Putative amino acid transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease 24, putative

Species:

Leishmania braziliensis

UniProt:

A4H662_LEIBR

TriTrypDb:

LbrM.10.0840 , LBRM2903_100016600

Length:

483

Annotations

LeishMANIAdb annotations

Related to animal and plant proton-coupled amino acid transporters. The family has modestly expanded in kinetoplastid parazites.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19
GO:0005774	vacuolar membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2

Expansion

Sequence features

A4H662

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H662

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	2
GO:0006810	transport	3	2
GO:0006865	amino acid transport	5	2
GO:0009987	cellular process	1	2
GO:0015849	organic acid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0015171	amino acid transmembrane transporter activity	5	2
GO:0015179	L-amino acid transmembrane transporter activity	6	2
GO:0022857	transmembrane transporter activity	2	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	291	293	PF00082	0.353
CLV_PCSK_KEX2_1	457	459	PF00082	0.389
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.353
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.383
CLV_PCSK_SKI1_1	342	346	PF00082	0.321
CLV_PCSK_SKI1_1	445	449	PF00082	0.336
CLV_PCSK_SKI1_1	83	87	PF00082	0.246
DEG_APCC_KENBOX_2	75	79	PF00400	0.616
DEG_Nend_UBRbox_3	1	3	PF02207	0.576
DEG_SCF_FBW7_1	449	455	PF00400	0.594
DOC_CKS1_1	449	454	PF01111	0.600
DOC_MAPK_FxFP_2	351	354	PF00069	0.347
DOC_MAPK_gen_1	290	298	PF00069	0.416
DOC_MAPK_gen_1	369	378	PF00069	0.475
DOC_MAPK_gen_1	457	465	PF00069	0.501
DOC_MAPK_HePTP_8	368	380	PF00069	0.515
DOC_MAPK_MEF2A_6	194	202	PF00069	0.382
DOC_MAPK_MEF2A_6	291	300	PF00069	0.412
DOC_MAPK_MEF2A_6	342	351	PF00069	0.347
DOC_MAPK_MEF2A_6	371	380	PF00069	0.467
DOC_MAPK_MEF2A_6	381	388	PF00069	0.271
DOC_MAPK_NFAT4_5	373	381	PF00069	0.496
DOC_PP1_RVXF_1	340	346	PF00149	0.347
DOC_PP4_FxxP_1	351	354	PF00568	0.347
DOC_PP4_FxxP_1	98	101	PF00568	0.307
DOC_USP7_MATH_1	219	223	PF00917	0.321
DOC_USP7_MATH_1	225	229	PF00917	0.421
DOC_USP7_MATH_1	409	413	PF00917	0.378
DOC_USP7_MATH_1	66	70	PF00917	0.645
DOC_WW_Pin1_4	332	337	PF00397	0.326
DOC_WW_Pin1_4	43	48	PF00397	0.696
DOC_WW_Pin1_4	448	453	PF00397	0.595
LIG_14-3-3_CanoR_1	19	25	PF00244	0.733
LIG_14-3-3_CanoR_1	371	376	PF00244	0.406
LIG_BRCT_BRCA1_1	176	180	PF00533	0.419
LIG_EH1_1	108	116	PF00400	0.320
LIG_EH1_1	463	471	PF00400	0.236
LIG_eIF4E_1	195	201	PF01652	0.237
LIG_eIF4E_1	464	470	PF01652	0.235
LIG_FHA_1	125	131	PF00498	0.402
LIG_FHA_1	224	230	PF00498	0.342
LIG_FHA_1	297	303	PF00498	0.483
LIG_FHA_1	305	311	PF00498	0.322
LIG_FHA_1	31	37	PF00498	0.713
LIG_FHA_1	313	319	PF00498	0.264
LIG_FHA_1	323	329	PF00498	0.241
LIG_FHA_1	350	356	PF00498	0.354
LIG_FHA_1	395	401	PF00498	0.326
LIG_FHA_1	474	480	PF00498	0.339
LIG_FHA_1	49	55	PF00498	0.687
LIG_FHA_2	181	187	PF00498	0.337
LIG_FHA_2	21	27	PF00498	0.743
LIG_GBD_Chelix_1	378	386	PF00786	0.170
LIG_Integrin_RGD_1	139	141	PF01839	0.157
LIG_LIR_Apic_2	95	101	PF02991	0.326
LIG_LIR_Gen_1	143	152	PF02991	0.509
LIG_LIR_Gen_1	193	203	PF02991	0.320
LIG_LIR_Gen_1	228	238	PF02991	0.378
LIG_LIR_Gen_1	26	36	PF02991	0.718
LIG_LIR_Gen_1	307	317	PF02991	0.285
LIG_LIR_Gen_1	56	65	PF02991	0.737
LIG_LIR_Gen_1	84	93	PF02991	0.364
LIG_LIR_Nem_3	143	148	PF02991	0.467
LIG_LIR_Nem_3	193	198	PF02991	0.328
LIG_LIR_Nem_3	228	234	PF02991	0.361
LIG_LIR_Nem_3	307	312	PF02991	0.326
LIG_LIR_Nem_3	315	320	PF02991	0.367
LIG_LIR_Nem_3	374	378	PF02991	0.492
LIG_LIR_Nem_3	455	459	PF02991	0.529
LIG_LIR_Nem_3	8	14	PF02991	0.738
LIG_LIR_Nem_3	84	89	PF02991	0.364
LIG_LYPXL_yS_3	11	14	PF13949	0.562
LIG_PALB2_WD40_1	260	268	PF16756	0.315
LIG_PDZ_Class_3	478	483	PF00595	0.416
LIG_Pex14_1	308	312	PF04695	0.370
LIG_Pex14_1	444	448	PF04695	0.581
LIG_SH2_CRK	145	149	PF00017	0.488
LIG_SH2_CRK	176	180	PF00017	0.390
LIG_SH2_CRK	231	235	PF00017	0.414
LIG_SH2_NCK_1	477	481	PF00017	0.399
LIG_SH2_PTP2	195	198	PF00017	0.328
LIG_SH2_PTP2	462	465	PF00017	0.445
LIG_SH2_STAP1	176	180	PF00017	0.386
LIG_SH2_STAT3	353	356	PF00017	0.314
LIG_SH2_STAT5	109	112	PF00017	0.339
LIG_SH2_STAT5	151	154	PF00017	0.490
LIG_SH2_STAT5	195	198	PF00017	0.339
LIG_SH2_STAT5	309	312	PF00017	0.313
LIG_SH2_STAT5	317	320	PF00017	0.332
LIG_SH2_STAT5	462	465	PF00017	0.300
LIG_SH2_STAT5	57	60	PF00017	0.740
LIG_SH3_3	428	434	PF00018	0.529
LIG_SH3_3	446	452	PF00018	0.611
LIG_SH3_3	6	12	PF00018	0.653
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.356
LIG_SUMO_SIM_anti_2	199	204	PF11976	0.295
LIG_SUMO_SIM_anti_2	212	219	PF11976	0.487
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.370
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.313
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.397
LIG_SUMO_SIM_par_1	216	222	PF11976	0.496
LIG_TYR_ITIM	174	179	PF00017	0.353
LIG_TYR_ITIM	229	234	PF00017	0.414
LIG_TYR_ITSM	141	148	PF00017	0.532
LIG_UBA3_1	128	134	PF00899	0.170
LIG_WRC_WIRS_1	100	105	PF05994	0.353
LIG_WRC_WIRS_1	187	192	PF05994	0.214
MOD_CK1_1	323	329	PF00069	0.327
MOD_CK2_1	180	186	PF00069	0.338
MOD_CK2_1	2	8	PF00069	0.722
MOD_CK2_1	20	26	PF00069	0.741
MOD_CK2_1	29	35	PF00069	0.716
MOD_CK2_1	475	481	PF00069	0.457
MOD_GlcNHglycan	119	122	PF01048	0.325
MOD_GlcNHglycan	190	193	PF01048	0.392
MOD_GlcNHglycan	358	361	PF01048	0.365
MOD_GlcNHglycan	397	400	PF01048	0.510
MOD_GlcNHglycan	466	469	PF01048	0.441
MOD_GlcNHglycan	66	69	PF01048	0.405
MOD_GlcNHglycan	83	86	PF01048	0.296
MOD_GSK3_1	186	193	PF00069	0.210
MOD_GSK3_1	209	216	PF00069	0.353
MOD_GSK3_1	219	226	PF00069	0.324
MOD_GSK3_1	320	327	PF00069	0.320
MOD_GSK3_1	332	339	PF00069	0.256
MOD_GSK3_1	395	402	PF00069	0.469
MOD_GSK3_1	448	455	PF00069	0.519
MOD_N-GLC_1	20	25	PF02516	0.421
MOD_N-GLC_1	213	218	PF02516	0.278
MOD_N-GLC_1	29	34	PF02516	0.376
MOD_NEK2_1	124	129	PF00069	0.201
MOD_NEK2_1	174	179	PF00069	0.343
MOD_NEK2_1	180	185	PF00069	0.278
MOD_NEK2_1	190	195	PF00069	0.269
MOD_NEK2_1	237	242	PF00069	0.349
MOD_NEK2_1	296	301	PF00069	0.507
MOD_NEK2_1	312	317	PF00069	0.295
MOD_NEK2_1	324	329	PF00069	0.213
MOD_NEK2_1	349	354	PF00069	0.347
MOD_NEK2_2	225	230	PF00069	0.442
MOD_NEK2_2	337	342	PF00069	0.306
MOD_NEK2_2	452	457	PF00069	0.628
MOD_PIKK_1	143	149	PF00454	0.514
MOD_PIKK_1	174	180	PF00454	0.350
MOD_PIKK_1	242	248	PF00454	0.335
MOD_PIKK_1	48	54	PF00454	0.583
MOD_Plk_1	124	130	PF00069	0.347
MOD_Plk_1	140	146	PF00069	0.484
MOD_Plk_1	185	191	PF00069	0.176
MOD_Plk_1	20	26	PF00069	0.712
MOD_Plk_1	213	219	PF00069	0.478
MOD_Plk_1	29	35	PF00069	0.604
MOD_Plk_1	364	370	PF00069	0.525
MOD_Plk_4	109	115	PF00069	0.302
MOD_Plk_4	124	130	PF00069	0.315
MOD_Plk_4	196	202	PF00069	0.320
MOD_Plk_4	20	26	PF00069	0.734
MOD_Plk_4	213	219	PF00069	0.397
MOD_Plk_4	225	231	PF00069	0.374
MOD_Plk_4	237	243	PF00069	0.277
MOD_Plk_4	296	302	PF00069	0.482
MOD_Plk_4	304	310	PF00069	0.343
MOD_Plk_4	324	330	PF00069	0.257
MOD_Plk_4	399	405	PF00069	0.279
MOD_Plk_4	418	424	PF00069	0.192
MOD_Plk_4	99	105	PF00069	0.317
MOD_ProDKin_1	332	338	PF00069	0.326
MOD_ProDKin_1	43	49	PF00069	0.697
MOD_ProDKin_1	448	454	PF00069	0.598
MOD_SUMO_for_1	330	333	PF00179	0.157
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.414
TRG_ENDOCYTIC_2	11	14	PF00928	0.724
TRG_ENDOCYTIC_2	145	148	PF00928	0.453
TRG_ENDOCYTIC_2	176	179	PF00928	0.339
TRG_ENDOCYTIC_2	195	198	PF00928	0.314
TRG_ENDOCYTIC_2	231	234	PF00928	0.404
TRG_ENDOCYTIC_2	309	312	PF00928	0.315
TRG_ENDOCYTIC_2	462	465	PF00928	0.305
TRG_ENDOCYTIC_2	57	60	PF00928	0.740
TRG_NLS_Bipartite_1	445	461	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D2	Leptomonas seymouri	22%	100%
A0A0N0P6H0	Leptomonas seymouri	73%	100%
A0A0N1PCP5	Leptomonas seymouri	71%	100%
A0A1X0NHS6	Trypanosomatidae	45%	100%
A0A1X0NRL3	Trypanosomatidae	23%	100%
A0A1X0NYI3	Trypanosomatidae	22%	97%
A0A1X0NZK6	Trypanosomatidae	52%	100%
A0A1X0P7Z8	Trypanosomatidae	30%	77%
A0A381MBS1	Leishmania infantum	79%	99%
A0A3Q8IB21	Leishmania donovani	79%	99%
A0A3Q8IFZ0	Leishmania donovani	21%	95%
A0A3S5H6G5	Leishmania donovani	80%	99%
A0A3S5H6T4	Leishmania donovani	23%	95%
A0A422MZQ8	Trypanosoma rangeli	35%	82%
A4HJ07	Leishmania braziliensis	22%	97%
A4HJ09	Leishmania braziliensis	22%	100%
A4HNZ6	Leishmania braziliensis	34%	100%
A4HUI4	Leishmania infantum	78%	99%
C9ZW15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	99%
D0A2X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	84%
E9AN82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
F4ILY9	Arabidopsis thaliana	23%	100%
P36062	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	70%
P50944	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	68%
Q10074	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	74%
Q495M3	Homo sapiens	22%	100%
Q495N2	Homo sapiens	22%	100%
Q4KL91	Xenopus laevis	23%	93%
Q4QHE2	Leishmania major	78%	100%
Q4QHE4	Leishmania major	78%	100%
Q4V8B1	Rattus norvegicus	22%	100%
Q6YBV0	Homo sapiens	21%	96%
Q7Z2H8	Homo sapiens	22%	100%
Q811P0	Mus musculus	22%	100%
Q8BHK3	Mus musculus	23%	100%
Q8CH36	Mus musculus	21%	97%
Q8K415	Rattus norvegicus	22%	100%
Q8K4D3	Mus musculus	22%	100%
Q924A5	Rattus norvegicus	22%	100%
Q9FKY3	Arabidopsis thaliana	24%	100%
Q9SS86	Arabidopsis thaliana	22%	100%
Q9SVG0	Arabidopsis thaliana	22%	100%
Q9VT04	Drosophila melanogaster	21%	100%
Q9W056	Drosophila melanogaster	24%	100%
V5BHF0	Trypanosoma cruzi	42%	100%
V5BJY7	Trypanosoma cruzi	33%	81%