Flagellar glycoprotein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum adhesion protein 1

Species:

Leishmania braziliensis

UniProt:

A4H655_LEIBR

TriTrypDb:

LbrM.10.0770 , LBRM2903_100015800

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 8, no: 1
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0016020	membrane	2	6
GO:0031514	motile cilium	5	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A4H655

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H655

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.275
CLV_C14_Caspase3-7	291	295	PF00656	0.395
CLV_NRD_NRD_1	47	49	PF00675	0.699
CLV_PCSK_SKI1_1	206	210	PF00082	0.469
CLV_PCSK_SKI1_1	400	404	PF00082	0.597
CLV_PCSK_SKI1_1	410	414	PF00082	0.542
CLV_PCSK_SKI1_1	436	440	PF00082	0.738
DEG_APCC_DBOX_1	409	417	PF00400	0.339
DEG_SPOP_SBC_1	189	193	PF00917	0.305
DOC_CDC14_PxL_1	163	171	PF14671	0.318
DOC_CKS1_1	110	115	PF01111	0.429
DOC_CYCLIN_yCln2_LP_2	347	350	PF00134	0.495
DOC_MAPK_MEF2A_6	111	120	PF00069	0.279
DOC_PP1_RVXF_1	244	251	PF00149	0.278
DOC_PP2B_LxvP_1	138	141	PF13499	0.437
DOC_PP2B_LxvP_1	347	350	PF13499	0.558
DOC_PP4_FxxP_1	157	160	PF00568	0.258
DOC_PP4_FxxP_1	346	349	PF00568	0.478
DOC_PP4_FxxP_1	386	389	PF00568	0.429
DOC_USP7_MATH_1	288	292	PF00917	0.578
DOC_USP7_MATH_1	350	354	PF00917	0.472
DOC_USP7_MATH_1	458	462	PF00917	0.369
DOC_WW_Pin1_4	109	114	PF00397	0.376
DOC_WW_Pin1_4	142	147	PF00397	0.495
DOC_WW_Pin1_4	232	237	PF00397	0.433
DOC_WW_Pin1_4	263	268	PF00397	0.297
DOC_WW_Pin1_4	281	286	PF00397	0.418
DOC_WW_Pin1_4	476	481	PF00397	0.559
LIG_14-3-3_CanoR_1	111	117	PF00244	0.357
LIG_14-3-3_CanoR_1	390	395	PF00244	0.296
LIG_14-3-3_CanoR_1	70	75	PF00244	0.446
LIG_AP2alpha_2	155	157	PF02296	0.304
LIG_APCC_ABBA_1	259	264	PF00400	0.359
LIG_APCC_ABBAyCdc20_2	258	264	PF00400	0.337
LIG_BRCT_BRCA1_1	153	157	PF00533	0.336
LIG_BRCT_BRCA1_1	169	173	PF00533	0.377
LIG_eIF4E_1	342	348	PF01652	0.335
LIG_FHA_1	176	182	PF00498	0.263
LIG_FHA_1	213	219	PF00498	0.413
LIG_FHA_1	250	256	PF00498	0.465
LIG_FHA_1	338	344	PF00498	0.414
LIG_FHA_1	352	358	PF00498	0.520
LIG_FHA_1	370	376	PF00498	0.428
LIG_FHA_1	378	384	PF00498	0.383
LIG_FHA_1	391	397	PF00498	0.368
LIG_FHA_1	55	61	PF00498	0.363
LIG_FHA_1	99	105	PF00498	0.414
LIG_FHA_2	208	214	PF00498	0.272
LIG_IRF3_LxIS_1	113	119	PF10401	0.369
LIG_LIR_Apic_2	154	160	PF02991	0.418
LIG_LIR_Apic_2	185	189	PF02991	0.473
LIG_LIR_Apic_2	344	349	PF02991	0.498
LIG_LIR_Apic_2	385	389	PF02991	0.264
LIG_LIR_Gen_1	249	255	PF02991	0.291
LIG_LIR_Gen_1	275	286	PF02991	0.496
LIG_LIR_Nem_3	203	207	PF02991	0.396
LIG_LIR_Nem_3	249	253	PF02991	0.309
LIG_LIR_Nem_3	268	273	PF02991	0.335
LIG_LIR_Nem_3	275	281	PF02991	0.383
LIG_LIR_Nem_3	58	64	PF02991	0.458
LIG_MYND_1	240	244	PF01753	0.396
LIG_PCNA_yPIPBox_3	124	138	PF02747	0.248
LIG_REV1ctd_RIR_1	260	266	PF16727	0.439
LIG_SH2_CRK	186	190	PF00017	0.308
LIG_SH2_CRK	4	8	PF00017	0.484
LIG_SH2_NCK_1	186	190	PF00017	0.481
LIG_SH2_STAP1	392	396	PF00017	0.290
LIG_SH2_STAT3	392	395	PF00017	0.291
LIG_SH2_STAT5	139	142	PF00017	0.433
LIG_SH2_STAT5	182	185	PF00017	0.377
LIG_SH2_STAT5	219	222	PF00017	0.381
LIG_SH2_STAT5	271	274	PF00017	0.330
LIG_SH2_STAT5	342	345	PF00017	0.313
LIG_SH2_STAT5	38	41	PF00017	0.401
LIG_SH2_STAT5	392	395	PF00017	0.350
LIG_SH2_STAT5	82	85	PF00017	0.308
LIG_SH3_3	193	199	PF00018	0.450
LIG_SH3_3	282	288	PF00018	0.473
LIG_SH3_3	485	491	PF00018	0.719
LIG_SUMO_SIM_anti_2	380	385	PF11976	0.437
LIG_SUMO_SIM_par_1	378	385	PF11976	0.297
LIG_SUMO_SIM_par_1	473	479	PF11976	0.446
LIG_TRAF2_2	285	290	PF00917	0.386
LIG_WRC_WIRS_1	383	388	PF05994	0.315
MOD_CK1_1	212	218	PF00069	0.432
MOD_CK1_1	222	228	PF00069	0.351
MOD_CK1_1	292	298	PF00069	0.721
MOD_CK1_1	353	359	PF00069	0.476
MOD_CK1_1	404	410	PF00069	0.466
MOD_CK1_1	66	72	PF00069	0.407
MOD_CK1_1	73	79	PF00069	0.300
MOD_CK1_1	97	103	PF00069	0.460
MOD_GlcNHglycan	230	233	PF01048	0.502
MOD_GlcNHglycan	25	28	PF01048	0.518
MOD_GlcNHglycan	281	284	PF01048	0.639
MOD_GlcNHglycan	299	302	PF01048	0.633
MOD_GlcNHglycan	364	367	PF01048	0.515
MOD_GlcNHglycan	418	421	PF01048	0.560
MOD_GlcNHglycan	448	451	PF01048	0.639
MOD_GlcNHglycan	65	68	PF01048	0.650
MOD_GlcNHglycan	75	78	PF01048	0.471
MOD_GlcNHglycan	88	91	PF01048	0.294
MOD_GSK3_1	105	112	PF00069	0.500
MOD_GSK3_1	123	130	PF00069	0.463
MOD_GSK3_1	190	197	PF00069	0.567
MOD_GSK3_1	208	215	PF00069	0.474
MOD_GSK3_1	218	225	PF00069	0.440
MOD_GSK3_1	228	235	PF00069	0.311
MOD_GSK3_1	288	295	PF00069	0.626
MOD_GSK3_1	337	344	PF00069	0.543
MOD_GSK3_1	369	376	PF00069	0.573
MOD_GSK3_1	390	397	PF00069	0.446
MOD_GSK3_1	400	407	PF00069	0.475
MOD_GSK3_1	412	419	PF00069	0.474
MOD_GSK3_1	430	437	PF00069	0.578
MOD_GSK3_1	66	73	PF00069	0.628
MOD_GSK3_1	93	100	PF00069	0.546
MOD_N-GLC_1	105	110	PF02516	0.397
MOD_N-GLC_1	150	155	PF02516	0.532
MOD_N-GLC_1	175	180	PF02516	0.457
MOD_N-GLC_1	222	227	PF02516	0.553
MOD_N-GLC_1	316	321	PF02516	0.560
MOD_N-GLC_1	337	342	PF02516	0.501
MOD_N-GLC_1	350	355	PF02516	0.660
MOD_N-GLC_1	362	367	PF02516	0.526
MOD_N-GLC_1	369	374	PF02516	0.550
MOD_N-GLC_1	429	434	PF02516	0.595
MOD_N-GLC_1	44	49	PF02516	0.418
MOD_N-GLC_1	94	99	PF02516	0.586
MOD_NEK2_1	105	110	PF00069	0.369
MOD_NEK2_1	116	121	PF00069	0.509
MOD_NEK2_1	129	134	PF00069	0.490
MOD_NEK2_1	218	223	PF00069	0.504
MOD_NEK2_1	23	28	PF00069	0.560
MOD_NEK2_1	273	278	PF00069	0.540
MOD_NEK2_1	279	284	PF00069	0.589
MOD_NEK2_1	362	367	PF00069	0.571
MOD_NEK2_1	382	387	PF00069	0.362
MOD_NEK2_1	401	406	PF00069	0.477
MOD_NEK2_1	412	417	PF00069	0.414
MOD_NEK2_1	429	434	PF00069	0.383
MOD_NEK2_1	93	98	PF00069	0.400
MOD_NEK2_2	431	436	PF00069	0.460
MOD_PIKK_1	394	400	PF00454	0.591
MOD_PIKK_1	95	101	PF00454	0.329
MOD_Plk_1	105	111	PF00069	0.341
MOD_Plk_1	122	128	PF00069	0.564
MOD_Plk_1	175	181	PF00069	0.438
MOD_Plk_1	316	322	PF00069	0.563
MOD_Plk_1	377	383	PF00069	0.547
MOD_Plk_2-3	290	296	PF00069	0.492
MOD_Plk_4	100	106	PF00069	0.455
MOD_Plk_4	123	129	PF00069	0.455
MOD_Plk_4	249	255	PF00069	0.461
MOD_Plk_4	266	272	PF00069	0.323
MOD_Plk_4	353	359	PF00069	0.716
MOD_Plk_4	377	383	PF00069	0.523
MOD_Plk_4	459	465	PF00069	0.401
MOD_ProDKin_1	109	115	PF00069	0.461
MOD_ProDKin_1	142	148	PF00069	0.625
MOD_ProDKin_1	232	238	PF00069	0.544
MOD_ProDKin_1	263	269	PF00069	0.349
MOD_ProDKin_1	281	287	PF00069	0.532
MOD_ProDKin_1	476	482	PF00069	0.563
MOD_SUMO_rev_2	119	126	PF00179	0.330
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.525
TRG_ENDOCYTIC_2	326	329	PF00928	0.509
TRG_ENDOCYTIC_2	359	362	PF00928	0.446
TRG_ENDOCYTIC_2	4	7	PF00928	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NRY9	Trypanosomatidae	29%	87%
A0A3S7WR66	Leishmania donovani	69%	82%
A0A422NWX8	Trypanosoma rangeli	28%	86%
A4HUH5	Leishmania infantum	71%	83%
C9ZVK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	90%
E9AN73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	82%
Q4QHF2	Leishmania major	72%	100%
V5BP43	Trypanosoma cruzi	28%	85%