Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ARP2/3 complex subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H688_LEIBR

TriTrypDb:

LbrM.10.1100 , LBRM2903_100020000

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005885	Arp2/3 protein complex	2	6
GO:0032991	protein-containing complex	1	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H688

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H688

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	6
GO:0008064	regulation of actin polymerization or depolymerization	6	6
GO:0008154	actin polymerization or depolymerization	6	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0030041	actin filament polymerization	7	6
GO:0030832	regulation of actin filament length	5	6
GO:0030833	regulation of actin filament polymerization	7	6
GO:0032271	regulation of protein polymerization	6	6
GO:0032535	regulation of cellular component size	4	6
GO:0032956	regulation of actin cytoskeleton organization	5	6
GO:0032970	regulation of actin filament-based process	4	6
GO:0033043	regulation of organelle organization	5	6
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	6
GO:0043254	regulation of protein-containing complex assembly	5	6
GO:0043933	protein-containing complex organization	4	6
GO:0044087	regulation of cellular component biogenesis	4	6
GO:0045010	actin nucleation	6	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051128	regulation of cellular component organization	4	6
GO:0051258	protein polymerization	6	6
GO:0051493	regulation of cytoskeleton organization	6	6
GO:0065003	protein-containing complex assembly	5	6
GO:0065007	biological regulation	1	6
GO:0065008	regulation of biological quality	2	6
GO:0071840	cellular component organization or biogenesis	2	6
GO:0090066	regulation of anatomical structure size	3	6
GO:0097435	supramolecular fiber organization	4	6
GO:0110053	regulation of actin filament organization	6	6
GO:1902903	regulation of supramolecular fiber organization	5	6

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.572
CLV_NRD_NRD_1	313	315	PF00675	0.613
CLV_PCSK_KEX2_1	313	315	PF00082	0.613
CLV_PCSK_SKI1_1	2	6	PF00082	0.614
CLV_PCSK_SKI1_1	238	242	PF00082	0.513
CLV_PCSK_SKI1_1	314	318	PF00082	0.381
CLV_PCSK_SKI1_1	396	400	PF00082	0.413
DEG_Nend_UBRbox_1	1	4	PF02207	0.586
DEG_SPOP_SBC_1	120	124	PF00917	0.619
DOC_MAPK_gen_1	382	390	PF00069	0.467
DOC_MAPK_MEF2A_6	324	331	PF00069	0.513
DOC_MAPK_MEF2A_6	382	390	PF00069	0.496
DOC_PP1_RVXF_1	374	381	PF00149	0.485
DOC_PP2B_LxvP_1	187	190	PF13499	0.571
DOC_PP2B_LxvP_1	234	237	PF13499	0.663
DOC_PP2B_PxIxI_1	338	344	PF00149	0.433
DOC_PP4_FxxP_1	132	135	PF00568	0.738
DOC_USP7_MATH_1	121	125	PF00917	0.649
DOC_USP7_MATH_1	178	182	PF00917	0.708
DOC_USP7_MATH_1	344	348	PF00917	0.494
DOC_USP7_MATH_1	351	355	PF00917	0.378
DOC_USP7_MATH_2	365	371	PF00917	0.383
DOC_USP7_MATH_2	63	69	PF00917	0.600
DOC_WW_Pin1_4	165	170	PF00397	0.719
DOC_WW_Pin1_4	191	196	PF00397	0.679
DOC_WW_Pin1_4	265	270	PF00397	0.621
DOC_WW_Pin1_4	273	278	PF00397	0.686
DOC_WW_Pin1_4	59	64	PF00397	0.600
DOC_WW_Pin1_4	8	13	PF00397	0.552
LIG_14-3-3_CanoR_1	223	233	PF00244	0.567
LIG_14-3-3_CanoR_1	40	45	PF00244	0.595
LIG_14-3-3_CanoR_1	404	414	PF00244	0.495
LIG_14-3-3_CanoR_1	6	12	PF00244	0.720
LIG_Actin_WH2_2	371	387	PF00022	0.488
LIG_BRCT_BRCA1_1	128	132	PF00533	0.484
LIG_FHA_1	161	167	PF00498	0.640
LIG_FHA_1	230	236	PF00498	0.424
LIG_FHA_1	292	298	PF00498	0.485
LIG_FHA_1	358	364	PF00498	0.433
LIG_FHA_1	73	79	PF00498	0.583
LIG_FHA_2	192	198	PF00498	0.566
LIG_FHA_2	226	232	PF00498	0.449
LIG_FHA_2	41	47	PF00498	0.533
LIG_FHA_2	79	85	PF00498	0.576
LIG_GBD_Chelix_1	147	155	PF00786	0.399
LIG_HCF-1_HBM_1	352	355	PF13415	0.632
LIG_LIR_Apic_2	129	135	PF02991	0.486
LIG_LIR_Apic_2	163	167	PF02991	0.719
LIG_LIR_Gen_1	142	151	PF02991	0.436
LIG_LIR_Nem_3	10	16	PF02991	0.675
LIG_LIR_Nem_3	122	128	PF02991	0.721
LIG_LIR_Nem_3	142	147	PF02991	0.451
LIG_LIR_Nem_3	33	37	PF02991	0.714
LIG_LYPXL_yS_3	125	128	PF13949	0.717
LIG_LYPXL_yS_3	13	16	PF13949	0.486
LIG_LYPXL_yS_3	34	37	PF13949	0.569
LIG_PAM2_1	405	417	PF00658	0.361
LIG_PCNA_yPIPBox_3	211	221	PF02747	0.515
LIG_Pex14_1	357	361	PF04695	0.555
LIG_SH2_CRK	144	148	PF00017	0.465
LIG_SH2_CRK	164	168	PF00017	0.733
LIG_SH2_GRB2like	144	147	PF00017	0.446
LIG_SH2_NCK_1	49	53	PF00017	0.585
LIG_SH2_STAP1	410	414	PF00017	0.531
LIG_SH2_STAT5	315	318	PF00017	0.492
LIG_SH2_STAT5	355	358	PF00017	0.321
LIG_SH3_3	268	274	PF00018	0.590
LIG_SH3_3	359	365	PF00018	0.539
LIG_SH3_3	64	70	PF00018	0.731
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.647
LIG_SUMO_SIM_par_1	293	298	PF11976	0.477
LIG_SUMO_SIM_par_1	327	334	PF11976	0.524
LIG_TRAF2_1	194	197	PF00917	0.571
LIG_TRAF2_1	228	231	PF00917	0.417
LIG_TRFH_1	361	365	PF08558	0.585
LIG_TYR_ITIM	136	141	PF00017	0.503
LIG_TYR_ITSM	121	128	PF00017	0.724
LIG_UBA3_1	16	21	PF00899	0.471
LIG_UBA3_1	233	241	PF00899	0.450
LIG_WRC_WIRS_1	41	46	PF05994	0.633
MOD_CDK_SPxxK_3	191	198	PF00069	0.673
MOD_CK1_1	181	187	PF00069	0.657
MOD_CK1_1	206	212	PF00069	0.405
MOD_CK1_1	224	230	PF00069	0.599
MOD_CK1_1	276	282	PF00069	0.791
MOD_CK1_1	73	79	PF00069	0.758
MOD_CK1_1	96	102	PF00069	0.563
MOD_CK2_1	191	197	PF00069	0.672
MOD_CK2_1	225	231	PF00069	0.418
MOD_CK2_1	50	56	PF00069	0.677
MOD_CK2_1	59	65	PF00069	0.646
MOD_CK2_1	78	84	PF00069	0.504
MOD_CK2_1	87	93	PF00069	0.713
MOD_GlcNHglycan	102	105	PF01048	0.539
MOD_GlcNHglycan	110	113	PF01048	0.506
MOD_GlcNHglycan	258	261	PF01048	0.574
MOD_GlcNHglycan	333	336	PF01048	0.660
MOD_GlcNHglycan	346	349	PF01048	0.359
MOD_GlcNHglycan	369	372	PF01048	0.579
MOD_GlcNHglycan	407	410	PF01048	0.510
MOD_GlcNHglycan	89	92	PF01048	0.720
MOD_GlcNHglycan	95	98	PF01048	0.712
MOD_GSK3_1	165	172	PF00069	0.580
MOD_GSK3_1	221	228	PF00069	0.471
MOD_GSK3_1	247	254	PF00069	0.634
MOD_GSK3_1	26	33	PF00069	0.700
MOD_GSK3_1	263	270	PF00069	0.545
MOD_GSK3_1	291	298	PF00069	0.371
MOD_GSK3_1	96	103	PF00069	0.625
MOD_N-GLC_1	279	284	PF02516	0.534
MOD_N-GLC_1	59	64	PF02516	0.592
MOD_N-GLC_1	8	13	PF02516	0.576
MOD_N-GLC_1	87	92	PF02516	0.576
MOD_NEK2_1	221	226	PF00069	0.621
MOD_NEK2_1	256	261	PF00069	0.537
MOD_NEK2_1	263	268	PF00069	0.475
MOD_NEK2_1	30	35	PF00069	0.591
MOD_NEK2_1	72	77	PF00069	0.586
MOD_PIKK_1	225	231	PF00454	0.465
MOD_PKA_2	331	337	PF00069	0.642
MOD_PKA_2	384	390	PF00069	0.482
MOD_Plk_1	2	8	PF00069	0.661
MOD_Plk_1	206	212	PF00069	0.626
MOD_Plk_1	279	285	PF00069	0.532
MOD_Plk_1	351	357	PF00069	0.357
MOD_Plk_2-3	50	56	PF00069	0.716
MOD_Plk_4	229	235	PF00069	0.393
MOD_Plk_4	247	253	PF00069	0.632
MOD_Plk_4	351	357	PF00069	0.347
MOD_Plk_4	384	390	PF00069	0.490
MOD_ProDKin_1	165	171	PF00069	0.727
MOD_ProDKin_1	191	197	PF00069	0.672
MOD_ProDKin_1	265	271	PF00069	0.634
MOD_ProDKin_1	273	279	PF00069	0.686
MOD_ProDKin_1	59	65	PF00069	0.603
MOD_ProDKin_1	8	14	PF00069	0.550
MOD_SUMO_rev_2	50	59	PF00179	0.567
MOD_SUMO_rev_2	90	97	PF00179	0.572
TRG_DiLeu_BaEn_1	231	236	PF01217	0.641
TRG_ENDOCYTIC_2	125	128	PF00928	0.721
TRG_ENDOCYTIC_2	13	16	PF00928	0.486
TRG_ENDOCYTIC_2	138	141	PF00928	0.458
TRG_ENDOCYTIC_2	144	147	PF00928	0.663
TRG_ENDOCYTIC_2	34	37	PF00928	0.715
TRG_ER_diArg_1	312	314	PF00400	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P323	Leptomonas seymouri	33%	100%
A0A3Q8I8S8	Leishmania donovani	62%	100%
E9AGA0	Leishmania infantum	63%	100%
E9ANB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4QHB4	Leishmania major	64%	100%