Rhomboid domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H659_LEIBR

TriTrypDb:

LbrM.10.0810 , LBRM2903_100016200

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H659

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H659

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.622
CLV_NRD_NRD_1	87	89	PF00675	0.507
CLV_PCSK_KEX2_1	87	89	PF00082	0.507
CLV_PCSK_SKI1_1	12	16	PF00082	0.430
CLV_PCSK_SKI1_1	373	377	PF00082	0.446
CLV_PCSK_SKI1_1	90	94	PF00082	0.520
CLV_Separin_Metazoa	9	13	PF03568	0.558
DEG_APCC_DBOX_1	217	225	PF00400	0.257
DEG_Nend_Nbox_1	1	3	PF02207	0.568
DEG_SPOP_SBC_1	25	29	PF00917	0.569
DOC_CKS1_1	91	96	PF01111	0.663
DOC_CYCLIN_yCln2_LP_2	91	97	PF00134	0.589
DOC_MAPK_FxFP_2	63	66	PF00069	0.679
DOC_MAPK_gen_1	61	70	PF00069	0.653
DOC_MAPK_HePTP_8	58	70	PF00069	0.580
DOC_MAPK_MEF2A_6	61	70	PF00069	0.698
DOC_PP4_FxxP_1	63	66	PF00568	0.750
DOC_USP7_UBL2_3	110	114	PF12436	0.612
DOC_USP7_UBL2_3	162	166	PF12436	0.696
DOC_USP7_UBL2_3	376	380	PF12436	0.597
DOC_WW_Pin1_4	321	326	PF00397	0.292
DOC_WW_Pin1_4	70	75	PF00397	0.718
DOC_WW_Pin1_4	77	82	PF00397	0.729
DOC_WW_Pin1_4	90	95	PF00397	0.703
LIG_14-3-3_CanoR_1	12	22	PF00244	0.775
LIG_14-3-3_CanoR_1	231	236	PF00244	0.396
LIG_Clathr_ClatBox_1	313	317	PF01394	0.419
LIG_FHA_1	221	227	PF00498	0.428
LIG_FHA_1	232	238	PF00498	0.381
LIG_FHA_1	26	32	PF00498	0.625
LIG_FHA_1	70	76	PF00498	0.704
LIG_FHA_1	91	97	PF00498	0.661
LIG_LIR_Gen_1	183	192	PF02991	0.573
LIG_LIR_Gen_1	242	253	PF02991	0.297
LIG_LIR_Nem_3	183	188	PF02991	0.572
LIG_LIR_Nem_3	317	323	PF02991	0.408
LIG_LIR_Nem_3	333	338	PF02991	0.508
LIG_Pex14_1	287	291	PF04695	0.357
LIG_PTB_Apo_2	287	294	PF02174	0.436
LIG_PTB_Phospho_1	287	293	PF10480	0.435
LIG_SH2_CRK	192	196	PF00017	0.497
LIG_SH2_CRK	320	324	PF00017	0.195
LIG_SH2_GRB2like	185	188	PF00017	0.612
LIG_SH2_NCK_1	192	196	PF00017	0.439
LIG_SH2_SRC	318	321	PF00017	0.195
LIG_SH2_STAP1	250	254	PF00017	0.419
LIG_SH2_STAP1	338	342	PF00017	0.494
LIG_SH2_STAT5	274	277	PF00017	0.277
LIG_SH2_STAT5	291	294	PF00017	0.310
LIG_SH2_STAT5	349	352	PF00017	0.537
LIG_SH3_3	19	25	PF00018	0.648
LIG_SH3_3	91	97	PF00018	0.589
LIG_TRAF2_1	126	129	PF00917	0.676
LIG_WRC_WIRS_1	237	242	PF05994	0.306
LIG_WRC_WIRS_1	329	334	PF05994	0.495
MOD_CK1_1	152	158	PF00069	0.817
MOD_CK1_1	210	216	PF00069	0.434
MOD_CK1_1	239	245	PF00069	0.423
MOD_CK1_1	26	32	PF00069	0.649
MOD_CK1_1	73	79	PF00069	0.761
MOD_CK2_1	123	129	PF00069	0.710
MOD_CK2_1	210	216	PF00069	0.400
MOD_CK2_1	73	79	PF00069	0.597
MOD_GlcNHglycan	123	128	PF01048	0.430
MOD_GlcNHglycan	15	18	PF01048	0.483
MOD_GlcNHglycan	281	284	PF01048	0.287
MOD_GlcNHglycan	332	335	PF01048	0.363
MOD_GSK3_1	145	152	PF00069	0.812
MOD_GSK3_1	20	27	PF00069	0.718
MOD_GSK3_1	208	215	PF00069	0.434
MOD_GSK3_1	352	359	PF00069	0.475
MOD_GSK3_1	375	382	PF00069	0.644
MOD_GSK3_1	69	76	PF00069	0.762
MOD_GSK3_1	77	84	PF00069	0.763
MOD_NEK2_1	208	213	PF00069	0.299
MOD_NEK2_1	236	241	PF00069	0.317
MOD_NEK2_1	246	251	PF00069	0.318
MOD_NEK2_1	254	259	PF00069	0.274
MOD_NEK2_1	356	361	PF00069	0.585
MOD_NEK2_1	53	58	PF00069	0.783
MOD_PIKK_1	56	62	PF00454	0.671
MOD_PIKK_1	95	101	PF00454	0.740
MOD_PK_1	64	70	PF00069	0.637
MOD_PKA_1	170	176	PF00069	0.641
MOD_PKA_2	156	162	PF00069	0.744
MOD_PKA_2	20	26	PF00069	0.681
MOD_Plk_1	226	232	PF00069	0.330
MOD_Plk_4	170	176	PF00069	0.677
MOD_Plk_4	236	242	PF00069	0.239
MOD_Plk_4	352	358	PF00069	0.493
MOD_Plk_4	53	59	PF00069	0.594
MOD_Plk_4	81	87	PF00069	0.731
MOD_ProDKin_1	321	327	PF00069	0.292
MOD_ProDKin_1	70	76	PF00069	0.718
MOD_ProDKin_1	77	83	PF00069	0.727
MOD_ProDKin_1	90	96	PF00069	0.703
MOD_SUMO_for_1	38	41	PF00179	0.568
TRG_DiLeu_BaEn_4	216	222	PF01217	0.368
TRG_ENDOCYTIC_2	185	188	PF00928	0.588
TRG_ENDOCYTIC_2	192	195	PF00928	0.523
TRG_ENDOCYTIC_2	250	253	PF00928	0.419
TRG_ENDOCYTIC_2	320	323	PF00928	0.419
TRG_ER_diArg_1	86	88	PF00400	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE4	Leptomonas seymouri	55%	99%
A0A0S4ILW7	Bodo saltans	47%	100%
A0A1X0NQ98	Trypanosomatidae	52%	100%
A0A3S5IS56	Trypanosoma rangeli	51%	100%
A0A3S7WR67	Leishmania donovani	80%	100%
A4HUH9	Leishmania infantum	81%	100%
C9ZVK4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AN77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QHE8	Leishmania major	78%	98%
V5BP48	Trypanosoma cruzi	51%	100%