Cilia- and flagella-associated protein 300

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H651_LEIBR

TriTrypDb:

LbrM.10.0720 , LBRM2903_100015400

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H651

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H651

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	76	84	PF00400	0.627
DOC_MAPK_gen_1	77	85	PF00069	0.710
DOC_MAPK_MEF2A_6	79	87	PF00069	0.703
DOC_PP1_RVXF_1	176	183	PF00149	0.460
DOC_USP7_MATH_1	168	172	PF00917	0.604
DOC_WW_Pin1_4	170	175	PF00397	0.477
DOC_WW_Pin1_4	6	11	PF00397	0.589
LIG_14-3-3_CanoR_1	106	114	PF00244	0.647
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_FHA_1	106	112	PF00498	0.638
LIG_FHA_1	145	151	PF00498	0.424
LIG_FHA_1	162	168	PF00498	0.610
LIG_FHA_1	2	8	PF00498	0.586
LIG_FHA_1	88	94	PF00498	0.662
LIG_FHA_2	117	123	PF00498	0.675
LIG_FHA_2	127	133	PF00498	0.469
LIG_FHA_2	171	177	PF00498	0.547
LIG_LIR_Gen_1	125	133	PF02991	0.538
LIG_LIR_Nem_3	125	130	PF02991	0.571
LIG_LIR_Nem_3	176	180	PF02991	0.556
LIG_NRBOX	154	160	PF00104	0.651
LIG_NRBOX	79	85	PF00104	0.700
LIG_Pex14_2	127	131	PF04695	0.524
LIG_Pex14_2	197	201	PF04695	0.462
LIG_REV1ctd_RIR_1	180	189	PF16727	0.453
LIG_SH2_STAT3	95	98	PF00017	0.634
LIG_SH3_3	4	10	PF00018	0.635
LIG_SUMO_SIM_par_1	136	141	PF11976	0.402
LIG_SUMO_SIM_par_1	3	9	PF11976	0.589
MOD_CDC14_SPxK_1	9	12	PF00782	0.592
MOD_CDK_SPK_2	170	175	PF00069	0.477
MOD_CDK_SPxK_1	6	12	PF00069	0.591
MOD_CK1_1	166	172	PF00069	0.577
MOD_CK2_1	114	120	PF00069	0.641
MOD_CK2_1	126	132	PF00069	0.463
MOD_CK2_1	170	176	PF00069	0.586
MOD_GlcNHglycan	116	119	PF01048	0.484
MOD_GlcNHglycan	132	136	PF01048	0.589
MOD_GSK3_1	1	8	PF00069	0.710
MOD_GSK3_1	105	112	PF00069	0.657
MOD_GSK3_1	122	129	PF00069	0.437
MOD_GSK3_1	138	145	PF00069	0.556
MOD_GSK3_1	157	164	PF00069	0.558
MOD_GSK3_1	166	173	PF00069	0.675
MOD_N-GLC_1	142	147	PF02516	0.413
MOD_N-GLC_1	58	63	PF02516	0.558
MOD_NEK2_1	87	92	PF00069	0.625
MOD_PIKK_1	166	172	PF00454	0.514
MOD_PIKK_1	53	59	PF00454	0.709
MOD_PK_1	110	116	PF00069	0.647
MOD_PKA_2	105	111	PF00069	0.644
MOD_Plk_1	58	64	PF00069	0.556
MOD_Plk_4	110	116	PF00069	0.647
MOD_Plk_4	126	132	PF00069	0.532
MOD_Plk_4	58	64	PF00069	0.556
MOD_ProDKin_1	170	176	PF00069	0.474
MOD_ProDKin_1	6	12	PF00069	0.591
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKR2	Leptomonas seymouri	44%	100%
A0A3Q8I8T9	Leishmania donovani	69%	77%
A4HUH1	Leishmania infantum	69%	77%
E9AI41	Leishmania braziliensis	98%	77%
E9AN69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	77%
Q4QHF6	Leishmania major	68%	100%