Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H647_LEIBR

TriTrypDb:

LbrM.10.0680 , LBRM2903_100015000

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H647

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H647

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	329	331	PF00675	0.405
CLV_NRD_NRD_1	384	386	PF00675	0.597
CLV_NRD_NRD_1	420	422	PF00675	0.732
CLV_NRD_NRD_1	63	65	PF00675	0.432
CLV_PCSK_KEX2_1	270	272	PF00082	0.552
CLV_PCSK_KEX2_1	420	422	PF00082	0.745
CLV_PCSK_KEX2_1	63	65	PF00082	0.432
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.552
CLV_PCSK_SKI1_1	42	46	PF00082	0.619
CLV_PCSK_SKI1_1	95	99	PF00082	0.314
CLV_Separin_Metazoa	102	106	PF03568	0.356
DEG_SCF_FBW7_1	28	35	PF00400	0.746
DOC_CYCLIN_RxL_1	39	49	PF00134	0.441
DOC_MAPK_DCC_7	225	234	PF00069	0.437
DOC_MAPK_gen_1	201	210	PF00069	0.387
DOC_MAPK_gen_1	39	47	PF00069	0.588
DOC_MAPK_MEF2A_6	33	40	PF00069	0.442
DOC_PP2B_LxvP_1	137	140	PF13499	0.364
DOC_PP2B_LxvP_1	45	48	PF13499	0.434
DOC_USP7_MATH_1	32	36	PF00917	0.535
DOC_USP7_MATH_1	374	378	PF00917	0.511
DOC_USP7_UBL2_3	270	274	PF12436	0.568
DOC_WW_Pin1_4	235	240	PF00397	0.470
DOC_WW_Pin1_4	28	33	PF00397	0.654
DOC_WW_Pin1_4	389	394	PF00397	0.656
DOC_WW_Pin1_4	426	431	PF00397	0.506
DOC_WW_Pin1_4	79	84	PF00397	0.466
LIG_14-3-3_CanoR_1	105	113	PF00244	0.418
LIG_14-3-3_CanoR_1	204	208	PF00244	0.325
LIG_14-3-3_CanoR_1	33	37	PF00244	0.686
LIG_14-3-3_CanoR_1	362	367	PF00244	0.507
LIG_14-3-3_CanoR_1	95	101	PF00244	0.488
LIG_Actin_WH2_2	90	107	PF00022	0.397
LIG_BRCT_BRCA1_1	376	380	PF00533	0.578
LIG_EH_1	319	323	PF12763	0.400
LIG_FHA_1	125	131	PF00498	0.299
LIG_FHA_1	164	170	PF00498	0.547
LIG_FHA_1	188	194	PF00498	0.444
LIG_FHA_1	200	206	PF00498	0.350
LIG_FHA_1	209	215	PF00498	0.596
LIG_FHA_1	222	228	PF00498	0.515
LIG_FHA_1	250	256	PF00498	0.417
LIG_FHA_1	64	70	PF00498	0.501
LIG_FHA_1	73	79	PF00498	0.550
LIG_LIR_Apic_2	325	329	PF02991	0.382
LIG_LIR_Gen_1	62	73	PF02991	0.399
LIG_LIR_Gen_1	99	109	PF02991	0.386
LIG_LIR_Nem_3	129	135	PF02991	0.290
LIG_LIR_Nem_3	62	68	PF02991	0.350
LIG_LIR_Nem_3	99	104	PF02991	0.327
LIG_Pex14_2	322	326	PF04695	0.384
LIG_PTB_Apo_2	125	132	PF02174	0.456
LIG_PTB_Apo_2	64	71	PF02174	0.387
LIG_PTB_Phospho_1	64	70	PF10480	0.409
LIG_SH2_CRK	135	139	PF00017	0.342
LIG_SH2_CRK	299	303	PF00017	0.346
LIG_SH2_CRK	408	412	PF00017	0.534
LIG_SH2_CRK	414	418	PF00017	0.612
LIG_SH2_CRK	65	69	PF00017	0.367
LIG_SH2_CRK	70	74	PF00017	0.333
LIG_SH2_GRB2like	355	358	PF00017	0.505
LIG_SH2_GRB2like	65	68	PF00017	0.383
LIG_SH2_SRC	355	358	PF00017	0.561
LIG_SH2_SRC	408	411	PF00017	0.520
LIG_SH2_SRC	414	417	PF00017	0.453
LIG_SH2_STAP1	122	126	PF00017	0.348
LIG_SH2_STAP1	135	139	PF00017	0.388
LIG_SH2_STAP1	65	69	PF00017	0.500
LIG_SH2_STAT5	297	300	PF00017	0.535
LIG_SH2_STAT5	65	68	PF00017	0.423
LIG_SH3_1	270	276	PF00018	0.454
LIG_SH3_3	233	239	PF00018	0.438
LIG_SH3_3	270	276	PF00018	0.430
LIG_SH3_3	404	410	PF00018	0.665
LIG_SH3_4	405	412	PF00018	0.691
LIG_TRAF2_1	84	87	PF00917	0.511
LIG_TRFH_1	70	74	PF08558	0.511
LIG_UBA3_1	137	143	PF00899	0.501
LIG_WRC_WIRS_1	97	102	PF05994	0.308
MOD_CDK_SPK_2	28	33	PF00069	0.445
MOD_CK1_1	206	212	PF00069	0.375
MOD_CK1_1	27	33	PF00069	0.688
MOD_CK2_1	253	259	PF00069	0.554
MOD_CK2_1	81	87	PF00069	0.540
MOD_CK2_1	96	102	PF00069	0.475
MOD_GlcNHglycan	149	152	PF01048	0.538
MOD_GlcNHglycan	181	184	PF01048	0.360
MOD_GlcNHglycan	316	319	PF01048	0.543
MOD_GlcNHglycan	83	86	PF01048	0.522
MOD_GSK3_1	147	154	PF00069	0.410
MOD_GSK3_1	199	206	PF00069	0.453
MOD_GSK3_1	235	242	PF00069	0.567
MOD_GSK3_1	24	31	PF00069	0.717
MOD_GSK3_1	249	256	PF00069	0.502
MOD_GSK3_1	335	342	PF00069	0.497
MOD_GSK3_1	420	427	PF00069	0.673
MOD_GSK3_1	53	60	PF00069	0.618
MOD_GSK3_1	77	84	PF00069	0.529
MOD_GSK3_1	8	15	PF00069	0.697
MOD_NEK2_1	104	109	PF00069	0.377
MOD_NEK2_1	186	191	PF00069	0.376
MOD_NEK2_1	208	213	PF00069	0.414
MOD_NEK2_1	24	29	PF00069	0.686
MOD_NEK2_1	314	319	PF00069	0.563
MOD_NEK2_1	332	337	PF00069	0.360
MOD_NEK2_1	57	62	PF00069	0.539
MOD_PIKK_1	104	110	PF00454	0.366
MOD_PIKK_1	72	78	PF00454	0.546
MOD_PKA_1	420	426	PF00069	0.734
MOD_PKA_1	63	69	PF00069	0.442
MOD_PKA_2	104	110	PF00069	0.397
MOD_PKA_2	15	21	PF00069	0.715
MOD_PKA_2	179	185	PF00069	0.508
MOD_PKA_2	203	209	PF00069	0.322
MOD_PKA_2	32	38	PF00069	0.664
MOD_PKA_2	346	352	PF00069	0.526
MOD_PKA_2	361	367	PF00069	0.537
MOD_PKA_2	420	426	PF00069	0.742
MOD_PKA_2	63	69	PF00069	0.535
MOD_Plk_4	203	209	PF00069	0.482
MOD_Plk_4	420	426	PF00069	0.741
MOD_Plk_4	53	59	PF00069	0.483
MOD_Plk_4	96	102	PF00069	0.428
MOD_ProDKin_1	235	241	PF00069	0.463
MOD_ProDKin_1	28	34	PF00069	0.652
MOD_ProDKin_1	389	395	PF00069	0.649
MOD_ProDKin_1	79	85	PF00069	0.466
MOD_SUMO_for_1	280	283	PF00179	0.455
MOD_SUMO_rev_2	111	118	PF00179	0.466
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.447
TRG_ENDOCYTIC_2	122	125	PF00928	0.336
TRG_ENDOCYTIC_2	135	138	PF00928	0.410
TRG_ENDOCYTIC_2	299	302	PF00928	0.351
TRG_ENDOCYTIC_2	408	411	PF00928	0.603
TRG_ENDOCYTIC_2	65	68	PF00928	0.392
TRG_ER_diArg_1	2	5	PF00400	0.679
TRG_ER_diArg_1	63	65	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y0	Leptomonas seymouri	73%	100%
A0A0N1PDA3	Leptomonas seymouri	32%	100%
A0A0S4INL4	Bodo saltans	48%	100%
A0A0S4JAJ5	Bodo saltans	31%	100%
A0A1X0NQR5	Trypanosomatidae	68%	100%
A0A1X0P2H5	Trypanosomatidae	31%	100%
A0A3Q8IH71	Leishmania donovani	89%	100%
A0A3R7M1X1	Trypanosoma rangeli	65%	100%
A0A3R7MCA7	Trypanosoma rangeli	31%	100%
A0A3S7X6N8	Leishmania donovani	33%	100%
A4HLI1	Leishmania braziliensis	31%	100%
A4HUG7	Leishmania infantum	89%	100%
A4I8Z1	Leishmania infantum	33%	100%
C9ZVI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	86%
D0A4Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AN65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B3W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q464	Leishmania major	32%	100%
Q4QHG0	Leishmania major	89%	100%
V5B205	Trypanosoma cruzi	67%	100%
V5BLV5	Trypanosoma cruzi	30%	100%