Histone H3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H3

Gene product:

histone H3

Species:

Leishmania braziliensis

UniProt:

A4H675_LEIBR

TriTrypDb:

LbrM.10.1070 , LBRM2903_100019500

Length:

130

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 50

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	15
GO:0032991	protein-containing complex	1	15
GO:0032993	protein-DNA complex	2	15
GO:0044815	DNA packaging complex	2	15
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H675

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H675

PDB structure(s): 6kxv_A , 6kxv_E

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003677	DNA binding	4	15
GO:0005198	structural molecule activity	1	15
GO:0005488	binding	1	15
GO:0005515	protein binding	2	15
GO:0030527	structural constituent of chromatin	2	15
GO:0046982	protein heterodimerization activity	4	15
GO:0046983	protein dimerization activity	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	34	36	PF00675	0.305
CLV_NRD_NRD_1	47	49	PF00675	0.412
CLV_PCSK_FUR_1	9	13	PF00082	0.334
CLV_PCSK_KEX2_1	11	13	PF00082	0.331
CLV_PCSK_KEX2_1	110	112	PF00082	0.400
CLV_PCSK_KEX2_1	34	36	PF00082	0.305
CLV_PCSK_KEX2_1	47	49	PF00082	0.331
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.331
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.400
CLV_PCSK_SKI1_1	110	114	PF00082	0.398
CLV_PCSK_SKI1_1	12	16	PF00082	0.316
DOC_USP7_MATH_1	16	20	PF00917	0.430
DOC_USP7_UBL2_3	17	21	PF12436	0.512
LIG_14-3-3_CanoR_1	48	57	PF00244	0.430
LIG_14-3-3_CanoR_1	78	87	PF00244	0.515
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_FHA_1	38	44	PF00498	0.502
LIG_FHA_1	51	57	PF00498	0.516
LIG_Integrin_RGD_1	126	128	PF01839	0.406
LIG_SH2_STAT5	94	97	PF00017	0.533
LIG_SUMO_SIM_par_1	81	89	PF11976	0.430
LIG_TRAF2_1	86	89	PF00917	0.533
MOD_CK1_1	24	30	PF00069	0.530
MOD_GlcNHglycan	23	26	PF01048	0.366
MOD_GlcNHglycan	70	73	PF01048	0.322
MOD_GlcNHglycan	81	84	PF01048	0.331
MOD_GSK3_1	12	19	PF00069	0.516
MOD_LATS_1	108	114	PF00433	0.600
MOD_NEK2_1	79	84	PF00069	0.515
MOD_NEK2_1	99	104	PF00069	0.533
MOD_PKA_1	110	116	PF00069	0.600
MOD_PKA_2	110	116	PF00069	0.519
MOD_PKB_1	35	43	PF00069	0.516
MOD_Plk_4	94	100	PF00069	0.546
TRG_ER_diArg_1	123	126	PF00400	0.600
TRG_ER_diArg_1	34	36	PF00400	0.507
TRG_ER_diArg_1	46	48	PF00400	0.430
TRG_NLS_MonoExtC_3	16	21	PF00514	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE44	Leptomonas seymouri	62%	90%
A0A0S4IWA8	Bodo saltans	55%	90%
A0A0S4J721	Bodo saltans	69%	99%
A0A1X0P6L2	Trypanosomatidae	50%	84%
A0A3Q8IC67	Leishmania donovani	87%	100%
A0A3R7KFK4	Trypanosoma rangeli	54%	86%
A0A3S7WVC7	Leishmania donovani	55%	90%
A0A422MY47	Trypanosoma rangeli	74%	98%
A0A422MY58	Trypanosoma rangeli	74%	100%
A1CP80	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	60%	96%
A1D240	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	60%	96%
A2QRR5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	60%	96%
A2XHJ3	Oryza sativa subsp. indica	57%	96%
A2Y533	Oryza sativa subsp. indica	58%	96%
A3GHN6	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	59%	96%
A3LXD5	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	58%	96%
A4HA21	Leishmania braziliensis	56%	90%
A4HUJ9	Leishmania infantum	87%	100%
A4HUL0	Leishmania infantum	86%	100%
A4HWV9	Leishmania infantum	86%	100%
A4HY84	Leishmania infantum	53%	90%
A4RCX7	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	58%	96%
A5DFC5	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	58%	96%
A5DG57	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	59%	96%
A5DWE2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	58%	96%
A5E094	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	58%	96%
A5PK61	Bos taurus	56%	96%
C0HL66	Drosophila melanogaster	58%	96%
C0HL67	Drosophila melanogaster	58%	96%
C9ZIG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	98%
E9AN97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AQL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AS15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	90%
G9CU80	Leishmania donovani	86%	100%
O15819	Dictyostelium discoideum	58%	94%
O35216	Mus musculus	39%	97%
P02299	Drosophila melanogaster	59%	96%
P02301	Mus musculus	57%	96%
P02302	Xenopus laevis	59%	96%
P06352	Strongylocentrotus purpuratus	59%	96%
P06902	Cairina moschata	54%	96%
P07041	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	58%	96%
P08437	Volvox carteri	59%	96%
P08898	Caenorhabditis elegans	60%	96%
P08903	Encephalartos altensteinii	59%	96%
P09988	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	62%	96%
P0CO04	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	65%	94%
P0CO05	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	65%	94%
P0DPK2	Homo sapiens	55%	96%
P0DPK5	Homo sapiens	56%	88%
P10651	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	61%	96%
P15512	Tetrahymena pyriformis	53%	96%
P22843	Acropora formosa	60%	96%
P23753	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	60%	96%
P40285	Leishmania infantum	83%	100%
P41353	Tetrahymena thermophila (strain SB210)	52%	96%
P49449	Bos taurus	51%	94%
P49450	Homo sapiens	52%	93%
P50564	Chlamydomonas reinhardtii	57%	96%
P59169	Arabidopsis thaliana	57%	96%
P59226	Arabidopsis thaliana	58%	96%
P61830	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	58%	96%
P61831	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	58%	96%
P61832	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	60%	96%
P61833	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	58%	96%
P61834	Talaromyces funiculosus	60%	96%
P61835	Hypocrea jecorina	58%	96%
P61836	Zygosaccharomyces bailii	58%	96%
P68427	Pisum sativum	58%	96%
P68428	Triticum aestivum	58%	96%
P68429	Medicago sativa	58%	96%
P68430	Onobrychis viciifolia	58%	96%
P68431	Homo sapiens	59%	96%
P68432	Bos taurus	59%	96%
P68433	Mus musculus	59%	96%
P69071	Dermasterias imbricata	59%	96%
P69072	Lytechinus pictus	59%	96%
P69073	Paracentrotus lividus	59%	96%
P69074	Pisaster brevispinus	59%	96%
P69075	Pisaster ochraceus	59%	96%
P69076	Psammechinus miliaris	59%	96%
P69077	Pycnopodia helianthoides	59%	96%
P69078	Solaster stimpsoni	59%	96%
P69079	Strongylocentrotus droebachiensis	59%	96%
P69149	Tetrahymena pyriformis	56%	96%
P69150	Tetrahymena thermophila	56%	96%
P69244	Medicago sativa	57%	96%
P69245	Lolium temulentum	57%	96%
P69246	Zea mays	58%	96%
P69248	Petroselinum crispum	58%	96%
P80553	Narcissus pseudonarcissus	57%	96%
P81195	Stylonychia lemnae	66%	100%
P81196	Stylonychia lemnae	70%	100%
P81197	Stylonychia lemnae	69%	100%
P81198	Stylonychia lemnae	60%	100%
P81199	Stylonychia lemnae	68%	100%
P81200	Stylonychia lemnae	67%	100%
P81201	Stylonychia lemnae	70%	100%
P81202	Stylonychia lemnae	64%	100%
P84227	Bos taurus	59%	96%
P84228	Mus musculus	59%	96%
P84229	Gallus gallus	59%	96%
P84230	Cairina moschata	59%	96%
P84231	Ictiobus bubalus	59%	96%
P84232	Poroderma africanum	59%	96%
P84233	Xenopus laevis	59%	96%
P84234	Oncorhynchus mykiss	59%	96%
P84235	Platynereis dumerilii	59%	96%
P84236	Drosophila hydei	59%	96%
P84237	Tigriopus californicus	59%	96%
P84238	Chironomus thummi thummi	59%	96%
P84239	Urechis caupo	59%	96%
P84243	Homo sapiens	58%	96%
P84244	Mus musculus	58%	96%
P84245	Rattus norvegicus	58%	96%
P84246	Oryctolagus cuniculus	58%	96%
P84247	Gallus gallus	58%	96%
P84248	Spisula solidissima	58%	96%
P84250	Drosophila hydei	58%	96%
P90543	Euplotes crassus	61%	96%
Q06196	Entamoeba histolytica	51%	96%
Q0D0E8	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	60%	96%
Q0JCT1	Oryza sativa subsp. japonica	57%	96%
Q0MTC0	Kluyveromyces marxianus	54%	68%
Q0MXD1	Millerozyma farinosa	53%	82%
Q0UY45	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	59%	96%
Q10453	Caenorhabditis elegans	58%	96%
Q16695	Homo sapiens	57%	96%
Q1E225	Coccidioides immitis (strain RS)	61%	96%
Q22RG7	Tetrahymena thermophila (strain SB210)	54%	96%
Q27489	Caenorhabditis elegans	57%	100%
Q27490	Caenorhabditis elegans	53%	97%
Q27532	Caenorhabditis elegans	58%	96%
Q28D37	Xenopus tropicalis	59%	96%
Q28I31	Xenopus tropicalis	51%	87%
Q2N2K6	Tetrahymena thermophila (strain SB210)	40%	70%
Q2RAD9	Oryza sativa subsp. japonica	58%	96%
Q2UCQ0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	60%	96%
Q2Z2F4	Lilium longiflorum	55%	95%
Q2Z2F6	Lilium longiflorum	49%	84%
Q3C2E5	Lolium multiflorum	57%	96%
Q3SZB8	Bos taurus	47%	96%
Q402E1	Lilium longiflorum	57%	96%
Q402E2	Lilium longiflorum	57%	96%
Q42681	Chlamydomonas reinhardtii	58%	96%
Q4IER8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	58%	96%
Q4P7J7	Ustilago maydis (strain 521 / FGSC 9021)	61%	96%
Q4PB04	Ustilago maydis (strain 521 / FGSC 9021)	60%	96%
Q4QDF8	Leishmania major	56%	100%
Q4QEV9	Leishmania major	87%	100%
Q4QHB5	Leishmania major	88%	100%
Q4QRF4	Danio rerio	59%	96%
Q55BN9	Dictyostelium discoideum	57%	96%
Q55BP0	Dictyostelium discoideum	57%	96%
Q569M3	Xenopus laevis	55%	87%
Q59VN2	Candida albicans (strain SC5314 / ATCC MYA-2876)	58%	96%
Q5ADQ0	Candida albicans (strain SC5314 / ATCC MYA-2876)	58%	96%
Q5DWI3	Marchantia polymorpha	58%	96%
Q5E9F8	Bos taurus	58%	96%
Q5MYA4	Cichorium intybus	57%	96%
Q5RCC9	Pongo abelii	57%	96%
Q5TEC6	Homo sapiens	58%	96%
Q64400	Cricetulus longicaudatus	58%	96%
Q6BMU4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	59%	96%
Q6BRZ5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	58%	96%
Q6C0C4	Yarrowia lipolytica (strain CLIB 122 / E 150)	56%	94%
Q6CER9	Yarrowia lipolytica (strain CLIB 122 / E 150)	55%	87%
Q6CTI2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	55%	71%
Q6DL03	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	58%	96%
Q6LBE3	Asparagus officinalis	58%	96%
Q6LBE8	Mus pahari	59%	96%
Q6LBF0	Mus pahari	59%	96%
Q6LCK1	Brassica napus	58%	96%
Q6LCW8	Chlamydomonas reinhardtii	59%	96%
Q6LED0	Rattus norvegicus	59%	96%
Q6NXT2	Homo sapiens	56%	96%
Q6P823	Xenopus tropicalis	58%	96%
Q6PI20	Danio rerio	58%	96%
Q6PI79	Xenopus laevis	58%	96%
Q6RUR1	Capsicum annuum	57%	96%
Q6T367	Oryza sativa subsp. japonica	48%	79%
Q6XXM1	Gallus gallus	55%	99%
Q711T2	Pinus pinaster	57%	96%
Q71DI3	Homo sapiens	59%	96%
Q71H73	Vitis vinifera	57%	96%
Q71LE2	Sus scrofa	58%	96%
Q71T45	Euphorbia esula	58%	96%
Q71U98	Oryza coarctata	57%	96%
Q71V89	Gossypium hirsutum	57%	96%
Q757N1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	58%	96%
Q76MV0	Nicotiana tabacum	58%	96%
Q76N23	Nicotiana tabacum	57%	96%
Q7RXR3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	59%	84%
Q7XYZ0	Griffithsia japonica	59%	96%
Q803H4	Danio rerio	54%	90%
Q8R565	Cricetulus griseus	46%	100%
Q8RVQ9	Arabidopsis thaliana	45%	73%
Q8SQP3	Encephalitozoon cuniculi (strain GB-M1)	44%	93%
Q8SS77	Encephalitozoon cuniculi (strain GB-M1)	45%	90%
Q8WSF1	Trichinella pseudospiralis	58%	96%
Q98RY4	Guillardia theta	57%	96%
Q9FKQ3	Arabidopsis thaliana	55%	94%
Q9FX60	Arabidopsis thaliana	59%	96%
Q9FXI7	Arabidopsis thaliana	55%	95%
Q9HDN1	Mortierella alpina	62%	96%
Q9LR02	Arabidopsis thaliana	61%	96%
Q9LXU8	Arabidopsis thaliana	58%	99%
Q9MBF6	Lilium longiflorum	38%	87%
Q9P427	Ajellomyces capsulatus	59%	96%
Q9U281	Caenorhabditis elegans	58%	96%
Q9U7D1	Mastigamoeba balamuthi	61%	96%
Q9Y812	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	100%
V5BEW0	Trypanosoma cruzi	74%	98%
V5BSE9	Trypanosoma cruzi	52%	86%