Zinc-binding dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-binding dehydrogenase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H649_LEIBR

TriTrypDb:

LbrM.10.0700 , LBRM2903_100015200

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H649

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H649

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016491	oxidoreductase activity	2	17
GO:0003960	NADPH:quinone reductase activity	5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.250
CLV_NRD_NRD_1	356	358	PF00675	0.328
CLV_NRD_NRD_1	440	442	PF00675	0.536
CLV_NRD_NRD_1	60	62	PF00675	0.415
CLV_PCSK_FUR_1	437	441	PF00082	0.626
CLV_PCSK_KEX2_1	356	358	PF00082	0.346
CLV_PCSK_KEX2_1	439	441	PF00082	0.542
CLV_PCSK_KEX2_1	60	62	PF00082	0.517
CLV_PCSK_SKI1_1	169	173	PF00082	0.362
CLV_PCSK_SKI1_1	248	252	PF00082	0.357
CLV_PCSK_SKI1_1	304	308	PF00082	0.368
CLV_PCSK_SKI1_1	42	46	PF00082	0.497
CLV_PCSK_SKI1_1	422	426	PF00082	0.335
DEG_APCC_DBOX_1	375	383	PF00400	0.453
DOC_CKS1_1	346	351	PF01111	0.283
DOC_MAPK_FxFP_2	122	125	PF00069	0.437
DOC_MAPK_JIP1_4	30	36	PF00069	0.538
DOC_PP1_RVXF_1	167	173	PF00149	0.386
DOC_PP1_RVXF_1	215	222	PF00149	0.455
DOC_PP4_FxxP_1	122	125	PF00568	0.437
DOC_USP7_MATH_1	142	146	PF00917	0.571
DOC_USP7_MATH_1	155	159	PF00917	0.734
DOC_USP7_MATH_1	206	210	PF00917	0.501
DOC_USP7_MATH_1	25	29	PF00917	0.608
DOC_USP7_MATH_1	276	280	PF00917	0.273
DOC_USP7_MATH_1	322	326	PF00917	0.368
DOC_USP7_MATH_1	37	41	PF00917	0.553
DOC_USP7_MATH_1	468	472	PF00917	0.605
DOC_USP7_MATH_1	7	11	PF00917	0.527
DOC_WW_Pin1_4	201	206	PF00397	0.421
DOC_WW_Pin1_4	277	282	PF00397	0.398
DOC_WW_Pin1_4	345	350	PF00397	0.393
DOC_WW_Pin1_4	99	104	PF00397	0.549
LIG_14-3-3_CanoR_1	112	120	PF00244	0.426
LIG_14-3-3_CanoR_1	356	362	PF00244	0.326
LIG_Actin_WH2_2	14	32	PF00022	0.554
LIG_APCC_ABBA_1	306	311	PF00400	0.181
LIG_BRCT_BRCA1_1	203	207	PF00533	0.381
LIG_BRCT_BRCA1_1	32	36	PF00533	0.401
LIG_eIF4E_1	313	319	PF01652	0.401
LIG_EVH1_2	120	124	PF00568	0.456
LIG_FHA_1	208	214	PF00498	0.584
LIG_FHA_1	231	237	PF00498	0.364
LIG_FHA_1	278	284	PF00498	0.253
LIG_FHA_1	298	304	PF00498	0.232
LIG_FHA_1	331	337	PF00498	0.395
LIG_FHA_1	406	412	PF00498	0.348
LIG_FHA_1	94	100	PF00498	0.566
LIG_FHA_2	296	302	PF00498	0.313
LIG_LIR_Apic_2	193	199	PF02991	0.455
LIG_LIR_Gen_1	233	242	PF02991	0.334
LIG_LIR_Gen_1	360	368	PF02991	0.310
LIG_LIR_Nem_3	183	187	PF02991	0.299
LIG_LIR_Nem_3	233	238	PF02991	0.331
LIG_LIR_Nem_3	360	366	PF02991	0.310
LIG_MYND_1	27	31	PF01753	0.636
LIG_Pex14_2	172	176	PF04695	0.466
LIG_SH2_NCK_1	187	191	PF00017	0.435
LIG_SH2_NCK_1	446	450	PF00017	0.613
LIG_SH2_PTP2	19	22	PF00017	0.552
LIG_SH2_PTP2	235	238	PF00017	0.342
LIG_SH2_PTP2	363	366	PF00017	0.326
LIG_SH2_SRC	273	276	PF00017	0.310
LIG_SH2_STAP1	309	313	PF00017	0.310
LIG_SH2_STAP1	65	69	PF00017	0.508
LIG_SH2_STAT5	126	129	PF00017	0.393
LIG_SH2_STAT5	19	22	PF00017	0.646
LIG_SH2_STAT5	235	238	PF00017	0.342
LIG_SH2_STAT5	269	272	PF00017	0.321
LIG_SH2_STAT5	273	276	PF00017	0.320
LIG_SH2_STAT5	285	288	PF00017	0.284
LIG_SH2_STAT5	293	296	PF00017	0.345
LIG_SH2_STAT5	297	300	PF00017	0.345
LIG_SH2_STAT5	309	312	PF00017	0.247
LIG_SH2_STAT5	317	320	PF00017	0.309
LIG_SH2_STAT5	363	366	PF00017	0.326
LIG_SH2_STAT5	390	393	PF00017	0.504
LIG_SH3_1	19	25	PF00018	0.561
LIG_SH3_2	118	123	PF14604	0.481
LIG_SH3_3	115	121	PF00018	0.562
LIG_SH3_3	19	25	PF00018	0.605
LIG_SH3_3	199	205	PF00018	0.607
LIG_SH3_3	9	15	PF00018	0.717
LIG_SH3_3	97	103	PF00018	0.681
LIG_SUMO_SIM_anti_2	408	416	PF11976	0.423
LIG_TYR_ITIM	361	366	PF00017	0.345
LIG_WW_1	16	19	PF00397	0.552
MOD_CDK_SPxxK_3	277	284	PF00069	0.310
MOD_CK1_1	180	186	PF00069	0.488
MOD_CK1_1	253	259	PF00069	0.317
MOD_CK1_1	277	283	PF00069	0.288
MOD_CK1_1	3	9	PF00069	0.653
MOD_CK2_1	142	148	PF00069	0.679
MOD_CK2_1	322	328	PF00069	0.376
MOD_CK2_1	64	70	PF00069	0.603
MOD_GlcNHglycan	148	154	PF01048	0.744
MOD_GlcNHglycan	157	160	PF01048	0.473
MOD_GlcNHglycan	179	182	PF01048	0.444
MOD_GlcNHglycan	252	255	PF01048	0.345
MOD_GlcNHglycan	38	42	PF01048	0.547
MOD_GlcNHglycan	415	418	PF01048	0.509
MOD_GlcNHglycan	470	473	PF01048	0.647
MOD_GlcNHglycan	5	8	PF01048	0.682
MOD_GlcNHglycan	9	12	PF01048	0.687
MOD_GSK3_1	155	162	PF00069	0.688
MOD_GSK3_1	246	253	PF00069	0.266
MOD_GSK3_1	25	32	PF00069	0.646
MOD_GSK3_1	3	10	PF00069	0.701
MOD_GSK3_1	341	348	PF00069	0.389
MOD_GSK3_1	468	475	PF00069	0.629
MOD_N-GLC_1	7	12	PF02516	0.566
MOD_NEK2_1	336	341	PF00069	0.216
MOD_NEK2_1	36	41	PF00069	0.532
MOD_NMyristoyl	1	7	PF02799	0.522
MOD_PIKK_1	174	180	PF00454	0.468
MOD_PIKK_1	243	249	PF00454	0.380
MOD_PK_1	357	363	PF00069	0.345
MOD_PKA_2	111	117	PF00069	0.640
MOD_Plk_1	322	328	PF00069	0.283
MOD_Plk_1	7	13	PF00069	0.471
MOD_ProDKin_1	201	207	PF00069	0.428
MOD_ProDKin_1	277	283	PF00069	0.398
MOD_ProDKin_1	345	351	PF00069	0.393
MOD_ProDKin_1	99	105	PF00069	0.552
TRG_DiLeu_BaEn_2	399	405	PF01217	0.463
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.541
TRG_ENDOCYTIC_2	187	190	PF00928	0.358
TRG_ENDOCYTIC_2	235	238	PF00928	0.339
TRG_ENDOCYTIC_2	269	272	PF00928	0.288
TRG_ENDOCYTIC_2	363	366	PF00928	0.326
TRG_ER_diArg_1	355	357	PF00400	0.345
TRG_ER_diArg_1	437	440	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C6DWS6	Neocamarosporium betae	24%	100%
A0A0N0P3I0	Leptomonas seymouri	24%	100%
A0A0N0P5I8	Leptomonas seymouri	45%	100%
A0A0N1I4X2	Leptomonas seymouri	69%	100%
A0A0S4ILS9	Bodo saltans	28%	100%
A0A0S4JMB1	Bodo saltans	27%	100%
A0A1X0NRR2	Trypanosomatidae	45%	98%
A0A3Q8IRG0	Leishmania donovani	27%	100%
A0A3S7WR50	Leishmania donovani	43%	100%
A0A3S7WR58	Leishmania donovani	85%	100%
A0A3S7X2E3	Leishmania donovani	26%	100%
A4H648	Leishmania braziliensis	43%	98%
A4HUG8	Leishmania infantum	43%	100%
A4HUG9	Leishmania infantum	85%	100%
A4I4G0	Leishmania infantum	26%	100%
A4IE56	Leishmania infantum	27%	100%
C9ZVI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AN66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	91%
K4BW79	Solanum lycopersicum	29%	100%
O94038	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q0CJC5	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	27%	100%
Q0VC50	Bos taurus	25%	100%
Q24K16	Bos taurus	25%	100%
Q4QHF8	Leishmania major	84%	100%
Q4QHF9	Leishmania major	44%	97%
Q4W4Z2	Caenorhabditis elegans	27%	100%
Q5HM44	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	25%	100%
Q5JI69	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	24%	100%
Q7T3C7	Danio rerio	25%	100%
Q84V25	Fragaria ananassa	25%	100%
Q8BGC4	Mus musculus	22%	100%
Q8CRJ7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	25%	100%
Q8H0M1	Spinacia oleracea	26%	100%
Q8JFV8	Danio rerio	25%	99%
Q8KQL2	Enterococcus avium	21%	100%
Q8N4Q0	Homo sapiens	25%	100%
Q8WWV3	Homo sapiens	25%	100%
Q924D0	Mus musculus	25%	100%
Q99536	Homo sapiens	26%	100%
Q9AYU1	Triphysaria versicolor	24%	100%
Q9SV68	Arabidopsis thaliana	25%	100%
Q9ZUC1	Arabidopsis thaliana	28%	100%
V5ALK9	Trypanosoma cruzi	47%	100%
V5B1P3	Trypanosoma cruzi	29%	100%