Leishmanolysin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

metallo-peptidase, Clan MA(M), Family M8

Species:

Leishmania braziliensis

UniProt:

A4H636_LEIBR

TriTrypDb:

LbrM.10.0570 , LBRM2903_100011100

Length:

450

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 51

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 41, no: 8
NetGPI	no	yes: 0, no: 49

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	50
GO:0110165	cellular anatomical entity	1	50
GO:0005737	cytoplasm	2	4
GO:0018995	host cellular component	2	4
GO:0033643	host cell part	3	4
GO:0033646	host intracellular part	4	4
GO:0033647	host intracellular organelle	5	4
GO:0033648	host intracellular membrane-bounded organelle	6	4
GO:0042025	host cell nucleus	7	4

Expansion

Sequence features

A4H636

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H636

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	50
GO:0006807	nitrogen compound metabolic process	2	50
GO:0007155	cell adhesion	2	50
GO:0008152	metabolic process	1	50
GO:0009987	cellular process	1	50
GO:0019538	protein metabolic process	3	50
GO:0043170	macromolecule metabolic process	3	50
GO:0044238	primary metabolic process	2	50
GO:0071704	organic substance metabolic process	2	50
GO:1901564	organonitrogen compound metabolic process	3	50
GO:0009966	regulation of signal transduction	4	4
GO:0010646	regulation of cell communication	4	4
GO:0010749	regulation of nitric oxide mediated signal transduction	6	4
GO:0023051	regulation of signaling	3	4
GO:0035821	modulation of process of another organism	2	4
GO:0044003	modulation by symbiont of host process	3	4
GO:0044068	modulation by symbiont of host cellular process	4	4
GO:0044081	modulation by symbiont of host nitric oxide-mediated signal transduction	5	4
GO:0044403	biological process involved in symbiotic interaction	2	4
GO:0044419	biological process involved in interspecies interaction between organisms	1	4
GO:0044501	modulation of signal transduction in another organism	3	4
GO:0048583	regulation of response to stimulus	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051701	biological process involved in interaction with host	3	4
GO:0052027	modulation by symbiont of host signal transduction pathway	4	4
GO:0065007	biological regulation	1	4
GO:0075130	modulation by symbiont of host protein kinase-mediated signal transduction	5	4
GO:1902531	regulation of intracellular signal transduction	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	50
GO:0004175	endopeptidase activity	4	50
GO:0004222	metalloendopeptidase activity	5	50
GO:0005488	binding	1	50
GO:0008233	peptidase activity	3	50
GO:0008237	metallopeptidase activity	4	50
GO:0016787	hydrolase activity	2	50
GO:0043167	ion binding	2	50
GO:0043169	cation binding	3	50
GO:0046872	metal ion binding	4	50
GO:0140096	catalytic activity, acting on a protein	2	50
GO:0008047	enzyme activator activity	3	4
GO:0008160	protein tyrosine phosphatase activator activity	6	4
GO:0019208	phosphatase regulator activity	3	4
GO:0019211	phosphatase activator activity	4	4
GO:0019888	protein phosphatase regulator activity	4	4
GO:0030234	enzyme regulator activity	2	4
GO:0072542	protein phosphatase activator activity	5	4
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.206
CLV_NRD_NRD_1	16	18	PF00675	0.391
CLV_NRD_NRD_1	293	295	PF00675	0.395
CLV_PCSK_KEX2_1	16	18	PF00082	0.558
CLV_PCSK_KEX2_1	295	297	PF00082	0.392
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.392
CLV_PCSK_SKI1_1	138	142	PF00082	0.449
CLV_PCSK_SKI1_1	17	21	PF00082	0.537
CLV_PCSK_SKI1_1	202	206	PF00082	0.499
CLV_PCSK_SKI1_1	260	264	PF00082	0.464
CLV_PCSK_SKI1_1	9	13	PF00082	0.492
DEG_APCC_DBOX_1	16	24	PF00400	0.199
DEG_SCF_FBW7_1	398	405	PF00400	0.238
DEG_SPOP_SBC_1	409	413	PF00917	0.192
DOC_CKS1_1	163	168	PF01111	0.203
DOC_MAPK_gen_1	16	23	PF00069	0.200
DOC_MAPK_MEF2A_6	16	25	PF00069	0.199
DOC_PP1_RVXF_1	136	142	PF00149	0.190
DOC_PP4_FxxP_1	58	61	PF00568	0.386
DOC_USP7_MATH_1	338	342	PF00917	0.245
DOC_USP7_MATH_1	402	406	PF00917	0.247
DOC_USP7_MATH_1	409	413	PF00917	0.231
DOC_WW_Pin1_4	113	118	PF00397	0.208
DOC_WW_Pin1_4	162	167	PF00397	0.247
DOC_WW_Pin1_4	311	316	PF00397	0.215
DOC_WW_Pin1_4	336	341	PF00397	0.252
DOC_WW_Pin1_4	398	403	PF00397	0.399
LIG_14-3-3_CanoR_1	260	269	PF00244	0.218
LIG_14-3-3_CanoR_1	278	286	PF00244	0.273
LIG_14-3-3_CanoR_1	386	390	PF00244	0.373
LIG_AP2alpha_1	140	144	PF02296	0.205
LIG_AP2alpha_1	305	309	PF02296	0.208
LIG_APCC_ABBA_1	223	228	PF00400	0.377
LIG_APCC_ABBA_1	29	34	PF00400	0.386
LIG_APCC_ABBA_1	313	318	PF00400	0.236
LIG_APCC_ABBA_1	345	350	PF00400	0.403
LIG_BRCT_BRCA1_1	248	252	PF00533	0.275
LIG_BRCT_BRCA1_1	411	415	PF00533	0.399
LIG_FHA_1	146	152	PF00498	0.222
LIG_FHA_1	163	169	PF00498	0.199
LIG_FHA_1	220	226	PF00498	0.393
LIG_FHA_1	270	276	PF00498	0.290
LIG_FHA_1	279	285	PF00498	0.372
LIG_FHA_1	411	417	PF00498	0.275
LIG_FHA_1	42	48	PF00498	0.294
LIG_FHA_2	323	329	PF00498	0.207
LIG_FHA_2	46	52	PF00498	0.225
LIG_LIR_Apic_2	157	161	PF02991	0.291
LIG_LIR_Apic_2	57	61	PF02991	0.372
LIG_LIR_Gen_1	116	126	PF02991	0.340
LIG_LIR_Gen_1	182	188	PF02991	0.378
LIG_LIR_Gen_1	300	310	PF02991	0.291
LIG_LIR_Gen_1	344	352	PF02991	0.280
LIG_LIR_Gen_1	66	77	PF02991	0.206
LIG_LIR_Gen_1	91	98	PF02991	0.201
LIG_LIR_Nem_3	116	121	PF02991	0.340
LIG_LIR_Nem_3	142	147	PF02991	0.245
LIG_LIR_Nem_3	157	162	PF02991	0.197
LIG_LIR_Nem_3	182	186	PF02991	0.346
LIG_LIR_Nem_3	300	305	PF02991	0.326
LIG_LIR_Nem_3	314	319	PF02991	0.287
LIG_LIR_Nem_3	344	348	PF02991	0.287
LIG_LIR_Nem_3	66	72	PF02991	0.335
LIG_LIR_Nem_3	73	77	PF02991	0.367
LIG_LIR_Nem_3	91	96	PF02991	0.191
LIG_Pex14_1	265	269	PF04695	0.392
LIG_Pex14_2	136	140	PF04695	0.345
LIG_Pex14_2	305	309	PF04695	0.230
LIG_Pex14_2	93	97	PF04695	0.201
LIG_PTB_Apo_2	68	75	PF02174	0.382
LIG_SH2_CRK	118	122	PF00017	0.336
LIG_SH2_CRK	159	163	PF00017	0.197
LIG_SH2_CRK	218	222	PF00017	0.403
LIG_SH2_CRK	371	375	PF00017	0.354
LIG_SH2_PTP2	426	429	PF00017	0.395
LIG_SH2_SRC	159	162	PF00017	0.205
LIG_SH2_SRC	426	429	PF00017	0.395
LIG_SH2_STAP1	118	122	PF00017	0.345
LIG_SH2_STAP1	387	391	PF00017	0.399
LIG_SH2_STAT3	387	390	PF00017	0.384
LIG_SH2_STAT5	218	221	PF00017	0.329
LIG_SH2_STAT5	246	249	PF00017	0.195
LIG_SH2_STAT5	301	304	PF00017	0.387
LIG_SH2_STAT5	319	322	PF00017	0.215
LIG_SH2_STAT5	397	400	PF00017	0.334
LIG_SH2_STAT5	420	423	PF00017	0.395
LIG_SH2_STAT5	426	429	PF00017	0.330
LIG_SH2_STAT5	77	80	PF00017	0.375
LIG_SH3_3	355	361	PF00018	0.249
LIG_SH3_5	315	319	PF00018	0.214
LIG_WRC_WIRS_1	141	146	PF05994	0.195
LIG_WRC_WIRS_1	180	185	PF05994	0.195
MOD_CK1_1	194	200	PF00069	0.424
MOD_CK1_1	336	342	PF00069	0.356
MOD_CK1_1	80	86	PF00069	0.472
MOD_CK2_1	179	185	PF00069	0.239
MOD_CK2_1	234	240	PF00069	0.493
MOD_CK2_1	338	344	PF00069	0.259
MOD_CK2_1	45	51	PF00069	0.242
MOD_GlcNHglycan	394	397	PF01048	0.417
MOD_GlcNHglycan	90	93	PF01048	0.214
MOD_GSK3_1	278	285	PF00069	0.345
MOD_GSK3_1	398	405	PF00069	0.253
MOD_GSK3_1	41	48	PF00069	0.319
MOD_GSK3_1	63	70	PF00069	0.465
MOD_N-GLC_1	260	265	PF02516	0.397
MOD_N-GLC_1	270	275	PF02516	0.331
MOD_N-GLC_2	255	257	PF02516	0.306
MOD_NEK2_1	122	127	PF00069	0.360
MOD_NEK2_1	140	145	PF00069	0.339
MOD_NEK2_1	186	191	PF00069	0.252
MOD_NEK2_1	208	213	PF00069	0.203
MOD_NEK2_1	305	310	PF00069	0.303
MOD_NEK2_1	408	413	PF00069	0.221
MOD_NEK2_1	88	93	PF00069	0.220
MOD_PIKK_1	260	266	PF00454	0.382
MOD_PIKK_1	289	295	PF00454	0.206
MOD_PKA_2	277	283	PF00069	0.340
MOD_PKA_2	385	391	PF00069	0.286
MOD_Plk_1	234	240	PF00069	0.246
MOD_Plk_1	260	266	PF00069	0.407
MOD_Plk_2-3	10	16	PF00069	0.384
MOD_Plk_4	164	170	PF00069	0.317
MOD_Plk_4	176	182	PF00069	0.239
MOD_Plk_4	208	214	PF00069	0.195
MOD_Plk_4	297	303	PF00069	0.334
MOD_Plk_4	305	311	PF00069	0.269
MOD_Plk_4	338	344	PF00069	0.231
MOD_Plk_4	416	422	PF00069	0.330
MOD_ProDKin_1	113	119	PF00069	0.221
MOD_ProDKin_1	162	168	PF00069	0.275
MOD_ProDKin_1	311	317	PF00069	0.230
MOD_ProDKin_1	336	342	PF00069	0.283
MOD_ProDKin_1	398	404	PF00069	0.488
MOD_SUMO_for_1	204	207	PF00179	0.348
MOD_SUMO_rev_2	4	11	PF00179	0.216
MOD_SUMO_rev_2	51	61	PF00179	0.332
TRG_DiLeu_BaEn_3	14	20	PF01217	0.265
TRG_ENDOCYTIC_2	118	121	PF00928	0.415
TRG_ENDOCYTIC_2	159	162	PF00928	0.221
TRG_ENDOCYTIC_2	218	221	PF00928	0.493
TRG_ENDOCYTIC_2	371	374	PF00928	0.461
TRG_ENDOCYTIC_2	426	429	PF00928	0.483
TRG_ER_diArg_1	294	297	PF00400	0.218
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.223

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL11	Leptomonas seymouri	35%	69%
A0A0S4IS53	Bodo saltans	36%	94%
A0A0S4IUU1	Bodo saltans	29%	68%
A0A1D5NSK0	Danio rerio	24%	72%
A0A1X0NDG7	Trypanosomatidae	30%	69%
A0A1X0NDK2	Trypanosomatidae	33%	78%
A0A1X0NDK9	Trypanosomatidae	34%	92%
A0A1X0NDM7	Trypanosomatidae	31%	70%
A0A1X0NDU8	Trypanosomatidae	32%	68%
A0A1X0NE71	Trypanosomatidae	31%	88%
A0A1X0NER9	Trypanosomatidae	34%	70%
A0A1X0NES0	Trypanosomatidae	33%	100%
A0A1X0NET7	Trypanosomatidae	32%	87%
A0A1X0NEX7	Trypanosomatidae	33%	69%
A0A1X0NEZ6	Trypanosomatidae	31%	69%
A0A1X0NF32	Trypanosomatidae	33%	96%
A0A1X0NF41	Trypanosomatidae	33%	73%
A0A1X0NFJ0	Trypanosomatidae	32%	86%
A0A1X0NFK3	Trypanosomatidae	31%	67%
A0A1X0NFZ9	Trypanosomatidae	32%	98%
A0A1X0NG20	Trypanosomatidae	32%	73%
A0A1X0NGN3	Trypanosomatidae	34%	100%
A0A1X0NGZ3	Trypanosomatidae	33%	75%
A0A1X0NHP4	Trypanosomatidae	33%	100%
A0A1X0NHP6	Trypanosomatidae	31%	86%
A0A1X0NHQ6	Trypanosomatidae	32%	87%
A0A1X0NIJ6	Trypanosomatidae	32%	100%
A0A1X0NIZ3	Trypanosomatidae	33%	80%
A0A1X0NJC6	Trypanosomatidae	35%	100%
A0A1X0NK66	Trypanosomatidae	33%	68%
A0A1X0NKW9	Trypanosomatidae	29%	88%
A0A1X0NME2	Trypanosomatidae	32%	72%
A0A1X0NMK3	Trypanosomatidae	30%	87%
A0A1X0NMK7	Trypanosomatidae	37%	87%
A0A1X0NNK8	Trypanosomatidae	32%	68%
A0A1X0NPW0	Trypanosomatidae	32%	70%
A0A1X0NQJ5	Trypanosomatidae	34%	98%
A0A1X0NQM4	Trypanosomatidae	33%	98%
A0A1X0NQN3	Trypanosomatidae	35%	100%
A0A1X0NQU3	Trypanosomatidae	38%	100%
A0A1X0NQU4	Trypanosomatidae	33%	70%
A0A1X0NQW6	Trypanosomatidae	33%	79%
A0A1X0NR02	Trypanosomatidae	38%	100%
A0A1X0NRF3	Trypanosomatidae	33%	67%
A0A1X0NRY8	Trypanosomatidae	38%	82%
A0A1X0NTJ1	Trypanosomatidae	33%	100%
A0A1X0NU16	Trypanosomatidae	36%	75%
A0A1X0NV28	Trypanosomatidae	37%	76%
A0A1X0NW07	Trypanosomatidae	30%	72%
A0A1X0NX94	Trypanosomatidae	33%	69%
A0A1X0NXQ4	Trypanosomatidae	31%	66%
A0A1X0NY94	Trypanosomatidae	38%	100%
A0A1X0NYE3	Trypanosomatidae	33%	72%
A0A1X0NYE7	Trypanosomatidae	32%	88%
A0A1X0NYN2	Trypanosomatidae	33%	85%
A0A1X0NYS5	Trypanosomatidae	36%	75%
A0A1X0NYZ2	Trypanosomatidae	37%	80%
A0A1X0NZ46	Trypanosomatidae	30%	77%
A0A1X0NZ63	Trypanosomatidae	31%	71%
A0A1X0NZN6	Trypanosomatidae	29%	69%
A0A1X0P055	Trypanosomatidae	37%	76%
A0A1X0P0C4	Trypanosomatidae	31%	88%
A0A1X0P154	Trypanosomatidae	30%	75%
A0A1X0P331	Trypanosomatidae	34%	79%
A0A1X0P3S2	Trypanosomatidae	29%	81%
A0A1X0P4L8	Trypanosomatidae	32%	88%
A0A1X0P4Y5	Trypanosomatidae	30%	70%
A0A1X0P544	Trypanosomatidae	31%	70%
A0A1X0P5K2	Trypanosomatidae	36%	100%
A0A1X0P7R3	Trypanosomatidae	35%	80%
A0A1X0P8B4	Trypanosomatidae	34%	90%
A0A1X0P9Z4	Trypanosomatidae	33%	82%
A0A1X0PB04	Trypanosomatidae	33%	88%
A0A3Q8I8N3	Leishmania donovani	59%	75%
A0A3Q8I8P8	Leishmania donovani	60%	75%
A0A3Q8I8S6	Leishmania donovani	61%	70%
A0A3Q8I8S9	Leishmania donovani	60%	75%
A0A3Q8IAZ8	Leishmania donovani	60%	75%
A0A3Q8IC35	Leishmania donovani	60%	75%
A0A3Q8IC44	Leishmania donovani	60%	76%
A0A3Q8IH61	Leishmania donovani	60%	76%
A0A3Q8IIN4	Leishmania donovani	34%	71%
A0A3R7JUH9	Trypanosoma rangeli	39%	100%
A0A3R7JUS0	Trypanosoma rangeli	34%	97%
A0A3R7JV87	Trypanosoma rangeli	33%	85%
A0A3R7K7T9	Trypanosoma rangeli	35%	75%
A0A3R7K9S1	Trypanosoma rangeli	33%	87%
A0A3R7KFR4	Trypanosoma rangeli	33%	100%
A0A3R7KLR6	Trypanosoma rangeli	34%	70%
A0A3R7KMY2	Trypanosoma rangeli	36%	67%
A0A3R7LFC4	Trypanosoma rangeli	34%	67%
A0A3R7LFZ4	Trypanosoma rangeli	38%	82%
A0A3R7LWG1	Trypanosoma rangeli	33%	79%
A0A3R7LX11	Trypanosoma rangeli	36%	80%
A0A3R7M1R8	Trypanosoma rangeli	35%	78%
A0A3R7M574	Trypanosoma rangeli	35%	70%
A0A3R7M5K4	Trypanosoma rangeli	38%	87%
A0A3R7MTS2	Trypanosoma rangeli	39%	99%
A0A3R7MW36	Trypanosoma rangeli	34%	85%
A0A3R7MXF4	Trypanosoma rangeli	36%	74%
A0A3R7N1W7	Trypanosoma rangeli	33%	77%
A0A3R7N7I3	Trypanosoma rangeli	44%	100%
A0A3R7NTI8	Trypanosoma rangeli	34%	78%
A0A3R7R2J4	Trypanosoma rangeli	34%	70%
A0A3R7R5R1	Trypanosoma rangeli	37%	75%
A0A3R7R818	Trypanosoma rangeli	32%	86%
A0A3S5H6G0	Leishmania donovani	60%	75%
A0A3S5IQY2	Trypanosoma rangeli	40%	87%
A0A3S7WR43	Leishmania donovani	60%	75%
A0A3S7WR46	Leishmania donovani	60%	75%
A0A3S7WR60	Leishmania donovani	60%	75%
A0A3S7X192	Leishmania donovani	38%	80%
A0A422MP17	Trypanosoma rangeli	38%	100%
A0A422MQQ6	Trypanosoma rangeli	32%	100%
A0A422MTE4	Trypanosoma rangeli	32%	97%
A0A422MU95	Trypanosoma rangeli	34%	79%
A0A422MUP1	Trypanosoma rangeli	40%	100%
A0A422MVF5	Trypanosoma rangeli	31%	80%
A0A422MVS3	Trypanosoma rangeli	36%	87%
A0A422MZ47	Trypanosoma rangeli	38%	80%
A0A422MZG4	Trypanosoma rangeli	35%	77%
A0A422N361	Trypanosoma rangeli	34%	81%
A0A422N7Q6	Trypanosoma rangeli	33%	70%
A0A422NDS2	Trypanosoma rangeli	31%	77%
A0A422NDT3	Trypanosoma rangeli	31%	79%
A0A422NP82	Trypanosoma rangeli	39%	79%
A4H626	Leishmania braziliensis	74%	100%
A4H627	Leishmania braziliensis	97%	100%
A4H629	Leishmania braziliensis	68%	100%
A4H630	Leishmania braziliensis	67%	100%
A4H631	Leishmania braziliensis	68%	100%
A4H632	Leishmania braziliensis	68%	100%
A4H633	Leishmania braziliensis	67%	100%
A4H634	Leishmania braziliensis	69%	100%
A4H635	Leishmania braziliensis	68%	100%
A4H637	Leishmania braziliensis	69%	72%
A4H638	Leishmania braziliensis	65%	76%
A4H639	Leishmania braziliensis	69%	74%
A4H640	Leishmania braziliensis	69%	72%
A4H6D3	Leishmania braziliensis	79%	77%
A4H6D7	Leishmania braziliensis	96%	77%
A4H6D8	Leishmania braziliensis	71%	77%
A4H6D9	Leishmania braziliensis	73%	77%
A4H6E1	Leishmania braziliensis	79%	77%
A4H6E2	Leishmania braziliensis	78%	78%
A4H6E3	Leishmania braziliensis	69%	78%
A4H6E4	Leishmania braziliensis	72%	100%
A4H6E5	Leishmania braziliensis	65%	88%
A4H6E7	Leishmania braziliensis	66%	100%
A4HJI2	Leishmania braziliensis	33%	69%
A4HUF6	Leishmania infantum	60%	75%
A4HUF8	Leishmania infantum	61%	75%
A4HUF9	Leishmania infantum	62%	70%
A4I6X5	Leishmania infantum	34%	71%
C9ZUT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	77%
D0A1R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	76%
D0A7S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	67%
D0A7W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A855	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	73%
E9AHH5	Leishmania infantum	38%	80%
E9AN53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	69%
E9AN54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	75%
E9AN55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	70%
E9AN56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	70%
E9AN57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	75%
E9AZL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	80%
E9B1Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	71%
O62446	Caenorhabditis elegans	24%	68%
P08148	Leishmania major	61%	75%
P15706	Leishmania chagasi	61%	75%
P23223	Leishmania donovani	60%	76%
P43150	Leishmania mexicana	59%	70%
Q00689	Leishmania guyanensis	66%	72%
Q06031	Crithidia fasciculata	52%	69%
Q27673	Leishmania amazonensis	60%	75%
Q4Q662	Leishmania major	33%	100%
Q4Q8L3	Leishmania major	39%	100%
Q4QHG9	Leishmania major	60%	100%
Q4QHH0	Leishmania major	61%	100%
Q4QHH1	Leishmania major	61%	100%
Q4QHH2	Leishmania major	61%	100%
Q61YG1	Caenorhabditis briggsae	24%	68%
Q6LA77	Leishmania infantum	61%	75%
Q8BMN4	Mus musculus	25%	66%
Q8MNZ1	Leishmania tropica	61%	68%
Q96KR4	Homo sapiens	23%	69%
V5A2X8	Trypanosoma cruzi	34%	93%
V5A303	Trypanosoma cruzi	38%	100%
V5A359	Trypanosoma cruzi	39%	83%
V5AII7	Trypanosoma cruzi	39%	83%
V5AJE7	Trypanosoma cruzi	34%	86%
V5AMH8	Trypanosoma cruzi	33%	95%
V5AN34	Trypanosoma cruzi	37%	100%
V5APB3	Trypanosoma cruzi	38%	100%
V5AZG8	Trypanosoma cruzi	31%	94%
V5B7J8	Trypanosoma cruzi	33%	93%
V5B9W5	Trypanosoma cruzi	30%	67%
V5BAL3	Trypanosoma cruzi	41%	89%
V5BD39	Trypanosoma cruzi	43%	100%
V5BLT3	Trypanosoma cruzi	31%	71%
V5CI97	Trypanosoma cruzi	31%	71%
V5CIA7	Trypanosoma cruzi	34%	94%