Putative endonuclease G

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease G, putative

Species:

Leishmania braziliensis

UniProt:

A4H653_LEIBR

TriTrypDb:

LbrM.10.0750 , LBRM2903_100015600

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H653

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H653

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004519	endonuclease activity	5	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	6	1
GO:0004520	DNA endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0004540	RNA nuclease activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.205
CLV_NRD_NRD_1	139	141	PF00675	0.205
CLV_NRD_NRD_1	146	148	PF00675	0.118
CLV_NRD_NRD_1	254	256	PF00675	0.233
CLV_NRD_NRD_1	273	275	PF00675	0.239
CLV_NRD_NRD_1	332	334	PF00675	0.186
CLV_NRD_NRD_1	483	485	PF00675	0.232
CLV_NRD_NRD_1	502	504	PF00675	0.437
CLV_PCSK_KEX2_1	127	129	PF00082	0.205
CLV_PCSK_KEX2_1	146	148	PF00082	0.118
CLV_PCSK_KEX2_1	273	275	PF00082	0.241
CLV_PCSK_KEX2_1	33	35	PF00082	0.441
CLV_PCSK_KEX2_1	483	485	PF00082	0.274
CLV_PCSK_KEX2_1	502	504	PF00082	0.391
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.460
CLV_PCSK_PC7_1	479	485	PF00082	0.217
CLV_PCSK_PC7_1	498	504	PF00082	0.332
CLV_PCSK_SKI1_1	365	369	PF00082	0.238
CLV_PCSK_SKI1_1	449	453	PF00082	0.362
DOC_CYCLIN_yCln2_LP_2	73	79	PF00134	0.570
DOC_MAPK_gen_1	255	263	PF00069	0.478
DOC_MAPK_gen_1	33	39	PF00069	0.643
DOC_MAPK_gen_1	333	341	PF00069	0.350
DOC_MAPK_MEF2A_6	334	343	PF00069	0.451
DOC_PP4_FxxP_1	382	385	PF00568	0.405
DOC_USP7_MATH_1	154	158	PF00917	0.470
DOC_USP7_MATH_1	29	33	PF00917	0.688
DOC_USP7_MATH_1	322	326	PF00917	0.518
DOC_USP7_MATH_1	358	362	PF00917	0.557
DOC_USP7_MATH_1	41	45	PF00917	0.673
DOC_USP7_MATH_1	450	454	PF00917	0.446
DOC_USP7_MATH_1	492	496	PF00917	0.625
DOC_USP7_MATH_1	51	55	PF00917	0.722
DOC_USP7_MATH_1	86	90	PF00917	0.637
DOC_WW_Pin1_4	147	152	PF00397	0.500
DOC_WW_Pin1_4	274	279	PF00397	0.531
DOC_WW_Pin1_4	352	357	PF00397	0.396
DOC_WW_Pin1_4	49	54	PF00397	0.705
DOC_WW_Pin1_4	81	86	PF00397	0.556
LIG_14-3-3_CanoR_1	140	148	PF00244	0.350
LIG_14-3-3_CanoR_1	333	341	PF00244	0.452
LIG_14-3-3_CanoR_1	375	384	PF00244	0.511
LIG_14-3-3_CanoR_1	449	455	PF00244	0.437
LIG_14-3-3_CanoR_1	456	462	PF00244	0.508
LIG_BIR_II_1	1	5	PF00653	0.405
LIG_BIR_III_2	160	164	PF00653	0.350
LIG_BIR_III_2	432	436	PF00653	0.615
LIG_BRCT_BRCA1_1	360	364	PF00533	0.451
LIG_CSL_BTD_1	73	76	PF09270	0.433
LIG_EVH1_2	435	439	PF00568	0.454
LIG_FHA_1	108	114	PF00498	0.492
LIG_FHA_1	252	258	PF00498	0.416
LIG_FHA_1	342	348	PF00498	0.470
LIG_FHA_2	154	160	PF00498	0.462
LIG_Integrin_RGD_1	274	276	PF01839	0.212
LIG_LIR_Apic_2	396	401	PF02991	0.430
LIG_LIR_Gen_1	246	253	PF02991	0.416
LIG_LIR_Gen_1	460	469	PF02991	0.609
LIG_LIR_LC3C_4	35	39	PF02991	0.552
LIG_LIR_Nem_3	138	142	PF02991	0.451
LIG_LIR_Nem_3	246	250	PF02991	0.405
LIG_LIR_Nem_3	361	367	PF02991	0.416
LIG_LIR_Nem_3	460	464	PF02991	0.590
LIG_Pex14_2	303	307	PF04695	0.350
LIG_SH2_CRK	139	143	PF00017	0.510
LIG_SH2_CRK	398	402	PF00017	0.416
LIG_SH2_CRK	442	446	PF00017	0.499
LIG_SH2_CRK	461	465	PF00017	0.524
LIG_SH2_STAP1	125	129	PF00017	0.425
LIG_SH2_STAP1	27	31	PF00017	0.688
LIG_SH2_STAP1	481	485	PF00017	0.416
LIG_SH2_STAT3	27	30	PF00017	0.617
LIG_SH2_STAT5	119	122	PF00017	0.486
LIG_SH2_STAT5	202	205	PF00017	0.438
LIG_SH2_STAT5	296	299	PF00017	0.488
LIG_SH3_3	145	151	PF00018	0.534
LIG_SH3_3	295	301	PF00018	0.411
LIG_SH3_3	35	41	PF00018	0.598
LIG_SH3_3	354	360	PF00018	0.416
LIG_SH3_3	382	388	PF00018	0.405
LIG_SH3_3	74	80	PF00018	0.556
LIG_SUMO_SIM_par_1	355	361	PF11976	0.509
LIG_TRAF2_1	163	166	PF00917	0.350
LIG_TYR_ITIM	137	142	PF00017	0.510
MOD_CK1_1	201	207	PF00069	0.515
MOD_CK1_1	32	38	PF00069	0.661
MOD_CK1_1	44	50	PF00069	0.663
MOD_CK1_1	54	60	PF00069	0.744
MOD_CK1_1	63	69	PF00069	0.712
MOD_CK1_1	89	95	PF00069	0.512
MOD_CK2_1	106	112	PF00069	0.504
MOD_CK2_1	218	224	PF00069	0.407
MOD_DYRK1A_RPxSP_1	147	151	PF00069	0.451
MOD_GlcNHglycan	156	159	PF01048	0.225
MOD_GlcNHglycan	27	30	PF01048	0.366
MOD_GlcNHglycan	290	293	PF01048	0.309
MOD_GlcNHglycan	298	301	PF01048	0.236
MOD_GlcNHglycan	324	327	PF01048	0.272
MOD_GlcNHglycan	328	331	PF01048	0.261
MOD_GlcNHglycan	377	380	PF01048	0.150
MOD_GlcNHglycan	466	469	PF01048	0.410
MOD_GlcNHglycan	494	497	PF01048	0.326
MOD_GSK3_1	176	183	PF00069	0.483
MOD_GSK3_1	201	208	PF00069	0.449
MOD_GSK3_1	25	32	PF00069	0.565
MOD_GSK3_1	251	258	PF00069	0.472
MOD_GSK3_1	322	329	PF00069	0.473
MOD_GSK3_1	341	348	PF00069	0.509
MOD_GSK3_1	41	48	PF00069	0.626
MOD_GSK3_1	460	467	PF00069	0.572
MOD_GSK3_1	51	58	PF00069	0.682
MOD_GSK3_1	59	66	PF00069	0.531
MOD_N-GLC_1	180	185	PF02516	0.345
MOD_N-GLC_1	59	64	PF02516	0.576
MOD_NEK2_1	225	230	PF00069	0.413
MOD_NEK2_1	332	337	PF00069	0.350
MOD_NEK2_1	417	422	PF00069	0.525
MOD_NEK2_1	425	430	PF00069	0.510
MOD_NEK2_1	45	50	PF00069	0.661
MOD_NEK2_1	457	462	PF00069	0.584
MOD_NEK2_1	464	469	PF00069	0.626
MOD_NEK2_1	473	478	PF00069	0.529
MOD_PIKK_1	218	224	PF00454	0.472
MOD_PIKK_1	32	38	PF00454	0.596
MOD_PIKK_1	60	66	PF00454	0.656
MOD_PK_1	259	265	PF00069	0.451
MOD_PKA_1	146	152	PF00069	0.451
MOD_PKA_1	255	261	PF00069	0.472
MOD_PKA_2	146	152	PF00069	0.451
MOD_PKA_2	332	338	PF00069	0.429
MOD_PKA_2	406	412	PF00069	0.439
MOD_PKA_2	457	463	PF00069	0.588
MOD_Plk_1	187	193	PF00069	0.429
MOD_Plk_1	225	231	PF00069	0.439
MOD_Plk_1	238	244	PF00069	0.366
MOD_Plk_1	259	265	PF00069	0.509
MOD_Plk_1	417	423	PF00069	0.523
MOD_Plk_1	473	479	PF00069	0.463
MOD_Plk_4	41	47	PF00069	0.737
MOD_Plk_4	473	479	PF00069	0.463
MOD_ProDKin_1	147	153	PF00069	0.500
MOD_ProDKin_1	274	280	PF00069	0.531
MOD_ProDKin_1	352	358	PF00069	0.396
MOD_ProDKin_1	49	55	PF00069	0.708
MOD_ProDKin_1	81	87	PF00069	0.557
TRG_ENDOCYTIC_2	139	142	PF00928	0.510
TRG_ENDOCYTIC_2	442	445	PF00928	0.476
TRG_ENDOCYTIC_2	461	464	PF00928	0.519
TRG_ER_diArg_1	127	129	PF00400	0.445
TRG_ER_diArg_1	146	148	PF00400	0.318
TRG_ER_diArg_1	455	458	PF00400	0.426
TRG_ER_diArg_1	501	503	PF00400	0.564
TRG_NES_CRM1_1	251	267	PF08389	0.509
TRG_NLS_Bipartite_1	127	144	PF00514	0.350
TRG_NLS_MonoExtC_3	139	145	PF00514	0.350
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.150
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK94	Leptomonas seymouri	63%	100%
A0A0S4JFH6	Bodo saltans	37%	100%
A0A1X0NQR8	Trypanosomatidae	35%	100%
A0A3Q8I8T5	Leishmania donovani	81%	99%
A0A422NX36	Trypanosoma rangeli	38%	100%
A4HUH3	Leishmania infantum	81%	99%
C9ZVJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AN71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4QHF4	Leishmania major	83%	100%
Q502K1	Danio rerio	29%	100%
Q8C163	Mus musculus	26%	100%
Q9Y2C4	Homo sapiens	27%	100%
V5BJI6	Trypanosoma cruzi	40%	100%