LeishMANIAdb
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Nuclear transport factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nuclear transport factor 2
Gene product:
nuclear transport factor 2, putative
Species:
Leishmania braziliensis
UniProt:
A4H673_LEIBR
TriTrypDb:
LbrM.10.0950 , LBRM2903_100018000
Length:
124

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0032991 protein-containing complex 1 1
GO:0044613 nuclear pore central transport channel 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

A4H673
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H673

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 10
GO:0006913 nucleocytoplasmic transport 5 10
GO:0009987 cellular process 1 10
GO:0046907 intracellular transport 3 10
GO:0051169 nuclear transport 4 10
GO:0051179 localization 1 10
GO:0051234 establishment of localization 2 10
GO:0051641 cellular localization 2 10
GO:0051649 establishment of localization in cell 3 10
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 22 26 PF00082 0.225
DEG_APCC_DBOX_1 21 29 PF00400 0.307
LIG_14-3-3_CanoR_1 30 35 PF00244 0.307
LIG_AP2alpha_1 96 100 PF02296 0.307
LIG_BIR_II_1 1 5 PF00653 0.397
LIG_BRCT_BRCA1_1 92 96 PF00533 0.383
LIG_eIF4E_1 29 35 PF01652 0.307
LIG_LIR_Gen_1 2 11 PF02991 0.351
LIG_LIR_Gen_1 93 103 PF02991 0.423
LIG_LIR_Nem_3 2 6 PF02991 0.370
LIG_LIR_Nem_3 93 99 PF02991 0.423
LIG_Pex14_2 96 100 PF04695 0.307
LIG_PTB_Apo_2 110 117 PF02174 0.307
LIG_PTB_Apo_2 51 58 PF02174 0.405
LIG_SH2_GRB2like 14 17 PF00017 0.423
LIG_SH2_STAT5 110 113 PF00017 0.310
MOD_GlcNHglycan 73 76 PF01048 0.371
MOD_NEK2_1 17 22 PF00069 0.253
MOD_PIKK_1 17 23 PF00454 0.279
MOD_Plk_4 30 36 PF00069 0.307
MOD_SUMO_for_1 87 90 PF00179 0.220
TRG_DiLeu_BaEn_4 89 95 PF01217 0.225
TRG_ENDOCYTIC_2 14 17 PF00928 0.307

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL30 Leptomonas seymouri 89% 100%
A0A1X0NS09 Trypanosomatidae 71% 100%
A0A3R7JTH9 Trypanosoma rangeli 69% 100%
A0A3S5H6G7 Leishmania donovani 86% 100%
A4HUJ7 Leishmania infantum 86% 100%
C9ZVM2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 100%
E9AN95 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
O42242 Xenopus laevis 28% 98%
P33331 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 99%
P61970 Homo sapiens 29% 98%
P61971 Mus musculus 29% 98%
P61972 Rattus norvegicus 29% 98%
P87102 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 34% 100%
Q10100 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 100%
Q21735 Caenorhabditis elegans 29% 93%
Q32KP9 Bos taurus 29% 98%
Q4QHC9 Leishmania major 86% 100%
Q5R8G4 Pongo abelii 29% 98%
Q6BWC0 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 33% 100%
Q6CC82 Yarrowia lipolytica (strain CLIB 122 / E 150) 33% 100%
Q6CQX4 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 33% 99%
Q6FRC6 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 34% 99%
Q75AA5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 34% 99%
Q86HW7 Dictyostelium discoideum 38% 98%
Q8NJ52 Davidiella tassiana 36% 99%
Q96VN3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 34% 99%
Q9C7F5 Arabidopsis thaliana 42% 98%
Q9FZK4 Arabidopsis thaliana 39% 100%
Q9P926 Candida albicans 38% 100%
Q9XJ54 Oryza sativa subsp. japonica 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS