Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H684_LEIBR

TriTrypDb:

LbrM.10.1060 , LBRM2903_100019200

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0035253	ciliary rootlet	2	1
GO:0036064	ciliary basal body	3	1
GO:0097542	ciliary tip	2	1

Expansion

Sequence features

A4H684

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H684

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036158	outer dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.398
CLV_C14_Caspase3-7	551	555	PF00656	0.694
CLV_C14_Caspase3-7	704	708	PF00656	0.731
CLV_NRD_NRD_1	128	130	PF00675	0.431
CLV_NRD_NRD_1	265	267	PF00675	0.433
CLV_NRD_NRD_1	277	279	PF00675	0.483
CLV_NRD_NRD_1	292	294	PF00675	0.560
CLV_NRD_NRD_1	55	57	PF00675	0.486
CLV_NRD_NRD_1	587	589	PF00675	0.651
CLV_NRD_NRD_1	608	610	PF00675	0.677
CLV_NRD_NRD_1	652	654	PF00675	0.720
CLV_NRD_NRD_1	735	737	PF00675	0.744
CLV_NRD_NRD_1	770	772	PF00675	0.649
CLV_NRD_NRD_1	783	785	PF00675	0.427
CLV_NRD_NRD_1	79	81	PF00675	0.579
CLV_NRD_NRD_1	794	796	PF00675	0.622
CLV_PCSK_FUR_1	126	130	PF00082	0.481
CLV_PCSK_FUR_1	650	654	PF00082	0.644
CLV_PCSK_FUR_1	732	736	PF00082	0.744
CLV_PCSK_FUR_1	77	81	PF00082	0.521
CLV_PCSK_KEX2_1	126	128	PF00082	0.451
CLV_PCSK_KEX2_1	277	279	PF00082	0.476
CLV_PCSK_KEX2_1	292	294	PF00082	0.567
CLV_PCSK_KEX2_1	513	515	PF00082	0.591
CLV_PCSK_KEX2_1	55	57	PF00082	0.479
CLV_PCSK_KEX2_1	587	589	PF00082	0.651
CLV_PCSK_KEX2_1	608	610	PF00082	0.677
CLV_PCSK_KEX2_1	650	652	PF00082	0.723
CLV_PCSK_KEX2_1	734	736	PF00082	0.742
CLV_PCSK_KEX2_1	77	79	PF00082	0.569
CLV_PCSK_KEX2_1	770	772	PF00082	0.588
CLV_PCSK_KEX2_1	794	796	PF00082	0.649
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.591
CLV_PCSK_SKI1_1	266	270	PF00082	0.465
CLV_PCSK_SKI1_1	326	330	PF00082	0.569
CLV_PCSK_SKI1_1	378	382	PF00082	0.499
CLV_PCSK_SKI1_1	625	629	PF00082	0.694
DEG_APCC_DBOX_1	202	210	PF00400	0.521
DEG_APCC_DBOX_1	231	239	PF00400	0.533
DEG_APCC_DBOX_1	325	333	PF00400	0.663
DEG_APCC_DBOX_1	54	62	PF00400	0.509
DEG_COP1_1	498	505	PF00400	0.379
DEG_SPOP_SBC_1	574	578	PF00917	0.568
DOC_CDC14_PxL_1	23	31	PF14671	0.370
DOC_CKS1_1	506	511	PF01111	0.400
DOC_CYCLIN_RxL_1	230	243	PF00134	0.480
DOC_CYCLIN_RxL_1	449	460	PF00134	0.356
DOC_CYCLIN_RxL_1	525	536	PF00134	0.550
DOC_MAPK_gen_1	126	138	PF00069	0.521
DOC_MAPK_gen_1	191	199	PF00069	0.505
DOC_MAPK_gen_1	230	237	PF00069	0.455
DOC_MAPK_gen_1	513	520	PF00069	0.547
DOC_MAPK_MEF2A_6	513	522	PF00069	0.641
DOC_MAPK_RevD_3	113	128	PF00069	0.351
DOC_PP1_RVXF_1	684	691	PF00149	0.728
DOC_PP2B_LxvP_1	580	583	PF13499	0.543
DOC_PP2B_LxvP_1	680	683	PF13499	0.608
DOC_USP7_MATH_1	149	153	PF00917	0.528
DOC_USP7_MATH_1	170	174	PF00917	0.426
DOC_USP7_MATH_1	355	359	PF00917	0.596
DOC_USP7_MATH_1	501	505	PF00917	0.566
DOC_USP7_MATH_1	512	516	PF00917	0.670
DOC_USP7_MATH_1	548	552	PF00917	0.780
DOC_USP7_MATH_1	573	577	PF00917	0.685
DOC_USP7_MATH_1	635	639	PF00917	0.499
DOC_USP7_MATH_1	730	734	PF00917	0.628
DOC_USP7_UBL2_3	187	191	PF12436	0.463
DOC_USP7_UBL2_3	267	271	PF12436	0.403
DOC_USP7_UBL2_3	786	790	PF12436	0.391
DOC_WW_Pin1_4	356	361	PF00397	0.496
DOC_WW_Pin1_4	444	449	PF00397	0.602
DOC_WW_Pin1_4	505	510	PF00397	0.492
DOC_WW_Pin1_4	720	725	PF00397	0.734
LIG_14-3-3_CanoR_1	11	18	PF00244	0.615
LIG_14-3-3_CanoR_1	193	198	PF00244	0.380
LIG_14-3-3_CanoR_1	326	332	PF00244	0.598
LIG_14-3-3_CanoR_1	514	519	PF00244	0.564
LIG_14-3-3_CanoR_1	587	592	PF00244	0.488
LIG_14-3-3_CanoR_1	608	616	PF00244	0.749
LIG_14-3-3_CanoR_1	734	741	PF00244	0.599
LIG_Actin_WH2_2	54	71	PF00022	0.441
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_BIR_III_4	709	713	PF00653	0.670
LIG_CaM_IQ_9	252	268	PF13499	0.462
LIG_CaM_IQ_9	284	300	PF13499	0.557
LIG_FHA_1	13	19	PF00498	0.446
LIG_FHA_1	241	247	PF00498	0.291
LIG_FHA_1	506	512	PF00498	0.665
LIG_FHA_1	515	521	PF00498	0.553
LIG_FHA_1	576	582	PF00498	0.594
LIG_FHA_1	695	701	PF00498	0.734
LIG_FHA_2	107	113	PF00498	0.487
LIG_FHA_2	20	26	PF00498	0.611
LIG_FHA_2	219	225	PF00498	0.544
LIG_FHA_2	248	254	PF00498	0.528
LIG_FHA_2	274	280	PF00498	0.402
LIG_FHA_2	370	376	PF00498	0.450
LIG_FHA_2	610	616	PF00498	0.670
LIG_FHA_2	691	697	PF00498	0.516
LIG_LIR_Gen_1	173	181	PF02991	0.330
LIG_LYPXL_SIV_4	247	255	PF13949	0.467
LIG_PCNA_yPIPBox_3	473	483	PF02747	0.390
LIG_RPA_C_Fungi	646	658	PF08784	0.650
LIG_SH2_CRK	30	34	PF00017	0.445
LIG_SH2_STAP1	248	252	PF00017	0.515
LIG_SH2_STAP1	369	373	PF00017	0.475
LIG_SH2_STAT3	216	219	PF00017	0.525
LIG_SH2_STAT3	28	31	PF00017	0.403
LIG_SH2_STAT3	400	403	PF00017	0.494
LIG_SH2_STAT3	54	57	PF00017	0.454
LIG_SH2_STAT5	175	178	PF00017	0.513
LIG_SH2_STAT5	28	31	PF00017	0.380
LIG_SH2_STAT5	432	435	PF00017	0.666
LIG_SH3_3	497	503	PF00018	0.497
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.375
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.589
LIG_SUMO_SIM_anti_2	568	578	PF11976	0.609
LIG_SUMO_SIM_par_1	89	94	PF11976	0.434
LIG_TRAF2_1	272	275	PF00917	0.581
LIG_UBA3_1	184	191	PF00899	0.285
LIG_Vh1_VBS_1	518	536	PF01044	0.546
MOD_CDC14_SPxK_1	723	726	PF00782	0.501
MOD_CDK_SPxK_1	720	726	PF00069	0.509
MOD_CK1_1	335	341	PF00069	0.710
MOD_CK1_1	359	365	PF00069	0.671
MOD_CK1_1	464	470	PF00069	0.500
MOD_CK1_1	546	552	PF00069	0.764
MOD_CK1_1	673	679	PF00069	0.519
MOD_CK1_1	694	700	PF00069	0.624
MOD_CK2_1	106	112	PF00069	0.496
MOD_CK2_1	149	155	PF00069	0.489
MOD_CK2_1	19	25	PF00069	0.527
MOD_CK2_1	218	224	PF00069	0.622
MOD_CK2_1	247	253	PF00069	0.526
MOD_CK2_1	273	279	PF00069	0.404
MOD_CK2_1	38	44	PF00069	0.418
MOD_Cter_Amidation	606	609	PF01082	0.682
MOD_GlcNHglycan	100	103	PF01048	0.643
MOD_GlcNHglycan	260	263	PF01048	0.413
MOD_GlcNHglycan	3	6	PF01048	0.663
MOD_GlcNHglycan	548	551	PF01048	0.675
MOD_GlcNHglycan	569	572	PF01048	0.717
MOD_GlcNHglycan	621	624	PF01048	0.667
MOD_GlcNHglycan	654	657	PF01048	0.645
MOD_GlcNHglycan	715	718	PF01048	0.728
MOD_GSK3_1	207	214	PF00069	0.426
MOD_GSK3_1	355	362	PF00069	0.543
MOD_GSK3_1	501	508	PF00069	0.531
MOD_GSK3_1	533	540	PF00069	0.567
MOD_GSK3_1	542	549	PF00069	0.722
MOD_GSK3_1	690	697	PF00069	0.641
MOD_GSK3_1	701	708	PF00069	0.650
MOD_GSK3_1	730	737	PF00069	0.660
MOD_GSK3_1	91	98	PF00069	0.615
MOD_N-GLC_1	170	175	PF02516	0.405
MOD_N-GLC_1	461	466	PF02516	0.337
MOD_N-GLC_1	64	69	PF02516	0.565
MOD_N-GLC_1	705	710	PF02516	0.638
MOD_NEK2_1	1	6	PF00069	0.671
MOD_NEK2_1	119	124	PF00069	0.339
MOD_NEK2_1	18	23	PF00069	0.411
MOD_NEK2_1	240	245	PF00069	0.521
MOD_NEK2_1	273	278	PF00069	0.538
MOD_NEK2_1	332	337	PF00069	0.680
MOD_NEK2_1	690	695	PF00069	0.586
MOD_NEK2_1	700	705	PF00069	0.561
MOD_NEK2_1	93	98	PF00069	0.496
MOD_NEK2_2	170	175	PF00069	0.358
MOD_NEK2_2	369	374	PF00069	0.391
MOD_NEK2_2	548	553	PF00069	0.521
MOD_PIKK_1	211	217	PF00454	0.320
MOD_PIKK_1	284	290	PF00454	0.439
MOD_PIKK_1	95	101	PF00454	0.467
MOD_PK_1	193	199	PF00069	0.287
MOD_PKA_1	513	519	PF00069	0.549
MOD_PKA_1	587	593	PF00069	0.491
MOD_PKA_1	651	657	PF00069	0.718
MOD_PKA_1	734	740	PF00069	0.526
MOD_PKA_2	332	338	PF00069	0.586
MOD_PKA_2	347	353	PF00069	0.635
MOD_PKA_2	513	519	PF00069	0.568
MOD_PKA_2	587	593	PF00069	0.507
MOD_PKA_2	651	657	PF00069	0.690
MOD_PKA_2	734	740	PF00069	0.627
MOD_PKB_1	650	658	PF00069	0.644
MOD_PKB_1	732	740	PF00069	0.528
MOD_PKB_1	9	17	PF00069	0.471
MOD_Plk_1	170	176	PF00069	0.383
MOD_Plk_1	211	217	PF00069	0.408
MOD_Plk_1	369	375	PF00069	0.355
MOD_Plk_1	461	467	PF00069	0.405
MOD_Plk_1	64	70	PF00069	0.439
MOD_Plk_1	670	676	PF00069	0.505
MOD_Plk_4	162	168	PF00069	0.489
MOD_Plk_4	193	199	PF00069	0.287
MOD_Plk_4	218	224	PF00069	0.565
MOD_Plk_4	327	333	PF00069	0.620
MOD_Plk_4	461	467	PF00069	0.538
MOD_ProDKin_1	356	362	PF00069	0.488
MOD_ProDKin_1	444	450	PF00069	0.598
MOD_ProDKin_1	505	511	PF00069	0.486
MOD_ProDKin_1	720	726	PF00069	0.739
MOD_SUMO_rev_2	140	149	PF00179	0.499
MOD_SUMO_rev_2	767	777	PF00179	0.638
TRG_DiLeu_BaEn_1	114	119	PF01217	0.332
TRG_DiLeu_BaEn_1	461	466	PF01217	0.458
TRG_DiLeu_BaEn_2	452	458	PF01217	0.567
TRG_DiLeu_BaEn_3	302	308	PF01217	0.533
TRG_DiLeu_BaEn_4	303	309	PF01217	0.551
TRG_ENDOCYTIC_2	175	178	PF00928	0.513
TRG_ENDOCYTIC_2	30	33	PF00928	0.451
TRG_ER_diArg_1	126	129	PF00400	0.421
TRG_ER_diArg_1	320	323	PF00400	0.517
TRG_ER_diArg_1	54	56	PF00400	0.594
TRG_ER_diArg_1	587	589	PF00400	0.702
TRG_ER_diArg_1	608	611	PF00400	0.785
TRG_ER_diArg_1	650	653	PF00400	0.721
TRG_ER_diArg_1	732	735	PF00400	0.747
TRG_ER_diArg_1	769	771	PF00400	0.651
TRG_ER_diArg_1	77	80	PF00400	0.568
TRG_ER_diArg_1	781	784	PF00400	0.428
TRG_ER_diArg_1	794	796	PF00400	0.574
TRG_ER_diArg_1	9	12	PF00400	0.676
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	644	649	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	686	691	PF00026	0.709
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P488	Leptomonas seymouri	49%	88%
A0A1X0NQB6	Trypanosomatidae	27%	100%
A0A3Q8I8W1	Leishmania donovani	71%	99%
A0A422NCY5	Trypanosoma rangeli	27%	100%
A4HUK9	Leishmania infantum	70%	99%
C9ZVN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ANA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4QHB8	Leishmania major	71%	100%
V5BJM8	Trypanosoma cruzi	26%	100%