A_deaminase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H672_LEIBR

TriTrypDb:

LbrM.10.0940 , LBRM2903_100017900

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H672

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H672

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006152	purine nucleoside catabolic process	6	1
GO:0006154	adenosine catabolic process	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009058	biosynthetic process	2	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009119	ribonucleoside metabolic process	5	1
GO:0009163	nucleoside biosynthetic process	5	1
GO:0009164	nucleoside catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034656	nucleobase-containing small molecule catabolic process	4	1
GO:0042278	purine nucleoside metabolic process	5	1
GO:0042451	purine nucleoside biosynthetic process	6	1
GO:0042454	ribonucleoside catabolic process	6	1
GO:0042455	ribonucleoside biosynthetic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046085	adenosine metabolic process	7	1
GO:0046102	inosine metabolic process	7	1
GO:0046103	inosine biosynthetic process	8	1
GO:0046128	purine ribonucleoside metabolic process	6	1
GO:0046129	purine ribonucleoside biosynthetic process	7	1
GO:0046130	purine ribonucleoside catabolic process	7	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1
GO:1901658	glycosyl compound catabolic process	5	1
GO:1901659	glycosyl compound biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0019239	deaminase activity	3	11
GO:0004000	adenosine deaminase activity	4	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.523
CLV_C14_Caspase3-7	354	358	PF00656	0.628
CLV_C14_Caspase3-7	608	612	PF00656	0.620
CLV_NRD_NRD_1	172	174	PF00675	0.486
CLV_NRD_NRD_1	274	276	PF00675	0.515
CLV_NRD_NRD_1	367	369	PF00675	0.370
CLV_NRD_NRD_1	399	401	PF00675	0.427
CLV_NRD_NRD_1	535	537	PF00675	0.438
CLV_NRD_NRD_1	96	98	PF00675	0.578
CLV_PCSK_KEX2_1	172	174	PF00082	0.486
CLV_PCSK_KEX2_1	273	275	PF00082	0.492
CLV_PCSK_KEX2_1	367	369	PF00082	0.397
CLV_PCSK_KEX2_1	535	537	PF00082	0.437
CLV_PCSK_KEX2_1	96	98	PF00082	0.637
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.637
CLV_PCSK_PC7_1	168	174	PF00082	0.483
CLV_PCSK_SKI1_1	124	128	PF00082	0.419
CLV_PCSK_SKI1_1	275	279	PF00082	0.463
CLV_PCSK_SKI1_1	292	296	PF00082	0.304
CLV_PCSK_SKI1_1	299	303	PF00082	0.373
CLV_PCSK_SKI1_1	573	577	PF00082	0.388
DEG_APCC_DBOX_1	274	282	PF00400	0.475
DEG_APCC_DBOX_1	630	638	PF00400	0.337
DEG_Nend_UBRbox_2	1	3	PF02207	0.622
DEG_SCF_FBW7_1	705	712	PF00400	0.479
DEG_SCF_TRCP1_1	553	559	PF00400	0.444
DOC_CYCLIN_RxL_1	288	296	PF00134	0.411
DOC_CYCLIN_RxL_1	579	588	PF00134	0.400
DOC_CYCLIN_yCln2_LP_2	640	646	PF00134	0.441
DOC_MAPK_gen_1	535	543	PF00069	0.532
DOC_MAPK_HePTP_8	285	297	PF00069	0.316
DOC_MAPK_MEF2A_6	288	297	PF00069	0.311
DOC_PP2B_LxvP_1	443	446	PF13499	0.428
DOC_PP2B_LxvP_1	640	643	PF13499	0.342
DOC_PP4_FxxP_1	561	564	PF00568	0.332
DOC_PP4_FxxP_1	638	641	PF00568	0.298
DOC_USP7_MATH_1	216	220	PF00917	0.528
DOC_USP7_MATH_1	709	713	PF00917	0.525
DOC_USP7_UBL2_3	227	231	PF12436	0.307
DOC_WW_Pin1_4	102	107	PF00397	0.661
DOC_WW_Pin1_4	114	119	PF00397	0.493
DOC_WW_Pin1_4	613	618	PF00397	0.489
DOC_WW_Pin1_4	694	699	PF00397	0.496
DOC_WW_Pin1_4	705	710	PF00397	0.394
LIG_14-3-3_CanoR_1	124	129	PF00244	0.379
LIG_14-3-3_CanoR_1	164	168	PF00244	0.348
LIG_14-3-3_CanoR_1	172	176	PF00244	0.404
LIG_14-3-3_CanoR_1	299	307	PF00244	0.374
LIG_14-3-3_CanoR_1	3	13	PF00244	0.628
LIG_14-3-3_CanoR_1	347	353	PF00244	0.692
LIG_14-3-3_CanoR_1	368	378	PF00244	0.302
LIG_14-3-3_CanoR_1	420	427	PF00244	0.364
LIG_14-3-3_CanoR_1	599	605	PF00244	0.428
LIG_14-3-3_CanoR_1	631	635	PF00244	0.295
LIG_BRCT_BRCA1_1	137	141	PF00533	0.301
LIG_deltaCOP1_diTrp_1	447	454	PF00928	0.362
LIG_deltaCOP1_diTrp_1	680	687	PF00928	0.510
LIG_deltaCOP1_diTrp_1	718	726	PF00928	0.340
LIG_FHA_1	192	198	PF00498	0.336
LIG_FHA_1	208	214	PF00498	0.346
LIG_FHA_1	28	34	PF00498	0.309
LIG_FHA_1	370	376	PF00498	0.327
LIG_FHA_1	386	392	PF00498	0.322
LIG_FHA_1	420	426	PF00498	0.477
LIG_FHA_1	473	479	PF00498	0.343
LIG_FHA_1	519	525	PF00498	0.530
LIG_FHA_1	558	564	PF00498	0.464
LIG_FHA_1	599	605	PF00498	0.527
LIG_FHA_2	115	121	PF00498	0.494
LIG_FHA_2	125	131	PF00498	0.331
LIG_FHA_2	233	239	PF00498	0.559
LIG_FHA_2	338	344	PF00498	0.554
LIG_FHA_2	374	380	PF00498	0.304
LIG_FHA_2	5	11	PF00498	0.492
LIG_FHA_2	540	546	PF00498	0.655
LIG_FHA_2	606	612	PF00498	0.682
LIG_GBD_Chelix_1	159	167	PF00786	0.459
LIG_KLC1_Yacidic_2	187	191	PF13176	0.268
LIG_LIR_Apic_2	559	564	PF02991	0.474
LIG_LIR_Gen_1	127	136	PF02991	0.342
LIG_LIR_Gen_1	138	149	PF02991	0.300
LIG_LIR_Gen_1	254	263	PF02991	0.322
LIG_LIR_Gen_1	326	332	PF02991	0.401
LIG_LIR_Gen_1	388	397	PF02991	0.360
LIG_LIR_Gen_1	653	663	PF02991	0.484
LIG_LIR_Gen_1	683	690	PF02991	0.483
LIG_LIR_Gen_1	718	726	PF02991	0.463
LIG_LIR_Nem_3	127	132	PF02991	0.364
LIG_LIR_Nem_3	138	144	PF02991	0.328
LIG_LIR_Nem_3	254	260	PF02991	0.378
LIG_LIR_Nem_3	326	330	PF02991	0.395
LIG_LIR_Nem_3	359	364	PF02991	0.379
LIG_LIR_Nem_3	388	392	PF02991	0.358
LIG_LIR_Nem_3	447	452	PF02991	0.332
LIG_LIR_Nem_3	512	518	PF02991	0.566
LIG_LIR_Nem_3	653	658	PF02991	0.430
LIG_LIR_Nem_3	683	687	PF02991	0.491
LIG_LIR_Nem_3	718	722	PF02991	0.412
LIG_LIR_Nem_3	723	729	PF02991	0.404
LIG_NRBOX	490	496	PF00104	0.496
LIG_NRBOX	56	62	PF00104	0.446
LIG_Pex14_1	249	253	PF04695	0.323
LIG_PTB_Apo_2	562	569	PF02174	0.313
LIG_SH2_CRK	257	261	PF00017	0.428
LIG_SH2_CRK	655	659	PF00017	0.476
LIG_SH2_GRB2like	253	256	PF00017	0.247
LIG_SH2_NCK_1	253	257	PF00017	0.456
LIG_SH2_NCK_1	655	659	PF00017	0.635
LIG_SH2_SRC	253	256	PF00017	0.247
LIG_SH2_STAP1	253	257	PF00017	0.456
LIG_SH2_STAT5	133	136	PF00017	0.345
LIG_SH2_STAT5	189	192	PF00017	0.333
LIG_SH2_STAT5	257	260	PF00017	0.355
LIG_SH2_STAT5	276	279	PF00017	0.424
LIG_SH2_STAT5	518	521	PF00017	0.318
LIG_SH3_3	388	394	PF00018	0.496
LIG_SH3_3	46	52	PF00018	0.251
LIG_SH3_3	655	661	PF00018	0.400
LIG_SUMO_SIM_anti_2	156	162	PF11976	0.391
LIG_SUMO_SIM_par_1	10	16	PF11976	0.519
LIG_SUMO_SIM_par_1	204	210	PF11976	0.434
LIG_SUMO_SIM_par_1	539	549	PF11976	0.460
LIG_TRAF2_1	180	183	PF00917	0.632
LIG_TRAF2_1	240	243	PF00917	0.505
LIG_WRC_WIRS_1	361	366	PF05994	0.304
MOD_CDK_SPxxK_3	102	109	PF00069	0.712
MOD_CK1_1	265	271	PF00069	0.381
MOD_CK1_1	283	289	PF00069	0.466
MOD_CK1_1	351	357	PF00069	0.614
MOD_CK1_1	409	415	PF00069	0.547
MOD_CK1_1	544	550	PF00069	0.612
MOD_CK1_1	554	560	PF00069	0.539
MOD_CK1_1	567	573	PF00069	0.343
MOD_CK1_1	618	624	PF00069	0.265
MOD_CK1_1	656	662	PF00069	0.655
MOD_CK1_1	712	718	PF00069	0.449
MOD_CK1_1	86	92	PF00069	0.499
MOD_CK2_1	114	120	PF00069	0.570
MOD_CK2_1	124	130	PF00069	0.487
MOD_CK2_1	150	156	PF00069	0.303
MOD_CK2_1	4	10	PF00069	0.551
MOD_CK2_1	497	503	PF00069	0.588
MOD_CK2_1	539	545	PF00069	0.498
MOD_CK2_1	712	718	PF00069	0.241
MOD_CMANNOS	681	684	PF00535	0.514
MOD_GlcNHglycan	152	155	PF01048	0.308
MOD_GlcNHglycan	214	217	PF01048	0.521
MOD_GlcNHglycan	218	221	PF01048	0.512
MOD_GlcNHglycan	264	267	PF01048	0.696
MOD_GlcNHglycan	379	383	PF01048	0.312
MOD_GlcNHglycan	460	463	PF01048	0.459
MOD_GlcNHglycan	49	52	PF01048	0.461
MOD_GlcNHglycan	553	556	PF01048	0.689
MOD_GlcNHglycan	617	620	PF01048	0.315
MOD_GlcNHglycan	68	71	PF01048	0.503
MOD_GSK3_1	131	138	PF00069	0.358
MOD_GSK3_1	189	196	PF00069	0.385
MOD_GSK3_1	212	219	PF00069	0.436
MOD_GSK3_1	347	354	PF00069	0.667
MOD_GSK3_1	356	363	PF00069	0.528
MOD_GSK3_1	369	376	PF00069	0.226
MOD_GSK3_1	409	416	PF00069	0.562
MOD_GSK3_1	419	426	PF00069	0.379
MOD_GSK3_1	452	459	PF00069	0.412
MOD_GSK3_1	473	480	PF00069	0.358
MOD_GSK3_1	497	504	PF00069	0.489
MOD_GSK3_1	539	546	PF00069	0.553
MOD_GSK3_1	611	618	PF00069	0.413
MOD_GSK3_1	690	697	PF00069	0.466
MOD_GSK3_1	699	706	PF00069	0.588
MOD_GSK3_1	86	93	PF00069	0.565
MOD_N-GLC_1	27	32	PF02516	0.517
MOD_N-GLC_1	283	288	PF02516	0.516
MOD_N-GLC_1	409	414	PF02516	0.502
MOD_N-GLC_1	45	50	PF02516	0.308
MOD_N-GLC_1	456	461	PF02516	0.396
MOD_N-GLC_1	564	569	PF02516	0.309
MOD_NEK2_1	139	144	PF00069	0.320
MOD_NEK2_1	150	155	PF00069	0.273
MOD_NEK2_1	171	176	PF00069	0.440
MOD_NEK2_1	293	298	PF00069	0.346
MOD_NEK2_1	369	374	PF00069	0.398
MOD_NEK2_1	378	383	PF00069	0.400
MOD_NEK2_1	4	9	PF00069	0.546
MOD_NEK2_1	45	50	PF00069	0.327
MOD_NEK2_1	472	477	PF00069	0.340
MOD_NEK2_1	497	502	PF00069	0.519
MOD_NEK2_1	576	581	PF00069	0.353
MOD_NEK2_1	600	605	PF00069	0.515
MOD_NEK2_1	651	656	PF00069	0.597
MOD_NEK2_2	226	231	PF00069	0.295
MOD_NEK2_2	423	428	PF00069	0.479
MOD_NEK2_2	564	569	PF00069	0.338
MOD_PIKK_1	313	319	PF00454	0.466
MOD_PIKK_1	585	591	PF00454	0.480
MOD_PIKK_1	611	617	PF00454	0.412
MOD_PIKK_1	90	96	PF00454	0.615
MOD_PKA_2	163	169	PF00069	0.356
MOD_PKA_2	171	177	PF00069	0.409
MOD_PKA_2	310	316	PF00069	0.476
MOD_PKA_2	346	352	PF00069	0.755
MOD_PKA_2	369	375	PF00069	0.328
MOD_PKA_2	419	425	PF00069	0.368
MOD_PKA_2	598	604	PF00069	0.530
MOD_PKA_2	630	636	PF00069	0.294
MOD_PKA_2	712	718	PF00069	0.541
MOD_Plk_1	356	362	PF00069	0.513
MOD_Plk_1	455	461	PF00069	0.484
MOD_Plk_1	564	570	PF00069	0.322
MOD_Plk_2-3	238	244	PF00069	0.510
MOD_Plk_4	131	137	PF00069	0.246
MOD_Plk_4	256	262	PF00069	0.409
MOD_Plk_4	356	362	PF00069	0.386
MOD_Plk_4	385	391	PF00069	0.436
MOD_Plk_4	557	563	PF00069	0.548
MOD_Plk_4	683	689	PF00069	0.537
MOD_Plk_4	86	92	PF00069	0.479
MOD_ProDKin_1	102	108	PF00069	0.663
MOD_ProDKin_1	114	120	PF00069	0.487
MOD_ProDKin_1	613	619	PF00069	0.474
MOD_ProDKin_1	694	700	PF00069	0.507
MOD_ProDKin_1	705	711	PF00069	0.379
MOD_SUMO_for_1	236	239	PF00179	0.458
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.342
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.333
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.392
TRG_ENDOCYTIC_2	133	136	PF00928	0.330
TRG_ENDOCYTIC_2	253	256	PF00928	0.384
TRG_ENDOCYTIC_2	257	260	PF00928	0.345
TRG_ENDOCYTIC_2	389	392	PF00928	0.475
TRG_ENDOCYTIC_2	655	658	PF00928	0.468
TRG_ER_diArg_1	171	173	PF00400	0.478
TRG_ER_diArg_1	273	275	PF00400	0.438
TRG_ER_diArg_1	367	370	PF00400	0.385
TRG_ER_diArg_1	534	536	PF00400	0.444
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F9	Leptomonas seymouri	48%	98%
A0A1X0NRU3	Trypanosomatidae	35%	100%
A0A3S5IS54	Trypanosoma rangeli	35%	100%
A0A3S7WR98	Leishmania donovani	74%	100%
A4HUJ6	Leishmania infantum	74%	100%
C9ZVM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AN94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QHD0	Leishmania major	74%	99%
V5BTS5	Trypanosoma cruzi	36%	100%