LeishMANIAdb
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Leishmanolysin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leishmanolysin
Gene product:
metallo-peptidase, Clan MA(M), Family M8
Species:
Leishmania braziliensis
UniProt:
A4H635_LEIBR
TriTrypDb:
LbrM.10.0560 , LBRM2903_100013100
Length:
623

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 51
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 41, no: 9
NetGPI no yes: 0, no: 50
Cellular components
Term Name Level Count
GO:0016020 membrane 2 51
GO:0110165 cellular anatomical entity 1 51
GO:0005737 cytoplasm 2 4
GO:0018995 host cellular component 2 4
GO:0033643 host cell part 3 4
GO:0033646 host intracellular part 4 4
GO:0033647 host intracellular organelle 5 4
GO:0033648 host intracellular membrane-bounded organelle 6 4
GO:0042025 host cell nucleus 7 4

Expansion

Sequence features

A4H635
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H635

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 51
GO:0006807 nitrogen compound metabolic process 2 51
GO:0007155 cell adhesion 2 51
GO:0008152 metabolic process 1 51
GO:0009987 cellular process 1 51
GO:0019538 protein metabolic process 3 51
GO:0043170 macromolecule metabolic process 3 51
GO:0044238 primary metabolic process 2 51
GO:0071704 organic substance metabolic process 2 51
GO:1901564 organonitrogen compound metabolic process 3 51
GO:0009966 regulation of signal transduction 4 4
GO:0010646 regulation of cell communication 4 4
GO:0010749 regulation of nitric oxide mediated signal transduction 6 4
GO:0023051 regulation of signaling 3 4
GO:0035821 modulation of process of another organism 2 4
GO:0044003 modulation by symbiont of host process 3 4
GO:0044068 modulation by symbiont of host cellular process 4 4
GO:0044081 modulation by symbiont of host nitric oxide-mediated signal transduction 5 4
GO:0044403 biological process involved in symbiotic interaction 2 4
GO:0044419 biological process involved in interspecies interaction between organisms 1 4
GO:0044501 modulation of signal transduction in another organism 3 4
GO:0048583 regulation of response to stimulus 3 4
GO:0050789 regulation of biological process 2 4
GO:0050794 regulation of cellular process 3 4
GO:0051701 biological process involved in interaction with host 3 4
GO:0052027 modulation by symbiont of host signal transduction pathway 4 4
GO:0065007 biological regulation 1 4
GO:0075130 modulation by symbiont of host protein kinase-mediated signal transduction 5 4
GO:1902531 regulation of intracellular signal transduction 5 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 51
GO:0004175 endopeptidase activity 4 51
GO:0004222 metalloendopeptidase activity 5 51
GO:0005488 binding 1 51
GO:0008233 peptidase activity 3 51
GO:0008237 metallopeptidase activity 4 51
GO:0016787 hydrolase activity 2 51
GO:0043167 ion binding 2 51
GO:0043169 cation binding 3 51
GO:0046872 metal ion binding 4 51
GO:0140096 catalytic activity, acting on a protein 2 51
GO:0008047 enzyme activator activity 3 4
GO:0008160 protein tyrosine phosphatase activator activity 6 4
GO:0019208 phosphatase regulator activity 3 4
GO:0019211 phosphatase activator activity 4 4
GO:0019888 protein phosphatase regulator activity 4 4
GO:0030234 enzyme regulator activity 2 4
GO:0072542 protein phosphatase activator activity 5 4
GO:0098772 molecular function regulator activity 1 4
GO:0140677 molecular function activator activity 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 126 132 PF00089 0.461
CLV_NRD_NRD_1 11 13 PF00675 0.711
CLV_PCSK_KEX2_1 10 12 PF00082 0.720
CLV_PCSK_KEX2_1 150 152 PF00082 0.623
CLV_PCSK_PC1ET2_1 150 152 PF00082 0.612
CLV_PCSK_SKI1_1 151 155 PF00082 0.597
CLV_PCSK_SKI1_1 258 262 PF00082 0.605
CLV_PCSK_SKI1_1 336 340 PF00082 0.541
DEG_SCF_FBW7_1 533 540 PF00400 0.283
DEG_SPOP_SBC_1 91 95 PF00917 0.315
DOC_CKS1_1 429 434 PF01111 0.262
DOC_CYCLIN_yCln2_LP_2 342 348 PF00134 0.343
DOC_PP2B_LxvP_1 342 345 PF13499 0.428
DOC_PP2B_LxvP_1 70 73 PF13499 0.315
DOC_PP4_FxxP_1 192 195 PF00568 0.448
DOC_PP4_FxxP_1 292 295 PF00568 0.334
DOC_USP7_MATH_1 2 6 PF00917 0.581
DOC_USP7_MATH_1 201 205 PF00917 0.242
DOC_USP7_MATH_1 496 500 PF00917 0.339
DOC_USP7_MATH_1 537 541 PF00917 0.295
DOC_USP7_MATH_1 63 67 PF00917 0.280
DOC_USP7_MATH_1 73 77 PF00917 0.319
DOC_WW_Pin1_4 428 433 PF00397 0.268
DOC_WW_Pin1_4 471 476 PF00397 0.302
DOC_WW_Pin1_4 533 538 PF00397 0.448
DOC_WW_Pin1_4 59 64 PF00397 0.240
DOC_WW_Pin1_4 92 97 PF00397 0.333
LIG_14-3-3_CanoR_1 10 19 PF00244 0.643
LIG_14-3-3_CanoR_1 108 116 PF00244 0.433
LIG_14-3-3_CanoR_1 380 387 PF00244 0.272
LIG_14-3-3_CanoR_1 413 421 PF00244 0.334
LIG_14-3-3_CanoR_1 427 432 PF00244 0.307
LIG_14-3-3_CanoR_1 52 58 PF00244 0.424
LIG_14-3-3_CanoR_1 520 525 PF00244 0.431
LIG_14-3-3_CanoR_1 586 595 PF00244 0.407
LIG_APCC_ABBA_1 163 168 PF00400 0.452
LIG_APCC_ABBA_1 357 362 PF00400 0.422
LIG_APCC_ABBA_1 480 485 PF00400 0.448
LIG_BRCT_BRCA1_1 270 274 PF00533 0.373
LIG_BRCT_BRCA1_1 382 386 PF00533 0.313
LIG_BRCT_BRCA1_1 546 550 PF00533 0.448
LIG_FHA_1 104 110 PF00498 0.370
LIG_FHA_1 111 117 PF00498 0.372
LIG_FHA_1 183 189 PF00498 0.314
LIG_FHA_1 194 200 PF00498 0.330
LIG_FHA_1 225 231 PF00498 0.343
LIG_FHA_1 255 261 PF00498 0.395
LIG_FHA_1 354 360 PF00498 0.439
LIG_FHA_1 414 420 PF00498 0.421
LIG_FHA_1 421 427 PF00498 0.358
LIG_FHA_1 519 525 PF00498 0.430
LIG_FHA_1 597 603 PF00498 0.382
LIG_FHA_2 115 121 PF00498 0.282
LIG_FHA_2 139 145 PF00498 0.373
LIG_FHA_2 369 375 PF00498 0.281
LIG_FHA_2 404 410 PF00498 0.238
LIG_FHA_2 534 540 PF00498 0.301
LIG_GBD_Chelix_1 614 622 PF00786 0.305
LIG_IRF3_LxIS_1 614 621 PF10401 0.255
LIG_LIR_Apic_2 156 160 PF02991 0.275
LIG_LIR_Apic_2 191 195 PF02991 0.434
LIG_LIR_Apic_2 308 313 PF02991 0.269
LIG_LIR_Apic_2 428 432 PF02991 0.249
LIG_LIR_Gen_1 314 322 PF02991 0.447
LIG_LIR_Gen_1 435 445 PF02991 0.333
LIG_LIR_Gen_1 479 487 PF02991 0.323
LIG_LIR_Nem_3 103 107 PF02991 0.341
LIG_LIR_Nem_3 207 211 PF02991 0.419
LIG_LIR_Nem_3 314 320 PF02991 0.410
LIG_LIR_Nem_3 435 440 PF02991 0.369
LIG_LIR_Nem_3 449 454 PF02991 0.336
LIG_LIR_Nem_3 479 483 PF02991 0.331
LIG_MLH1_MIPbox_1 271 275 PF16413 0.260
LIG_PCNA_yPIPBox_3 566 577 PF02747 0.301
LIG_Pex14_1 399 403 PF04695 0.437
LIG_Pex14_2 270 274 PF04695 0.386
LIG_Pex14_2 440 444 PF04695 0.273
LIG_PTB_Apo_2 202 209 PF02174 0.437
LIG_SH2_CRK 310 314 PF00017 0.270
LIG_SH2_CRK 352 356 PF00017 0.452
LIG_SH2_CRK 429 433 PF00017 0.281
LIG_SH2_GRB2like 461 464 PF00017 0.264
LIG_SH2_PTP2 561 564 PF00017 0.445
LIG_SH2_SRC 157 160 PF00017 0.292
LIG_SH2_SRC 317 320 PF00017 0.336
LIG_SH2_SRC 561 564 PF00017 0.445
LIG_SH2_STAP1 522 526 PF00017 0.448
LIG_SH2_STAT3 522 525 PF00017 0.433
LIG_SH2_STAT5 157 160 PF00017 0.317
LIG_SH2_STAT5 211 214 PF00017 0.430
LIG_SH2_STAT5 317 320 PF00017 0.409
LIG_SH2_STAT5 352 355 PF00017 0.375
LIG_SH2_STAT5 436 439 PF00017 0.432
LIG_SH2_STAT5 454 457 PF00017 0.265
LIG_SH2_STAT5 532 535 PF00017 0.381
LIG_SH2_STAT5 555 558 PF00017 0.445
LIG_SH2_STAT5 561 564 PF00017 0.379
LIG_SH2_STAT5 74 77 PF00017 0.422
LIG_SH3_3 213 219 PF00018 0.302
LIG_SH3_3 490 496 PF00018 0.298
LIG_SUMO_SIM_par_1 616 621 PF11976 0.286
LIG_TYR_ITIM 315 320 PF00017 0.432
MOD_CK1_1 193 199 PF00069 0.232
MOD_CK1_1 214 220 PF00069 0.529
MOD_CK1_1 328 334 PF00069 0.467
MOD_CK1_1 471 477 PF00069 0.400
MOD_CK1_1 5 11 PF00069 0.668
MOD_CK1_1 554 560 PF00069 0.357
MOD_CK1_1 76 82 PF00069 0.337
MOD_CK2_1 368 374 PF00069 0.542
MOD_CK2_1 403 409 PF00069 0.242
MOD_CK2_1 533 539 PF00069 0.342
MOD_GlcNHglycan 325 328 PF01048 0.455
MOD_GlcNHglycan 346 349 PF01048 0.320
MOD_GlcNHglycan 448 451 PF01048 0.398
MOD_GlcNHglycan 529 532 PF01048 0.469
MOD_GlcNHglycan 546 549 PF01048 0.273
MOD_GlcNHglycan 67 70 PF01048 0.506
MOD_GlcNHglycan 75 78 PF01048 0.390
MOD_GlcNHglycan 81 84 PF01048 0.308
MOD_GSK3_1 110 117 PF00069 0.370
MOD_GSK3_1 175 182 PF00069 0.387
MOD_GSK3_1 193 200 PF00069 0.364
MOD_GSK3_1 254 261 PF00069 0.425
MOD_GSK3_1 428 435 PF00069 0.321
MOD_GSK3_1 496 503 PF00069 0.324
MOD_GSK3_1 514 521 PF00069 0.384
MOD_GSK3_1 533 540 PF00069 0.302
MOD_GSK3_1 586 593 PF00069 0.377
MOD_GSK3_1 59 66 PF00069 0.248
MOD_GSK3_1 78 85 PF00069 0.319
MOD_GSK3_1 90 97 PF00069 0.304
MOD_N-GLC_1 282 287 PF02516 0.311
MOD_N-GLC_1 297 302 PF02516 0.365
MOD_N-GLC_1 380 385 PF02516 0.333
MOD_N-GLC_1 394 399 PF02516 0.442
MOD_N-GLC_1 404 409 PF02516 0.292
MOD_NEK2_1 268 273 PF00069 0.469
MOD_NEK2_1 3 8 PF00069 0.546
MOD_NEK2_1 514 519 PF00069 0.252
MOD_NEK2_1 618 623 PF00069 0.433
MOD_NEK2_1 90 95 PF00069 0.301
MOD_NEK2_2 269 274 PF00069 0.274
MOD_PIKK_1 394 400 PF00454 0.421
MOD_PK_1 520 526 PF00069 0.416
MOD_PKA_1 10 16 PF00069 0.573
MOD_PKA_2 10 16 PF00069 0.541
MOD_PKA_2 128 134 PF00069 0.308
MOD_PKA_2 179 185 PF00069 0.254
MOD_PKA_2 412 418 PF00069 0.378
MOD_PKA_2 496 502 PF00069 0.275
MOD_PKA_2 526 532 PF00069 0.355
MOD_PKA_2 590 596 PF00069 0.376
MOD_Plk_1 190 196 PF00069 0.242
MOD_Plk_1 394 400 PF00069 0.420
MOD_Plk_2-3 144 150 PF00069 0.440
MOD_Plk_4 153 159 PF00069 0.347
MOD_Plk_4 269 275 PF00069 0.372
MOD_Plk_4 432 438 PF00069 0.373
MOD_Plk_4 551 557 PF00069 0.374
MOD_Plk_4 94 100 PF00069 0.340
MOD_ProDKin_1 428 434 PF00069 0.285
MOD_ProDKin_1 471 477 PF00069 0.332
MOD_ProDKin_1 533 539 PF00069 0.537
MOD_ProDKin_1 59 65 PF00069 0.245
MOD_ProDKin_1 92 98 PF00069 0.376
MOD_SUMO_for_1 338 341 PF00179 0.387
TRG_DiLeu_BaEn_3 148 154 PF01217 0.316
TRG_ENDOCYTIC_2 317 320 PF00928 0.481
TRG_ENDOCYTIC_2 352 355 PF00928 0.542
TRG_ENDOCYTIC_2 454 457 PF00928 0.420
TRG_ENDOCYTIC_2 561 564 PF00928 0.532
TRG_ER_diArg_1 10 12 PF00400 0.637
TRG_ER_diArg_1 169 172 PF00400 0.282

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL11 Leptomonas seymouri 36% 95%
A0A0S4IN60 Bodo saltans 31% 69%
A0A0S4IUT6 Bodo saltans 30% 76%
A0A0S4IYM3 Bodo saltans 31% 86%
A0A1L8HYT7 Xenopus laevis 23% 87%
A0A1X0NDG7 Trypanosomatidae 30% 95%
A0A1X0NDJ3 Trypanosomatidae 27% 86%
A0A1X0NDK2 Trypanosomatidae 33% 100%
A0A1X0NDK7 Trypanosomatidae 29% 87%
A0A1X0NDK9 Trypanosomatidae 30% 100%
A0A1X0NDM7 Trypanosomatidae 29% 97%
A0A1X0NDU8 Trypanosomatidae 29% 94%
A0A1X0NE71 Trypanosomatidae 30% 100%
A0A1X0NEE9 Trypanosomatidae 28% 67%
A0A1X0NER9 Trypanosomatidae 33% 97%
A0A1X0NET7 Trypanosomatidae 35% 100%
A0A1X0NEX7 Trypanosomatidae 32% 95%
A0A1X0NEZ6 Trypanosomatidae 31% 95%
A0A1X0NF32 Trypanosomatidae 32% 100%
A0A1X0NF41 Trypanosomatidae 30% 100%
A0A1X0NFJ0 Trypanosomatidae 31% 100%
A0A1X0NFK3 Trypanosomatidae 29% 93%
A0A1X0NFS0 Trypanosomatidae 31% 72%
A0A1X0NFT1 Trypanosomatidae 31% 68%
A0A1X0NFU4 Trypanosomatidae 29% 76%
A0A1X0NFZ9 Trypanosomatidae 34% 100%
A0A1X0NG20 Trypanosomatidae 31% 100%
A0A1X0NGP3 Trypanosomatidae 30% 73%
A0A1X0NGY3 Trypanosomatidae 30% 81%
A0A1X0NGZ3 Trypanosomatidae 32% 100%
A0A1X0NH86 Trypanosomatidae 32% 71%
A0A1X0NHP6 Trypanosomatidae 32% 100%
A0A1X0NHQ6 Trypanosomatidae 33% 100%
A0A1X0NI38 Trypanosomatidae 28% 71%
A0A1X0NI74 Trypanosomatidae 31% 83%
A0A1X0NII4 Trypanosomatidae 29% 74%
A0A1X0NIZ3 Trypanosomatidae 32% 100%
A0A1X0NJS3 Trypanosomatidae 29% 95%
A0A1X0NJU4 Trypanosomatidae 29% 72%
A0A1X0NK29 Trypanosomatidae 30% 67%
A0A1X0NK66 Trypanosomatidae 32% 94%
A0A1X0NKJ8 Trypanosomatidae 29% 84%
A0A1X0NKW9 Trypanosomatidae 31% 100%
A0A1X0NME2 Trypanosomatidae 31% 99%
A0A1X0NMK3 Trypanosomatidae 28% 100%
A0A1X0NMK7 Trypanosomatidae 38% 100%
A0A1X0NMV0 Trypanosomatidae 32% 85%
A0A1X0NN43 Trypanosomatidae 30% 87%
A0A1X0NNK8 Trypanosomatidae 29% 95%
A0A1X0NP64 Trypanosomatidae 29% 70%
A0A1X0NPW0 Trypanosomatidae 31% 97%
A0A1X0NQM4 Trypanosomatidae 34% 100%
A0A1X0NQN3 Trypanosomatidae 37% 100%
A0A1X0NQU4 Trypanosomatidae 37% 97%
A0A1X0NQW6 Trypanosomatidae 35% 100%
A0A1X0NRF3 Trypanosomatidae 32% 93%
A0A1X0NRY8 Trypanosomatidae 39% 100%
A0A1X0NU16 Trypanosomatidae 34% 100%
A0A1X0NUR2 Trypanosomatidae 34% 85%
A0A1X0NV28 Trypanosomatidae 35% 100%
A0A1X0NVC3 Trypanosomatidae 30% 91%
A0A1X0NVE0 Trypanosomatidae 28% 80%
A0A1X0NW07 Trypanosomatidae 26% 100%
A0A1X0NX94 Trypanosomatidae 30% 96%
A0A1X0NX98 Trypanosomatidae 30% 78%
A0A1X0NXB6 Trypanosomatidae 30% 88%
A0A1X0NXH6 Trypanosomatidae 33% 85%
A0A1X0NXQ4 Trypanosomatidae 29% 92%
A0A1X0NXR7 Trypanosomatidae 33% 83%
A0A1X0NYE3 Trypanosomatidae 33% 100%
A0A1X0NYE7 Trypanosomatidae 32% 100%
A0A1X0NYN2 Trypanosomatidae 35% 100%
A0A1X0NYN4 Trypanosomatidae 29% 88%
A0A1X0NYS5 Trypanosomatidae 35% 100%
A0A1X0NYZ2 Trypanosomatidae 39% 100%
A0A1X0NZ46 Trypanosomatidae 28% 100%
A0A1X0NZ63 Trypanosomatidae 30% 98%
A0A1X0NZN6 Trypanosomatidae 28% 96%
A0A1X0P055 Trypanosomatidae 37% 100%
A0A1X0P154 Trypanosomatidae 28% 100%
A0A1X0P331 Trypanosomatidae 33% 100%
A0A1X0P3K0 Trypanosomatidae 28% 86%
A0A1X0P3S2 Trypanosomatidae 27% 100%
A0A1X0P4L8 Trypanosomatidae 31% 100%
A0A1X0P4Y5 Trypanosomatidae 28% 97%
A0A1X0P5J0 Trypanosomatidae 31% 91%
A0A1X0P7K5 Trypanosomatidae 28% 70%
A0A1X0P7R3 Trypanosomatidae 37% 100%
A0A1X0P8B4 Trypanosomatidae 34% 100%
A0A1X0P9Z4 Trypanosomatidae 32% 100%
A0A1X0PB04 Trypanosomatidae 32% 100%
A0A3Q8I8N3 Leishmania donovani 62% 100%
A0A3Q8I8P8 Leishmania donovani 63% 100%
A0A3Q8I8S6 Leishmania donovani 66% 97%
A0A3Q8I8S9 Leishmania donovani 63% 100%
A0A3Q8IAZ8 Leishmania donovani 62% 100%
A0A3Q8IC35 Leishmania donovani 63% 100%
A0A3Q8IC44 Leishmania donovani 63% 100%
A0A3Q8IH61 Leishmania donovani 63% 100%
A0A3Q8IIN4 Leishmania donovani 39% 98%
A0A3R7JT49 Trypanosoma rangeli 36% 74%
A0A3R7JTB6 Trypanosoma rangeli 33% 89%
A0A3R7JV87 Trypanosoma rangeli 35% 100%
A0A3R7K7T9 Trypanosoma rangeli 35% 100%
A0A3R7K9S1 Trypanosoma rangeli 35% 100%
A0A3R7KB14 Trypanosoma rangeli 35% 71%
A0A3R7KLR6 Trypanosoma rangeli 34% 97%
A0A3R7KMY2 Trypanosoma rangeli 33% 93%
A0A3R7LFC4 Trypanosoma rangeli 34% 92%
A0A3R7LFZ4 Trypanosoma rangeli 36% 100%
A0A3R7LWG1 Trypanosoma rangeli 35% 100%
A0A3R7LX11 Trypanosoma rangeli 37% 100%
A0A3R7M1R8 Trypanosoma rangeli 36% 100%
A0A3R7M574 Trypanosoma rangeli 33% 97%
A0A3R7M7N6 Trypanosoma rangeli 37% 91%
A0A3R7MTS2 Trypanosoma rangeli 38% 100%
A0A3R7MW36 Trypanosoma rangeli 33% 100%
A0A3R7MXF4 Trypanosoma rangeli 38% 100%
A0A3R7N1W7 Trypanosoma rangeli 35% 100%
A0A3R7N289 Trypanosoma rangeli 34% 86%
A0A3R7NTI8 Trypanosoma rangeli 36% 100%
A0A3R7R2J4 Trypanosoma rangeli 35% 96%
A0A3R7R5R1 Trypanosoma rangeli 33% 100%
A0A3R7R818 Trypanosoma rangeli 33% 100%
A0A3S5H6G0 Leishmania donovani 63% 100%
A0A3S5IQY2 Trypanosoma rangeli 38% 100%
A0A3S7WR43 Leishmania donovani 62% 100%
A0A3S7WR46 Leishmania donovani 63% 100%
A0A3S7WR60 Leishmania donovani 64% 100%
A0A3S7X192 Leishmania donovani 39% 100%
A0A422MRQ6 Trypanosoma rangeli 37% 83%
A0A422MTA9 Trypanosoma rangeli 35% 86%
A0A422MU95 Trypanosoma rangeli 36% 100%
A0A422MVF5 Trypanosoma rangeli 35% 100%
A0A422MVS3 Trypanosoma rangeli 35% 100%
A0A422MW99 Trypanosoma rangeli 33% 84%
A0A422MZ47 Trypanosoma rangeli 38% 100%
A0A422MZG4 Trypanosoma rangeli 37% 100%
A0A422N361 Trypanosoma rangeli 36% 100%
A0A422N7Q6 Trypanosoma rangeli 35% 96%
A0A422NDS2 Trypanosoma rangeli 33% 100%
A0A422NDT3 Trypanosoma rangeli 32% 100%
A0A422NP82 Trypanosoma rangeli 38% 100%
A4H626 Leishmania braziliensis 73% 100%
A4H627 Leishmania braziliensis 71% 100%
A4H630 Leishmania braziliensis 89% 100%
A4H631 Leishmania braziliensis 72% 98%
A4H632 Leishmania braziliensis 80% 100%
A4H633 Leishmania braziliensis 72% 99%
A4H634 Leishmania braziliensis 95% 100%
A4H636 Leishmania braziliensis 68% 100%
A4H637 Leishmania braziliensis 94% 100%
A4H638 Leishmania braziliensis 78% 100%
A4H639 Leishmania braziliensis 81% 100%
A4H640 Leishmania braziliensis 95% 100%
A4H6D1 Leishmania braziliensis 73% 100%
A4H6D3 Leishmania braziliensis 73% 100%
A4H6D5 Leishmania braziliensis 73% 88%
A4H6D7 Leishmania braziliensis 70% 100%
A4H6D8 Leishmania braziliensis 71% 100%
A4H6D9 Leishmania braziliensis 71% 100%
A4H6E0 Leishmania braziliensis 74% 88%
A4H6E1 Leishmania braziliensis 72% 100%
A4H6E2 Leishmania braziliensis 73% 100%
A4H6E3 Leishmania braziliensis 72% 100%
A4H6E5 Leishmania braziliensis 89% 100%
A4HJI2 Leishmania braziliensis 38% 96%
A4HUF6 Leishmania infantum 63% 100%
A4HUF8 Leishmania infantum 63% 100%
A4HUF9 Leishmania infantum 67% 97%
A4HUG0 Leishmania infantum 62% 82%
A4I6X5 Leishmania infantum 39% 98%
C9ZUT5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A1R8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
D0A7S8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 92%
D0A855 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9AHH5 Leishmania infantum 40% 100%
E9AN53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 95%
E9AN54 Leishmania mexicana (strain MHOM/GT/2001/U1103) 63% 100%
E9AN55 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 97%
E9AN56 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 96%
E9AN57 Leishmania mexicana (strain MHOM/GT/2001/U1103) 63% 100%
E9AZL8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B1Z9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 98%
P08148 Leishmania major 65% 100%
P15706 Leishmania chagasi 63% 100%
P23223 Leishmania donovani 63% 100%
P43150 Leishmania mexicana 65% 96%
Q00689 Leishmania guyanensis 87% 100%
Q06031 Crithidia fasciculata 55% 95%
Q27673 Leishmania amazonensis 63% 100%
Q29AK2 Drosophila pseudoobscura pseudoobscura 24% 91%
Q4Q662 Leishmania major 37% 100%
Q4Q8L3 Leishmania major 38% 100%
Q4QHG9 Leishmania major 64% 98%
Q4QHH0 Leishmania major 67% 100%
Q4QHH1 Leishmania major 65% 98%
Q4QHH2 Leishmania major 64% 98%
Q61YG1 Caenorhabditis briggsae 26% 94%
Q6LA77 Leishmania infantum 63% 100%
Q8BMN4 Mus musculus 26% 91%
Q8MNZ1 Leishmania tropica 67% 95%
Q96KR4 Homo sapiens 24% 95%
Q9VH19 Drosophila melanogaster 23% 91%
V5A359 Trypanosoma cruzi 39% 100%
V5A488 Trypanosoma cruzi 33% 77%
V5AII7 Trypanosoma cruzi 40% 100%
V5APQ4 Trypanosoma cruzi 33% 78%
V5AX72 Trypanosoma cruzi 36% 85%
V5B5M0 Trypanosoma cruzi 36% 84%
V5BAN1 Trypanosoma cruzi 35% 79%
V5BD39 Trypanosoma cruzi 41% 100%
V5BLT3 Trypanosoma cruzi 31% 99%
V5CI97 Trypanosoma cruzi 32% 98%
V5D358 Trypanosoma cruzi 35% 73%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS