Nucleoside phosphorylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside phosphorylase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H689_LEIBR

TriTrypDb:

LbrM.10.1110 , LBRM2903_100020100

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4H689

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H689

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006213	pyrimidine nucleoside metabolic process	5	1
GO:0006218	uridine catabolic process	8	1
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	1
GO:0009116	nucleoside metabolic process	4	12
GO:0009119	ribonucleoside metabolic process	5	1
GO:0009164	nucleoside catabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004731	purine-nucleoside phosphorylase activity	5	1
GO:0004850	uridine phosphorylase activity	5	1
GO:0016740	transferase activity	2	8
GO:0016757	glycosyltransferase activity	3	8
GO:0016763	pentosyltransferase activity	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.350
CLV_PCSK_KEX2_1	109	111	PF00082	0.359
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.443
CLV_PCSK_SKI1_1	314	318	PF00082	0.326
CLV_PCSK_SKI1_1	37	41	PF00082	0.315
DEG_SPOP_SBC_1	187	191	PF00917	0.219
DOC_CKS1_1	316	321	PF01111	0.394
DOC_CYCLIN_yClb5_NLxxxL_5	255	264	PF00134	0.246
DOC_PP1_RVXF_1	35	41	PF00149	0.329
DOC_PP2B_LxvP_1	255	258	PF13499	0.315

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N4	Leptomonas seymouri	76%	100%
A0A0S4JKY9	Bodo saltans	52%	83%
A0A1X0NEA3	Trypanosomatidae	54%	100%
A0A3S5H6H0	Leishmania donovani	82%	100%
A0A422NGL0	Trypanosoma rangeli	57%	99%
A4HUL2	Leishmania infantum	82%	100%
A4VWC2	Streptococcus suis (strain 05ZYH33)	24%	100%
A4W2M2	Streptococcus suis (strain 98HAH33)	24%	100%
C9ZVN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ANB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%

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