RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4H661_LEIBR

TriTrypDb:

LbrM.10.0830 , LBRM2903_100016500

Length:

943

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H661

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H661

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.701
CLV_C14_Caspase3-7	323	327	PF00656	0.584
CLV_C14_Caspase3-7	334	338	PF00656	0.515
CLV_C14_Caspase3-7	595	599	PF00656	0.443
CLV_C14_Caspase3-7	824	828	PF00656	0.514
CLV_MEL_PAP_1	605	611	PF00089	0.397
CLV_NRD_NRD_1	122	124	PF00675	0.546
CLV_NRD_NRD_1	166	168	PF00675	0.747
CLV_NRD_NRD_1	195	197	PF00675	0.533
CLV_NRD_NRD_1	234	236	PF00675	0.564
CLV_NRD_NRD_1	248	250	PF00675	0.678
CLV_NRD_NRD_1	309	311	PF00675	0.680
CLV_NRD_NRD_1	42	44	PF00675	0.615
CLV_NRD_NRD_1	492	494	PF00675	0.539
CLV_NRD_NRD_1	57	59	PF00675	0.574
CLV_NRD_NRD_1	837	839	PF00675	0.555
CLV_NRD_NRD_1	889	891	PF00675	0.223
CLV_PCSK_FUR_1	245	249	PF00082	0.524
CLV_PCSK_KEX2_1	168	170	PF00082	0.686
CLV_PCSK_KEX2_1	195	197	PF00082	0.554
CLV_PCSK_KEX2_1	247	249	PF00082	0.713
CLV_PCSK_KEX2_1	309	311	PF00082	0.698
CLV_PCSK_KEX2_1	42	44	PF00082	0.512
CLV_PCSK_KEX2_1	451	453	PF00082	0.510
CLV_PCSK_KEX2_1	492	494	PF00082	0.548
CLV_PCSK_KEX2_1	57	59	PF00082	0.542
CLV_PCSK_KEX2_1	744	746	PF00082	0.435
CLV_PCSK_KEX2_1	836	838	PF00082	0.552
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.686
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.510
CLV_PCSK_PC1ET2_1	744	746	PF00082	0.435
CLV_PCSK_PC7_1	488	494	PF00082	0.640
CLV_PCSK_SKI1_1	272	276	PF00082	0.560
CLV_PCSK_SKI1_1	43	47	PF00082	0.530
CLV_PCSK_SKI1_1	635	639	PF00082	0.319
CLV_PCSK_SKI1_1	644	648	PF00082	0.347
CLV_PCSK_SKI1_1	71	75	PF00082	0.498
CLV_PCSK_SKI1_1	745	749	PF00082	0.381
CLV_PCSK_SKI1_1	754	758	PF00082	0.360
CLV_PCSK_SKI1_1	838	842	PF00082	0.668
CLV_PCSK_SKI1_1	874	878	PF00082	0.213
CLV_PCSK_SKI1_1	96	100	PF00082	0.337
DEG_APCC_DBOX_1	367	375	PF00400	0.284
DEG_APCC_DBOX_1	57	65	PF00400	0.442
DEG_APCC_DBOX_1	744	752	PF00400	0.272
DEG_SCF_FBW7_1	221	228	PF00400	0.496
DEG_SPOP_SBC_1	330	334	PF00917	0.798
DEG_SPOP_SBC_1	844	848	PF00917	0.472
DOC_ANK_TNKS_1	248	255	PF00023	0.558
DOC_CYCLIN_RxL_1	2	12	PF00134	0.366
DOC_CYCLIN_RxL_1	586	595	PF00134	0.497
DOC_CYCLIN_RxL_1	858	870	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.509
DOC_MAPK_gen_1	195	203	PF00069	0.653
DOC_MAPK_gen_1	406	416	PF00069	0.413
DOC_MAPK_gen_1	579	588	PF00069	0.358
DOC_MAPK_gen_1	644	653	PF00069	0.362
DOC_MAPK_gen_1	68	78	PF00069	0.481
DOC_MAPK_MEF2A_6	100	108	PF00069	0.493
DOC_MAPK_MEF2A_6	110	119	PF00069	0.611
DOC_MAPK_MEF2A_6	28	35	PF00069	0.511
DOC_MAPK_MEF2A_6	68	76	PF00069	0.498
DOC_PP1_RVXF_1	633	639	PF00149	0.324
DOC_PP2B_LxvP_1	218	221	PF13499	0.712
DOC_PP2B_LxvP_1	7	10	PF13499	0.390
DOC_PP4_FxxP_1	628	631	PF00568	0.236
DOC_SPAK_OSR1_1	608	612	PF12202	0.468
DOC_USP7_MATH_1	146	150	PF00917	0.712
DOC_USP7_MATH_1	225	229	PF00917	0.674
DOC_USP7_MATH_1	318	322	PF00917	0.678
DOC_USP7_MATH_1	330	334	PF00917	0.651
DOC_USP7_MATH_1	363	367	PF00917	0.571
DOC_USP7_MATH_1	459	463	PF00917	0.578
DOC_USP7_MATH_1	616	620	PF00917	0.372
DOC_USP7_MATH_1	760	764	PF00917	0.456
DOC_USP7_MATH_1	844	848	PF00917	0.745
DOC_USP7_MATH_1	889	893	PF00917	0.443
DOC_USP7_UBL2_3	124	128	PF12436	0.524
DOC_USP7_UBL2_3	341	345	PF12436	0.498
DOC_USP7_UBL2_3	771	775	PF12436	0.436
DOC_USP7_UBL2_3	858	862	PF12436	0.249
DOC_WW_Pin1_4	221	226	PF00397	0.729
LIG_14-3-3_CanoR_1	204	213	PF00244	0.537
LIG_14-3-3_CanoR_1	364	371	PF00244	0.438
LIG_14-3-3_CanoR_1	415	423	PF00244	0.513
LIG_14-3-3_CanoR_1	440	448	PF00244	0.463
LIG_14-3-3_CanoR_1	581	588	PF00244	0.353
LIG_14-3-3_CanoR_1	627	631	PF00244	0.458
LIG_14-3-3_CanoR_1	640	644	PF00244	0.364
LIG_14-3-3_CanoR_1	754	760	PF00244	0.335
LIG_14-3-3_CanoR_1	82	90	PF00244	0.423
LIG_14-3-3_CanoR_1	890	896	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.367
LIG_BIR_III_2	730	734	PF00653	0.446
LIG_BRCT_BRCA1_1	480	484	PF00533	0.575
LIG_BRCT_BRCA1_1	891	895	PF00533	0.423
LIG_BRCT_BRCA1_2	480	486	PF00533	0.619
LIG_FHA_1	386	392	PF00498	0.402
LIG_FHA_1	468	474	PF00498	0.423
LIG_FHA_1	572	578	PF00498	0.530
LIG_FHA_1	582	588	PF00498	0.346
LIG_FHA_1	620	626	PF00498	0.372
LIG_FHA_1	707	713	PF00498	0.304
LIG_FHA_1	788	794	PF00498	0.433
LIG_FHA_1	829	835	PF00498	0.665
LIG_FHA_2	157	163	PF00498	0.657
LIG_FHA_2	185	191	PF00498	0.711
LIG_FHA_2	260	266	PF00498	0.589
LIG_FHA_2	332	338	PF00498	0.682
LIG_FHA_2	352	358	PF00498	0.568
LIG_FHA_2	44	50	PF00498	0.538
LIG_FHA_2	717	723	PF00498	0.364
LIG_FHA_2	756	762	PF00498	0.337
LIG_FHA_2	844	850	PF00498	0.492
LIG_FHA_2	867	873	PF00498	0.413
LIG_LIR_Gen_1	199	207	PF02991	0.659
LIG_LIR_Gen_1	507	513	PF02991	0.539
LIG_LIR_Gen_1	603	612	PF02991	0.415
LIG_LIR_Gen_1	622	631	PF02991	0.229
LIG_LIR_Gen_1	875	883	PF02991	0.413
LIG_LIR_Nem_3	199	203	PF02991	0.650
LIG_LIR_Nem_3	344	350	PF02991	0.487
LIG_LIR_Nem_3	603	609	PF02991	0.324
LIG_LIR_Nem_3	622	626	PF02991	0.306
LIG_LIR_Nem_3	642	646	PF02991	0.338
LIG_LIR_Nem_3	654	658	PF02991	0.345
LIG_LIR_Nem_3	875	880	PF02991	0.413
LIG_Pex14_1	508	512	PF04695	0.438
LIG_Pex14_2	413	417	PF04695	0.355
LIG_Pex14_2	94	98	PF04695	0.392
LIG_PTB_Apo_2	370	377	PF02174	0.423
LIG_PTB_Apo_2	711	718	PF02174	0.317
LIG_PTB_Apo_2	860	867	PF02174	0.413
LIG_PTB_Apo_2	92	99	PF02174	0.479
LIG_PTB_Phospho_1	370	376	PF10480	0.455
LIG_REV1ctd_RIR_1	96	104	PF16727	0.401
LIG_SH2_GRB2like	512	515	PF00017	0.436
LIG_SH2_GRB2like	93	96	PF00017	0.479
LIG_SH2_STAP1	708	712	PF00017	0.429
LIG_SH2_STAT5	376	379	PF00017	0.455
LIG_SH2_STAT5	551	554	PF00017	0.364
LIG_SH2_STAT5	708	711	PF00017	0.395
LIG_SH2_STAT5	767	770	PF00017	0.328
LIG_SH2_STAT5	93	96	PF00017	0.402
LIG_SH3_3	394	400	PF00018	0.413
LIG_SH3_3	883	889	PF00018	0.429
LIG_SUMO_SIM_par_1	31	37	PF11976	0.494
LIG_TRAF2_1	358	361	PF00917	0.483
LIG_TRAF2_1	378	381	PF00917	0.320
LIG_TRAF2_1	443	446	PF00917	0.543
LIG_TYR_ITIM	936	941	PF00017	0.354
MOD_CK1_1	133	139	PF00069	0.519
MOD_CK1_1	149	155	PF00069	0.560
MOD_CK1_1	156	162	PF00069	0.578
MOD_CK1_1	205	211	PF00069	0.585
MOD_CK1_1	333	339	PF00069	0.798
MOD_CK1_1	479	485	PF00069	0.403
MOD_CK1_1	582	588	PF00069	0.349
MOD_CK1_1	619	625	PF00069	0.436
MOD_CK1_1	685	691	PF00069	0.594
MOD_CK1_1	787	793	PF00069	0.417
MOD_CK1_1	843	849	PF00069	0.583
MOD_CK1_1	878	884	PF00069	0.284
MOD_CK2_1	156	162	PF00069	0.766
MOD_CK2_1	259	265	PF00069	0.501
MOD_CK2_1	316	322	PF00069	0.634
MOD_CK2_1	351	357	PF00069	0.403
MOD_CK2_1	439	445	PF00069	0.420
MOD_CK2_1	717	723	PF00069	0.367
MOD_CK2_1	843	849	PF00069	0.543
MOD_CK2_1	894	900	PF00069	0.292
MOD_CK2_1	910	916	PF00069	0.252
MOD_GlcNHglycan	100	103	PF01048	0.373
MOD_GlcNHglycan	142	145	PF01048	0.699
MOD_GlcNHglycan	151	154	PF01048	0.615
MOD_GlcNHglycan	417	420	PF01048	0.413
MOD_GlcNHglycan	441	444	PF01048	0.399
MOD_GlcNHglycan	461	464	PF01048	0.484
MOD_GlcNHglycan	478	481	PF01048	0.630
MOD_GlcNHglycan	61	64	PF01048	0.677
MOD_GlcNHglycan	613	617	PF01048	0.384
MOD_GlcNHglycan	618	621	PF01048	0.360
MOD_GlcNHglycan	668	671	PF01048	0.605
MOD_GlcNHglycan	687	690	PF01048	0.618
MOD_GlcNHglycan	813	816	PF01048	0.554
MOD_GlcNHglycan	83	86	PF01048	0.373
MOD_GlcNHglycan	842	845	PF01048	0.738
MOD_GlcNHglycan	877	880	PF01048	0.323
MOD_GSK3_1	149	156	PF00069	0.743
MOD_GSK3_1	181	188	PF00069	0.758
MOD_GSK3_1	205	212	PF00069	0.538
MOD_GSK3_1	221	228	PF00069	0.621
MOD_GSK3_1	259	266	PF00069	0.494
MOD_GSK3_1	329	336	PF00069	0.736
MOD_GSK3_1	467	474	PF00069	0.577
MOD_GSK3_1	577	584	PF00069	0.520
MOD_GSK3_1	612	619	PF00069	0.344
MOD_GSK3_1	666	673	PF00069	0.661
MOD_GSK3_1	706	713	PF00069	0.308
MOD_GSK3_1	780	787	PF00069	0.404
MOD_GSK3_1	802	809	PF00069	0.648
MOD_GSK3_1	839	846	PF00069	0.747
MOD_GSK3_1	878	885	PF00069	0.283
MOD_GSK3_1	889	896	PF00069	0.156
MOD_GSK3_1	920	927	PF00069	0.283
MOD_GSK3_1	94	101	PF00069	0.416
MOD_N-GLC_1	133	138	PF02516	0.624
MOD_N-GLC_1	185	190	PF02516	0.476
MOD_N-GLC_1	476	481	PF02516	0.430
MOD_N-GLC_1	582	587	PF02516	0.347
MOD_N-GLC_1	94	99	PF02516	0.383
MOD_NEK2_1	154	159	PF00069	0.652
MOD_NEK2_1	22	27	PF00069	0.403
MOD_NEK2_1	386	391	PF00069	0.249
MOD_NEK2_1	439	444	PF00069	0.390
MOD_NEK2_1	478	483	PF00069	0.659
MOD_NEK2_1	577	582	PF00069	0.515
MOD_NEK2_1	612	617	PF00069	0.344
MOD_NEK2_1	626	631	PF00069	0.395
MOD_NEK2_1	639	644	PF00069	0.372
MOD_NEK2_1	710	715	PF00069	0.296
MOD_NEK2_1	81	86	PF00069	0.408
MOD_NEK2_1	924	929	PF00069	0.275
MOD_NEK2_1	94	99	PF00069	0.293
MOD_NEK2_2	920	925	PF00069	0.284
MOD_PIKK_1	240	246	PF00454	0.625
MOD_PIKK_1	479	485	PF00454	0.602
MOD_PIKK_1	571	577	PF00454	0.585
MOD_PIKK_1	788	794	PF00454	0.283
MOD_PKA_2	363	369	PF00069	0.425
MOD_PKA_2	439	445	PF00069	0.374
MOD_PKA_2	626	632	PF00069	0.369
MOD_PKA_2	639	645	PF00069	0.375
MOD_PKA_2	81	87	PF00069	0.469
MOD_PKA_2	889	895	PF00069	0.264
MOD_PKB_1	836	844	PF00069	0.521
MOD_Plk_1	582	588	PF00069	0.363
MOD_Plk_1	612	618	PF00069	0.322
MOD_Plk_1	760	766	PF00069	0.336
MOD_Plk_1	94	100	PF00069	0.421
MOD_Plk_2-3	263	269	PF00069	0.474
MOD_Plk_2-3	910	916	PF00069	0.249
MOD_Plk_4	386	392	PF00069	0.310
MOD_Plk_4	507	513	PF00069	0.463
MOD_Plk_4	582	588	PF00069	0.330
MOD_Plk_4	706	712	PF00069	0.362
MOD_Plk_4	738	744	PF00069	0.399
MOD_ProDKin_1	221	227	PF00069	0.729
MOD_SUMO_for_1	104	107	PF00179	0.373
MOD_SUMO_rev_2	129	133	PF00179	0.553
MOD_SUMO_rev_2	228	238	PF00179	0.641
TRG_AP2beta_CARGO_1	875	884	PF09066	0.284
TRG_DiLeu_BaEn_2	722	728	PF01217	0.430
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.519
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.254
TRG_ENDOCYTIC_2	643	646	PF00928	0.329
TRG_ENDOCYTIC_2	708	711	PF00928	0.426
TRG_ENDOCYTIC_2	938	941	PF00928	0.344
TRG_ER_diArg_1	195	198	PF00400	0.564
TRG_ER_diArg_1	245	248	PF00400	0.690
TRG_ER_diArg_1	3	6	PF00400	0.348
TRG_ER_diArg_1	368	371	PF00400	0.254
TRG_ER_diArg_1	41	43	PF00400	0.589
TRG_ER_diArg_1	836	838	PF00400	0.680
TRG_NES_CRM1_1	107	121	PF08389	0.580
TRG_NES_CRM1_1	601	613	PF08389	0.401
TRG_NLS_MonoExtC_3	122	127	PF00514	0.528
TRG_NLS_MonoExtC_3	166	171	PF00514	0.735
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	932	937	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY42	Leptomonas seymouri	65%	100%
A0A0S4J8G6	Bodo saltans	40%	100%
A0A1X0NQT4	Trypanosomatidae	48%	100%
A0A3Q8I7R0	Leishmania donovani	80%	99%
A0A3R7NQE9	Trypanosoma rangeli	48%	100%
A4HUI2	Leishmania infantum	80%	99%
C9ZVK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AN80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q06106	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q4QHE5	Leishmania major	80%	99%
Q4WJT7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	100%
Q5BGA9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
V5B419	Trypanosoma cruzi	51%	100%