Leishmanolysin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

GP63, leishmanolysin

Species:

Leishmania braziliensis

UniProt:

A4H639_LEIBR

TriTrypDb:

LbrM.10.0600 , LBRM2903_100012500

Length:

611

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 51

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 41, no: 8
NetGPI	no	yes: 0, no: 49

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	50
GO:0110165	cellular anatomical entity	1	50
GO:0005737	cytoplasm	2	4
GO:0018995	host cellular component	2	4
GO:0033643	host cell part	3	4
GO:0033646	host intracellular part	4	4
GO:0033647	host intracellular organelle	5	4
GO:0033648	host intracellular membrane-bounded organelle	6	4
GO:0042025	host cell nucleus	7	4

Expansion

Sequence features

A4H639

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H639

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	50
GO:0006807	nitrogen compound metabolic process	2	50
GO:0007155	cell adhesion	2	50
GO:0008152	metabolic process	1	50
GO:0009987	cellular process	1	50
GO:0019538	protein metabolic process	3	50
GO:0043170	macromolecule metabolic process	3	50
GO:0044238	primary metabolic process	2	50
GO:0071704	organic substance metabolic process	2	50
GO:1901564	organonitrogen compound metabolic process	3	50
GO:0009966	regulation of signal transduction	4	4
GO:0010646	regulation of cell communication	4	4
GO:0010749	regulation of nitric oxide mediated signal transduction	6	4
GO:0023051	regulation of signaling	3	4
GO:0035821	modulation of process of another organism	2	4
GO:0044003	modulation by symbiont of host process	3	4
GO:0044068	modulation by symbiont of host cellular process	4	4
GO:0044081	modulation by symbiont of host nitric oxide-mediated signal transduction	5	4
GO:0044403	biological process involved in symbiotic interaction	2	4
GO:0044419	biological process involved in interspecies interaction between organisms	1	4
GO:0044501	modulation of signal transduction in another organism	3	4
GO:0048583	regulation of response to stimulus	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051701	biological process involved in interaction with host	3	4
GO:0052027	modulation by symbiont of host signal transduction pathway	4	4
GO:0065007	biological regulation	1	4
GO:0075130	modulation by symbiont of host protein kinase-mediated signal transduction	5	4
GO:1902531	regulation of intracellular signal transduction	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	50
GO:0004175	endopeptidase activity	4	50
GO:0004222	metalloendopeptidase activity	5	50
GO:0005488	binding	1	50
GO:0008233	peptidase activity	3	50
GO:0008237	metallopeptidase activity	4	50
GO:0016787	hydrolase activity	2	50
GO:0043167	ion binding	2	50
GO:0043169	cation binding	3	50
GO:0046872	metal ion binding	4	50
GO:0140096	catalytic activity, acting on a protein	2	50
GO:0008047	enzyme activator activity	3	4
GO:0008160	protein tyrosine phosphatase activator activity	6	4
GO:0019208	phosphatase regulator activity	3	4
GO:0019211	phosphatase activator activity	4	4
GO:0019888	protein phosphatase regulator activity	4	4
GO:0030234	enzyme regulator activity	2	4
GO:0072542	protein phosphatase activator activity	5	4
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	115	121	PF00089	0.463
CLV_NRD_NRD_1	11	13	PF00675	0.700
CLV_NRD_NRD_1	398	400	PF00675	0.473
CLV_NRD_NRD_1	574	576	PF00675	0.584
CLV_NRD_NRD_1	64	66	PF00675	0.459
CLV_PCSK_KEX2_1	10	12	PF00082	0.713
CLV_PCSK_KEX2_1	139	141	PF00082	0.624
CLV_PCSK_KEX2_1	398	400	PF00082	0.472
CLV_PCSK_KEX2_1	574	576	PF00082	0.584
CLV_PCSK_KEX2_1	64	66	PF00082	0.459
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.613
CLV_PCSK_SKI1_1	140	144	PF00082	0.601
CLV_PCSK_SKI1_1	247	251	PF00082	0.605
CLV_PCSK_SKI1_1	271	275	PF00082	0.466
CLV_PCSK_SKI1_1	325	329	PF00082	0.541
DEG_APCC_DBOX_1	527	535	PF00400	0.373
DOC_CKS1_1	417	422	PF01111	0.264
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.346
DOC_MAPK_gen_1	182	192	PF00069	0.251
DOC_MAPK_MEF2A_6	185	192	PF00069	0.251
DOC_PP2B_LxvP_1	331	334	PF13499	0.428
DOC_PP4_FxxP_1	181	184	PF00568	0.449
DOC_PP4_FxxP_1	281	284	PF00568	0.337
DOC_PP4_MxPP_1	545	548	PF00568	0.241
DOC_USP7_MATH_1	2	6	PF00917	0.574
DOC_USP7_MATH_1	484	488	PF00917	0.343
DOC_WW_Pin1_4	41	46	PF00397	0.420
DOC_WW_Pin1_4	416	421	PF00397	0.271
DOC_WW_Pin1_4	486	491	PF00397	0.274
DOC_WW_Pin1_4	521	526	PF00397	0.453
LIG_14-3-3_CanoR_1	10	15	PF00244	0.642
LIG_14-3-3_CanoR_1	369	376	PF00244	0.274
LIG_14-3-3_CanoR_1	415	420	PF00244	0.310
LIG_14-3-3_CanoR_1	485	490	PF00244	0.329
LIG_14-3-3_CanoR_1	505	511	PF00244	0.417
LIG_14-3-3_CanoR_1	579	586	PF00244	0.300
LIG_14-3-3_CanoR_1	97	105	PF00244	0.434
LIG_AP2alpha_1	428	432	PF02296	0.257
LIG_APCC_ABBA_1	152	157	PF00400	0.453
LIG_APCC_ABBA_1	346	351	PF00400	0.426
LIG_APCC_ABBA_1	468	473	PF00400	0.453
LIG_BRCT_BRCA1_1	259	263	PF00533	0.377
LIG_BRCT_BRCA1_1	371	375	PF00533	0.316
LIG_BRCT_BRCA1_1	534	538	PF00533	0.453
LIG_FHA_1	100	106	PF00498	0.373
LIG_FHA_1	172	178	PF00498	0.317
LIG_FHA_1	187	193	PF00498	0.336
LIG_FHA_1	214	220	PF00498	0.347
LIG_FHA_1	244	250	PF00498	0.400
LIG_FHA_1	265	271	PF00498	0.270
LIG_FHA_1	343	349	PF00498	0.444
LIG_FHA_1	402	408	PF00498	0.425
LIG_FHA_1	409	415	PF00498	0.361
LIG_FHA_1	507	513	PF00498	0.434
LIG_FHA_1	534	540	PF00498	0.326
LIG_FHA_1	585	591	PF00498	0.343
LIG_FHA_1	93	99	PF00498	0.370
LIG_FHA_2	104	110	PF00498	0.284
LIG_FHA_2	128	134	PF00498	0.377
LIG_FHA_2	358	364	PF00498	0.281
LIG_FHA_2	522	528	PF00498	0.304
LIG_LIR_Apic_2	145	149	PF02991	0.278
LIG_LIR_Apic_2	180	184	PF02991	0.435
LIG_LIR_Apic_2	297	302	PF02991	0.271
LIG_LIR_Apic_2	397	403	PF02991	0.282
LIG_LIR_Apic_2	416	420	PF02991	0.251
LIG_LIR_Gen_1	303	311	PF02991	0.448
LIG_LIR_Gen_1	423	433	PF02991	0.336
LIG_LIR_Gen_1	467	475	PF02991	0.326
LIG_LIR_Nem_3	196	200	PF02991	0.420
LIG_LIR_Nem_3	303	309	PF02991	0.411
LIG_LIR_Nem_3	423	428	PF02991	0.372
LIG_LIR_Nem_3	437	442	PF02991	0.339
LIG_LIR_Nem_3	467	471	PF02991	0.334
LIG_LIR_Nem_3	92	96	PF02991	0.340
LIG_MLH1_MIPbox_1	260	264	PF16413	0.262
LIG_Pex14_1	388	392	PF04695	0.442
LIG_Pex14_2	259	263	PF04695	0.390
LIG_Pex14_2	428	432	PF04695	0.275
LIG_PTB_Apo_2	191	198	PF02174	0.438
LIG_PTB_Apo_2	426	433	PF02174	0.236
LIG_SH2_CRK	299	303	PF00017	0.268
LIG_SH2_CRK	341	345	PF00017	0.453
LIG_SH2_CRK	400	404	PF00017	0.286
LIG_SH2_CRK	417	421	PF00017	0.283
LIG_SH2_GRB2like	341	344	PF00017	0.260
LIG_SH2_GRB2like	427	430	PF00017	0.249
LIG_SH2_PTP2	549	552	PF00017	0.449
LIG_SH2_PTP2	78	81	PF00017	0.341
LIG_SH2_SRC	146	149	PF00017	0.295
LIG_SH2_SRC	306	309	PF00017	0.339
LIG_SH2_SRC	549	552	PF00017	0.449
LIG_SH2_STAP1	436	440	PF00017	0.247
LIG_SH2_STAP1	510	514	PF00017	0.453
LIG_SH2_STAT3	510	513	PF00017	0.438
LIG_SH2_STAT5	146	149	PF00017	0.320
LIG_SH2_STAT5	200	203	PF00017	0.430
LIG_SH2_STAT5	306	309	PF00017	0.413
LIG_SH2_STAT5	341	344	PF00017	0.375
LIG_SH2_STAT5	424	427	PF00017	0.437
LIG_SH2_STAT5	442	445	PF00017	0.267
LIG_SH2_STAT5	520	523	PF00017	0.384
LIG_SH2_STAT5	543	546	PF00017	0.449
LIG_SH2_STAT5	549	552	PF00017	0.383
LIG_SH2_STAT5	78	81	PF00017	0.423
LIG_SH3_3	202	208	PF00018	0.301
LIG_SH3_3	478	484	PF00018	0.301
LIG_SH3_3	71	77	PF00018	0.337
LIG_SUMO_SIM_par_1	604	609	PF11976	0.289
LIG_TYR_ITIM	304	309	PF00017	0.436
LIG_TYR_ITIM	76	81	PF00017	0.386
MOD_CDK_SPK_2	488	493	PF00069	0.286
MOD_CDK_SPxK_1	41	47	PF00069	0.416
MOD_CDK_SPxxK_3	486	493	PF00069	0.255
MOD_CDK_SPxxK_3	521	528	PF00069	0.463
MOD_CK1_1	203	209	PF00069	0.530
MOD_CK1_1	317	323	PF00069	0.473
MOD_CK1_1	469	475	PF00069	0.328
MOD_CK1_1	5	11	PF00069	0.666
MOD_CK1_1	69	75	PF00069	0.297
MOD_CK2_1	357	363	PF00069	0.543
MOD_CK2_1	521	527	PF00069	0.345
MOD_GlcNHglycan	314	317	PF01048	0.460
MOD_GlcNHglycan	335	338	PF01048	0.323
MOD_GlcNHglycan	436	439	PF01048	0.402
MOD_GlcNHglycan	517	520	PF01048	0.475
MOD_GlcNHglycan	59	62	PF01048	0.354
MOD_GlcNHglycan	68	71	PF01048	0.474
MOD_GSK3_1	164	171	PF00069	0.386
MOD_GSK3_1	186	193	PF00069	0.533
MOD_GSK3_1	243	250	PF00069	0.430
MOD_GSK3_1	416	423	PF00069	0.324
MOD_GSK3_1	484	491	PF00069	0.327
MOD_GSK3_1	578	585	PF00069	0.249
MOD_GSK3_1	99	106	PF00069	0.373
MOD_N-GLC_1	286	291	PF02516	0.369
MOD_N-GLC_1	342	347	PF02516	0.273
MOD_N-GLC_1	369	374	PF02516	0.336
MOD_N-GLC_1	383	388	PF02516	0.457
MOD_N-GLC_1	393	398	PF02516	0.382
MOD_N-GLC_1	428	433	PF02516	0.282
MOD_N-GLC_1	485	490	PF02516	0.271
MOD_N-GLC_2	378	380	PF02516	0.345
MOD_NEK2_1	257	262	PF00069	0.472
MOD_NEK2_1	264	269	PF00069	0.368
MOD_NEK2_1	3	8	PF00069	0.540
MOD_NEK2_1	428	433	PF00069	0.356
MOD_NEK2_1	606	611	PF00069	0.432
MOD_NEK2_2	258	263	PF00069	0.276
MOD_PIKK_1	383	389	PF00454	0.426
MOD_PK_1	10	16	PF00069	0.633
MOD_PK_1	466	472	PF00069	0.271
MOD_PKA_1	10	16	PF00069	0.560
MOD_PKA_2	10	16	PF00069	0.532
MOD_PKA_2	117	123	PF00069	0.311
MOD_PKA_2	484	490	PF00069	0.278
MOD_PKA_2	514	520	PF00069	0.359
MOD_PKA_2	57	63	PF00069	0.380
MOD_PKA_2	578	584	PF00069	0.262
MOD_PKB_1	399	407	PF00069	0.307
MOD_Plk_1	342	348	PF00069	0.288
MOD_Plk_1	383	389	PF00069	0.453
MOD_Plk_1	428	434	PF00069	0.295
MOD_Plk_1	466	472	PF00069	0.286
MOD_Plk_2-3	133	139	PF00069	0.445
MOD_Plk_4	142	148	PF00069	0.346
MOD_Plk_4	258	264	PF00069	0.376
MOD_Plk_4	420	426	PF00069	0.376
MOD_Plk_4	428	434	PF00069	0.315
MOD_Plk_4	539	545	PF00069	0.378
MOD_ProDKin_1	41	47	PF00069	0.416
MOD_ProDKin_1	416	422	PF00069	0.288
MOD_ProDKin_1	486	492	PF00069	0.293
MOD_ProDKin_1	521	527	PF00069	0.543
MOD_SUMO_for_1	327	330	PF00179	0.386
MOD_SUMO_rev_2	176	184	PF00179	0.395
TRG_DiLeu_BaEn_3	137	143	PF01217	0.319
TRG_ENDOCYTIC_2	306	309	PF00928	0.486
TRG_ENDOCYTIC_2	341	344	PF00928	0.543
TRG_ENDOCYTIC_2	436	439	PF00928	0.377
TRG_ENDOCYTIC_2	442	445	PF00928	0.425
TRG_ENDOCYTIC_2	494	497	PF00928	0.518
TRG_ENDOCYTIC_2	549	552	PF00928	0.538
TRG_ENDOCYTIC_2	78	81	PF00928	0.386
TRG_ER_diArg_1	10	12	PF00400	0.627
TRG_ER_diArg_1	158	161	PF00400	0.284
TRG_ER_diArg_1	398	400	PF00400	0.310
TRG_ER_diArg_1	406	409	PF00400	0.305
TRG_ER_diArg_1	573	575	PF00400	0.402
TRG_ER_diArg_1	64	66	PF00400	0.273
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL11	Leptomonas seymouri	36%	93%
A0A0S4IN60	Bodo saltans	32%	68%
A0A0S4IUT6	Bodo saltans	30%	74%
A0A0S4IUU1	Bodo saltans	31%	93%
A0A0S4IYM3	Bodo saltans	30%	84%
A0A1X0NDG7	Trypanosomatidae	29%	94%
A0A1X0NDJ3	Trypanosomatidae	27%	85%
A0A1X0NDK2	Trypanosomatidae	33%	100%
A0A1X0NDK7	Trypanosomatidae	30%	86%
A0A1X0NDK9	Trypanosomatidae	31%	100%
A0A1X0NDM7	Trypanosomatidae	30%	95%
A0A1X0NDU8	Trypanosomatidae	28%	92%
A0A1X0NE71	Trypanosomatidae	29%	100%
A0A1X0NER9	Trypanosomatidae	33%	95%
A0A1X0NET7	Trypanosomatidae	33%	100%
A0A1X0NEX7	Trypanosomatidae	34%	93%
A0A1X0NEZ6	Trypanosomatidae	30%	93%
A0A1X0NF32	Trypanosomatidae	31%	100%
A0A1X0NF41	Trypanosomatidae	31%	100%
A0A1X0NFJ0	Trypanosomatidae	31%	100%
A0A1X0NFK3	Trypanosomatidae	30%	91%
A0A1X0NFS0	Trypanosomatidae	32%	70%
A0A1X0NFT1	Trypanosomatidae	31%	67%
A0A1X0NFU4	Trypanosomatidae	27%	75%
A0A1X0NG20	Trypanosomatidae	30%	99%
A0A1X0NGP3	Trypanosomatidae	28%	71%
A0A1X0NGY3	Trypanosomatidae	30%	80%
A0A1X0NGZ3	Trypanosomatidae	31%	100%
A0A1X0NH86	Trypanosomatidae	31%	69%
A0A1X0NHP6	Trypanosomatidae	31%	100%
A0A1X0NHQ6	Trypanosomatidae	31%	100%
A0A1X0NI38	Trypanosomatidae	29%	70%
A0A1X0NI74	Trypanosomatidae	30%	82%
A0A1X0NII4	Trypanosomatidae	30%	73%
A0A1X0NIZ3	Trypanosomatidae	32%	100%
A0A1X0NJS3	Trypanosomatidae	28%	93%
A0A1X0NJU4	Trypanosomatidae	29%	71%
A0A1X0NK29	Trypanosomatidae	31%	66%
A0A1X0NK66	Trypanosomatidae	33%	92%
A0A1X0NKJ8	Trypanosomatidae	29%	82%
A0A1X0NKW9	Trypanosomatidae	30%	100%
A0A1X0NME2	Trypanosomatidae	31%	97%
A0A1X0NMK3	Trypanosomatidae	28%	100%
A0A1X0NMK7	Trypanosomatidae	36%	100%
A0A1X0NMV0	Trypanosomatidae	32%	83%
A0A1X0NN43	Trypanosomatidae	30%	85%
A0A1X0NNK8	Trypanosomatidae	32%	93%
A0A1X0NP64	Trypanosomatidae	30%	69%
A0A1X0NPW0	Trypanosomatidae	31%	95%
A0A1X0NQM4	Trypanosomatidae	35%	100%
A0A1X0NQN3	Trypanosomatidae	34%	100%
A0A1X0NQU4	Trypanosomatidae	35%	95%
A0A1X0NQW6	Trypanosomatidae	32%	100%
A0A1X0NRF3	Trypanosomatidae	33%	91%
A0A1X0NRY8	Trypanosomatidae	35%	100%
A0A1X0NU16	Trypanosomatidae	35%	100%
A0A1X0NUR2	Trypanosomatidae	31%	83%
A0A1X0NV28	Trypanosomatidae	36%	100%
A0A1X0NVE0	Trypanosomatidae	29%	78%
A0A1X0NW07	Trypanosomatidae	27%	98%
A0A1X0NX94	Trypanosomatidae	32%	94%
A0A1X0NX98	Trypanosomatidae	31%	76%
A0A1X0NXB6	Trypanosomatidae	30%	87%
A0A1X0NXH6	Trypanosomatidae	33%	84%
A0A1X0NXQ4	Trypanosomatidae	28%	90%
A0A1X0NXR7	Trypanosomatidae	34%	81%
A0A1X0NYE3	Trypanosomatidae	30%	98%
A0A1X0NYE7	Trypanosomatidae	31%	100%
A0A1X0NYN2	Trypanosomatidae	34%	100%
A0A1X0NYN4	Trypanosomatidae	26%	86%
A0A1X0NYS5	Trypanosomatidae	32%	100%
A0A1X0NYZ2	Trypanosomatidae	36%	100%
A0A1X0NZ46	Trypanosomatidae	26%	100%
A0A1X0NZ63	Trypanosomatidae	30%	96%
A0A1X0NZN6	Trypanosomatidae	28%	94%
A0A1X0P055	Trypanosomatidae	36%	100%
A0A1X0P154	Trypanosomatidae	28%	100%
A0A1X0P331	Trypanosomatidae	33%	100%
A0A1X0P3K0	Trypanosomatidae	27%	84%
A0A1X0P3S2	Trypanosomatidae	28%	100%
A0A1X0P4L8	Trypanosomatidae	32%	100%
A0A1X0P4Y5	Trypanosomatidae	28%	95%
A0A1X0P544	Trypanosomatidae	31%	95%
A0A1X0P5J0	Trypanosomatidae	32%	89%
A0A1X0P7K5	Trypanosomatidae	29%	69%
A0A1X0P7R3	Trypanosomatidae	35%	100%
A0A1X0P8B4	Trypanosomatidae	32%	100%
A0A1X0P9Z4	Trypanosomatidae	33%	100%
A0A1X0PB04	Trypanosomatidae	33%	100%
A0A3Q8I8N3	Leishmania donovani	65%	100%
A0A3Q8I8P8	Leishmania donovani	67%	100%
A0A3Q8I8S6	Leishmania donovani	68%	95%
A0A3Q8I8S9	Leishmania donovani	67%	100%
A0A3Q8IAZ8	Leishmania donovani	65%	100%
A0A3Q8IC35	Leishmania donovani	65%	100%
A0A3Q8IC44	Leishmania donovani	67%	100%
A0A3Q8IH61	Leishmania donovani	68%	100%
A0A3Q8IIN4	Leishmania donovani	38%	96%
A0A3R7JT49	Trypanosoma rangeli	35%	72%
A0A3R7JTB6	Trypanosoma rangeli	33%	87%
A0A3R7JV87	Trypanosoma rangeli	34%	100%
A0A3R7K7T9	Trypanosoma rangeli	33%	100%
A0A3R7K9S1	Trypanosoma rangeli	34%	100%
A0A3R7KB14	Trypanosoma rangeli	35%	70%
A0A3R7KLR6	Trypanosoma rangeli	33%	95%
A0A3R7KMY2	Trypanosoma rangeli	34%	91%
A0A3R7LFC4	Trypanosoma rangeli	34%	91%
A0A3R7LFZ4	Trypanosoma rangeli	35%	100%
A0A3R7LWG1	Trypanosoma rangeli	34%	100%
A0A3R7LX11	Trypanosoma rangeli	36%	100%
A0A3R7M1R8	Trypanosoma rangeli	35%	100%
A0A3R7M574	Trypanosoma rangeli	34%	95%
A0A3R7M7N6	Trypanosoma rangeli	35%	89%
A0A3R7MTS2	Trypanosoma rangeli	37%	100%
A0A3R7MW36	Trypanosoma rangeli	34%	100%
A0A3R7MXF4	Trypanosoma rangeli	35%	100%
A0A3R7N1W7	Trypanosoma rangeli	35%	100%
A0A3R7N289	Trypanosoma rangeli	34%	84%
A0A3R7NTI8	Trypanosoma rangeli	35%	100%
A0A3R7R2J4	Trypanosoma rangeli	33%	95%
A0A3R7R5R1	Trypanosoma rangeli	34%	100%
A0A3R7R818	Trypanosoma rangeli	31%	100%
A0A3S5H6G0	Leishmania donovani	67%	100%
A0A3S5IQY2	Trypanosoma rangeli	37%	100%
A0A3S7WR43	Leishmania donovani	65%	100%
A0A3S7WR46	Leishmania donovani	67%	100%
A0A3S7WR60	Leishmania donovani	68%	100%
A0A3S7X192	Leishmania donovani	37%	100%
A0A422MRQ6	Trypanosoma rangeli	35%	82%
A0A422MU95	Trypanosoma rangeli	36%	100%
A0A422MVF5	Trypanosoma rangeli	32%	100%
A0A422MVS3	Trypanosoma rangeli	34%	100%
A0A422MW99	Trypanosoma rangeli	32%	82%
A0A422MZ47	Trypanosoma rangeli	36%	100%
A0A422MZG4	Trypanosoma rangeli	36%	100%
A0A422N361	Trypanosoma rangeli	33%	100%
A0A422N7Q6	Trypanosoma rangeli	33%	94%
A0A422NDS2	Trypanosoma rangeli	34%	100%
A0A422NDT3	Trypanosoma rangeli	31%	100%
A0A422NP82	Trypanosoma rangeli	36%	100%
A4H626	Leishmania braziliensis	69%	100%
A4H627	Leishmania braziliensis	64%	99%
A4H630	Leishmania braziliensis	87%	100%
A4H631	Leishmania braziliensis	70%	99%
A4H632	Leishmania braziliensis	82%	100%
A4H633	Leishmania braziliensis	69%	100%
A4H634	Leishmania braziliensis	82%	100%
A4H635	Leishmania braziliensis	81%	100%
A4H636	Leishmania braziliensis	69%	100%
A4H637	Leishmania braziliensis	80%	99%
A4H638	Leishmania braziliensis	84%	99%
A4H640	Leishmania braziliensis	80%	98%
A4H6D3	Leishmania braziliensis	67%	100%
A4H6D5	Leishmania braziliensis	68%	86%
A4H6D7	Leishmania braziliensis	64%	100%
A4H6D8	Leishmania braziliensis	68%	100%
A4H6D9	Leishmania braziliensis	68%	100%
A4H6E0	Leishmania braziliensis	69%	86%
A4H6E1	Leishmania braziliensis	66%	100%
A4H6E2	Leishmania braziliensis	66%	100%
A4H6E3	Leishmania braziliensis	67%	100%
A4H6E5	Leishmania braziliensis	84%	100%
A4HJI2	Leishmania braziliensis	37%	94%
A4HUF6	Leishmania infantum	65%	100%
A4HUF8	Leishmania infantum	67%	100%
A4HUF9	Leishmania infantum	68%	95%
A4HUG0	Leishmania infantum	66%	80%
A4I6X5	Leishmania infantum	38%	96%
C9ZUT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A1R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A7S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	91%
D0A855	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
E9AHH5	Leishmania infantum	37%	100%
E9AN53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	93%
E9AN54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
E9AN55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	95%
E9AN56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	95%
E9AN57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
E9AZL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B1Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	96%
O62446	Caenorhabditis elegans	26%	92%
P08148	Leishmania major	66%	100%
P15706	Leishmania chagasi	67%	100%
P23223	Leishmania donovani	67%	100%
P43150	Leishmania mexicana	65%	95%
Q00689	Leishmania guyanensis	82%	98%
Q06031	Crithidia fasciculata	52%	94%
Q27673	Leishmania amazonensis	66%	100%
Q29AK2	Drosophila pseudoobscura pseudoobscura	25%	89%
Q4Q662	Leishmania major	36%	100%
Q4Q8L3	Leishmania major	37%	100%
Q4QHG9	Leishmania major	65%	99%
Q4QHH0	Leishmania major	67%	100%
Q4QHH1	Leishmania major	66%	99%
Q4QHH2	Leishmania major	66%	99%
Q61YG1	Caenorhabditis briggsae	26%	92%
Q6LA77	Leishmania infantum	67%	100%
Q8BMN4	Mus musculus	25%	90%
Q8MNZ1	Leishmania tropica	67%	93%
Q96KR4	Homo sapiens	21%	93%
Q9VH19	Drosophila melanogaster	24%	89%
V5A359	Trypanosoma cruzi	38%	100%
V5A488	Trypanosoma cruzi	34%	76%
V5AII7	Trypanosoma cruzi	39%	100%
V5APQ4	Trypanosoma cruzi	35%	77%
V5AX72	Trypanosoma cruzi	36%	83%
V5B5M0	Trypanosoma cruzi	35%	83%
V5B9W5	Trypanosoma cruzi	29%	90%
V5BAL3	Trypanosoma cruzi	38%	100%
V5BAN1	Trypanosoma cruzi	35%	78%
V5BD39	Trypanosoma cruzi	41%	100%
V5BLT3	Trypanosoma cruzi	32%	97%
V5CI97	Trypanosoma cruzi	32%	96%
V5D358	Trypanosoma cruzi	34%	72%