Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H665_LEIBR

TriTrypDb:

LbrM.10.0870 , LBRM2903_100017100

Length:

861

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H665

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H665

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	539	543	PF00656	0.511
CLV_C14_Caspase3-7	678	682	PF00656	0.535
CLV_MEL_PAP_1	98	104	PF00089	0.479
CLV_NRD_NRD_1	27	29	PF00675	0.468
CLV_NRD_NRD_1	493	495	PF00675	0.376
CLV_NRD_NRD_1	583	585	PF00675	0.619
CLV_NRD_NRD_1	619	621	PF00675	0.681
CLV_NRD_NRD_1	627	629	PF00675	0.585
CLV_PCSK_KEX2_1	182	184	PF00082	0.465
CLV_PCSK_KEX2_1	242	244	PF00082	0.523
CLV_PCSK_KEX2_1	27	29	PF00082	0.468
CLV_PCSK_KEX2_1	493	495	PF00082	0.376
CLV_PCSK_KEX2_1	583	585	PF00082	0.619
CLV_PCSK_KEX2_1	619	621	PF00082	0.681
CLV_PCSK_KEX2_1	627	629	PF00082	0.585
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.465
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.539
CLV_PCSK_SKI1_1	27	31	PF00082	0.497
CLV_PCSK_SKI1_1	369	373	PF00082	0.468
CLV_PCSK_SKI1_1	602	606	PF00082	0.514
CLV_PCSK_SKI1_1	608	612	PF00082	0.537
CLV_PCSK_SKI1_1	645	649	PF00082	0.527
CLV_PCSK_SKI1_1	93	97	PF00082	0.476
CLV_Separin_Metazoa	421	425	PF03568	0.365
DEG_APCC_DBOX_1	247	255	PF00400	0.389
DEG_APCC_DBOX_1	828	836	PF00400	0.489
DEG_SCF_FBW7_1	321	328	PF00400	0.501
DEG_SPOP_SBC_1	234	238	PF00917	0.529
DOC_CKS1_1	94	99	PF01111	0.487
DOC_CYCLIN_RxL_1	22	34	PF00134	0.467
DOC_CYCLIN_RxL_1	602	615	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.345
DOC_MAPK_gen_1	493	500	PF00069	0.364
DOC_MAPK_MEF2A_6	248	256	PF00069	0.374
DOC_MAPK_MEF2A_6	305	314	PF00069	0.428
DOC_MAPK_MEF2A_6	443	451	PF00069	0.478
DOC_PP1_RVXF_1	210	217	PF00149	0.345
DOC_PP1_RVXF_1	494	501	PF00149	0.498
DOC_PP1_RVXF_1	88	95	PF00149	0.477
DOC_PP2B_LxvP_1	110	113	PF13499	0.449
DOC_PP2B_LxvP_1	120	123	PF13499	0.312
DOC_PP4_FxxP_1	94	97	PF00568	0.476
DOC_USP7_MATH_1	207	211	PF00917	0.364
DOC_USP7_MATH_1	247	251	PF00917	0.375
DOC_USP7_MATH_1	271	275	PF00917	0.648
DOC_USP7_MATH_1	285	289	PF00917	0.520
DOC_USP7_MATH_1	327	331	PF00917	0.656
DOC_USP7_MATH_1	387	391	PF00917	0.685
DOC_USP7_MATH_1	4	8	PF00917	0.469
DOC_USP7_MATH_1	406	410	PF00917	0.462
DOC_WW_Pin1_4	126	131	PF00397	0.650
DOC_WW_Pin1_4	138	143	PF00397	0.602
DOC_WW_Pin1_4	198	203	PF00397	0.506
DOC_WW_Pin1_4	274	279	PF00397	0.699
DOC_WW_Pin1_4	281	286	PF00397	0.487
DOC_WW_Pin1_4	321	326	PF00397	0.498
DOC_WW_Pin1_4	335	340	PF00397	0.725
DOC_WW_Pin1_4	347	352	PF00397	0.461
DOC_WW_Pin1_4	36	41	PF00397	0.637
DOC_WW_Pin1_4	374	379	PF00397	0.613
DOC_WW_Pin1_4	610	615	PF00397	0.596
DOC_WW_Pin1_4	695	700	PF00397	0.663
DOC_WW_Pin1_4	93	98	PF00397	0.639
LIG_14-3-3_CanoR_1	101	111	PF00244	0.485
LIG_14-3-3_CanoR_1	183	191	PF00244	0.376
LIG_14-3-3_CanoR_1	248	252	PF00244	0.398
LIG_14-3-3_CanoR_1	309	315	PF00244	0.467
LIG_14-3-3_CanoR_1	32	36	PF00244	0.466
LIG_14-3-3_CanoR_1	331	336	PF00244	0.657
LIG_14-3-3_CanoR_1	443	451	PF00244	0.478
LIG_14-3-3_CanoR_1	462	471	PF00244	0.398
LIG_14-3-3_CanoR_1	493	499	PF00244	0.452
LIG_14-3-3_CanoR_1	557	567	PF00244	0.448
LIG_14-3-3_CanoR_1	578	583	PF00244	0.515
LIG_14-3-3_CanoR_1	584	594	PF00244	0.609
LIG_14-3-3_CanoR_1	78	88	PF00244	0.613
LIG_14-3-3_CanoR_1	801	811	PF00244	0.442
LIG_Actin_WH2_2	18	34	PF00022	0.466
LIG_Actin_WH2_2	565	582	PF00022	0.318
LIG_BIR_II_1	1	5	PF00653	0.480
LIG_BIR_III_3	1	5	PF00653	0.480
LIG_BRCT_BRCA1_1	496	500	PF00533	0.481
LIG_BRCT_BRCA1_1	548	552	PF00533	0.486
LIG_BRCT_BRCA1_1	803	807	PF00533	0.316
LIG_deltaCOP1_diTrp_1	211	216	PF00928	0.347
LIG_DLG_GKlike_1	494	501	PF00625	0.498
LIG_EVH1_2	112	116	PF00568	0.331
LIG_FHA_1	127	133	PF00498	0.376
LIG_FHA_1	152	158	PF00498	0.452
LIG_FHA_1	171	177	PF00498	0.515
LIG_FHA_1	185	191	PF00498	0.367
LIG_FHA_1	311	317	PF00498	0.453
LIG_FHA_1	393	399	PF00498	0.512
LIG_FHA_1	400	406	PF00498	0.492
LIG_FHA_1	418	424	PF00498	0.335
LIG_FHA_1	510	516	PF00498	0.481
LIG_FHA_1	636	642	PF00498	0.501
LIG_FHA_1	646	652	PF00498	0.490
LIG_FHA_1	779	785	PF00498	0.561
LIG_FHA_1	813	819	PF00498	0.431
LIG_FHA_2	176	182	PF00498	0.525
LIG_FHA_2	375	381	PF00498	0.566
LIG_FHA_2	641	647	PF00498	0.460
LIG_FHA_2	760	766	PF00498	0.419
LIG_FHA_2	769	775	PF00498	0.467
LIG_Integrin_RGD_1	628	630	PF01839	0.501
LIG_IRF3_LxIS_1	310	317	PF10401	0.313
LIG_LIR_Gen_1	210	219	PF02991	0.340
LIG_LIR_Gen_1	720	730	PF02991	0.464
LIG_LIR_Nem_3	210	216	PF02991	0.348
LIG_LIR_Nem_3	360	364	PF02991	0.303
LIG_LIR_Nem_3	37	41	PF02991	0.464
LIG_LIR_Nem_3	720	726	PF02991	0.464
LIG_Pex14_2	304	308	PF04695	0.436
LIG_Pex14_2	500	504	PF04695	0.471
LIG_Pex14_2	807	811	PF04695	0.335
LIG_SH2_CRK	723	727	PF00017	0.469
LIG_SH2_STAP1	104	108	PF00017	0.578
LIG_SH2_STAP1	471	475	PF00017	0.557
LIG_SH2_STAP1	513	517	PF00017	0.400
LIG_SH2_STAP1	560	564	PF00017	0.419
LIG_SH2_STAP1	723	727	PF00017	0.453
LIG_SH2_STAP1	739	743	PF00017	0.314
LIG_SH2_STAT3	851	854	PF00017	0.425
LIG_SH2_STAT5	262	265	PF00017	0.439
LIG_SH2_STAT5	513	516	PF00017	0.396
LIG_SH2_STAT5	650	653	PF00017	0.478
LIG_SH3_2	123	128	PF14604	0.390
LIG_SH3_2	614	619	PF14604	0.497
LIG_SH3_3	120	126	PF00018	0.520
LIG_SH3_3	199	205	PF00018	0.631
LIG_SH3_3	241	247	PF00018	0.620
LIG_SH3_3	251	257	PF00018	0.338
LIG_SH3_3	333	339	PF00018	0.633
LIG_SH3_3	376	382	PF00018	0.535
LIG_SH3_3	402	408	PF00018	0.610
LIG_SH3_3	561	567	PF00018	0.467
LIG_SH3_3	611	617	PF00018	0.521
LIG_SH3_3	703	709	PF00018	0.561
LIG_SUMO_SIM_anti_2	368	374	PF11976	0.344
LIG_SUMO_SIM_anti_2	698	704	PF11976	0.596
LIG_SUMO_SIM_anti_2	813	821	PF11976	0.494
LIG_SUMO_SIM_par_1	310	315	PF11976	0.429
LIG_SUMO_SIM_par_1	368	374	PF11976	0.344
LIG_SUMO_SIM_par_1	759	767	PF11976	0.433
LIG_SUMO_SIM_par_1	780	785	PF11976	0.559
LIG_SxIP_EBH_1	4	14	PF03271	0.465
LIG_TRAF2_1	186	189	PF00917	0.406
LIG_TYR_ITIM	721	726	PF00017	0.465
LIG_UBA3_1	717	725	PF00899	0.458
LIG_UBA3_1	832	839	PF00899	0.493
LIG_WRC_WIRS_1	35	40	PF05994	0.464
MOD_CK1_1	103	109	PF00069	0.528
MOD_CK1_1	168	174	PF00069	0.541
MOD_CK1_1	201	207	PF00069	0.494
MOD_CK1_1	236	242	PF00069	0.567
MOD_CK1_1	274	280	PF00069	0.596
MOD_CK1_1	374	380	PF00069	0.497
MOD_CK1_1	39	45	PF00069	0.529
MOD_CK1_1	399	405	PF00069	0.692
MOD_CK1_1	442	448	PF00069	0.473
MOD_CK1_1	465	471	PF00069	0.575
MOD_CK1_1	535	541	PF00069	0.556
MOD_CK1_1	546	552	PF00069	0.602
MOD_CK1_1	588	594	PF00069	0.382
MOD_CK1_1	675	681	PF00069	0.623
MOD_CK1_1	802	808	PF00069	0.318
MOD_CK2_1	175	181	PF00069	0.532
MOD_CK2_1	183	189	PF00069	0.374
MOD_CK2_1	286	292	PF00069	0.651
MOD_CK2_1	323	329	PF00069	0.700
MOD_CK2_1	442	448	PF00069	0.529
MOD_CK2_1	587	593	PF00069	0.379
MOD_CK2_1	640	646	PF00069	0.484
MOD_CK2_1	768	774	PF00069	0.532
MOD_GlcNHglycan	106	109	PF01048	0.549
MOD_GlcNHglycan	146	149	PF01048	0.527
MOD_GlcNHglycan	167	170	PF01048	0.538
MOD_GlcNHglycan	263	266	PF01048	0.534
MOD_GlcNHglycan	273	276	PF01048	0.604
MOD_GlcNHglycan	325	328	PF01048	0.683
MOD_GlcNHglycan	373	376	PF01048	0.566
MOD_GlcNHglycan	385	388	PF01048	0.618
MOD_GlcNHglycan	426	429	PF01048	0.504
MOD_GlcNHglycan	444	447	PF01048	0.597
MOD_GlcNHglycan	467	470	PF01048	0.636
MOD_GlcNHglycan	473	476	PF01048	0.632
MOD_GlcNHglycan	479	482	PF01048	0.625
MOD_GlcNHglycan	529	532	PF01048	0.635
MOD_GlcNHglycan	548	551	PF01048	0.589
MOD_GlcNHglycan	623	626	PF01048	0.799
MOD_GlcNHglycan	630	633	PF01048	0.618
MOD_GlcNHglycan	674	677	PF01048	0.604
MOD_GlcNHglycan	728	731	PF01048	0.511
MOD_GlcNHglycan	8	11	PF01048	0.575
MOD_GlcNHglycan	801	804	PF01048	0.478
MOD_GlcNHglycan	808	811	PF01048	0.595
MOD_GlcNHglycan	857	860	PF01048	0.546
MOD_GSK3_1	100	107	PF00069	0.568
MOD_GSK3_1	114	121	PF00069	0.339
MOD_GSK3_1	138	145	PF00069	0.540
MOD_GSK3_1	168	175	PF00069	0.540
MOD_GSK3_1	197	204	PF00069	0.504
MOD_GSK3_1	233	240	PF00069	0.586
MOD_GSK3_1	281	288	PF00069	0.584
MOD_GSK3_1	30	37	PF00069	0.670
MOD_GSK3_1	310	317	PF00069	0.484
MOD_GSK3_1	321	328	PF00069	0.693
MOD_GSK3_1	331	338	PF00069	0.759
MOD_GSK3_1	383	390	PF00069	0.606
MOD_GSK3_1	392	399	PF00069	0.612
MOD_GSK3_1	460	467	PF00069	0.593
MOD_GSK3_1	482	489	PF00069	0.690
MOD_GSK3_1	509	516	PF00069	0.371
MOD_GSK3_1	532	539	PF00069	0.612
MOD_GSK3_1	542	549	PF00069	0.599
MOD_GSK3_1	57	64	PF00069	0.534
MOD_GSK3_1	584	591	PF00069	0.367
MOD_GSK3_1	635	642	PF00069	0.658
MOD_GSK3_1	671	678	PF00069	0.640
MOD_GSK3_1	717	724	PF00069	0.459
MOD_GSK3_1	764	771	PF00069	0.609
MOD_GSK3_1	778	785	PF00069	0.540
MOD_GSK3_1	801	808	PF00069	0.460
MOD_N-GLC_1	321	326	PF02516	0.627
MOD_N-GLC_1	533	538	PF02516	0.485
MOD_NEK2_1	219	224	PF00069	0.316
MOD_NEK2_1	294	299	PF00069	0.466
MOD_NEK2_1	30	35	PF00069	0.467
MOD_NEK2_1	314	319	PF00069	0.463
MOD_NEK2_1	460	465	PF00069	0.510
MOD_NEK2_1	572	577	PF00069	0.422
MOD_NEK2_1	585	590	PF00069	0.524
MOD_NEK2_1	640	645	PF00069	0.462
MOD_NEK2_1	717	722	PF00069	0.434
MOD_NEK2_1	768	773	PF00069	0.511
MOD_NEK2_1	77	82	PF00069	0.743
MOD_NEK2_2	412	417	PF00069	0.424
MOD_OFUCOSY	43	49	PF10250	0.470
MOD_PIKK_1	294	300	PF00454	0.420
MOD_PIKK_1	331	337	PF00454	0.698
MOD_PIKK_1	406	412	PF00454	0.474
MOD_PIKK_1	558	564	PF00454	0.477
MOD_PIKK_1	635	641	PF00454	0.507
MOD_PKA_2	100	106	PF00069	0.576
MOD_PKA_2	136	142	PF00069	0.494
MOD_PKA_2	151	157	PF00069	0.419
MOD_PKA_2	247	253	PF00069	0.440
MOD_PKA_2	31	37	PF00069	0.544
MOD_PKA_2	442	448	PF00069	0.563
MOD_PKA_2	52	58	PF00069	0.488
MOD_PKA_2	72	78	PF00069	0.451
MOD_PKB_1	59	67	PF00069	0.516
MOD_Plk_1	118	124	PF00069	0.350
MOD_Plk_1	460	466	PF00069	0.659
MOD_Plk_1	486	492	PF00069	0.716
MOD_Plk_1	536	542	PF00069	0.561
MOD_Plk_1	764	770	PF00069	0.590
MOD_Plk_4	172	178	PF00069	0.715
MOD_Plk_4	219	225	PF00069	0.394
MOD_Plk_4	247	253	PF00069	0.402
MOD_Plk_4	258	264	PF00069	0.334
MOD_Plk_4	72	78	PF00069	0.642
MOD_Plk_4	764	770	PF00069	0.590
MOD_ProDKin_1	126	132	PF00069	0.656
MOD_ProDKin_1	138	144	PF00069	0.600
MOD_ProDKin_1	198	204	PF00069	0.506
MOD_ProDKin_1	274	280	PF00069	0.700
MOD_ProDKin_1	281	287	PF00069	0.483
MOD_ProDKin_1	321	327	PF00069	0.500
MOD_ProDKin_1	335	341	PF00069	0.715
MOD_ProDKin_1	347	353	PF00069	0.453
MOD_ProDKin_1	36	42	PF00069	0.636
MOD_ProDKin_1	374	380	PF00069	0.616
MOD_ProDKin_1	610	616	PF00069	0.598
MOD_ProDKin_1	695	701	PF00069	0.656
MOD_ProDKin_1	93	99	PF00069	0.638
MOD_SUMO_rev_2	167	176	PF00179	0.540
TRG_DiLeu_BaEn_1	814	819	PF01217	0.436
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.461
TRG_ENDOCYTIC_2	723	726	PF00928	0.476
TRG_ER_diArg_1	27	29	PF00400	0.532
TRG_ER_diArg_1	493	496	PF00400	0.395
TRG_ER_diArg_1	58	61	PF00400	0.505
TRG_ER_diArg_1	582	584	PF00400	0.612
TRG_ER_diArg_1	619	621	PF00400	0.661
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	748	752	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ1	Leptomonas seymouri	32%	100%
A4HUI9	Leishmania infantum	69%	100%
E9AN86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%