Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H664_LEIBR

TriTrypDb:

LbrM.10.0860 , LBRM2903_100017000

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H664

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H664

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.641
CLV_C14_Caspase3-7	299	303	PF00656	0.542
CLV_C14_Caspase3-7	328	332	PF00656	0.320
CLV_NRD_NRD_1	177	179	PF00675	0.425
CLV_NRD_NRD_1	291	293	PF00675	0.363
CLV_NRD_NRD_1	342	344	PF00675	0.588
CLV_NRD_NRD_1	374	376	PF00675	0.566
CLV_NRD_NRD_1	393	395	PF00675	0.360
CLV_NRD_NRD_1	545	547	PF00675	0.566
CLV_NRD_NRD_1	568	570	PF00675	0.535
CLV_NRD_NRD_1	9	11	PF00675	0.449
CLV_PCSK_FUR_1	340	344	PF00082	0.331
CLV_PCSK_KEX2_1	177	179	PF00082	0.425
CLV_PCSK_KEX2_1	342	344	PF00082	0.569
CLV_PCSK_KEX2_1	374	376	PF00082	0.582
CLV_PCSK_KEX2_1	393	395	PF00082	0.313
CLV_PCSK_KEX2_1	9	11	PF00082	0.513
CLV_PCSK_SKI1_1	193	197	PF00082	0.669
CLV_PCSK_SKI1_1	399	403	PF00082	0.468
CLV_PCSK_SKI1_1	446	450	PF00082	0.470
CLV_PCSK_SKI1_1	457	461	PF00082	0.582
DEG_SCF_FBW7_2	55	62	PF00400	0.436
DOC_CDC14_PxL_1	1	9	PF14671	0.390
DOC_CDC14_PxL_1	497	505	PF14671	0.470
DOC_CYCLIN_RxL_1	6	17	PF00134	0.346
DOC_MAPK_gen_1	197	206	PF00069	0.549
DOC_MAPK_MEF2A_6	197	205	PF00069	0.497
DOC_MAPK_MEF2A_6	514	521	PF00069	0.491
DOC_MAPK_MEF2A_6	597	605	PF00069	0.359
DOC_MAPK_NFAT4_5	514	522	PF00069	0.497
DOC_PP2B_LxvP_1	402	405	PF13499	0.507
DOC_PP2B_LxvP_1	503	506	PF13499	0.475
DOC_USP7_MATH_1	106	110	PF00917	0.548
DOC_USP7_MATH_1	140	144	PF00917	0.646
DOC_USP7_MATH_1	225	229	PF00917	0.669
DOC_USP7_MATH_1	232	236	PF00917	0.539
DOC_USP7_MATH_1	255	259	PF00917	0.405
DOC_USP7_MATH_1	265	269	PF00917	0.503
DOC_USP7_MATH_1	297	301	PF00917	0.629
DOC_USP7_MATH_1	308	312	PF00917	0.738
DOC_USP7_MATH_1	448	452	PF00917	0.572
DOC_USP7_MATH_1	53	57	PF00917	0.440
DOC_USP7_MATH_1	537	541	PF00917	0.450
DOC_USP7_MATH_1	548	552	PF00917	0.464
DOC_USP7_MATH_1	571	575	PF00917	0.448
DOC_USP7_MATH_1	63	67	PF00917	0.585
DOC_USP7_MATH_1	98	102	PF00917	0.709
DOC_WW_Pin1_4	147	152	PF00397	0.815
DOC_WW_Pin1_4	178	183	PF00397	0.645
DOC_WW_Pin1_4	227	232	PF00397	0.709
DOC_WW_Pin1_4	25	30	PF00397	0.596
DOC_WW_Pin1_4	347	352	PF00397	0.406
DOC_WW_Pin1_4	491	496	PF00397	0.638
DOC_WW_Pin1_4	521	526	PF00397	0.295
DOC_WW_Pin1_4	55	60	PF00397	0.666
DOC_WW_Pin1_4	81	86	PF00397	0.548
LIG_14-3-3_CanoR_1	136	140	PF00244	0.632
LIG_14-3-3_CanoR_1	177	182	PF00244	0.574
LIG_14-3-3_CanoR_1	197	202	PF00244	0.333
LIG_14-3-3_CanoR_1	374	380	PF00244	0.589
LIG_14-3-3_CanoR_1	514	518	PF00244	0.412
LIG_Actin_WH2_2	326	344	PF00022	0.457
LIG_APCC_ABBA_1	236	241	PF00400	0.428
LIG_BIR_II_1	1	5	PF00653	0.500
LIG_BIR_III_3	1	5	PF00653	0.435
LIG_BIR_III_4	417	421	PF00653	0.468
LIG_BIR_III_4	628	632	PF00653	0.413
LIG_BRCT_BRCA1_1	322	326	PF00533	0.496
LIG_BRCT_BRCA1_1	43	47	PF00533	0.420
LIG_BRCT_BRCA1_1	523	527	PF00533	0.434
LIG_BRCT_BRCA1_1	83	87	PF00533	0.571
LIG_FHA_1	15	21	PF00498	0.407
LIG_FHA_1	155	161	PF00498	0.617
LIG_FHA_1	427	433	PF00498	0.416
LIG_FHA_1	434	440	PF00498	0.429
LIG_FHA_1	473	479	PF00498	0.516
LIG_FHA_1	514	520	PF00498	0.450
LIG_FHA_1	600	606	PF00498	0.418
LIG_FHA_2	294	300	PF00498	0.399
LIG_FHA_2	393	399	PF00498	0.411
LIG_FHA_2	477	483	PF00498	0.511
LIG_FHA_2	86	92	PF00498	0.467
LIG_GBD_Chelix_1	362	370	PF00786	0.256
LIG_IBAR_NPY_1	237	239	PF08397	0.578
LIG_Integrin_RGD_1	207	209	PF01839	0.567
LIG_Integrin_RGD_1	508	510	PF01839	0.284
LIG_LIR_Gen_1	44	55	PF02991	0.512
LIG_LIR_LC3C_4	494	499	PF02991	0.404
LIG_LIR_Nem_3	436	441	PF02991	0.422
LIG_LIR_Nem_3	44	50	PF02991	0.474
LIG_LIR_Nem_3	81	86	PF02991	0.497
LIG_MLH1_MIPbox_1	83	87	PF16413	0.571
LIG_MYND_1	234	238	PF01753	0.515
LIG_PTB_Apo_2	234	241	PF02174	0.446
LIG_Rb_LxCxE_1	473	496	PF01857	0.485
LIG_RPA_C_Fungi	364	376	PF08784	0.387
LIG_SH2_CRK	318	322	PF00017	0.372
LIG_SH2_CRK	348	352	PF00017	0.406
LIG_SH2_NCK_1	614	618	PF00017	0.448
LIG_SH2_STAP1	45	49	PF00017	0.414
LIG_SH2_STAT3	117	120	PF00017	0.449
LIG_SH2_STAT3	213	216	PF00017	0.563
LIG_SH2_STAT5	117	120	PF00017	0.501
LIG_SH2_STAT5	213	216	PF00017	0.615
LIG_SH2_STAT5	239	242	PF00017	0.590
LIG_SH2_STAT5	441	444	PF00017	0.424
LIG_SH2_STAT5	614	617	PF00017	0.448
LIG_SH2_STAT5	86	89	PF00017	0.527
LIG_SH3_1	348	354	PF00018	0.394
LIG_SH3_1	520	526	PF00018	0.489
LIG_SH3_3	13	19	PF00018	0.449
LIG_SH3_3	228	234	PF00018	0.759
LIG_SH3_3	348	354	PF00018	0.623
LIG_SH3_3	46	52	PF00018	0.441
LIG_SH3_3	495	501	PF00018	0.544
LIG_SH3_3	520	526	PF00018	0.489
LIG_SH3_3	69	75	PF00018	0.458
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.364
LIG_SUMO_SIM_anti_2	496	501	PF11976	0.584
LIG_SUMO_SIM_anti_2	602	608	PF11976	0.509
LIG_SUMO_SIM_par_1	128	133	PF11976	0.443
LIG_SUMO_SIM_par_1	596	602	PF11976	0.424
LIG_TRAF2_1	296	299	PF00917	0.452
LIG_TRAF2_1	470	473	PF00917	0.509
LIG_WRC_WIRS_1	619	624	PF05994	0.290
MOD_CDK_SPK_2	25	30	PF00069	0.499
MOD_CK1_1	150	156	PF00069	0.708
MOD_CK1_1	176	182	PF00069	0.649
MOD_CK1_1	230	236	PF00069	0.710
MOD_CK1_1	311	317	PF00069	0.676
MOD_CK1_1	355	361	PF00069	0.450
MOD_CK1_1	452	458	PF00069	0.478
MOD_CK1_1	493	499	PF00069	0.501
MOD_CK1_1	561	567	PF00069	0.640
MOD_CK1_1	89	95	PF00069	0.517
MOD_CK2_1	265	271	PF00069	0.640
MOD_CK2_1	293	299	PF00069	0.395
MOD_CK2_1	355	361	PF00069	0.502
MOD_CK2_1	431	437	PF00069	0.423
MOD_CK2_1	476	482	PF00069	0.512
MOD_CK2_1	537	543	PF00069	0.465
MOD_CK2_1	85	91	PF00069	0.640
MOD_GlcNHglycan	100	103	PF01048	0.515
MOD_GlcNHglycan	107	111	PF01048	0.550
MOD_GlcNHglycan	253	256	PF01048	0.547
MOD_GlcNHglycan	266	270	PF01048	0.653
MOD_GlcNHglycan	271	274	PF01048	0.637
MOD_GlcNHglycan	299	302	PF01048	0.684
MOD_GlcNHglycan	417	421	PF01048	0.582
MOD_GlcNHglycan	433	436	PF01048	0.284
MOD_GlcNHglycan	446	449	PF01048	0.372
MOD_GlcNHglycan	457	460	PF01048	0.537
MOD_GlcNHglycan	539	542	PF01048	0.522
MOD_GlcNHglycan	55	58	PF01048	0.551
MOD_GlcNHglycan	560	563	PF01048	0.789
MOD_GlcNHglycan	88	91	PF01048	0.632
MOD_GSK3_1	128	135	PF00069	0.487
MOD_GSK3_1	146	153	PF00069	0.675
MOD_GSK3_1	154	161	PF00069	0.551
MOD_GSK3_1	173	180	PF00069	0.527
MOD_GSK3_1	189	196	PF00069	0.672
MOD_GSK3_1	21	28	PF00069	0.633
MOD_GSK3_1	226	233	PF00069	0.666
MOD_GSK3_1	251	258	PF00069	0.468
MOD_GSK3_1	265	272	PF00069	0.553
MOD_GSK3_1	293	300	PF00069	0.609
MOD_GSK3_1	30	37	PF00069	0.642
MOD_GSK3_1	375	382	PF00069	0.346
MOD_GSK3_1	412	419	PF00069	0.659
MOD_GSK3_1	426	433	PF00069	0.468
MOD_GSK3_1	444	451	PF00069	0.338
MOD_GSK3_1	464	471	PF00069	0.459
MOD_GSK3_1	472	479	PF00069	0.561
MOD_GSK3_1	489	496	PF00069	0.552
MOD_GSK3_1	537	544	PF00069	0.526
MOD_GSK3_1	548	555	PF00069	0.618
MOD_GSK3_1	557	564	PF00069	0.618
MOD_GSK3_1	81	88	PF00069	0.523
MOD_GSK3_1	94	101	PF00069	0.564
MOD_N-GLC_1	25	30	PF02516	0.572
MOD_N-GLC_1	465	470	PF02516	0.502
MOD_N-GLC_1	571	576	PF02516	0.479
MOD_N-GLC_1	617	622	PF02516	0.467
MOD_NEK2_1	128	133	PF00069	0.435
MOD_NEK2_1	20	25	PF00069	0.570
MOD_NEK2_1	251	256	PF00069	0.484
MOD_NEK2_1	41	46	PF00069	0.441
MOD_NEK2_1	431	436	PF00069	0.418
MOD_NEK2_1	449	454	PF00069	0.617
MOD_NEK2_1	512	517	PF00069	0.439
MOD_NEK2_1	78	83	PF00069	0.346
MOD_NEK2_2	541	546	PF00069	0.457
MOD_PIKK_1	108	114	PF00454	0.536
MOD_PIKK_1	426	432	PF00454	0.419
MOD_PKA_1	177	183	PF00069	0.413
MOD_PKA_2	135	141	PF00069	0.661
MOD_PKA_2	176	182	PF00069	0.557
MOD_PKA_2	216	222	PF00069	0.514
MOD_PKA_2	392	398	PF00069	0.524
MOD_PKA_2	513	519	PF00069	0.409
MOD_Plk_1	311	317	PF00069	0.612
MOD_Plk_1	571	577	PF00069	0.466
MOD_Plk_1	599	605	PF00069	0.330
MOD_Plk_1	617	623	PF00069	0.547
MOD_Plk_4	113	119	PF00069	0.450
MOD_Plk_4	150	156	PF00069	0.579
MOD_Plk_4	311	317	PF00069	0.680
MOD_Plk_4	493	499	PF00069	0.547
MOD_Plk_4	64	70	PF00069	0.438
MOD_Plk_4	73	79	PF00069	0.445
MOD_ProDKin_1	147	153	PF00069	0.815
MOD_ProDKin_1	178	184	PF00069	0.658
MOD_ProDKin_1	227	233	PF00069	0.707
MOD_ProDKin_1	25	31	PF00069	0.598
MOD_ProDKin_1	347	353	PF00069	0.402
MOD_ProDKin_1	491	497	PF00069	0.619
MOD_ProDKin_1	521	527	PF00069	0.291
MOD_ProDKin_1	55	61	PF00069	0.655
MOD_ProDKin_1	81	87	PF00069	0.551
MOD_SUMO_rev_2	467	476	PF00179	0.508
TRG_ENDOCYTIC_2	239	242	PF00928	0.578
TRG_ENDOCYTIC_2	614	617	PF00928	0.448
TRG_ER_diArg_1	215	218	PF00400	0.638
TRG_ER_diArg_1	340	343	PF00400	0.471
TRG_ER_diArg_1	373	375	PF00400	0.575
TRG_ER_diArg_1	9	11	PF00400	0.443
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ1	Leptomonas seymouri	28%	94%
A0A0N1PDV8	Leptomonas seymouri	45%	100%
A0A3R7MYE1	Trypanosoma rangeli	23%	100%
A0A3S5H6G6	Leishmania donovani	31%	100%
A0A3S7WR70	Leishmania donovani	67%	100%
A4HUI8	Leishmania infantum	67%	100%
A4HUI9	Leishmania infantum	31%	98%
E9AN86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
E9AN87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4QHD7	Leishmania major	29%	100%
Q4QHD8	Leishmania major	66%	97%