Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H645_LEIBR

TriTrypDb:

LbrM.10.0660 , LBRM2903_100014800

Length:

1172

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H645

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H645

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	1044	1046	PF00675	0.536
CLV_NRD_NRD_1	277	279	PF00675	0.558
CLV_NRD_NRD_1	289	291	PF00675	0.603
CLV_NRD_NRD_1	431	433	PF00675	0.516
CLV_NRD_NRD_1	502	504	PF00675	0.593
CLV_NRD_NRD_1	666	668	PF00675	0.598
CLV_NRD_NRD_1	690	692	PF00675	0.558
CLV_NRD_NRD_1	765	767	PF00675	0.456
CLV_PCSK_KEX2_1	277	279	PF00082	0.502
CLV_PCSK_KEX2_1	353	355	PF00082	0.514
CLV_PCSK_KEX2_1	430	432	PF00082	0.539
CLV_PCSK_KEX2_1	501	503	PF00082	0.603
CLV_PCSK_KEX2_1	611	613	PF00082	0.708
CLV_PCSK_KEX2_1	666	668	PF00082	0.599
CLV_PCSK_KEX2_1	690	692	PF00082	0.558
CLV_PCSK_KEX2_1	765	767	PF00082	0.456
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.514
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.686
CLV_PCSK_PC7_1	607	613	PF00082	0.678
CLV_PCSK_PC7_1	662	668	PF00082	0.577
CLV_PCSK_SKI1_1	104	108	PF00082	0.754
CLV_PCSK_SKI1_1	337	341	PF00082	0.667
CLV_PCSK_SKI1_1	533	537	PF00082	0.491
CLV_PCSK_SKI1_1	650	654	PF00082	0.532
CLV_PCSK_SKI1_1	656	660	PF00082	0.503
CLV_PCSK_SKI1_1	827	831	PF00082	0.442
CLV_PCSK_SKI1_1	840	844	PF00082	0.413
CLV_PCSK_SKI1_1	941	945	PF00082	0.680
CLV_Separin_Metazoa	59	63	PF03568	0.589
CLV_Separin_Metazoa	82	86	PF03568	0.572
DEG_APCC_DBOX_1	725	733	PF00400	0.551
DOC_CDC14_PxL_1	1031	1039	PF14671	0.522
DOC_CKS1_1	1018	1023	PF01111	0.517
DOC_CKS1_1	1120	1125	PF01111	0.750
DOC_CKS1_1	904	909	PF01111	0.622
DOC_CYCLIN_RxL_1	518	530	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	1018	1024	PF00134	0.687
DOC_CYCLIN_yCln2_LP_2	27	33	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	904	910	PF00134	0.468
DOC_MAPK_gen_1	449	456	PF00069	0.630
DOC_MAPK_gen_1	688	695	PF00069	0.365
DOC_PP2B_LxvP_1	27	30	PF13499	0.480
DOC_PP4_FxxP_1	578	581	PF00568	0.578
DOC_SPAK_OSR1_1	523	527	PF12202	0.338
DOC_USP7_MATH_1	1064	1068	PF00917	0.575
DOC_USP7_MATH_1	1136	1140	PF00917	0.726
DOC_USP7_MATH_1	1145	1149	PF00917	0.746
DOC_USP7_MATH_1	150	154	PF00917	0.454
DOC_USP7_MATH_1	484	488	PF00917	0.486
DOC_USP7_MATH_1	50	54	PF00917	0.657
DOC_USP7_MATH_1	618	622	PF00917	0.810
DOC_USP7_MATH_1	786	790	PF00917	0.640
DOC_USP7_MATH_1	852	856	PF00917	0.539
DOC_USP7_MATH_1	908	912	PF00917	0.695
DOC_WW_Pin1_4	1004	1009	PF00397	0.730
DOC_WW_Pin1_4	1017	1022	PF00397	0.647
DOC_WW_Pin1_4	1052	1057	PF00397	0.706
DOC_WW_Pin1_4	1119	1124	PF00397	0.734
DOC_WW_Pin1_4	1159	1164	PF00397	0.755
DOC_WW_Pin1_4	16	21	PF00397	0.548
DOC_WW_Pin1_4	190	195	PF00397	0.637
DOC_WW_Pin1_4	44	49	PF00397	0.594
DOC_WW_Pin1_4	554	559	PF00397	0.709
DOC_WW_Pin1_4	628	633	PF00397	0.676
DOC_WW_Pin1_4	903	908	PF00397	0.617
DOC_WW_Pin1_4	912	917	PF00397	0.698
DOC_WW_Pin1_4	977	982	PF00397	0.679
LIG_14-3-3_CanoR_1	231	235	PF00244	0.419
LIG_14-3-3_CanoR_1	259	265	PF00244	0.571
LIG_14-3-3_CanoR_1	4	12	PF00244	0.502
LIG_14-3-3_CanoR_1	401	407	PF00244	0.413
LIG_14-3-3_CanoR_1	451	457	PF00244	0.578
LIG_14-3-3_CanoR_1	650	659	PF00244	0.579
LIG_14-3-3_CanoR_1	70	79	PF00244	0.614
LIG_14-3-3_CanoR_1	703	708	PF00244	0.547
LIG_14-3-3_CanoR_1	716	725	PF00244	0.459
LIG_14-3-3_CanoR_1	726	730	PF00244	0.509
LIG_14-3-3_CanoR_1	794	802	PF00244	0.525
LIG_14-3-3_CanoR_1	860	868	PF00244	0.546
LIG_14-3-3_CanoR_1	883	888	PF00244	0.539
LIG_Actin_WH2_2	386	403	PF00022	0.448
LIG_APCC_ABBA_1	525	530	PF00400	0.529
LIG_APCC_ABBA_1	630	635	PF00400	0.609
LIG_BIR_II_1	1	5	PF00653	0.549
LIG_BRCT_BRCA1_1	1053	1057	PF00533	0.592
LIG_FHA_1	1026	1032	PF00498	0.680
LIG_FHA_1	1053	1059	PF00498	0.530
LIG_FHA_1	206	212	PF00498	0.519
LIG_FHA_1	261	267	PF00498	0.368
LIG_FHA_1	292	298	PF00498	0.520
LIG_FHA_1	702	708	PF00498	0.518
LIG_FHA_1	717	723	PF00498	0.310
LIG_FHA_1	78	84	PF00498	0.532
LIG_FHA_1	794	800	PF00498	0.524
LIG_FHA_1	904	910	PF00498	0.555
LIG_FHA_1	988	994	PF00498	0.633
LIG_FHA_2	1076	1082	PF00498	0.742
LIG_FHA_2	1085	1091	PF00498	0.586
LIG_FHA_2	231	237	PF00498	0.467
LIG_FHA_2	414	420	PF00498	0.503
LIG_FHA_2	673	679	PF00498	0.530
LIG_FHA_2	725	731	PF00498	0.548
LIG_LIR_Apic_2	24	29	PF02991	0.525
LIG_LIR_Apic_2	575	581	PF02991	0.714
LIG_LIR_Gen_1	42	51	PF02991	0.492
LIG_LIR_Nem_3	42	46	PF02991	0.512
LIG_LIR_Nem_3	635	640	PF02991	0.614
LIG_MYND_1	25	29	PF01753	0.488
LIG_OCRL_FandH_1	636	648	PF00620	0.536
LIG_Pex14_1	872	876	PF04695	0.554
LIG_SH2_SRC	219	222	PF00017	0.361
LIG_SH2_SRC	26	29	PF00017	0.493
LIG_SH2_STAP1	718	722	PF00017	0.499
LIG_SH2_STAT3	586	589	PF00017	0.391
LIG_SH2_STAT5	26	29	PF00017	0.493
LIG_SH2_STAT5	586	589	PF00017	0.391
LIG_SH2_STAT5	718	721	PF00017	0.546
LIG_SH2_STAT5	805	808	PF00017	0.454
LIG_SH2_STAT5	824	827	PF00017	0.434
LIG_SH3_3	1063	1069	PF00018	0.677
LIG_SH3_3	1114	1120	PF00018	0.702
LIG_SH3_3	191	197	PF00018	0.638
LIG_SH3_3	22	28	PF00018	0.531
LIG_SH3_3	488	494	PF00018	0.503
LIG_SH3_3	993	999	PF00018	0.778
LIG_Sin3_3	975	982	PF02671	0.494
LIG_SUMO_SIM_anti_2	539	547	PF11976	0.501
LIG_SUMO_SIM_par_1	1020	1030	PF11976	0.515
LIG_SUMO_SIM_par_1	539	547	PF11976	0.573
LIG_TRAF2_1	1095	1098	PF00917	0.760
LIG_TRAF2_1	1111	1114	PF00917	0.781
LIG_TRAF2_1	331	334	PF00917	0.463
LIG_TRAF2_1	496	499	PF00917	0.580
LIG_TRAF2_1	56	59	PF00917	0.576
LIG_TRAF2_1	684	687	PF00917	0.557
LIG_UBA3_1	247	255	PF00899	0.549
LIG_WRC_WIRS_1	227	232	PF05994	0.499
MOD_CDK_SPxK_1	628	634	PF00069	0.621
MOD_CK1_1	1004	1010	PF00069	0.806
MOD_CK1_1	1023	1029	PF00069	0.522
MOD_CK1_1	1038	1044	PF00069	0.743
MOD_CK1_1	1108	1114	PF00069	0.777
MOD_CK1_1	1162	1168	PF00069	0.698
MOD_CK1_1	130	136	PF00069	0.467
MOD_CK1_1	19	25	PF00069	0.499
MOD_CK1_1	222	228	PF00069	0.532
MOD_CK1_1	309	315	PF00069	0.341
MOD_CK1_1	363	369	PF00069	0.614
MOD_CK1_1	44	50	PF00069	0.679
MOD_CK1_1	462	468	PF00069	0.555
MOD_CK1_1	549	555	PF00069	0.526
MOD_CK1_1	625	631	PF00069	0.645
MOD_CK1_1	720	726	PF00069	0.512
MOD_CK1_1	912	918	PF00069	0.693
MOD_CK1_1	980	986	PF00069	0.754
MOD_CK2_1	1023	1029	PF00069	0.525
MOD_CK2_1	1075	1081	PF00069	0.708
MOD_CK2_1	1084	1090	PF00069	0.690
MOD_CK2_1	1092	1098	PF00069	0.751
MOD_CK2_1	1108	1114	PF00069	0.535
MOD_CK2_1	1147	1153	PF00069	0.669
MOD_CK2_1	229	235	PF00069	0.577
MOD_CK2_1	413	419	PF00069	0.422
MOD_CK2_1	462	468	PF00069	0.576
MOD_CK2_1	672	678	PF00069	0.527
MOD_CK2_1	724	730	PF00069	0.551
MOD_CK2_1	853	859	PF00069	0.512
MOD_Cter_Amidation	609	612	PF01082	0.685
MOD_GlcNHglycan	1066	1069	PF01048	0.640
MOD_GlcNHglycan	1107	1110	PF01048	0.746
MOD_GlcNHglycan	115	119	PF01048	0.613
MOD_GlcNHglycan	21	24	PF01048	0.555
MOD_GlcNHglycan	305	311	PF01048	0.596
MOD_GlcNHglycan	486	489	PF01048	0.578
MOD_GlcNHglycan	53	56	PF01048	0.499
MOD_GlcNHglycan	548	551	PF01048	0.562
MOD_GlcNHglycan	561	564	PF01048	0.613
MOD_GlcNHglycan	618	621	PF01048	0.826
MOD_GlcNHglycan	719	722	PF01048	0.511
MOD_GlcNHglycan	788	791	PF01048	0.690
MOD_GlcNHglycan	847	851	PF01048	0.549
MOD_GlcNHglycan	861	864	PF01048	0.412
MOD_GlcNHglycan	911	914	PF01048	0.658
MOD_GlcNHglycan	975	978	PF01048	0.666
MOD_GlcNHglycan	996	999	PF01048	0.700
MOD_GSK3_1	1020	1027	PF00069	0.762
MOD_GSK3_1	1035	1042	PF00069	0.538
MOD_GSK3_1	1048	1055	PF00069	0.578
MOD_GSK3_1	1064	1071	PF00069	0.573
MOD_GSK3_1	1075	1082	PF00069	0.588
MOD_GSK3_1	1141	1148	PF00069	0.764
MOD_GSK3_1	1158	1165	PF00069	0.524
MOD_GSK3_1	127	134	PF00069	0.513
MOD_GSK3_1	186	193	PF00069	0.546
MOD_GSK3_1	219	226	PF00069	0.539
MOD_GSK3_1	337	344	PF00069	0.674
MOD_GSK3_1	35	42	PF00069	0.691
MOD_GSK3_1	360	367	PF00069	0.632
MOD_GSK3_1	452	459	PF00069	0.593
MOD_GSK3_1	46	53	PF00069	0.670
MOD_GSK3_1	572	579	PF00069	0.608
MOD_GSK3_1	618	625	PF00069	0.754
MOD_GSK3_1	701	708	PF00069	0.549
MOD_GSK3_1	716	723	PF00069	0.484
MOD_GSK3_1	908	915	PF00069	0.595
MOD_GSK3_1	973	980	PF00069	0.627
MOD_GSK3_1	983	990	PF00069	0.595
MOD_NEK2_1	1022	1027	PF00069	0.727
MOD_NEK2_1	1037	1042	PF00069	0.494
MOD_NEK2_1	1050	1055	PF00069	0.499
MOD_NEK2_1	1070	1075	PF00069	0.481
MOD_NEK2_1	131	136	PF00069	0.478
MOD_NEK2_1	186	191	PF00069	0.613
MOD_NEK2_1	400	405	PF00069	0.477
MOD_NEK2_1	452	457	PF00069	0.496
MOD_NEK2_1	651	656	PF00069	0.564
MOD_NEK2_1	672	677	PF00069	0.570
MOD_NEK2_1	724	729	PF00069	0.520
MOD_NEK2_1	846	851	PF00069	0.514
MOD_NEK2_1	91	96	PF00069	0.595
MOD_NEK2_1	933	938	PF00069	0.609
MOD_PIKK_1	1010	1016	PF00454	0.597
MOD_PIKK_1	1145	1151	PF00454	0.706
MOD_PIKK_1	337	343	PF00454	0.544
MOD_PIKK_1	400	406	PF00454	0.450
MOD_PIKK_1	41	47	PF00454	0.511
MOD_PIKK_1	644	650	PF00454	0.507
MOD_PIKK_1	77	83	PF00454	0.534
MOD_PIKK_1	99	105	PF00454	0.535
MOD_PK_1	883	889	PF00069	0.579
MOD_PKA_2	1079	1085	PF00069	0.546
MOD_PKA_2	205	211	PF00069	0.446
MOD_PKA_2	230	236	PF00069	0.422
MOD_PKA_2	282	288	PF00069	0.473
MOD_PKA_2	3	9	PF00069	0.503
MOD_PKA_2	400	406	PF00069	0.442
MOD_PKA_2	544	550	PF00069	0.666
MOD_PKA_2	633	639	PF00069	0.549
MOD_PKA_2	689	695	PF00069	0.529
MOD_PKA_2	702	708	PF00069	0.549
MOD_PKA_2	725	731	PF00069	0.518
MOD_PKA_2	77	83	PF00069	0.590
MOD_PKA_2	793	799	PF00069	0.600
MOD_PKA_2	859	865	PF00069	0.464
MOD_Plk_1	1071	1077	PF00069	0.617
MOD_Plk_1	150	156	PF00069	0.392
MOD_Plk_1	186	192	PF00069	0.616
MOD_Plk_1	220	226	PF00069	0.386
MOD_Plk_1	285	291	PF00069	0.619
MOD_Plk_1	292	298	PF00069	0.535
MOD_Plk_1	62	68	PF00069	0.526
MOD_Plk_1	626	632	PF00069	0.673
MOD_Plk_1	819	825	PF00069	0.500
MOD_Plk_1	868	874	PF00069	0.423
MOD_Plk_1	926	932	PF00069	0.657
MOD_Plk_2-3	1084	1090	PF00069	0.532
MOD_Plk_4	1039	1045	PF00069	0.545
MOD_Plk_4	127	133	PF00069	0.669
MOD_Plk_4	266	272	PF00069	0.365
MOD_Plk_4	292	298	PF00069	0.468
MOD_Plk_4	413	419	PF00069	0.361
MOD_Plk_4	459	465	PF00069	0.474
MOD_Plk_4	486	492	PF00069	0.501
MOD_Plk_4	633	639	PF00069	0.563
MOD_Plk_4	720	726	PF00069	0.505
MOD_Plk_4	820	826	PF00069	0.553
MOD_Plk_4	883	889	PF00069	0.513
MOD_Plk_4	890	896	PF00069	0.533
MOD_ProDKin_1	1004	1010	PF00069	0.730
MOD_ProDKin_1	1017	1023	PF00069	0.645
MOD_ProDKin_1	1052	1058	PF00069	0.705
MOD_ProDKin_1	1119	1125	PF00069	0.734
MOD_ProDKin_1	1159	1165	PF00069	0.696
MOD_ProDKin_1	16	22	PF00069	0.545
MOD_ProDKin_1	190	196	PF00069	0.637
MOD_ProDKin_1	44	50	PF00069	0.588
MOD_ProDKin_1	554	560	PF00069	0.709
MOD_ProDKin_1	628	634	PF00069	0.675
MOD_ProDKin_1	903	909	PF00069	0.623
MOD_ProDKin_1	912	918	PF00069	0.700
MOD_ProDKin_1	977	983	PF00069	0.680
MOD_SUMO_for_1	507	510	PF00179	0.435
MOD_SUMO_rev_2	429	438	PF00179	0.507
TRG_DiLeu_BaEn_1	175	180	PF01217	0.562
TRG_DiLeu_BaEn_1	207	212	PF01217	0.516
TRG_DiLeu_BaEn_1	448	453	PF01217	0.570
TRG_DiLeu_BaEn_1	537	542	PF01217	0.546
TRG_DiLeu_BaEn_1	962	967	PF01217	0.487
TRG_DiLeu_BaEn_4	292	298	PF01217	0.491
TRG_DiLeu_BaEn_4	345	351	PF01217	0.564
TRG_DiLeu_BaEn_4	433	439	PF01217	0.463
TRG_DiLeu_LyEn_5	448	453	PF01217	0.570
TRG_DiLeu_LyEn_5	962	967	PF01217	0.391
TRG_ENDOCYTIC_2	876	879	PF00928	0.590
TRG_ER_diArg_1	430	432	PF00400	0.539
TRG_ER_diArg_1	501	503	PF00400	0.602
TRG_ER_diArg_1	666	668	PF00400	0.608
TRG_ER_diArg_1	67	70	PF00400	0.466
TRG_ER_diArg_1	689	691	PF00400	0.361
TRG_ER_diArg_1	764	766	PF00400	0.595
TRG_NES_CRM1_1	956	970	PF08389	0.488
TRG_NLS_MonoExtC_3	352	358	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	533	537	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	965	969	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I9	Leptomonas seymouri	62%	100%
A0A1X0NQ72	Trypanosomatidae	27%	100%
A0A3R7KN13	Trypanosoma rangeli	29%	100%
A0A3S7WR55	Leishmania donovani	81%	100%
A4HUG5	Leishmania infantum	81%	100%
E9AN63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QHG2	Leishmania major	79%	100%
V5BB18	Trypanosoma cruzi	29%	100%