Putative deaminase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative deaminase

Gene product:

deaminase, putative

Species:

Leishmania braziliensis

UniProt:

A4H663_LEIBR

TriTrypDb:

LbrM.10.0850 , LBRM2903_100016700

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H663

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H663

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002100	tRNA wobble adenosine to inosine editing	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006382	adenosine to inosine editing	7	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016553	base conversion or substitution editing	6	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	9
GO:0004000	adenosine deaminase activity	4	2
GO:0008251	tRNA-specific adenosine deaminase activity	5	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	2
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	2
GO:0019239	deaminase activity	3	2
GO:0052717	tRNA-specific adenosine-34 deaminase activity	6	1
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	273	275	PF00675	0.627
CLV_PCSK_KEX2_1	221	223	PF00082	0.526
CLV_PCSK_KEX2_1	271	273	PF00082	0.587
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.526
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.576
CLV_PCSK_SKI1_1	11	15	PF00082	0.276
CLV_PCSK_SKI1_1	44	48	PF00082	0.361
DEG_APCC_KENBOX_2	132	136	PF00400	0.380
DEG_Nend_Nbox_1	1	3	PF02207	0.548
DOC_CKS1_1	194	199	PF01111	0.499
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.370
DOC_USP7_MATH_1	112	116	PF00917	0.512
DOC_USP7_UBL2_3	271	275	PF12436	0.594
DOC_WW_Pin1_4	141	146	PF00397	0.562
DOC_WW_Pin1_4	193	198	PF00397	0.562
DOC_WW_Pin1_4	220	225	PF00397	0.734
DOC_WW_Pin1_4	46	51	PF00397	0.489
DOC_WW_Pin1_4	54	59	PF00397	0.511
LIG_14-3-3_CanoR_1	11	21	PF00244	0.565
LIG_CSL_BTD_1	236	239	PF09270	0.493
LIG_FHA_1	123	129	PF00498	0.565
LIG_FHA_2	246	252	PF00498	0.542
LIG_LIR_Gen_1	39	50	PF02991	0.560
LIG_LIR_Nem_3	151	155	PF02991	0.487
LIG_LIR_Nem_3	39	45	PF02991	0.560
LIG_Pex14_1	237	241	PF04695	0.541
LIG_PTB_Apo_2	179	186	PF02174	0.405
LIG_REV1ctd_RIR_1	175	182	PF16727	0.537
LIG_SH2_NCK_1	170	174	PF00017	0.537
LIG_SH2_PTP2	155	158	PF00017	0.457
LIG_SH2_SRC	5	8	PF00017	0.451
LIG_SH2_STAT5	152	155	PF00017	0.446
LIG_SH2_STAT5	241	244	PF00017	0.540
LIG_SH2_STAT5	5	8	PF00017	0.357
LIG_SH3_1	262	268	PF00018	0.606
LIG_SH3_3	200	206	PF00018	0.720
LIG_SH3_3	262	268	PF00018	0.573
LIG_SUMO_SIM_anti_2	251	257	PF11976	0.413
LIG_SUMO_SIM_par_1	190	196	PF11976	0.400
LIG_TRAF2_1	20	23	PF00917	0.537
LIG_TYR_ITIM	153	158	PF00017	0.457
LIG_TYR_ITIM	168	173	PF00017	0.446
MOD_CK1_1	139	145	PF00069	0.555
MOD_CK1_1	220	226	PF00069	0.690
MOD_CK1_1	231	237	PF00069	0.375
MOD_CK1_1	57	63	PF00069	0.440
MOD_CK2_1	112	118	PF00069	0.397
MOD_CK2_1	12	18	PF00069	0.467
MOD_CK2_1	222	228	PF00069	0.759
MOD_CK2_1	245	251	PF00069	0.550
MOD_GlcNHglycan	109	113	PF01048	0.320
MOD_GlcNHglycan	114	117	PF01048	0.307
MOD_GlcNHglycan	164	167	PF01048	0.365
MOD_GlcNHglycan	224	227	PF01048	0.720
MOD_GlcNHglycan	232	236	PF01048	0.587
MOD_GSK3_1	108	115	PF00069	0.487
MOD_GSK3_1	135	142	PF00069	0.555
MOD_GSK3_1	216	223	PF00069	0.657
MOD_N-GLC_1	187	192	PF02516	0.392
MOD_N-GLC_1	228	233	PF02516	0.473
MOD_N-GLC_1	79	84	PF02516	0.248
MOD_NEK2_1	137	142	PF00069	0.523
MOD_NEK2_1	216	221	PF00069	0.655
MOD_NEK2_1	69	74	PF00069	0.560
MOD_PKB_1	77	85	PF00069	0.471
MOD_Plk_4	187	193	PF00069	0.387
MOD_ProDKin_1	141	147	PF00069	0.562
MOD_ProDKin_1	193	199	PF00069	0.578
MOD_ProDKin_1	220	226	PF00069	0.730
MOD_ProDKin_1	46	52	PF00069	0.489
MOD_ProDKin_1	54	60	PF00069	0.511
TRG_DiLeu_BaEn_1	251	256	PF01217	0.438
TRG_ENDOCYTIC_2	155	158	PF00928	0.457
TRG_ENDOCYTIC_2	170	173	PF00928	0.446
TRG_ENDOCYTIC_2	42	45	PF00928	0.560
TRG_ER_diArg_1	272	274	PF00400	0.633
TRG_NES_CRM1_1	148	159	PF08389	0.403
TRG_NLS_MonoCore_2	270	275	PF00514	0.612
TRG_NLS_MonoExtC_3	270	275	PF00514	0.589
TRG_NLS_MonoExtN_4	268	275	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V2	Leptomonas seymouri	48%	84%
A0A1X0NRT1	Trypanosomatidae	47%	100%
A0A3S7WR79	Leishmania donovani	77%	98%
A0A422NWX1	Trypanosoma rangeli	44%	100%
A4HUI5	Leishmania infantum	77%	98%
C9ZVK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AN83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
O94642	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	71%
P47058	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4QHE1	Leishmania major	74%	100%
Q5E9J7	Bos taurus	27%	100%
Q5RIV4	Danio rerio	28%	100%
Q6P6J0	Mus musculus	28%	100%
Q7Z6V5	Homo sapiens	27%	100%
V5DKK8	Trypanosoma cruzi	44%	100%