SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromatin assembly factor 1 subunit A, putative

Species:

Leishmania braziliensis

UniProt:

A4H650_LEIBR

TriTrypDb:

LbrM.10.0710 , LBRM2903_100015300

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H650

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H650

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.420
CLV_C14_Caspase3-7	351	355	PF00656	0.575
CLV_C14_Caspase3-7	581	585	PF00656	0.729
CLV_C14_Caspase3-7	66	70	PF00656	0.480
CLV_NRD_NRD_1	184	186	PF00675	0.728
CLV_NRD_NRD_1	19	21	PF00675	0.586
CLV_NRD_NRD_1	308	310	PF00675	0.273
CLV_NRD_NRD_1	32	34	PF00675	0.499
CLV_NRD_NRD_1	382	384	PF00675	0.526
CLV_NRD_NRD_1	475	477	PF00675	0.471
CLV_NRD_NRD_1	48	50	PF00675	0.484
CLV_NRD_NRD_1	524	526	PF00675	0.377
CLV_NRD_NRD_1	529	531	PF00675	0.411
CLV_NRD_NRD_1	60	62	PF00675	0.475
CLV_NRD_NRD_1	70	72	PF00675	0.462
CLV_NRD_NRD_1	82	84	PF00675	0.441
CLV_PCSK_FUR_1	380	384	PF00082	0.465
CLV_PCSK_KEX2_1	145	147	PF00082	0.517
CLV_PCSK_KEX2_1	184	186	PF00082	0.752
CLV_PCSK_KEX2_1	308	310	PF00082	0.273
CLV_PCSK_KEX2_1	31	33	PF00082	0.645
CLV_PCSK_KEX2_1	382	384	PF00082	0.514
CLV_PCSK_KEX2_1	462	464	PF00082	0.542
CLV_PCSK_KEX2_1	475	477	PF00082	0.385
CLV_PCSK_KEX2_1	524	526	PF00082	0.379
CLV_PCSK_KEX2_1	529	531	PF00082	0.423
CLV_PCSK_KEX2_1	60	62	PF00082	0.550
CLV_PCSK_KEX2_1	676	678	PF00082	0.656
CLV_PCSK_KEX2_1	82	84	PF00082	0.499
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.542
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.639
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.656
CLV_PCSK_PC7_1	304	310	PF00082	0.273
CLV_PCSK_PC7_1	525	531	PF00082	0.518
CLV_PCSK_SKI1_1	105	109	PF00082	0.639
CLV_PCSK_SKI1_1	238	242	PF00082	0.641
CLV_PCSK_SKI1_1	32	36	PF00082	0.554
CLV_PCSK_SKI1_1	459	463	PF00082	0.451
CLV_PCSK_SKI1_1	476	480	PF00082	0.422
CLV_PCSK_SKI1_1	499	503	PF00082	0.518
CLV_PCSK_SKI1_1	60	64	PF00082	0.496
CLV_PCSK_SKI1_1	655	659	PF00082	0.692
CLV_PCSK_SKI1_1	660	664	PF00082	0.666
CLV_PCSK_SKI1_1	7	11	PF00082	0.584
DEG_APCC_DBOX_1	498	506	PF00400	0.299
DEG_SPOP_SBC_1	337	341	PF00917	0.406
DOC_CYCLIN_RxL_1	529	539	PF00134	0.460
DOC_CYCLIN_RxL_1	655	667	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	202	208	PF00134	0.519
DOC_MAPK_gen_1	134	142	PF00069	0.512
DOC_MAPK_gen_1	529	536	PF00069	0.530
DOC_MAPK_MEF2A_6	506	514	PF00069	0.528
DOC_PP2B_LxvP_1	108	111	PF13499	0.584
DOC_PP2B_LxvP_1	202	205	PF13499	0.691
DOC_USP7_MATH_1	114	118	PF00917	0.490
DOC_USP7_MATH_1	187	191	PF00917	0.708
DOC_USP7_MATH_1	2	6	PF00917	0.672
DOC_USP7_MATH_1	255	259	PF00917	0.597
DOC_USP7_MATH_1	275	279	PF00917	0.507
DOC_USP7_MATH_1	337	341	PF00917	0.295
DOC_USP7_MATH_1	438	442	PF00917	0.600
DOC_USP7_MATH_1	491	495	PF00917	0.547
DOC_USP7_MATH_1	593	597	PF00917	0.529
DOC_USP7_MATH_1	664	668	PF00917	0.644
DOC_USP7_UBL2_3	105	109	PF12436	0.609
DOC_WW_Pin1_4	539	544	PF00397	0.472
DOC_WW_Pin1_4	635	640	PF00397	0.559
DOC_WW_Pin1_4	8	13	PF00397	0.645
LIG_14-3-3_CanoR_1	136	141	PF00244	0.607
LIG_14-3-3_CanoR_1	419	424	PF00244	0.432
LIG_14-3-3_CanoR_1	529	535	PF00244	0.483
LIG_14-3-3_CanoR_1	551	560	PF00244	0.751
LIG_Actin_WH2_2	293	310	PF00022	0.327
LIG_APCC_ABBAyCdc20_2	49	55	PF00400	0.323
LIG_BRCT_BRCA1_1	397	401	PF00533	0.517
LIG_CSL_BTD_1	540	543	PF09270	0.452
LIG_EVH1_2	204	208	PF00568	0.478
LIG_FHA_1	125	131	PF00498	0.530
LIG_FHA_1	496	502	PF00498	0.484
LIG_FHA_1	652	658	PF00498	0.750
LIG_FHA_2	477	483	PF00498	0.533
LIG_FHA_2	601	607	PF00498	0.798
LIG_FHA_2	622	628	PF00498	0.672
LIG_FHA_2	64	70	PF00498	0.622
LIG_FHA_2	656	662	PF00498	0.565
LIG_LIR_Apic_2	396	400	PF02991	0.654
LIG_LIR_Gen_1	222	229	PF02991	0.505
LIG_LIR_Gen_1	254	264	PF02991	0.633
LIG_LIR_Gen_1	285	294	PF02991	0.427
LIG_LIR_Gen_1	325	334	PF02991	0.292
LIG_LIR_Gen_1	418	428	PF02991	0.458
LIG_LIR_Gen_1	546	557	PF02991	0.427
LIG_LIR_Gen_1	669	678	PF02991	0.515
LIG_LIR_Nem_3	254	259	PF02991	0.515
LIG_LIR_Nem_3	262	268	PF02991	0.428
LIG_LIR_Nem_3	285	289	PF02991	0.429
LIG_LIR_Nem_3	398	404	PF02991	0.546
LIG_LIR_Nem_3	418	423	PF02991	0.358
LIG_LIR_Nem_3	426	431	PF02991	0.474
LIG_LIR_Nem_3	546	552	PF02991	0.539
LIG_LIR_Nem_3	669	674	PF02991	0.514
LIG_PCNA_yPIPBox_3	653	663	PF02747	0.609
LIG_Pex14_2	265	269	PF04695	0.599
LIG_PTB_Apo_2	313	320	PF02174	0.273
LIG_PTB_Phospho_1	313	319	PF10480	0.273
LIG_RPA_C_Fungi	525	537	PF08784	0.523
LIG_SH2_CRK	397	401	PF00017	0.649
LIG_SH2_GRB2like	671	674	PF00017	0.518
LIG_SH2_PTP2	671	674	PF00017	0.518
LIG_SH2_SRC	671	674	PF00017	0.518
LIG_SH2_STAT3	370	373	PF00017	0.422
LIG_SH2_STAT5	282	285	PF00017	0.319
LIG_SH2_STAT5	427	430	PF00017	0.557
LIG_SH2_STAT5	671	674	PF00017	0.518
LIG_SH3_1	537	543	PF00018	0.452
LIG_SH3_3	249	255	PF00018	0.568
LIG_SH3_3	399	405	PF00018	0.552
LIG_SH3_3	537	543	PF00018	0.461
LIG_SH3_3	6	12	PF00018	0.453
LIG_SH3_3	634	640	PF00018	0.544
LIG_SUMO_SIM_anti_2	296	301	PF11976	0.287
LIG_SUMO_SIM_par_1	621	627	PF11976	0.525
LIG_TRAF2_1	455	458	PF00917	0.555
LIG_TRAF2_1	628	631	PF00917	0.791
LIG_TRAF2_1	85	88	PF00917	0.512
LIG_UBA3_1	120	129	PF00899	0.574
LIG_UBA3_1	137	145	PF00899	0.402
LIG_UBA3_1	501	506	PF00899	0.286
LIG_WRC_WIRS_1	256	261	PF05994	0.614
MOD_CDC14_SPxK_1	11	14	PF00782	0.495
MOD_CDK_SPxK_1	8	14	PF00069	0.508
MOD_CDK_SPxxK_3	8	15	PF00069	0.584
MOD_CK1_1	163	169	PF00069	0.692
MOD_CK1_1	339	345	PF00069	0.277
MOD_CK1_1	352	358	PF00069	0.523
MOD_CK1_1	494	500	PF00069	0.522
MOD_CK1_1	638	644	PF00069	0.669
MOD_CK1_1	667	673	PF00069	0.680
MOD_CK2_1	353	359	PF00069	0.663
MOD_CK2_1	41	47	PF00069	0.404
MOD_CK2_1	446	452	PF00069	0.684
MOD_CK2_1	476	482	PF00069	0.537
MOD_CK2_1	621	627	PF00069	0.743
MOD_CK2_1	638	644	PF00069	0.561
MOD_CK2_1	655	661	PF00069	0.546
MOD_CK2_1	89	95	PF00069	0.382
MOD_GlcNHglycan	162	165	PF01048	0.650
MOD_GlcNHglycan	322	325	PF01048	0.273
MOD_GlcNHglycan	397	400	PF01048	0.523
MOD_GlcNHglycan	435	439	PF01048	0.518
MOD_GlcNHglycan	440	443	PF01048	0.617
MOD_GlcNHglycan	448	451	PF01048	0.626
MOD_GlcNHglycan	605	610	PF01048	0.652
MOD_GlcNHglycan	613	616	PF01048	0.639
MOD_GlcNHglycan	641	644	PF01048	0.817
MOD_GlcNHglycan	666	669	PF01048	0.643
MOD_GSK3_1	163	170	PF00069	0.529
MOD_GSK3_1	337	344	PF00069	0.288
MOD_GSK3_1	349	356	PF00069	0.522
MOD_GSK3_1	419	426	PF00069	0.471
MOD_GSK3_1	434	441	PF00069	0.390
MOD_GSK3_1	491	498	PF00069	0.513
MOD_GSK3_1	562	569	PF00069	0.692
MOD_GSK3_1	611	618	PF00069	0.763
MOD_GSK3_1	635	642	PF00069	0.721
MOD_GSK3_1	651	658	PF00069	0.620
MOD_N-GLC_1	172	177	PF02516	0.642
MOD_N-GLC_1	423	428	PF02516	0.364
MOD_N-GLC_1	584	589	PF02516	0.613
MOD_N-GLC_1	615	620	PF02516	0.598
MOD_N-GLC_1	681	686	PF02516	0.566
MOD_NEK2_1	123	128	PF00069	0.553
MOD_NEK2_1	423	428	PF00069	0.456
MOD_NEK2_2	2	7	PF00069	0.464
MOD_PKA_2	312	318	PF00069	0.352
MOD_Plk_1	167	173	PF00069	0.718
MOD_Plk_1	197	203	PF00069	0.597
MOD_Plk_1	423	429	PF00069	0.438
MOD_Plk_1	434	440	PF00069	0.436
MOD_Plk_1	519	525	PF00069	0.423
MOD_Plk_1	593	599	PF00069	0.667
MOD_Plk_2-3	349	355	PF00069	0.518
MOD_Plk_2-3	365	371	PF00069	0.511
MOD_Plk_2-3	452	458	PF00069	0.505
MOD_Plk_2-3	681	687	PF00069	0.519
MOD_Plk_2-3	89	95	PF00069	0.382
MOD_Plk_4	167	173	PF00069	0.695
MOD_Plk_4	197	203	PF00069	0.596
MOD_Plk_4	247	253	PF00069	0.400
MOD_Plk_4	423	429	PF00069	0.447
MOD_Plk_4	485	491	PF00069	0.572
MOD_Plk_4	667	673	PF00069	0.680
MOD_ProDKin_1	539	545	PF00069	0.467
MOD_ProDKin_1	635	641	PF00069	0.561
MOD_ProDKin_1	8	14	PF00069	0.642
MOD_SUMO_for_1	128	131	PF00179	0.579
MOD_SUMO_for_1	34	37	PF00179	0.466
MOD_SUMO_for_1	42	45	PF00179	0.392
MOD_SUMO_for_1	645	648	PF00179	0.755
MOD_SUMO_rev_2	11	16	PF00179	0.582
MOD_SUMO_rev_2	477	486	PF00179	0.526
MOD_SUMO_rev_2	638	647	PF00179	0.674
TRG_DiLeu_BaEn_1	37	42	PF01217	0.478
TRG_ENDOCYTIC_2	256	259	PF00928	0.641
TRG_ENDOCYTIC_2	286	289	PF00928	0.433
TRG_ENDOCYTIC_2	671	674	PF00928	0.518
TRG_ER_diArg_1	307	309	PF00400	0.273
TRG_ER_diArg_1	31	33	PF00400	0.508
TRG_ER_diArg_1	380	383	PF00400	0.510
TRG_ER_diArg_1	385	388	PF00400	0.540
TRG_ER_diArg_1	523	525	PF00400	0.394
TRG_ER_diArg_1	529	532	PF00400	0.442
TRG_ER_diArg_1	60	62	PF00400	0.492
TRG_NLS_MonoExtN_4	459	466	PF00514	0.370
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6G0	Leptomonas seymouri	59%	89%
A0A1X0NRX9	Trypanosomatidae	37%	85%
A0A3S5H6G3	Leishmania donovani	78%	91%
A0A422NX43	Trypanosoma rangeli	46%	99%
A4HUH0	Leishmania infantum	78%	91%
C9ZVJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	99%
E9AN68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	86%
Q4QHF7	Leishmania major	77%	100%
V5D2A3	Trypanosoma cruzi	44%	92%