Putative endonuclease G

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease G, putative

Species:

Leishmania braziliensis

UniProt:

A4H653_LEIBR

TriTrypDb:

LbrM.10.0750 , LBRM2903_100015600

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Expansion

Sequence features

A4H653

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H653

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	6	1
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004519	endonuclease activity	5	12
GO:0004520	DNA endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0004540	RNA nuclease activity	4	1
GO:0005488	binding	1	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.205
CLV_NRD_NRD_1	139	141	PF00675	0.205
CLV_NRD_NRD_1	146	148	PF00675	0.118
CLV_NRD_NRD_1	254	256	PF00675	0.233
CLV_NRD_NRD_1	273	275	PF00675	0.239
CLV_NRD_NRD_1	332	334	PF00675	0.186
CLV_NRD_NRD_1	483	485	PF00675	0.232
CLV_NRD_NRD_1	502	504	PF00675	0.437
CLV_PCSK_KEX2_1	127	129	PF00082	0.205
CLV_PCSK_KEX2_1	146	148	PF00082	0.118

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK94	Leptomonas seymouri	63%	100%
A0A0S4JFH6	Bodo saltans	37%	100%
A0A1X0NQR8	Trypanosomatidae	35%	100%
A0A3Q8I8T5	Leishmania donovani	81%	99%
A0A422NX36	Trypanosoma rangeli	38%	100%
A4HUH3	Leishmania infantum	81%	99%
C9ZVJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AN71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4QHF4	Leishmania major	83%	100%
Q502K1	Danio rerio	29%	100%

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