Nucleoside phosphorylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside phosphorylase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H689_LEIBR

TriTrypDb:

LbrM.10.1110 , LBRM2903_100020100

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H689

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H689

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009116	nucleoside metabolic process	4	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901657	glycosyl compound metabolic process	4	12
GO:0006213	pyrimidine nucleoside metabolic process	5	1
GO:0006218	uridine catabolic process	8	1
GO:0009056	catabolic process	2	1
GO:0009119	ribonucleoside metabolic process	5	1
GO:0009164	nucleoside catabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034656	nucleobase-containing small molecule catabolic process	4	1
GO:0042454	ribonucleoside catabolic process	6	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044282	small molecule catabolic process	3	1
GO:0046108	uridine metabolic process	7	1
GO:0046131	pyrimidine ribonucleoside metabolic process	6	1
GO:0046133	pyrimidine ribonucleoside catabolic process	7	1
GO:0046135	pyrimidine nucleoside catabolic process	6	1
GO:0046700	heterocycle catabolic process	4	1
GO:0072527	pyrimidine-containing compound metabolic process	4	1
GO:0072529	pyrimidine-containing compound catabolic process	5	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901658	glycosyl compound catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	8
GO:0016757	glycosyltransferase activity	3	8
GO:0004850	uridine phosphorylase activity	5	1
GO:0016763	pentosyltransferase activity	4	2
GO:0004731	purine-nucleoside phosphorylase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.350
CLV_PCSK_KEX2_1	109	111	PF00082	0.359
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.443
CLV_PCSK_SKI1_1	314	318	PF00082	0.326
CLV_PCSK_SKI1_1	37	41	PF00082	0.315
DEG_SPOP_SBC_1	187	191	PF00917	0.219
DOC_CKS1_1	316	321	PF01111	0.394
DOC_CYCLIN_yClb5_NLxxxL_5	255	264	PF00134	0.246
DOC_PP1_RVXF_1	35	41	PF00149	0.329
DOC_PP2B_LxvP_1	255	258	PF13499	0.315
DOC_PP4_FxxP_1	316	319	PF00568	0.394
DOC_USP7_MATH_1	173	177	PF00917	0.219
DOC_USP7_MATH_1	216	220	PF00917	0.356
DOC_USP7_MATH_1	221	225	PF00917	0.352
DOC_USP7_MATH_1	233	237	PF00917	0.217
DOC_USP7_MATH_1	28	32	PF00917	0.485
DOC_USP7_MATH_1	307	311	PF00917	0.443
DOC_WW_Pin1_4	140	145	PF00397	0.284
DOC_WW_Pin1_4	16	21	PF00397	0.499
DOC_WW_Pin1_4	315	320	PF00397	0.394
LIG_14-3-3_CanoR_1	252	258	PF00244	0.390
LIG_14-3-3_CanoR_1	314	319	PF00244	0.437
LIG_14-3-3_CanoR_1	46	51	PF00244	0.382
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_FHA_1	175	181	PF00498	0.423
LIG_FHA_1	187	193	PF00498	0.418
LIG_FHA_1	205	211	PF00498	0.321
LIG_FHA_1	22	28	PF00498	0.425
LIG_FHA_1	259	265	PF00498	0.431
LIG_FHA_1	329	335	PF00498	0.411
LIG_FHA_1	54	60	PF00498	0.297
LIG_FHA_1	87	93	PF00498	0.348
LIG_FHA_2	124	130	PF00498	0.457
LIG_FHA_2	141	147	PF00498	0.298
LIG_FHA_2	315	321	PF00498	0.329
LIG_LIR_Nem_3	72	78	PF02991	0.443
LIG_NRBOX	290	296	PF00104	0.394
LIG_SH2_CRK	169	173	PF00017	0.376
LIG_SH2_CRK	75	79	PF00017	0.466
LIG_SH2_NCK_1	169	173	PF00017	0.435
LIG_SH2_SRC	158	161	PF00017	0.297
LIG_SH2_STAP1	198	202	PF00017	0.315
LIG_SH2_STAT3	241	244	PF00017	0.300
LIG_SH2_STAT5	230	233	PF00017	0.318
LIG_SH2_STAT5	290	293	PF00017	0.339
LIG_SH2_STAT5	53	56	PF00017	0.386
LIG_SH3_3	11	17	PF00018	0.478
LIG_SH3_3	38	44	PF00018	0.315
LIG_SUMO_SIM_anti_2	89	96	PF11976	0.339
LIG_SUMO_SIM_par_1	330	335	PF11976	0.394
LIG_SUMO_SIM_par_1	78	85	PF11976	0.315
LIG_TRAF2_1	144	147	PF00917	0.276
LIG_ULM_U2AF65_1	108	113	PF00076	0.219
MOD_CK2_1	140	146	PF00069	0.420
MOD_CK2_1	269	275	PF00069	0.389
MOD_CK2_1	314	320	PF00069	0.329
MOD_CK2_1	61	67	PF00069	0.394
MOD_GlcNHglycan	235	238	PF01048	0.315
MOD_GlcNHglycan	284	288	PF01048	0.346
MOD_GlcNHglycan	3	6	PF01048	0.614
MOD_GlcNHglycan	311	314	PF01048	0.446
MOD_GlcNHglycan	8	11	PF01048	0.563
MOD_GSK3_1	124	131	PF00069	0.407
MOD_GSK3_1	212	219	PF00069	0.433
MOD_GSK3_1	231	238	PF00069	0.346
MOD_GSK3_1	324	331	PF00069	0.392
MOD_GSK3_1	53	60	PF00069	0.352
MOD_GSK3_1	78	85	PF00069	0.334
MOD_N-GLC_1	174	179	PF02516	0.407
MOD_N-GLC_1	221	226	PF02516	0.283
MOD_N-GLC_1	258	263	PF02516	0.345
MOD_N-GLC_1	269	274	PF02516	0.360
MOD_N-GLC_2	164	166	PF02516	0.315
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	153	158	PF00069	0.336
MOD_NEK2_1	162	167	PF00069	0.345
MOD_NEK2_1	283	288	PF00069	0.308
MOD_PIKK_1	153	159	PF00454	0.329
MOD_PIKK_1	204	210	PF00454	0.434
MOD_Plk_1	124	130	PF00069	0.219
MOD_Plk_1	283	289	PF00069	0.300
MOD_Plk_4	78	84	PF00069	0.315
MOD_ProDKin_1	140	146	PF00069	0.284
MOD_ProDKin_1	16	22	PF00069	0.493
MOD_ProDKin_1	315	321	PF00069	0.394
TRG_DiLeu_BaEn_4	262	268	PF01217	0.383
TRG_ENDOCYTIC_2	75	78	PF00928	0.443
TRG_ER_diArg_1	110	112	PF00400	0.324
TRG_NES_CRM1_1	90	104	PF08389	0.291
TRG_NLS_MonoCore_2	107	112	PF00514	0.219
TRG_NLS_MonoExtC_3	108	113	PF00514	0.376
TRG_NLS_MonoExtN_4	107	113	PF00514	0.219

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N4	Leptomonas seymouri	76%	100%
A0A0S4JKY9	Bodo saltans	52%	83%
A0A1X0NEA3	Trypanosomatidae	54%	100%
A0A3S5H6H0	Leishmania donovani	82%	100%
A0A422NGL0	Trypanosoma rangeli	57%	99%
A4HUL2	Leishmania infantum	82%	100%
A4VWC2	Streptococcus suis (strain 05ZYH33)	24%	100%
A4W2M2	Streptococcus suis (strain 98HAH33)	24%	100%
C9ZVN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ANB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QHB3	Leishmania major	81%	100%
V5BP86	Trypanosoma cruzi	58%	99%