C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H656_LEIBR

TriTrypDb:

LbrM.10.0780 , LBRM2903_100015900

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H656

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H656

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.579
CLV_NRD_NRD_1	19	21	PF00675	0.692
CLV_PCSK_KEX2_1	18	20	PF00082	0.744
CLV_PCSK_KEX2_1	180	182	PF00082	0.579
DEG_SPOP_SBC_1	142	146	PF00917	0.672
DOC_CKS1_1	215	220	PF01111	0.624
DOC_USP7_MATH_1	120	124	PF00917	0.580
DOC_USP7_MATH_1	141	145	PF00917	0.645
DOC_USP7_MATH_1	193	197	PF00917	0.687
DOC_WW_Pin1_4	158	163	PF00397	0.674
DOC_WW_Pin1_4	214	219	PF00397	0.634
DOC_WW_Pin1_4	30	35	PF00397	0.585
DOC_WW_Pin1_4	49	54	PF00397	0.404
DOC_WW_Pin1_4	67	72	PF00397	0.437
LIG_Actin_WH2_2	53	70	PF00022	0.636
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_EVH1_1	156	160	PF00568	0.727
LIG_FHA_1	198	204	PF00498	0.714
LIG_FHA_2	100	106	PF00498	0.749
LIG_LIR_Gen_1	54	62	PF02991	0.622
LIG_LIR_Nem_3	54	60	PF02991	0.604
LIG_LIR_Nem_3	80	84	PF02991	0.482
LIG_LIR_Nem_3	86	91	PF02991	0.556
LIG_MYND_1	154	158	PF01753	0.727
LIG_NRBOX	130	136	PF00104	0.760
LIG_PDZ_Class_1	240	245	PF00595	0.497
LIG_PTB_Apo_2	185	192	PF02174	0.631
LIG_PTB_Phospho_1	185	191	PF10480	0.630
LIG_SH2_CRK	48	52	PF00017	0.556
LIG_SH2_NCK_1	57	61	PF00017	0.627
LIG_SH2_STAT5	27	30	PF00017	0.553
LIG_SH2_STAT5	48	51	PF00017	0.583
LIG_SH3_3	148	154	PF00018	0.667
LIG_SH3_3	159	165	PF00018	0.622
LIG_SH3_3	7	13	PF00018	0.744
LIG_WRC_WIRS_1	101	106	PF05994	0.713
LIG_WW_2	154	157	PF00397	0.720
MOD_CK1_1	133	139	PF00069	0.703
MOD_CK1_1	197	203	PF00069	0.600
MOD_CK2_1	163	169	PF00069	0.594
MOD_CK2_1	99	105	PF00069	0.743
MOD_GlcNHglycan	1	4	PF01048	0.543
MOD_GlcNHglycan	114	117	PF01048	0.697
MOD_GlcNHglycan	122	125	PF01048	0.518
MOD_GlcNHglycan	126	129	PF01048	0.632
MOD_GlcNHglycan	135	138	PF01048	0.472
MOD_GlcNHglycan	139	142	PF01048	0.480
MOD_GlcNHglycan	196	199	PF01048	0.534
MOD_GlcNHglycan	207	210	PF01048	0.621
MOD_GSK3_1	120	127	PF00069	0.666
MOD_GSK3_1	129	136	PF00069	0.692
MOD_GSK3_1	137	144	PF00069	0.655
MOD_GSK3_1	193	200	PF00069	0.692
MOD_GSK3_1	63	70	PF00069	0.621
MOD_N-GLC_1	194	199	PF02516	0.654
MOD_N-GLC_1	30	35	PF02516	0.658
MOD_NEK2_1	135	140	PF00069	0.752
MOD_Plk_1	186	192	PF00069	0.685
MOD_Plk_1	194	200	PF00069	0.681
MOD_Plk_1	63	69	PF00069	0.653
MOD_Plk_2-3	163	169	PF00069	0.463
MOD_Plk_4	130	136	PF00069	0.770
MOD_Plk_4	186	192	PF00069	0.682
MOD_ProDKin_1	158	164	PF00069	0.668
MOD_ProDKin_1	214	220	PF00069	0.626
MOD_ProDKin_1	30	36	PF00069	0.578
MOD_ProDKin_1	49	55	PF00069	0.402
MOD_ProDKin_1	67	73	PF00069	0.432
TRG_ENDOCYTIC_2	48	51	PF00928	0.541
TRG_ENDOCYTIC_2	57	60	PF00928	0.539
TRG_ENDOCYTIC_2	88	91	PF00928	0.557
TRG_ER_diArg_1	179	181	PF00400	0.571
TRG_ER_diArg_1	18	20	PF00400	0.744
TRG_PTS1	242	245	PF00515	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD67	Leptomonas seymouri	60%	100%
A0A0S4J8D0	Bodo saltans	25%	100%
A0A3S7WR77	Leishmania donovani	79%	100%
A4HUH6	Leishmania infantum	79%	100%
C9ZVJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AN74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QHF1	Leishmania major	85%	99%