Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H657_LEIBR

TriTrypDb:

LbrM.10.0790 , LBRM2903_100016000

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H657

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H657

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.595
CLV_NRD_NRD_1	169	171	PF00675	0.559
CLV_NRD_NRD_1	181	183	PF00675	0.554
CLV_NRD_NRD_1	249	251	PF00675	0.703
CLV_NRD_NRD_1	252	254	PF00675	0.728
CLV_NRD_NRD_1	314	316	PF00675	0.681
CLV_NRD_NRD_1	78	80	PF00675	0.605
CLV_NRD_NRD_1	81	83	PF00675	0.567
CLV_NRD_NRD_1	84	86	PF00675	0.552
CLV_PCSK_FUR_1	115	119	PF00082	0.600
CLV_PCSK_FUR_1	250	254	PF00082	0.593
CLV_PCSK_FUR_1	76	80	PF00082	0.663
CLV_PCSK_FUR_1	82	86	PF00082	0.604
CLV_PCSK_KEX2_1	117	119	PF00082	0.593
CLV_PCSK_KEX2_1	181	183	PF00082	0.614
CLV_PCSK_KEX2_1	191	193	PF00082	0.565
CLV_PCSK_KEX2_1	249	251	PF00082	0.653
CLV_PCSK_KEX2_1	252	254	PF00082	0.669
CLV_PCSK_KEX2_1	286	288	PF00082	0.655
CLV_PCSK_KEX2_1	314	316	PF00082	0.681
CLV_PCSK_KEX2_1	5	7	PF00082	0.782
CLV_PCSK_KEX2_1	78	80	PF00082	0.605
CLV_PCSK_KEX2_1	81	83	PF00082	0.567
CLV_PCSK_KEX2_1	84	86	PF00082	0.552
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.625
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.492
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.782
CLV_PCSK_SKI1_1	171	175	PF00082	0.636
CLV_PCSK_SKI1_1	182	186	PF00082	0.468
CLV_PCSK_SKI1_1	232	236	PF00082	0.789
CLV_PCSK_SKI1_1	315	319	PF00082	0.737
CLV_PCSK_SKI1_1	64	68	PF00082	0.653
DEG_APCC_DBOX_1	180	188	PF00400	0.547
DEG_Kelch_Keap1_1	207	212	PF01344	0.773
DEG_Nend_Nbox_1	1	3	PF02207	0.793
DOC_CYCLIN_RxL_1	178	186	PF00134	0.590
DOC_CYCLIN_RxL_1	78	90	PF00134	0.417
DOC_MAPK_gen_1	178	187	PF00069	0.640
DOC_MAPK_gen_1	78	88	PF00069	0.420
DOC_MAPK_RevD_3	65	79	PF00069	0.718
DOC_PP1_RVXF_1	220	227	PF00149	0.645
DOC_PP2B_LxvP_1	203	206	PF13499	0.676
DOC_PP2B_LxvP_1	352	355	PF13499	0.589
DOC_PP4_FxxP_1	15	18	PF00568	0.782
DOC_WW_Pin1_4	20	25	PF00397	0.639
DOC_WW_Pin1_4	204	209	PF00397	0.675
LIG_14-3-3_CanoR_1	25	31	PF00244	0.805
LIG_14-3-3_CanoR_1	314	320	PF00244	0.737
LIG_APCC_ABBA_1	359	364	PF00400	0.660
LIG_deltaCOP1_diTrp_1	364	370	PF00928	0.660
LIG_FHA_1	103	109	PF00498	0.598
LIG_FHA_1	172	178	PF00498	0.443
LIG_FHA_1	208	214	PF00498	0.677
LIG_FHA_1	242	248	PF00498	0.594
LIG_FHA_1	25	31	PF00498	0.614
LIG_FHA_1	264	270	PF00498	0.576
LIG_FHA_1	354	360	PF00498	0.492
LIG_FHA_1	70	76	PF00498	0.560
LIG_FHA_2	27	33	PF00498	0.573
LIG_GBD_Chelix_1	339	347	PF00786	0.685
LIG_LIR_Apic_2	12	18	PF02991	0.773
LIG_LIR_Gen_1	323	334	PF02991	0.623
LIG_LIR_Gen_1	335	343	PF02991	0.669
LIG_LIR_Gen_1	344	353	PF02991	0.559
LIG_LIR_Nem_3	323	329	PF02991	0.706
LIG_LIR_Nem_3	335	339	PF02991	0.577
LIG_LIR_Nem_3	342	348	PF02991	0.502
LIG_LIR_Nem_3	349	354	PF02991	0.459
LIG_LIR_Nem_3	368	373	PF02991	0.590
LIG_MYND_1	14	18	PF01753	0.777
LIG_NRBOX	183	189	PF00104	0.656
LIG_PDZ_Class_2	370	375	PF00595	0.443
LIG_PTB_Apo_2	305	312	PF02174	0.702
LIG_PTB_Phospho_1	305	311	PF10480	0.697
LIG_SH2_CRK	221	225	PF00017	0.652
LIG_SH2_CRK	336	340	PF00017	0.484
LIG_SH2_NCK_1	336	340	PF00017	0.591
LIG_SH2_NCK_1	345	349	PF00017	0.654
LIG_SH2_SRC	326	329	PF00017	0.530
LIG_SH2_STAP1	336	340	PF00017	0.454
LIG_SH2_STAT3	301	304	PF00017	0.667
LIG_SH2_STAT5	298	301	PF00017	0.536
LIG_SH2_STAT5	351	354	PF00017	0.543
LIG_SH3_3	143	149	PF00018	0.604
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.661
LIG_SUMO_SIM_par_1	201	207	PF11976	0.672
LIG_SUMO_SIM_par_1	63	70	PF11976	0.595
LIG_TRFH_1	370	374	PF08558	0.689
LIG_TYR_ITIM	324	329	PF00017	0.545
LIG_TYR_ITIM	334	339	PF00017	0.559
LIG_TYR_ITIM	343	348	PF00017	0.605
LIG_UBA3_1	162	171	PF00899	0.654
LIG_UBA3_1	184	191	PF00899	0.669
MOD_CDK_SPK_2	20	25	PF00069	0.533
MOD_CK1_1	144	150	PF00069	0.715
MOD_CK1_1	164	170	PF00069	0.541
MOD_CK1_1	207	213	PF00069	0.671
MOD_CK1_1	262	268	PF00069	0.576
MOD_CK1_1	90	96	PF00069	0.583
MOD_CK2_1	26	32	PF00069	0.570
MOD_GlcNHglycan	146	149	PF01048	0.741
MOD_GlcNHglycan	163	166	PF01048	0.395
MOD_GSK3_1	190	197	PF00069	0.474
MOD_GSK3_1	20	27	PF00069	0.539
MOD_GSK3_1	239	246	PF00069	0.688
MOD_GSK3_1	259	266	PF00069	0.589
MOD_NEK2_1	102	107	PF00069	0.617
MOD_NEK2_1	69	74	PF00069	0.619
MOD_PIKK_1	190	196	PF00454	0.707
MOD_PKA_2	239	245	PF00069	0.830
MOD_PKA_2	24	30	PF00069	0.804
MOD_PKA_2	35	41	PF00069	0.619
MOD_PKA_2	90	96	PF00069	0.583
MOD_Plk_1	142	148	PF00069	0.557
MOD_Plk_1	277	283	PF00069	0.562
MOD_Plk_4	183	189	PF00069	0.606
MOD_ProDKin_1	20	26	PF00069	0.642
MOD_ProDKin_1	204	210	PF00069	0.674
MOD_SUMO_rev_2	278	288	PF00179	0.538
TRG_DiLeu_BaEn_1	12	17	PF01217	0.770
TRG_DiLeu_BaEn_1	183	188	PF01217	0.640
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.514
TRG_ENDOCYTIC_2	221	224	PF00928	0.655
TRG_ENDOCYTIC_2	326	329	PF00928	0.630
TRG_ENDOCYTIC_2	336	339	PF00928	0.537
TRG_ENDOCYTIC_2	345	348	PF00928	0.549
TRG_ENDOCYTIC_2	351	354	PF00928	0.510
TRG_ER_diArg_1	114	117	PF00400	0.579
TRG_ER_diArg_1	180	182	PF00400	0.581
TRG_ER_diArg_1	249	252	PF00400	0.588
TRG_ER_diArg_1	75	78	PF00400	0.667
TRG_ER_diArg_1	79	82	PF00400	0.650
TRG_ER_diArg_1	84	86	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X7	Leptomonas seymouri	34%	95%
A0A3S7WR94	Leishmania donovani	76%	100%
A4HUH7	Leishmania infantum	77%	100%
E9AN75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4QHF0	Leishmania major	75%	100%