991	0.464
LIG_LIR_Nem_3	212	216	PF02991	0.454
LIG_LIR_Nem_3	227	232	PF02991	0.331
LIG_LIR_Nem_3	255	261	PF02991	0.255
LIG_LIR_Nem_3	372	378	PF02991	0.231
LIG_LIR_Nem_3	50	56	PF02991	0.654
LIG_LIR_Nem_3	76	80	PF02991	0.524
LIG_LYPXL_SIV_4	319	327	PF13949	0.461
LIG_Pex14_1	246	250	PF04695	0.233
LIG_SH2_CRK	250	254	PF00017	0.343
LIG_SH2_CRK	352	356	PF00017	0.326
LIG_SH2_NCK_1	15	19	PF00017	0.696
LIG_SH2_SRC	15	18	PF00017	0.611
LIG_SH2_SRC	373	376	PF00017	0.217
LIG_SH2_STAP1	181	185	PF00017	0.513
LIG_SH2_STAP1	375	379	PF00017	0.226
LIG_SH2_STAP1	88	92	PF00017	0.424
LIG_SH2_STAT5	156	159	PF00017	0.466
LIG_SH2_STAT5	320	323	PF00017	0.445
LIG_SH3_3	187	193	PF00018	0.498
LIG_TYR_ITIM	154	159	PF00017	0.503
LIG_WRC_WIRS_1	253	258	PF05994	0.332
MOD_CDC14_SPxK_1	205	208	PF00782	0.381
MOD_CDK_SPxK_1	202	208	PF00069	0.381
MOD_CDK_SPxxK_3	202	209	PF00069	0.388
MOD_CK1_1	212	218	PF00069	0.484
MOD_CK1_1	22	28	PF00069	0.567
MOD_CK1_1	306	312	PF00069	0.258
MOD_CK1_1	43	49	PF00069	0.738
MOD_CK1_1	7	13	PF00069	0.561
MOD_CK2_1	290	296	PF00069	0.348
MOD_CK2_1	3	9	PF00069	0.740
MOD_CK2_1	368	374	PF00069	0.277
MOD_CK2_1	401	407	PF00069	0.513
MOD_GlcNHglycan	112	115	PF01048	0.414
MOD_GlcNHglycan	178	181	PF01048	0.245
MOD_GlcNHglycan	282	285	PF01048	0.619
MOD_GlcNHglycan	309	312	PF01048	0.242
MOD_GlcNHglycan	352	355	PF01048	0.313
MOD_GlcNHglycan	43	46	PF01048	0.551
MOD_GSK3_1	105	112	PF00069	0.554
MOD_GSK3_1	123	130	PF00069	0.471
MOD_GSK3_1	200	207	PF00069	0.491
MOD_GSK3_1	22	29	PF00069	0.658
MOD_GSK3_1	3	10	PF00069	0.631
MOD_GSK3_1	303	310	PF00069	0.246
MOD_GSK3_1	327	334	PF00069	0.473
MOD_GSK3_1	43	50	PF00069	0.696
MOD_GSK3_1	69	76	PF00069	0.606
MOD_LATS_1	33	39	PF00433	0.587
MOD_N-GLC_1	73	78	PF02516	0.362
MOD_N-GLC_2	290	292	PF02516	0.447
MOD_N-GLC_2	360	362	PF02516	0.406
MOD_NEK2_1	105	110	PF00069	0.494
MOD_NEK2_1	2	7	PF00069	0.704
MOD_NEK2_1	232	237	PF00069	0.313
MOD_NEK2_1	355	360	PF00069	0.300
MOD_NEK2_1	367	372	PF00069	0.238
MOD_NEK2_2	224	229	PF00069	0.412
MOD_PIKK_1	127	133	PF00454	0.454
MOD_PIKK_1	26	32	PF00454	0.588
MOD_PIKK_1	272	278	PF00454	0.500
MOD_PIKK_1	386	392	PF00454	0.429
MOD_PKA_1	109	115	PF00069	0.577
MOD_PKA_2	266	272	PF00069	0.458
MOD_Plk_1	3	9	PF00069	0.709
MOD_Plk_1	73	79	PF00069	0.517
MOD_Plk_2-3	11	17	PF00069	0.558
MOD_Plk_2-3	4	10	PF00069	0.556
MOD_Plk_4	192	198	PF00069	0.402
MOD_Plk_4	232	238	PF00069	0.309
MOD_Plk_4	252	258	PF00069	0.189
MOD_Plk_4	331	337	PF00069	0.513
MOD_ProDKin_1	202	208	PF00069	0.509
MOD_ProDKin_1	327	333	PF00069	0.443
MOD_ProDKin_1	48	54	PF00069	0.710
TRG_DiLeu_BaEn_1	296	301	PF01217	0.221
TRG_DiLeu_BaEn_4	61	67	PF01217	0.736
TRG_ENDOCYTIC_2	156	159	PF00928	0.462
TRG_ENDOCYTIC_2	250	253	PF00928	0.239
TRG_ENDOCYTIC_2	258	261	PF00928	0.296
TRG_ENDOCYTIC_2	320	323	PF00928	0.451
TRG_ENDOCYTIC_2	352	355	PF00928	0.281
TRG_ENDOCYTIC_2	375	378	PF00928	0.226
TRG_ENDOCYTIC_2	77	80	PF00928	0.499
TRG_ER_diArg_1	208	210	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S5	Leptomonas seymouri	30%	100%
A0A0N1IBB8	Leptomonas seymouri	23%	85%
A0A0N1IHK9	Leptomonas seymouri	67%	100%
A0A0S4JF45	Bodo saltans	30%	100%
A0A0S4JH99	Bodo saltans	43%	80%
A0A0S4JIT1	Bodo saltans	32%	100%
A0A0S4KJX8	Bodo saltans	22%	100%
A0A1X0NN16	Trypanosomatidae	31%	100%
A0A1X0NQB5	Trypanosomatidae	53%	100%
A0A1X0P6Z0	Trypanosomatidae	27%	100%
A0A3Q8IC78	Leishmania donovani	80%	100%
A0A3Q8IS12	Leishmania donovani	28%	100%
A0A3R7L1P3	Trypanosoma rangeli	32%	100%
A0A3S7WUZ5	Leishmania donovani	27%	91%
A0A422NGL1	Trypanosoma rangeli	55%	100%
A0A422P0Q3	Trypanosoma rangeli	27%	100%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	24%	100%
A4H9K7	Leishmania braziliensis	26%	89%
A4HQI4	Leishmania braziliensis	29%	100%
A4HUL3	Leishmania infantum	80%	100%
A4HXX3	Leishmania infantum	26%	91%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	25%	100%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AHZ3	Leishmania infantum	28%	100%
E9ANB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9ARN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	91%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q0CT66	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	26%	100%
Q1DRJ3	Coccidioides immitis (strain RS)	25%	100%
Q4Q094	Leishmania major	30%	100%
Q4QDU2	Leishmania major	27%	100%
Q4QHB2	Leishmania major	81%	100%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54VX4	Dictyostelium discoideum	22%	100%
V5BTU3	Trypanosoma cruzi	53%	100%
V5DDT9	Trypanosoma cruzi	30%	100%
V5DN72	Trypanosoma cruzi	30%	100%