Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FLA1-binding protein

Species:

Leishmania braziliensis

UniProt:

A4H654_LEIBR

TriTrypDb:

LbrM.10.0760 , LBRM2903_100015700

Length:

756

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 3
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H654

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H654

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.350
CLV_NRD_NRD_1	688	690	PF00675	0.752
CLV_NRD_NRD_1	722	724	PF00675	0.460
CLV_PCSK_KEX2_1	720	722	PF00082	0.454
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.454
CLV_PCSK_SKI1_1	488	492	PF00082	0.560
CLV_PCSK_SKI1_1	723	727	PF00082	0.560
DEG_APCC_DBOX_1	720	728	PF00400	0.662
DEG_ODPH_VHL_1	237	248	PF01847	0.383
DEG_SPOP_SBC_1	127	131	PF00917	0.315
DEG_SPOP_SBC_1	238	242	PF00917	0.391
DEG_SPOP_SBC_1	254	258	PF00917	0.282
DEG_SPOP_SBC_1	283	287	PF00917	0.467
DEG_SPOP_SBC_1	437	441	PF00917	0.289
DOC_CKS1_1	407	412	PF01111	0.388
DOC_CYCLIN_yClb1_LxF_4	527	533	PF00134	0.346
DOC_CYCLIN_yClb5_NLxxxL_5	468	477	PF00134	0.314
DOC_CYCLIN_yClb5_NLxxxL_5	630	639	PF00134	0.285
DOC_CYCLIN_yCln2_LP_2	491	497	PF00134	0.381
DOC_CYCLIN_yCln2_LP_2	517	523	PF00134	0.352
DOC_MAPK_MEF2A_6	332	340	PF00069	0.261
DOC_MAPK_MEF2A_6	377	385	PF00069	0.418
DOC_PP2B_LxvP_1	517	520	PF13499	0.311
DOC_PP2B_PxIxI_1	627	633	PF00149	0.285
DOC_PP4_FxxP_1	236	239	PF00568	0.397
DOC_PP4_FxxP_1	462	465	PF00568	0.401
DOC_USP7_MATH_1	229	233	PF00917	0.405
DOC_USP7_MATH_1	239	243	PF00917	0.385
DOC_USP7_MATH_1	284	288	PF00917	0.422
DOC_USP7_MATH_1	295	299	PF00917	0.358
DOC_USP7_MATH_1	346	350	PF00917	0.303
DOC_USP7_MATH_1	437	441	PF00917	0.446
DOC_USP7_MATH_1	554	558	PF00917	0.268
DOC_USP7_MATH_1	700	704	PF00917	0.489
DOC_USP7_MATH_1	731	735	PF00917	0.607
DOC_WW_Pin1_4	132	137	PF00397	0.517
DOC_WW_Pin1_4	365	370	PF00397	0.449
DOC_WW_Pin1_4	406	411	PF00397	0.490
DOC_WW_Pin1_4	438	443	PF00397	0.429
LIG_14-3-3_CanoR_1	128	137	PF00244	0.526
LIG_14-3-3_CanoR_1	291	299	PF00244	0.350
LIG_14-3-3_CanoR_1	377	385	PF00244	0.430
LIG_14-3-3_CanoR_1	428	433	PF00244	0.494
LIG_14-3-3_CanoR_1	481	491	PF00244	0.306
LIG_14-3-3_CanoR_1	7	16	PF00244	0.587
LIG_14-3-3_CanoR_1	722	728	PF00244	0.775
LIG_14-3-3_CanoR_1	92	97	PF00244	0.400
LIG_14-3-3_CterR_2	751	756	PF00244	0.603
LIG_BRCT_BRCA1_1	425	429	PF00533	0.392
LIG_BRCT_BRCA1_1	439	443	PF00533	0.281
LIG_BRCT_BRCA1_1	84	88	PF00533	0.390
LIG_deltaCOP1_diTrp_1	414	421	PF00928	0.398
LIG_EH_1	60	64	PF12763	0.373
LIG_EH1_1	708	716	PF00400	0.239
LIG_FHA_1	15	21	PF00498	0.525
LIG_FHA_1	255	261	PF00498	0.485
LIG_FHA_1	284	290	PF00498	0.386
LIG_FHA_1	298	304	PF00498	0.320
LIG_FHA_1	309	315	PF00498	0.390
LIG_FHA_1	378	384	PF00498	0.372
LIG_FHA_1	407	413	PF00498	0.404
LIG_FHA_1	455	461	PF00498	0.434
LIG_FHA_1	472	478	PF00498	0.346
LIG_FHA_1	54	60	PF00498	0.403
LIG_FHA_1	547	553	PF00498	0.402
LIG_FHA_1	634	640	PF00498	0.418
LIG_FHA_1	649	655	PF00498	0.399
LIG_FHA_1	69	75	PF00498	0.536
LIG_FHA_1	691	697	PF00498	0.415
LIG_FHA_1	76	82	PF00498	0.462
LIG_FHA_2	358	364	PF00498	0.504
LIG_FHA_2	413	419	PF00498	0.440
LIG_FHA_2	743	749	PF00498	0.652
LIG_LIR_Apic_2	605	611	PF02991	0.382
LIG_LIR_Gen_1	155	166	PF02991	0.440
LIG_LIR_Gen_1	211	219	PF02991	0.471
LIG_LIR_Gen_1	298	305	PF02991	0.485
LIG_LIR_Gen_1	562	573	PF02991	0.415
LIG_LIR_Gen_1	616	627	PF02991	0.363
LIG_LIR_Gen_1	671	681	PF02991	0.383
LIG_LIR_Gen_1	708	717	PF02991	0.272
LIG_LIR_Gen_1	94	101	PF02991	0.445
LIG_LIR_LC3C_4	708	712	PF02991	0.239
LIG_LIR_Nem_3	155	161	PF02991	0.420
LIG_LIR_Nem_3	211	217	PF02991	0.390
LIG_LIR_Nem_3	222	228	PF02991	0.337
LIG_LIR_Nem_3	242	248	PF02991	0.373
LIG_LIR_Nem_3	298	304	PF02991	0.482
LIG_LIR_Nem_3	324	330	PF02991	0.427
LIG_LIR_Nem_3	368	373	PF02991	0.472
LIG_LIR_Nem_3	562	568	PF02991	0.376
LIG_LIR_Nem_3	586	592	PF02991	0.411
LIG_LIR_Nem_3	656	662	PF02991	0.353
LIG_LIR_Nem_3	671	676	PF02991	0.342
LIG_LIR_Nem_3	708	712	PF02991	0.270
LIG_LIR_Nem_3	85	90	PF02991	0.364
LIG_LIR_Nem_3	94	99	PF02991	0.384
LIG_LYPXL_yS_3	493	496	PF13949	0.436
LIG_MLH1_MIPbox_1	84	88	PF16413	0.366
LIG_MYND_1	607	611	PF01753	0.396
LIG_NRBOX	513	519	PF00104	0.415
LIG_PCNA_yPIPBox_3	115	128	PF02747	0.277
LIG_Pex14_1	417	421	PF04695	0.328
LIG_Pex14_2	370	374	PF04695	0.370
LIG_PTB_Apo_2	142	149	PF02174	0.365
LIG_PTB_Apo_2	424	431	PF02174	0.393
LIG_SH2_CRK	188	192	PF00017	0.426
LIG_SH2_CRK	214	218	PF00017	0.346
LIG_SH2_CRK	301	305	PF00017	0.398
LIG_SH2_CRK	565	569	PF00017	0.375
LIG_SH2_CRK	592	596	PF00017	0.382
LIG_SH2_GRB2like	214	217	PF00017	0.293
LIG_SH2_GRB2like	453	456	PF00017	0.386
LIG_SH2_GRB2like	645	648	PF00017	0.385
LIG_SH2_GRB2like	659	662	PF00017	0.388
LIG_SH2_NCK_1	301	305	PF00017	0.387
LIG_SH2_NCK_1	33	37	PF00017	0.411
LIG_SH2_NCK_1	390	394	PF00017	0.408
LIG_SH2_NCK_1	565	569	PF00017	0.375
LIG_SH2_NCK_1	592	596	PF00017	0.364
LIG_SH2_PTP2	158	161	PF00017	0.274
LIG_SH2_PTP2	402	405	PF00017	0.464
LIG_SH2_SRC	33	36	PF00017	0.421
LIG_SH2_SRC	390	393	PF00017	0.454
LIG_SH2_STAP1	301	305	PF00017	0.385
LIG_SH2_STAP1	497	501	PF00017	0.376
LIG_SH2_STAP1	565	569	PF00017	0.375
LIG_SH2_STAT3	141	144	PF00017	0.406
LIG_SH2_STAT5	142	145	PF00017	0.312
LIG_SH2_STAT5	158	161	PF00017	0.325
LIG_SH2_STAT5	179	182	PF00017	0.303
LIG_SH2_STAT5	252	255	PF00017	0.291
LIG_SH2_STAT5	301	304	PF00017	0.470
LIG_SH2_STAT5	373	376	PF00017	0.454
LIG_SH2_STAT5	402	405	PF00017	0.432
LIG_SH2_STAT5	495	498	PF00017	0.423
LIG_SH2_STAT5	608	611	PF00017	0.596
LIG_SH2_STAT5	679	682	PF00017	0.409
LIG_SH2_STAT5	86	89	PF00017	0.416
LIG_SH2_STAT5	96	99	PF00017	0.436
LIG_SH3_3	273	279	PF00018	0.368
LIG_SH3_3	395	401	PF00018	0.470
LIG_SH3_3	638	644	PF00018	0.490
LIG_SH3_3	649	655	PF00018	0.277
LIG_SH3_3	724	730	PF00018	0.670
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.460
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.312
LIG_SUMO_SIM_par_1	334	339	PF11976	0.286
LIG_SUMO_SIM_par_1	379	386	PF11976	0.386
LIG_SUMO_SIM_par_1	474	480	PF11976	0.307
LIG_TRAF2_1	745	748	PF00917	0.788
LIG_TYR_ITIM	156	161	PF00017	0.268
LIG_TYR_ITIM	299	304	PF00017	0.398
LIG_TYR_ITIM	491	496	PF00017	0.442
LIG_TYR_ITIM	590	595	PF00017	0.376
LIG_WRC_WIRS_1	706	711	PF05994	0.239
LIG_WRC_WIRS_1	87	92	PF05994	0.308
LIG_WRC_WIRS_1	96	101	PF05994	0.278
MOD_CK1_1	132	138	PF00069	0.460
MOD_CK1_1	201	207	PF00069	0.481
MOD_CK1_1	218	224	PF00069	0.416
MOD_CK1_1	255	261	PF00069	0.365
MOD_CK1_1	357	363	PF00069	0.435
MOD_CK1_1	431	437	PF00069	0.418
MOD_CK1_1	613	619	PF00069	0.502
MOD_CK2_1	218	224	PF00069	0.349
MOD_CK2_1	405	411	PF00069	0.364
MOD_CK2_1	742	748	PF00069	0.691
MOD_GlcNHglycan	109	112	PF01048	0.615
MOD_GlcNHglycan	132	135	PF01048	0.638
MOD_GlcNHglycan	181	184	PF01048	0.617
MOD_GlcNHglycan	200	203	PF01048	0.626
MOD_GlcNHglycan	231	234	PF01048	0.614
MOD_GlcNHglycan	286	289	PF01048	0.621
MOD_GlcNHglycan	434	437	PF01048	0.626
MOD_GlcNHglycan	556	559	PF01048	0.624
MOD_GlcNHglycan	569	572	PF01048	0.495
MOD_GlcNHglycan	592	595	PF01048	0.560
MOD_GlcNHglycan	702	705	PF01048	0.479
MOD_GlcNHglycan	9	12	PF01048	0.788
MOD_GSK3_1	122	129	PF00069	0.334
MOD_GSK3_1	132	139	PF00069	0.345
MOD_GSK3_1	21	28	PF00069	0.458
MOD_GSK3_1	215	222	PF00069	0.440
MOD_GSK3_1	266	273	PF00069	0.396
MOD_GSK3_1	290	297	PF00069	0.413
MOD_GSK3_1	342	349	PF00069	0.350
MOD_GSK3_1	357	364	PF00069	0.437
MOD_GSK3_1	412	419	PF00069	0.371
MOD_GSK3_1	428	435	PF00069	0.346
MOD_GSK3_1	68	75	PF00069	0.481
MOD_GSK3_1	7	14	PF00069	0.684
MOD_GSK3_1	738	745	PF00069	0.798
MOD_GSK3_1	82	89	PF00069	0.364
MOD_GSK3_1	91	98	PF00069	0.345
MOD_N-GLC_1	215	220	PF02516	0.528
MOD_N-GLC_1	357	362	PF02516	0.648
MOD_N-GLC_1	412	417	PF02516	0.589
MOD_N-GLC_1	454	459	PF02516	0.588
MOD_N-GLC_1	471	476	PF02516	0.490
MOD_N-GLC_1	502	507	PF02516	0.637
MOD_N-GLC_1	510	515	PF02516	0.553
MOD_N-GLC_1	534	539	PF02516	0.551
MOD_N-GLC_1	547	552	PF02516	0.466
MOD_N-GLC_1	602	607	PF02516	0.534
MOD_N-GLC_1	613	618	PF02516	0.646
MOD_N-GLC_1	633	638	PF02516	0.563
MOD_N-GLC_1	648	653	PF02516	0.557
MOD_N-GLC_1	681	686	PF02516	0.619
MOD_NEK2_1	122	127	PF00069	0.302
MOD_NEK2_1	169	174	PF00069	0.374
MOD_NEK2_1	208	213	PF00069	0.292
MOD_NEK2_1	217	222	PF00069	0.375
MOD_NEK2_1	228	233	PF00069	0.336
MOD_NEK2_1	282	287	PF00069	0.354
MOD_NEK2_1	432	437	PF00069	0.397
MOD_NEK2_1	443	448	PF00069	0.314
MOD_NEK2_1	533	538	PF00069	0.430
MOD_NEK2_1	547	552	PF00069	0.286
MOD_NEK2_1	648	653	PF00069	0.360
MOD_NEK2_1	662	667	PF00069	0.387
MOD_NEK2_1	705	710	PF00069	0.419
MOD_NEK2_2	123	128	PF00069	0.433
MOD_NEK2_2	136	141	PF00069	0.394
MOD_NEK2_2	239	244	PF00069	0.247
MOD_PIKK_1	201	207	PF00454	0.368
MOD_PKA_2	116	122	PF00069	0.423
MOD_PKA_2	127	133	PF00069	0.431
MOD_PKA_2	270	276	PF00069	0.480
MOD_PKA_2	290	296	PF00069	0.246
MOD_PKA_2	361	367	PF00069	0.303
MOD_PKA_2	376	382	PF00069	0.269
MOD_PKA_2	6	12	PF00069	0.617
MOD_PKA_2	91	97	PF00069	0.357
MOD_PKB_1	721	729	PF00069	0.774
MOD_Plk_1	169	175	PF00069	0.377
MOD_Plk_1	357	363	PF00069	0.437
MOD_Plk_1	412	418	PF00069	0.398
MOD_Plk_1	502	508	PF00069	0.454
MOD_Plk_1	510	516	PF00069	0.362
MOD_Plk_1	547	553	PF00069	0.404
MOD_Plk_1	602	608	PF00069	0.521
MOD_Plk_1	648	654	PF00069	0.339
MOD_Plk_1	75	81	PF00069	0.458
MOD_Plk_2-3	743	749	PF00069	0.740
MOD_Plk_4	11	17	PF00069	0.480
MOD_Plk_4	136	142	PF00069	0.388
MOD_Plk_4	152	158	PF00069	0.319
MOD_Plk_4	169	175	PF00069	0.364
MOD_Plk_4	239	245	PF00069	0.427
MOD_Plk_4	277	283	PF00069	0.378
MOD_Plk_4	299	305	PF00069	0.357
MOD_Plk_4	346	352	PF00069	0.372
MOD_Plk_4	449	455	PF00069	0.308
MOD_Plk_4	510	516	PF00069	0.477
MOD_Plk_4	547	553	PF00069	0.384
MOD_Plk_4	654	660	PF00069	0.382
MOD_Plk_4	705	711	PF00069	0.400
MOD_Plk_4	723	729	PF00069	0.778
MOD_Plk_4	75	81	PF00069	0.390
MOD_Plk_4	82	88	PF00069	0.377
MOD_Plk_4	92	98	PF00069	0.302
MOD_ProDKin_1	132	138	PF00069	0.507
MOD_ProDKin_1	365	371	PF00069	0.446
MOD_ProDKin_1	406	412	PF00069	0.483
MOD_ProDKin_1	438	444	PF00069	0.435
MOD_SUMO_rev_2	218	228	PF00179	0.471
MOD_SUMO_rev_2	50	54	PF00179	0.301
MOD_SUMO_rev_2	734	739	PF00179	0.714
TRG_ENDOCYTIC_2	150	153	PF00928	0.245
TRG_ENDOCYTIC_2	158	161	PF00928	0.261
TRG_ENDOCYTIC_2	188	191	PF00928	0.425
TRG_ENDOCYTIC_2	214	217	PF00928	0.329
TRG_ENDOCYTIC_2	301	304	PF00928	0.498
TRG_ENDOCYTIC_2	390	393	PF00928	0.456
TRG_ENDOCYTIC_2	402	405	PF00928	0.454
TRG_ENDOCYTIC_2	493	496	PF00928	0.388
TRG_ENDOCYTIC_2	565	568	PF00928	0.458
TRG_ENDOCYTIC_2	592	595	PF00928	0.478
TRG_ENDOCYTIC_2	619	622	PF00928	0.366
TRG_ENDOCYTIC_2	645	648	PF00928	0.297
TRG_ENDOCYTIC_2	659	662	PF00928	0.388
TRG_ENDOCYTIC_2	96	99	PF00928	0.381
TRG_ER_diArg_1	721	723	PF00400	0.654
TRG_NLS_MonoCore_2	719	724	PF00514	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWL9	Leptomonas seymouri	39%	100%
A0A1X0NRS2	Trypanosomatidae	28%	100%
A0A3Q8I8Q8	Leishmania donovani	72%	100%
A0A422NWY1	Trypanosoma rangeli	29%	100%
A4HUH4	Leishmania infantum	73%	100%
C9ZQ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	92%
C9ZVJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZVJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AN72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QHF3	Leishmania major	74%	100%
V5B409	Trypanosoma cruzi	26%	100%