Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H644_LEIBR

TriTrypDb:

LbrM.10.0650 , LBRM2903_100014700

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H644

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H644

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	753	757	PF00656	0.526
CLV_C14_Caspase3-7	764	768	PF00656	0.541
CLV_C14_Caspase3-7	891	895	PF00656	0.416
CLV_MEL_PAP_1	584	590	PF00089	0.362
CLV_NRD_NRD_1	131	133	PF00675	0.495
CLV_NRD_NRD_1	213	215	PF00675	0.524
CLV_NRD_NRD_1	286	288	PF00675	0.540
CLV_NRD_NRD_1	29	31	PF00675	0.441
CLV_NRD_NRD_1	331	333	PF00675	0.583
CLV_NRD_NRD_1	361	363	PF00675	0.575
CLV_NRD_NRD_1	382	384	PF00675	0.706
CLV_NRD_NRD_1	393	395	PF00675	0.573
CLV_NRD_NRD_1	460	462	PF00675	0.498
CLV_NRD_NRD_1	866	868	PF00675	0.549
CLV_NRD_NRD_1	878	880	PF00675	0.522
CLV_PCSK_FUR_1	457	461	PF00082	0.515
CLV_PCSK_KEX2_1	131	133	PF00082	0.495
CLV_PCSK_KEX2_1	204	206	PF00082	0.581
CLV_PCSK_KEX2_1	286	288	PF00082	0.540
CLV_PCSK_KEX2_1	29	31	PF00082	0.441
CLV_PCSK_KEX2_1	331	333	PF00082	0.583
CLV_PCSK_KEX2_1	361	363	PF00082	0.584
CLV_PCSK_KEX2_1	382	384	PF00082	0.706
CLV_PCSK_KEX2_1	393	395	PF00082	0.573
CLV_PCSK_KEX2_1	459	461	PF00082	0.516
CLV_PCSK_KEX2_1	681	683	PF00082	0.530
CLV_PCSK_KEX2_1	866	868	PF00082	0.549
CLV_PCSK_KEX2_1	877	879	PF00082	0.525
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.598
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.530
CLV_PCSK_PC7_1	874	880	PF00082	0.547
CLV_PCSK_SKI1_1	201	205	PF00082	0.429
CLV_PCSK_SKI1_1	295	299	PF00082	0.440
CLV_PCSK_SKI1_1	3	7	PF00082	0.466
CLV_PCSK_SKI1_1	398	402	PF00082	0.556
CLV_PCSK_SKI1_1	532	536	PF00082	0.485
CLV_PCSK_SKI1_1	708	712	PF00082	0.614
CLV_PCSK_SKI1_1	780	784	PF00082	0.457
CLV_PCSK_SKI1_1	80	84	PF00082	0.410
CLV_Separin_Metazoa	26	30	PF03568	0.427
CLV_Separin_Metazoa	342	346	PF03568	0.445
DEG_APCC_DBOX_1	2	10	PF00400	0.542
DEG_APCC_DBOX_1	657	665	PF00400	0.531
DEG_APCC_DBOX_1	783	791	PF00400	0.469
DEG_Nend_Nbox_1	1	3	PF02207	0.495
DEG_SCF_FBW7_1	58	64	PF00400	0.554
DEG_SPOP_SBC_1	62	66	PF00917	0.554
DOC_CDC14_PxL_1	769	777	PF14671	0.456
DOC_CKS1_1	58	63	PF01111	0.553
DOC_CKS1_1	597	602	PF01111	0.555
DOC_CKS1_1	727	732	PF01111	0.477
DOC_CYCLIN_RxL_1	705	714	PF00134	0.504
DOC_CYCLIN_RxL_1	777	785	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	720	726	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	731	737	PF00134	0.444
DOC_MAPK_gen_1	214	224	PF00069	0.443
DOC_MAPK_gen_1	393	401	PF00069	0.553
DOC_MAPK_gen_1	457	466	PF00069	0.419
DOC_MAPK_gen_1	655	664	PF00069	0.417
DOC_MAPK_gen_1	681	689	PF00069	0.521
DOC_MAPK_MEF2A_6	457	466	PF00069	0.419
DOC_MAPK_MEF2A_6	822	830	PF00069	0.680
DOC_MAPK_MEF2A_6	93	102	PF00069	0.537
DOC_PP2B_LxvP_1	208	211	PF13499	0.473
DOC_PP2B_LxvP_1	428	431	PF13499	0.629
DOC_PP2B_LxvP_1	481	484	PF13499	0.635
DOC_PP2B_LxvP_1	720	723	PF13499	0.479
DOC_PP4_FxxP_1	689	692	PF00568	0.477
DOC_PP4_FxxP_1	713	716	PF00568	0.461
DOC_USP7_MATH_1	143	147	PF00917	0.648
DOC_USP7_MATH_1	170	174	PF00917	0.592
DOC_USP7_MATH_1	384	388	PF00917	0.747
DOC_USP7_MATH_1	39	43	PF00917	0.480
DOC_USP7_MATH_1	400	404	PF00917	0.565
DOC_USP7_MATH_1	436	440	PF00917	0.759
DOC_USP7_MATH_1	486	490	PF00917	0.667
DOC_USP7_MATH_1	495	499	PF00917	0.476
DOC_USP7_MATH_1	513	517	PF00917	0.536
DOC_USP7_MATH_1	592	596	PF00917	0.579
DOC_USP7_MATH_1	62	66	PF00917	0.570
DOC_USP7_MATH_1	638	642	PF00917	0.502
DOC_USP7_MATH_1	645	649	PF00917	0.522
DOC_USP7_MATH_1	844	848	PF00917	0.722
DOC_USP7_UBL2_3	215	219	PF12436	0.637
DOC_WW_Pin1_4	115	120	PF00397	0.456
DOC_WW_Pin1_4	325	330	PF00397	0.560
DOC_WW_Pin1_4	331	336	PF00397	0.511
DOC_WW_Pin1_4	365	370	PF00397	0.759
DOC_WW_Pin1_4	490	495	PF00397	0.602
DOC_WW_Pin1_4	57	62	PF00397	0.758
DOC_WW_Pin1_4	596	601	PF00397	0.559
DOC_WW_Pin1_4	668	673	PF00397	0.486
DOC_WW_Pin1_4	674	679	PF00397	0.463
DOC_WW_Pin1_4	726	731	PF00397	0.557
DOC_WW_Pin1_4	799	804	PF00397	0.525
DOC_WW_Pin1_4	94	99	PF00397	0.571
LIG_14-3-3_CanoR_1	147	153	PF00244	0.648
LIG_14-3-3_CanoR_1	205	209	PF00244	0.609
LIG_14-3-3_CanoR_1	280	286	PF00244	0.571
LIG_14-3-3_CanoR_1	29	39	PF00244	0.478
LIG_14-3-3_CanoR_1	345	353	PF00244	0.440
LIG_14-3-3_CanoR_1	383	392	PF00244	0.648
LIG_14-3-3_CanoR_1	450	456	PF00244	0.608
LIG_14-3-3_CanoR_1	480	484	PF00244	0.611
LIG_14-3-3_CanoR_1	540	545	PF00244	0.491
LIG_14-3-3_CanoR_1	745	754	PF00244	0.448
LIG_14-3-3_CanoR_1	80	88	PF00244	0.406
LIG_14-3-3_CanoR_1	822	827	PF00244	0.760
LIG_14-3-3_CanoR_1	867	876	PF00244	0.611
LIG_14-3-3_CanoR_1	877	887	PF00244	0.647
LIG_14-3-3_CanoR_1	901	907	PF00244	0.457
LIG_Actin_WH2_2	771	786	PF00022	0.490
LIG_BRCT_BRCA1_1	220	224	PF00533	0.524
LIG_BRCT_BRCA1_1	689	693	PF00533	0.555
LIG_BRCT_BRCA1_1	846	850	PF00533	0.523
LIG_CSL_BTD_1	433	436	PF09270	0.591
LIG_CtBP_PxDLS_1	829	833	PF00389	0.516
LIG_DCNL_PONY_1	1	4	PF03556	0.561
LIG_deltaCOP1_diTrp_1	237	243	PF00928	0.494
LIG_eIF4E_1	338	344	PF01652	0.576
LIG_FHA_1	120	126	PF00498	0.470
LIG_FHA_1	239	245	PF00498	0.566
LIG_FHA_1	248	254	PF00498	0.341
LIG_FHA_1	519	525	PF00498	0.546
LIG_FHA_1	565	571	PF00498	0.436
LIG_FHA_1	597	603	PF00498	0.457
LIG_FHA_1	675	681	PF00498	0.627
LIG_FHA_1	742	748	PF00498	0.380
LIG_FHA_1	757	763	PF00498	0.620
LIG_FHA_1	821	827	PF00498	0.688
LIG_FHA_1	895	901	PF00498	0.602
LIG_FHA_1	97	103	PF00498	0.608
LIG_FHA_2	223	229	PF00498	0.497
LIG_FHA_2	712	718	PF00498	0.570
LIG_FHA_2	751	757	PF00498	0.517
LIG_FHA_2	774	780	PF00498	0.580
LIG_FHA_2	792	798	PF00498	0.637
LIG_FHA_2	99	105	PF00498	0.491
LIG_GBD_Chelix_1	109	117	PF00786	0.389
LIG_LIR_Apic_2	334	340	PF02991	0.581
LIG_LIR_Apic_2	686	692	PF02991	0.509
LIG_LIR_Gen_1	237	244	PF02991	0.396
LIG_LIR_Gen_1	506	515	PF02991	0.442
LIG_LIR_Nem_3	237	243	PF02991	0.418
LIG_LIR_Nem_3	506	511	PF02991	0.441
LIG_PCNA_yPIPBox_3	621	632	PF02747	0.419
LIG_Pex14_2	689	693	PF04695	0.483
LIG_SH2_CRK	659	663	PF00017	0.389
LIG_SH2_STAT3	338	341	PF00017	0.603
LIG_SH2_STAT3	899	902	PF00017	0.587
LIG_SH2_STAT5	465	468	PF00017	0.499
LIG_SH2_STAT5	738	741	PF00017	0.391
LIG_SH2_STAT5	899	902	PF00017	0.587
LIG_SH3_3	378	384	PF00018	0.696
LIG_SH3_3	404	410	PF00018	0.547
LIG_SH3_3	482	488	PF00018	0.621
LIG_SH3_3	55	61	PF00018	0.540
LIG_SH3_3	558	564	PF00018	0.472
LIG_SH3_3	594	600	PF00018	0.574
LIG_SH3_3	731	737	PF00018	0.457
LIG_SH3_3	804	810	PF00018	0.724
LIG_SH3_3	823	829	PF00018	0.619
LIG_SUMO_SIM_anti_2	258	265	PF11976	0.457
LIG_SUMO_SIM_par_1	351	357	PF11976	0.526
LIG_SUMO_SIM_par_1	495	500	PF11976	0.407
LIG_SUMO_SIM_par_1	758	765	PF11976	0.523
LIG_SUMO_SIM_par_1	828	833	PF11976	0.513
LIG_SUMO_SIM_par_1	97	104	PF11976	0.414
LIG_TRAF2_1	315	318	PF00917	0.540
LIG_UBA3_1	152	157	PF00899	0.599
MOD_CDK_SPK_2	799	804	PF00069	0.525
MOD_CDK_SPxK_1	325	331	PF00069	0.514
MOD_CDK_SPxxK_3	325	332	PF00069	0.513
MOD_CDK_SPxxK_3	674	681	PF00069	0.556
MOD_CK1_1	142	148	PF00069	0.488
MOD_CK1_1	218	224	PF00069	0.548
MOD_CK1_1	34	40	PF00069	0.502
MOD_CK1_1	438	444	PF00069	0.608
MOD_CK1_1	479	485	PF00069	0.619
MOD_CK1_1	517	523	PF00069	0.575
MOD_CK1_1	750	756	PF00069	0.625
MOD_CK1_1	833	839	PF00069	0.570
MOD_CK1_1	862	868	PF00069	0.660
MOD_CK2_1	20	26	PF00069	0.541
MOD_CK2_1	312	318	PF00069	0.523
MOD_CK2_1	327	333	PF00069	0.508
MOD_CK2_1	365	371	PF00069	0.704
MOD_CK2_1	438	444	PF00069	0.604
MOD_CK2_1	63	69	PF00069	0.667
MOD_CK2_1	645	651	PF00069	0.536
MOD_CK2_1	711	717	PF00069	0.558
MOD_CK2_1	773	779	PF00069	0.493
MOD_CK2_1	808	814	PF00069	0.592
MOD_CK2_1	879	885	PF00069	0.510
MOD_GlcNHglycan	141	144	PF01048	0.673
MOD_GlcNHglycan	269	272	PF01048	0.581
MOD_GlcNHglycan	317	323	PF01048	0.453
MOD_GlcNHglycan	363	366	PF01048	0.720
MOD_GlcNHglycan	386	389	PF01048	0.766
MOD_GlcNHglycan	412	415	PF01048	0.563
MOD_GlcNHglycan	438	441	PF01048	0.517
MOD_GlcNHglycan	481	484	PF01048	0.549
MOD_GlcNHglycan	580	583	PF01048	0.488
MOD_GlcNHglycan	594	597	PF01048	0.493
MOD_GlcNHglycan	640	643	PF01048	0.582
MOD_GlcNHglycan	65	68	PF01048	0.527
MOD_GlcNHglycan	689	692	PF01048	0.580
MOD_GlcNHglycan	73	77	PF01048	0.406
MOD_GlcNHglycan	749	752	PF01048	0.473
MOD_GlcNHglycan	810	813	PF01048	0.718
MOD_GlcNHglycan	842	845	PF01048	0.654
MOD_GlcNHglycan	861	864	PF01048	0.729
MOD_GSK3_1	115	122	PF00069	0.577
MOD_GSK3_1	139	146	PF00069	0.605
MOD_GSK3_1	218	225	PF00069	0.509
MOD_GSK3_1	262	269	PF00069	0.453
MOD_GSK3_1	286	293	PF00069	0.692
MOD_GSK3_1	30	37	PF00069	0.501
MOD_GSK3_1	327	334	PF00069	0.565
MOD_GSK3_1	361	368	PF00069	0.719
MOD_GSK3_1	384	391	PF00069	0.654
MOD_GSK3_1	410	417	PF00069	0.763
MOD_GSK3_1	434	441	PF00069	0.516
MOD_GSK3_1	472	479	PF00069	0.571
MOD_GSK3_1	486	493	PF00069	0.613
MOD_GSK3_1	507	514	PF00069	0.421
MOD_GSK3_1	518	525	PF00069	0.508
MOD_GSK3_1	57	64	PF00069	0.575
MOD_GSK3_1	588	595	PF00069	0.672
MOD_GSK3_1	633	640	PF00069	0.674
MOD_GSK3_1	668	675	PF00069	0.469
MOD_GSK3_1	741	748	PF00069	0.516
MOD_GSK3_1	828	835	PF00069	0.635
MOD_GSK3_1	840	847	PF00069	0.625
MOD_GSK3_1	888	895	PF00069	0.705
MOD_GSK3_1	94	101	PF00069	0.567
MOD_NEK2_1	199	204	PF00069	0.552
MOD_NEK2_1	262	267	PF00069	0.441
MOD_NEK2_1	281	286	PF00069	0.539
MOD_NEK2_1	31	36	PF00069	0.485
MOD_NEK2_1	401	406	PF00069	0.679
MOD_NEK2_1	471	476	PF00069	0.696
MOD_NEK2_1	578	583	PF00069	0.409
MOD_NEK2_1	602	607	PF00069	0.510
MOD_NEK2_1	631	636	PF00069	0.475
MOD_NEK2_1	687	692	PF00069	0.531
MOD_NEK2_1	71	76	PF00069	0.478
MOD_NEK2_1	711	716	PF00069	0.541
MOD_NEK2_1	746	751	PF00069	0.408
MOD_NEK2_1	782	787	PF00069	0.527
MOD_NEK2_1	830	835	PF00069	0.525
MOD_NEK2_2	388	393	PF00069	0.562
MOD_NEK2_2	624	629	PF00069	0.446
MOD_NEK2_2	716	721	PF00069	0.474
MOD_PIKK_1	119	125	PF00454	0.481
MOD_PIKK_1	312	318	PF00454	0.569
MOD_PIKK_1	344	350	PF00454	0.438
MOD_PIKK_1	564	570	PF00454	0.421
MOD_PIKK_1	633	639	PF00454	0.676
MOD_PIKK_1	791	797	PF00454	0.606
MOD_PIKK_1	833	839	PF00454	0.517
MOD_PK_1	822	828	PF00069	0.527
MOD_PKA_1	204	210	PF00069	0.606
MOD_PKA_1	286	292	PF00069	0.599
MOD_PKA_1	361	367	PF00069	0.584
MOD_PKA_1	393	399	PF00069	0.554
MOD_PKA_1	878	884	PF00069	0.520
MOD_PKA_2	146	152	PF00069	0.659
MOD_PKA_2	204	210	PF00069	0.613
MOD_PKA_2	286	292	PF00069	0.599
MOD_PKA_2	344	350	PF00069	0.562
MOD_PKA_2	361	367	PF00069	0.585
MOD_PKA_2	393	399	PF00069	0.679
MOD_PKA_2	401	407	PF00069	0.565
MOD_PKA_2	449	455	PF00069	0.619
MOD_PKA_2	479	485	PF00069	0.669
MOD_PKA_2	645	651	PF00069	0.612
MOD_PKA_2	878	884	PF00069	0.664
MOD_PKB_1	877	885	PF00069	0.552
MOD_Plk_1	103	109	PF00069	0.300
MOD_Plk_1	370	376	PF00069	0.784
MOD_Plk_1	716	722	PF00069	0.476
MOD_Plk_1	741	747	PF00069	0.537
MOD_Plk_1	844	850	PF00069	0.575
MOD_Plk_2-3	20	26	PF00069	0.445
MOD_Plk_4	103	109	PF00069	0.320
MOD_Plk_4	177	183	PF00069	0.442
MOD_Plk_4	218	224	PF00069	0.415
MOD_Plk_4	566	572	PF00069	0.589
MOD_Plk_4	844	850	PF00069	0.524
MOD_ProDKin_1	115	121	PF00069	0.449
MOD_ProDKin_1	325	331	PF00069	0.562
MOD_ProDKin_1	365	371	PF00069	0.762
MOD_ProDKin_1	490	496	PF00069	0.590
MOD_ProDKin_1	57	63	PF00069	0.760
MOD_ProDKin_1	596	602	PF00069	0.557
MOD_ProDKin_1	668	674	PF00069	0.492
MOD_ProDKin_1	726	732	PF00069	0.551
MOD_ProDKin_1	799	805	PF00069	0.525
MOD_ProDKin_1	94	100	PF00069	0.558
TRG_DiLeu_BaEn_1	549	554	PF01217	0.388
TRG_DiLeu_BaEn_2	741	747	PF01217	0.380
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.403
TRG_ENDOCYTIC_2	659	662	PF00928	0.389
TRG_ER_diArg_1	131	133	PF00400	0.495
TRG_ER_diArg_1	28	30	PF00400	0.438
TRG_ER_diArg_1	285	287	PF00400	0.547
TRG_ER_diArg_1	381	383	PF00400	0.700
TRG_ER_diArg_1	392	394	PF00400	0.573
TRG_ER_diArg_1	456	459	PF00400	0.577
TRG_ER_diArg_1	460	462	PF00400	0.546
TRG_ER_diArg_1	539	542	PF00400	0.426
TRG_ER_diArg_1	876	879	PF00400	0.705
TRG_ER_diArg_1	900	903	PF00400	0.594
TRG_NES_CRM1_1	174	186	PF08389	0.460
TRG_NLS_Bipartite_1	204	218	PF00514	0.469
TRG_NLS_MonoExtN_4	211	218	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	390	395	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	682	686	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE49	Leptomonas seymouri	45%	94%
A0A3S7WR65	Leishmania donovani	76%	100%
A4HUG4	Leishmania infantum	76%	100%
E9AN62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QHG3	Leishmania major	77%	100%