Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FKBP-type peptidyl-prolyl cis-trans isomerase, putative

Species:

Leishmania braziliensis

UniProt:

A4H677_LEIBR

TriTrypDb:

LbrM.10.0990 , LBRM2903_100018400

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H677

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H677

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	1
GO:0006457	protein folding	2	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018208	peptidyl-proline modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	7
GO:0003824	catalytic activity	1	7
GO:0016853	isomerase activity	2	7
GO:0016859	cis-trans isomerase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.331
CLV_PCSK_SKI1_1	28	32	PF00082	0.440
CLV_PCSK_SKI1_1	70	74	PF00082	0.212
DEG_Nend_UBRbox_3	1	3	PF02207	0.367
DOC_MAPK_gen_1	142	150	PF00069	0.304
DOC_SPAK_OSR1_1	26	30	PF12202	0.319
DOC_USP7_MATH_1	105	109	PF00917	0.212
DOC_USP7_MATH_1	42	46	PF00917	0.263
DOC_USP7_UBL2_3	28	32	PF12436	0.420
DOC_WW_Pin1_4	12	17	PF00397	0.334
DOC_WW_Pin1_4	38	43	PF00397	0.348
LIG_14-3-3_CanoR_1	70	75	PF00244	0.234
LIG_BIR_III_2	13	17	PF00653	0.352
LIG_CtBP_PxDLS_1	101	105	PF00389	0.251
LIG_FHA_1	13	19	PF00498	0.327
LIG_FHA_1	34	40	PF00498	0.344
LIG_FHA_1	82	88	PF00498	0.315
LIG_IRF3_LxIS_1	144	151	PF10401	0.297
LIG_LIR_Apic_2	97	102	PF02991	0.251
LIG_LIR_Gen_1	149	155	PF02991	0.335
LIG_LIR_Nem_3	149	155	PF02991	0.335
LIG_LIR_Nem_3	94	99	PF02991	0.251
LIG_SH2_SRC	99	102	PF00017	0.251
LIG_SH2_STAT5	99	102	PF00017	0.364
LIG_SH3_3	36	42	PF00018	0.352
LIG_SH3_3	95	101	PF00018	0.251
LIG_TYR_ITIM	150	155	PF00017	0.290
LIG_UBA3_1	127	135	PF00899	0.357
MOD_CK1_1	38	44	PF00069	0.452
MOD_GlcNHglycan	22	25	PF01048	0.336
MOD_GSK3_1	31	38	PF00069	0.488
MOD_GSK3_1	42	49	PF00069	0.369
MOD_GSK3_1	8	15	PF00069	0.320
MOD_N-GLC_1	117	122	PF02516	0.218
MOD_N-GLC_1	42	47	PF02516	0.251
MOD_NEK2_1	148	153	PF00069	0.316
MOD_PKB_1	68	76	PF00069	0.468
MOD_Plk_1	117	123	PF00069	0.218
MOD_Plk_1	62	68	PF00069	0.251
MOD_Plk_4	117	123	PF00069	0.239
MOD_ProDKin_1	12	18	PF00069	0.327
MOD_ProDKin_1	38	44	PF00069	0.351
TRG_ENDOCYTIC_2	152	155	PF00928	0.324
TRG_ER_diArg_1	68	71	PF00400	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT4	Leptomonas seymouri	82%	100%
A0A0N1HUP7	Leptomonas seymouri	38%	100%
A0A0N1II12	Leptomonas seymouri	38%	78%
A0A1X0P7N1	Trypanosomatidae	48%	73%
A0A3Q8IB31	Leishmania donovani	85%	97%
A0A3Q8ICF9	Leishmania donovani	38%	100%
A0A3R7LCV9	Trypanosoma rangeli	38%	100%
A0A3S5H764	Leishmania donovani	31%	77%
A0A3S5H813	Leishmania donovani	37%	100%
A0A3S5IR72	Trypanosoma rangeli	44%	77%
A4HA48	Leishmania braziliensis	32%	76%
A4HNN1	Leishmania braziliensis	37%	100%
A4HUK1	Leishmania infantum	85%	97%
A4HYB4	Leishmania infantum	30%	77%
A4I002	Leishmania infantum	38%	100%
A4ICW4	Leishmania infantum	37%	100%
A5IGB8	Legionella pneumophila (strain Corby)	48%	67%
D0A0P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	79%
E9AN99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AS47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	76%
E9ASE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AVX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
P0A9L3	Escherichia coli (strain K12)	43%	75%
P0A9L4	Shigella flexneri	43%	75%
P0C1J5	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	36%	74%
P30417	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	37%	68%
P51752	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	46%	67%
P53605	Legionella longbeachae	48%	67%
Q09734	Trypanosoma cruzi	48%	79%
Q2U316	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	36%	100%
Q32PA9	Bos taurus	39%	100%
Q38936	Arabidopsis thaliana	40%	95%
Q4IN00	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	43%	79%
Q4Q255	Leishmania major	38%	100%
Q4QBK4	Leishmania major	38%	100%
Q4QDB9	Leishmania major	30%	100%
Q4QHC5	Leishmania major	83%	100%
Q54SR7	Dictyostelium discoideum	40%	100%
Q5ZXE0	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)	48%	67%
Q6BP84	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	44%	100%
Q6CGG3	Yarrowia lipolytica (strain CLIB 122 / E 150)	37%	100%
Q6FSC1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	47%	100%
Q70YI1	Legionella pneumophila	48%	67%