LeishMANIAdb
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Leishmanolysin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leishmanolysin
Gene product:
metallo-peptidase, Clan MA(M), Family M8
Species:
Leishmania braziliensis
UniProt:
A4H636_LEIBR
TriTrypDb:
LbrM.10.0570 , LBRM2903_100011100
Length:
450

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 51
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 41, no: 8
NetGPI no yes: 0, no: 49
Cellular components
Term Name Level Count
GO:0016020 membrane 2 50
GO:0110165 cellular anatomical entity 1 50
GO:0005737 cytoplasm 2 4
GO:0018995 host cellular component 2 4
GO:0033643 host cell part 3 4
GO:0033646 host intracellular part 4 4
GO:0033647 host intracellular organelle 5 4
GO:0033648 host intracellular membrane-bounded organelle 6 4
GO:0042025 host cell nucleus 7 4

Expansion

Sequence features

A4H636
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H636

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 50
GO:0006807 nitrogen compound metabolic process 2 50
GO:0007155 cell adhesion 2 50
GO:0008152 metabolic process 1 50
GO:0009987 cellular process 1 50
GO:0019538 protein metabolic process 3 50
GO:0043170 macromolecule metabolic process 3 50
GO:0044238 primary metabolic process 2 50
GO:0071704 organic substance metabolic process 2 50
GO:1901564 organonitrogen compound metabolic process 3 50
GO:0009966 regulation of signal transduction 4 4
GO:0010646 regulation of cell communication 4 4
GO:0010749 regulation of nitric oxide mediated signal transduction 6 4
GO:0023051 regulation of signaling 3 4
GO:0035821 modulation of process of another organism 2 4
GO:0044003 modulation by symbiont of host process 3 4
GO:0044068 modulation by symbiont of host cellular process 4 4
GO:0044081 modulation by symbiont of host nitric oxide-mediated signal transduction 5 4
GO:0044403 biological process involved in symbiotic interaction 2 4
GO:0044419 biological process involved in interspecies interaction between organisms 1 4
GO:0044501 modulation of signal transduction in another organism 3 4
GO:0048583 regulation of response to stimulus 3 4
GO:0050789 regulation of biological process 2 4
GO:0050794 regulation of cellular process 3 4
GO:0051701 biological process involved in interaction with host 3 4
GO:0052027 modulation by symbiont of host signal transduction pathway 4 4
GO:0065007 biological regulation 1 4
GO:0075130 modulation by symbiont of host protein kinase-mediated signal transduction 5 4
GO:1902531 regulation of intracellular signal transduction 5 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 50
GO:0004175 endopeptidase activity 4 50
GO:0004222 metalloendopeptidase activity 5 50
GO:0005488 binding 1 50
GO:0008233 peptidase activity 3 50
GO:0008237 metallopeptidase activity 4 50
GO:0016787 hydrolase activity 2 50
GO:0043167 ion binding 2 50
GO:0043169 cation binding 3 50
GO:0046872 metal ion binding 4 50
GO:0140096 catalytic activity, acting on a protein 2 50
GO:0008047 enzyme activator activity 3 4
GO:0008160 protein tyrosine phosphatase activator activity 6 4
GO:0019208 phosphatase regulator activity 3 4
GO:0019211 phosphatase activator activity 4 4
GO:0019888 protein phosphatase regulator activity 4 4
GO:0030234 enzyme regulator activity 2 4
GO:0072542 protein phosphatase activator activity 5 4
GO:0098772 molecular function regulator activity 1 4
GO:0140677 molecular function activator activity 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 325 329 PF00656 0.206
CLV_NRD_NRD_1 16 18 PF00675 0.391
CLV_NRD_NRD_1 293 295 PF00675 0.395
CLV_PCSK_KEX2_1 16 18 PF00082 0.558
CLV_PCSK_KEX2_1 295 297 PF00082 0.392
CLV_PCSK_PC1ET2_1 295 297 PF00082 0.392
CLV_PCSK_SKI1_1 138 142 PF00082 0.449
CLV_PCSK_SKI1_1 17 21 PF00082 0.537
CLV_PCSK_SKI1_1 202 206 PF00082 0.499
CLV_PCSK_SKI1_1 260 264 PF00082 0.464
CLV_PCSK_SKI1_1 9 13 PF00082 0.492
DEG_APCC_DBOX_1 16 24 PF00400 0.199
DEG_SCF_FBW7_1 398 405 PF00400 0.238
DEG_SPOP_SBC_1 409 413 PF00917 0.192
DOC_CKS1_1 163 168 PF01111 0.203
DOC_MAPK_gen_1 16 23 PF00069 0.200
DOC_MAPK_MEF2A_6 16 25 PF00069 0.199
DOC_PP1_RVXF_1 136 142 PF00149 0.190
DOC_PP4_FxxP_1 58 61 PF00568 0.386
DOC_USP7_MATH_1 338 342 PF00917 0.245
DOC_USP7_MATH_1 402 406 PF00917 0.247
DOC_USP7_MATH_1 409 413 PF00917 0.231
DOC_WW_Pin1_4 113 118 PF00397 0.208
DOC_WW_Pin1_4 162 167 PF00397 0.247
DOC_WW_Pin1_4 311 316 PF00397 0.215
DOC_WW_Pin1_4 336 341 PF00397 0.252
DOC_WW_Pin1_4 398 403 PF00397 0.399
LIG_14-3-3_CanoR_1 260 269 PF00244 0.218
LIG_14-3-3_CanoR_1 278 286 PF00244 0.273
LIG_14-3-3_CanoR_1 386 390 PF00244 0.373
LIG_AP2alpha_1 140 144 PF02296 0.205
LIG_AP2alpha_1 305 309 PF02296 0.208
LIG_APCC_ABBA_1 223 228 PF00400 0.377
LIG_APCC_ABBA_1 29 34 PF00400 0.386
LIG_APCC_ABBA_1 313 318 PF00400 0.236
LIG_APCC_ABBA_1 345 350 PF00400 0.403
LIG_BRCT_BRCA1_1 248 252 PF00533 0.275
LIG_BRCT_BRCA1_1 411 415 PF00533 0.399
LIG_FHA_1 146 152 PF00498 0.222
LIG_FHA_1 163 169 PF00498 0.199
LIG_FHA_1 220 226 PF00498 0.393
LIG_FHA_1 270 276 PF00498 0.290
LIG_FHA_1 279 285 PF00498 0.372
LIG_FHA_1 411 417 PF00498 0.275
LIG_FHA_1 42 48 PF00498 0.294
LIG_FHA_2 323 329 PF00498 0.207
LIG_FHA_2 46 52 PF00498 0.225
LIG_LIR_Apic_2 157 161 PF02991 0.291
LIG_LIR_Apic_2 57 61 PF02991 0.372
LIG_LIR_Gen_1 116 126 PF02991 0.340
LIG_LIR_Gen_1 182 188 PF02991 0.378
LIG_LIR_Gen_1 300 310 PF02991 0.291
LIG_LIR_Gen_1 344 352 PF02991 0.280
LIG_LIR_Gen_1 66 77 PF02991 0.206
LIG_LIR_Gen_1 91 98 PF02991 0.201
LIG_LIR_Nem_3 116 121 PF02991 0.340
LIG_LIR_Nem_3 142 147 PF02991 0.245
LIG_LIR_Nem_3 157 162 PF02991 0.197
LIG_LIR_Nem_3 182 186 PF02991 0.346
LIG_LIR_Nem_3 300 305 PF02991 0.326
LIG_LIR_Nem_3 314 319 PF02991 0.287
LIG_LIR_Nem_3 344 348 PF02991 0.287
LIG_LIR_Nem_3 66 72 PF02991 0.335
LIG_LIR_Nem_3 73 77 PF02991 0.367
LIG_LIR_Nem_3 91 96 PF02991 0.191
LIG_Pex14_1 265 269 PF04695 0.392
LIG_Pex14_2 136 140 PF04695 0.345
LIG_Pex14_2 305 309 PF04695 0.230
LIG_Pex14_2 93 97 PF04695 0.201
LIG_PTB_Apo_2 68 75 PF02174 0.382
LIG_SH2_CRK 118 122 PF00017 0.336
LIG_SH2_CRK 159 163 PF00017 0.197
LIG_SH2_CRK 218 222 PF00017 0.403
LIG_SH2_CRK 371 375 PF00017 0.354
LIG_SH2_PTP2 426 429 PF00017 0.395
LIG_SH2_SRC 159 162 PF00017 0.205
LIG_SH2_SRC 426 429 PF00017 0.395
LIG_SH2_STAP1 118 122 PF00017 0.345
LIG_SH2_STAP1 387 391 PF00017 0.399
LIG_SH2_STAT3 387 390 PF00017 0.384
LIG_SH2_STAT5 218 221 PF00017 0.329
LIG_SH2_STAT5 246 249 PF00017 0.195
LIG_SH2_STAT5 301 304 PF00017 0.387
LIG_SH2_STAT5 319 322 PF00017 0.215
LIG_SH2_STAT5 397 400 PF00017 0.334
LIG_SH2_STAT5 420 423 PF00017 0.395
LIG_SH2_STAT5 426 429 PF00017 0.330
LIG_SH2_STAT5 77 80 PF00017 0.375
LIG_SH3_3 355 361 PF00018 0.249
LIG_SH3_5 315 319 PF00018 0.214
LIG_WRC_WIRS_1 141 146 PF05994 0.195
LIG_WRC_WIRS_1 180 185 PF05994 0.195
MOD_CK1_1 194 200 PF00069 0.424
MOD_CK1_1 336 342 PF00069 0.356
MOD_CK1_1 80 86 PF00069 0.472
MOD_CK2_1 179 185 PF00069 0.239
MOD_CK2_1 234 240 PF00069 0.493
MOD_CK2_1 338 344 PF00069 0.259
MOD_CK2_1 45 51 PF00069 0.242
MOD_GlcNHglycan 394 397 PF01048 0.417
MOD_GlcNHglycan 90 93 PF01048 0.214
MOD_GSK3_1 278 285 PF00069 0.345
MOD_GSK3_1 398 405 PF00069 0.253
MOD_GSK3_1 41 48 PF00069 0.319
MOD_GSK3_1 63 70 PF00069 0.465
MOD_N-GLC_1 260 265 PF02516 0.397
MOD_N-GLC_1 270 275 PF02516 0.331
MOD_N-GLC_2 255 257 PF02516 0.306
MOD_NEK2_1 122 127 PF00069 0.360
MOD_NEK2_1 140 145 PF00069 0.339
MOD_NEK2_1 186 191 PF00069 0.252
MOD_NEK2_1 208 213 PF00069 0.203
MOD_NEK2_1 305 310 PF00069 0.303
MOD_NEK2_1 408 413 PF00069 0.221
MOD_NEK2_1 88 93 PF00069 0.220
MOD_PIKK_1 260 266 PF00454 0.382
MOD_PIKK_1 289 295 PF00454 0.206
MOD_PKA_2 277 283 PF00069 0.340
MOD_PKA_2 385 391 PF00069 0.286
MOD_Plk_1 234 240 PF00069 0.246
MOD_Plk_1 260 266 PF00069 0.407
MOD_Plk_2-3 10 16 PF00069 0.384
MOD_Plk_4 164 170 PF00069 0.317
MOD_Plk_4 176 182 PF00069 0.239
MOD_Plk_4 208 214 PF00069 0.195
MOD_Plk_4 297 303 PF00069 0.334
MOD_Plk_4 305 311 PF00069 0.269
MOD_Plk_4 338 344 PF00069 0.231
MOD_Plk_4 416 422 PF00069 0.330
MOD_ProDKin_1 113 119 PF00069 0.221
MOD_ProDKin_1 162 168 PF00069 0.275
MOD_ProDKin_1 311 317 PF00069 0.230
MOD_ProDKin_1 336 342 PF00069 0.283
MOD_ProDKin_1 398 404 PF00069 0.488
MOD_SUMO_for_1 204 207 PF00179 0.348
MOD_SUMO_rev_2 4 11 PF00179 0.216
MOD_SUMO_rev_2 51 61 PF00179 0.332
TRG_DiLeu_BaEn_3 14 20 PF01217 0.265
TRG_ENDOCYTIC_2 118 121 PF00928 0.415
TRG_ENDOCYTIC_2 159 162 PF00928 0.221
TRG_ENDOCYTIC_2 218 221 PF00928 0.493
TRG_ENDOCYTIC_2 371 374 PF00928 0.461
TRG_ENDOCYTIC_2 426 429 PF00928 0.483
TRG_ER_diArg_1 294 297 PF00400 0.218
TRG_Pf-PMV_PEXEL_1 260 264 PF00026 0.223

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL11 Leptomonas seymouri 35% 69%
A0A0S4IS53 Bodo saltans 36% 94%
A0A0S4IUU1 Bodo saltans 29% 68%
A0A1D5NSK0 Danio rerio 24% 72%
A0A1X0NDG7 Trypanosomatidae 30% 69%
A0A1X0NDK2 Trypanosomatidae 33% 78%
A0A1X0NDK9 Trypanosomatidae 34% 92%
A0A1X0NDM7 Trypanosomatidae 31% 70%
A0A1X0NDU8 Trypanosomatidae 32% 68%
A0A1X0NE71 Trypanosomatidae 31% 88%
A0A1X0NER9 Trypanosomatidae 34% 70%
A0A1X0NES0 Trypanosomatidae 33% 100%
A0A1X0NET7 Trypanosomatidae 32% 87%
A0A1X0NEX7 Trypanosomatidae 33% 69%
A0A1X0NEZ6 Trypanosomatidae 31% 69%
A0A1X0NF32 Trypanosomatidae 33% 96%
A0A1X0NF41 Trypanosomatidae 33% 73%
A0A1X0NFJ0 Trypanosomatidae 32% 86%
A0A1X0NFK3 Trypanosomatidae 31% 67%
A0A1X0NFZ9 Trypanosomatidae 32% 98%
A0A1X0NG20 Trypanosomatidae 32% 73%
A0A1X0NGN3 Trypanosomatidae 34% 100%
A0A1X0NGZ3 Trypanosomatidae 33% 75%
A0A1X0NHP4 Trypanosomatidae 33% 100%
A0A1X0NHP6 Trypanosomatidae 31% 86%
A0A1X0NHQ6 Trypanosomatidae 32% 87%
A0A1X0NIJ6 Trypanosomatidae 32% 100%
A0A1X0NIZ3 Trypanosomatidae 33% 80%
A0A1X0NJC6 Trypanosomatidae 35% 100%
A0A1X0NK66 Trypanosomatidae 33% 68%
A0A1X0NKW9 Trypanosomatidae 29% 88%
A0A1X0NME2 Trypanosomatidae 32% 72%
A0A1X0NMK3 Trypanosomatidae 30% 87%
A0A1X0NMK7 Trypanosomatidae 37% 87%
A0A1X0NNK8 Trypanosomatidae 32% 68%
A0A1X0NPW0 Trypanosomatidae 32% 70%
A0A1X0NQJ5 Trypanosomatidae 34% 98%
A0A1X0NQM4 Trypanosomatidae 33% 98%
A0A1X0NQN3 Trypanosomatidae 35% 100%
A0A1X0NQU3 Trypanosomatidae 38% 100%
A0A1X0NQU4 Trypanosomatidae 33% 70%
A0A1X0NQW6 Trypanosomatidae 33% 79%
A0A1X0NR02 Trypanosomatidae 38% 100%
A0A1X0NRF3 Trypanosomatidae 33% 67%
A0A1X0NRY8 Trypanosomatidae 38% 82%
A0A1X0NTJ1 Trypanosomatidae 33% 100%
A0A1X0NU16 Trypanosomatidae 36% 75%
A0A1X0NV28 Trypanosomatidae 37% 76%
A0A1X0NW07 Trypanosomatidae 30% 72%
A0A1X0NX94 Trypanosomatidae 33% 69%
A0A1X0NXQ4 Trypanosomatidae 31% 66%
A0A1X0NY94 Trypanosomatidae 38% 100%
A0A1X0NYE3 Trypanosomatidae 33% 72%
A0A1X0NYE7 Trypanosomatidae 32% 88%
A0A1X0NYN2 Trypanosomatidae 33% 85%
A0A1X0NYS5 Trypanosomatidae 36% 75%
A0A1X0NYZ2 Trypanosomatidae 37% 80%
A0A1X0NZ46 Trypanosomatidae 30% 77%
A0A1X0NZ63 Trypanosomatidae 31% 71%
A0A1X0NZN6 Trypanosomatidae 29% 69%
A0A1X0P055 Trypanosomatidae 37% 76%
A0A1X0P0C4 Trypanosomatidae 31% 88%
A0A1X0P154 Trypanosomatidae 30% 75%
A0A1X0P331 Trypanosomatidae 34% 79%
A0A1X0P3S2 Trypanosomatidae 29% 81%
A0A1X0P4L8 Trypanosomatidae 32% 88%
A0A1X0P4Y5 Trypanosomatidae 30% 70%
A0A1X0P544 Trypanosomatidae 31% 70%
A0A1X0P5K2 Trypanosomatidae 36% 100%
A0A1X0P7R3 Trypanosomatidae 35% 80%
A0A1X0P8B4 Trypanosomatidae 34% 90%
A0A1X0P9Z4 Trypanosomatidae 33% 82%
A0A1X0PB04 Trypanosomatidae 33% 88%
A0A3Q8I8N3 Leishmania donovani 59% 75%
A0A3Q8I8P8 Leishmania donovani 60% 75%
A0A3Q8I8S6 Leishmania donovani 61% 70%
A0A3Q8I8S9 Leishmania donovani 60% 75%
A0A3Q8IAZ8 Leishmania donovani 60% 75%
A0A3Q8IC35 Leishmania donovani 60% 75%
A0A3Q8IC44 Leishmania donovani 60% 76%
A0A3Q8IH61 Leishmania donovani 60% 76%
A0A3Q8IIN4 Leishmania donovani 34% 71%
A0A3R7JUH9 Trypanosoma rangeli 39% 100%
A0A3R7JUS0 Trypanosoma rangeli 34% 97%
A0A3R7JV87 Trypanosoma rangeli 33% 85%
A0A3R7K7T9 Trypanosoma rangeli 35% 75%
A0A3R7K9S1 Trypanosoma rangeli 33% 87%
A0A3R7KFR4 Trypanosoma rangeli 33% 100%
A0A3R7KLR6 Trypanosoma rangeli 34% 70%
A0A3R7KMY2 Trypanosoma rangeli 36% 67%
A0A3R7LFC4 Trypanosoma rangeli 34% 67%
A0A3R7LFZ4 Trypanosoma rangeli 38% 82%
A0A3R7LWG1 Trypanosoma rangeli 33% 79%
A0A3R7LX11 Trypanosoma rangeli 36% 80%
A0A3R7M1R8 Trypanosoma rangeli 35% 78%
A0A3R7M574 Trypanosoma rangeli 35% 70%
A0A3R7M5K4 Trypanosoma rangeli 38% 87%
A0A3R7MTS2 Trypanosoma rangeli 39% 99%
A0A3R7MW36 Trypanosoma rangeli 34% 85%
A0A3R7MXF4 Trypanosoma rangeli 36% 74%
A0A3R7N1W7 Trypanosoma rangeli 33% 77%
A0A3R7N7I3 Trypanosoma rangeli 44% 100%
A0A3R7NTI8 Trypanosoma rangeli 34% 78%
A0A3R7R2J4 Trypanosoma rangeli 34% 70%
A0A3R7R5R1 Trypanosoma rangeli 37% 75%
A0A3R7R818 Trypanosoma rangeli 32% 86%
A0A3S5H6G0 Leishmania donovani 60% 75%
A0A3S5IQY2 Trypanosoma rangeli 40% 87%
A0A3S7WR43 Leishmania donovani 60% 75%
A0A3S7WR46 Leishmania donovani 60% 75%
A0A3S7WR60 Leishmania donovani 60% 75%
A0A3S7X192 Leishmania donovani 38% 80%
A0A422MP17 Trypanosoma rangeli 38% 100%
A0A422MQQ6 Trypanosoma rangeli 32% 100%
A0A422MTE4 Trypanosoma rangeli 32% 97%
A0A422MU95 Trypanosoma rangeli 34% 79%
A0A422MUP1 Trypanosoma rangeli 40% 100%
A0A422MVF5 Trypanosoma rangeli 31% 80%
A0A422MVS3 Trypanosoma rangeli 36% 87%
A0A422MZ47 Trypanosoma rangeli 38% 80%
A0A422MZG4 Trypanosoma rangeli 35% 77%
A0A422N361 Trypanosoma rangeli 34% 81%
A0A422N7Q6 Trypanosoma rangeli 33% 70%
A0A422NDS2 Trypanosoma rangeli 31% 77%
A0A422NDT3 Trypanosoma rangeli 31% 79%
A0A422NP82 Trypanosoma rangeli 39% 79%
A4H626 Leishmania braziliensis 74% 100%
A4H627 Leishmania braziliensis 97% 100%
A4H629 Leishmania braziliensis 68% 100%
A4H630 Leishmania braziliensis 67% 100%
A4H631 Leishmania braziliensis 68% 100%
A4H632 Leishmania braziliensis 68% 100%
A4H633 Leishmania braziliensis 67% 100%
A4H634 Leishmania braziliensis 69% 100%
A4H635 Leishmania braziliensis 68% 100%
A4H637 Leishmania braziliensis 69% 72%
A4H638 Leishmania braziliensis 65% 76%
A4H639 Leishmania braziliensis 69% 74%
A4H640 Leishmania braziliensis 69% 72%
A4H6D3 Leishmania braziliensis 79% 77%
A4H6D7 Leishmania braziliensis 96% 77%
A4H6D8 Leishmania braziliensis 71% 77%
A4H6D9 Leishmania braziliensis 73% 77%
A4H6E1 Leishmania braziliensis 79% 77%
A4H6E2 Leishmania braziliensis 78% 78%
A4H6E3 Leishmania braziliensis 69% 78%
A4H6E4 Leishmania braziliensis 72% 100%
A4H6E5 Leishmania braziliensis 65% 88%
A4H6E7 Leishmania braziliensis 66% 100%
A4HJI2 Leishmania braziliensis 33% 69%
A4HUF6 Leishmania infantum 60% 75%
A4HUF8 Leishmania infantum 61% 75%
A4HUF9 Leishmania infantum 62% 70%
A4I6X5 Leishmania infantum 34% 71%
C9ZUT5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 77%
D0A1R8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 76%
D0A7S8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 67%
D0A7W4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
D0A855 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 73%
E9AHH5 Leishmania infantum 38% 80%
E9AN53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 69%
E9AN54 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 75%
E9AN55 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 70%
E9AN56 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 70%
E9AN57 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 75%
E9AZL8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 80%
E9B1Z9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 71%
O62446 Caenorhabditis elegans 24% 68%
P08148 Leishmania major 61% 75%
P15706 Leishmania chagasi 61% 75%
P23223 Leishmania donovani 60% 76%
P43150 Leishmania mexicana 59% 70%
Q00689 Leishmania guyanensis 66% 72%
Q06031 Crithidia fasciculata 52% 69%
Q27673 Leishmania amazonensis 60% 75%
Q4Q662 Leishmania major 33% 100%
Q4Q8L3 Leishmania major 39% 100%
Q4QHG9 Leishmania major 60% 100%
Q4QHH0 Leishmania major 61% 100%
Q4QHH1 Leishmania major 61% 100%
Q4QHH2 Leishmania major 61% 100%
Q61YG1 Caenorhabditis briggsae 24% 68%
Q6LA77 Leishmania infantum 61% 75%
Q8BMN4 Mus musculus 25% 66%
Q8MNZ1 Leishmania tropica 61% 68%
Q96KR4 Homo sapiens 23% 69%
V5A2X8 Trypanosoma cruzi 34% 93%
V5A303 Trypanosoma cruzi 38% 100%
V5A359 Trypanosoma cruzi 39% 83%
V5AII7 Trypanosoma cruzi 39% 83%
V5AJE7 Trypanosoma cruzi 34% 86%
V5AMH8 Trypanosoma cruzi 33% 95%
V5AN34 Trypanosoma cruzi 37% 100%
V5APB3 Trypanosoma cruzi 38% 100%
V5AZG8 Trypanosoma cruzi 31% 94%
V5B7J8 Trypanosoma cruzi 33% 93%
V5B9W5 Trypanosoma cruzi 30% 67%
V5BAL3 Trypanosoma cruzi 41% 89%
V5BD39 Trypanosoma cruzi 43% 100%
V5BLT3 Trypanosoma cruzi 31% 71%
V5CI97 Trypanosoma cruzi 31% 71%
V5CIA7 Trypanosoma cruzi 34% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS