Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)
by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 2 |
| Forrest at al. (procyclic) | no | yes: 4 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 51 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | yes | yes: 41, no: 9 |
| NetGPI | no | yes: 0, no: 50 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 51 |
| GO:0110165 | cellular anatomical entity | 1 | 51 |
| GO:0005737 | cytoplasm | 2 | 4 |
| GO:0018995 | host cellular component | 2 | 4 |
| GO:0033643 | host cell part | 3 | 4 |
| GO:0033646 | host intracellular part | 4 | 4 |
| GO:0033647 | host intracellular organelle | 5 | 4 |
| GO:0033648 | host intracellular membrane-bounded organelle | 6 | 4 |
| GO:0042025 | host cell nucleus | 7 | 4 |
Related structures:
AlphaFold database: A4H634
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006508 | proteolysis | 4 | 51 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 51 |
| GO:0007155 | cell adhesion | 2 | 51 |
| GO:0008152 | metabolic process | 1 | 51 |
| GO:0009987 | cellular process | 1 | 51 |
| GO:0019538 | protein metabolic process | 3 | 51 |
| GO:0043170 | macromolecule metabolic process | 3 | 51 |
| GO:0044238 | primary metabolic process | 2 | 51 |
| GO:0071704 | organic substance metabolic process | 2 | 51 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 51 |
| GO:0009966 | regulation of signal transduction | 4 | 4 |
| GO:0010646 | regulation of cell communication | 4 | 4 |
| GO:0010749 | regulation of nitric oxide mediated signal transduction | 6 | 4 |
| GO:0023051 | regulation of signaling | 3 | 4 |
| GO:0035821 | modulation of process of another organism | 2 | 4 |
| GO:0044003 | modulation by symbiont of host process | 3 | 4 |
| GO:0044068 | modulation by symbiont of host cellular process | 4 | 4 |
| GO:0044081 | modulation by symbiont of host nitric oxide-mediated signal transduction | 5 | 4 |
| GO:0044403 | biological process involved in symbiotic interaction | 2 | 4 |
| GO:0044419 | biological process involved in interspecies interaction between organisms | 1 | 4 |
| GO:0044501 | modulation of signal transduction in another organism | 3 | 4 |
| GO:0048583 | regulation of response to stimulus | 3 | 4 |
| GO:0050789 | regulation of biological process | 2 | 4 |
| GO:0050794 | regulation of cellular process | 3 | 4 |
| GO:0051701 | biological process involved in interaction with host | 3 | 4 |
| GO:0052027 | modulation by symbiont of host signal transduction pathway | 4 | 4 |
| GO:0065007 | biological regulation | 1 | 4 |
| GO:0075130 | modulation by symbiont of host protein kinase-mediated signal transduction | 5 | 4 |
| GO:1902531 | regulation of intracellular signal transduction | 5 | 4 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 51 |
| GO:0004175 | endopeptidase activity | 4 | 51 |
| GO:0004222 | metalloendopeptidase activity | 5 | 51 |
| GO:0005488 | binding | 1 | 51 |
| GO:0008233 | peptidase activity | 3 | 51 |
| GO:0008237 | metallopeptidase activity | 4 | 51 |
| GO:0016787 | hydrolase activity | 2 | 51 |
| GO:0043167 | ion binding | 2 | 51 |
| GO:0043169 | cation binding | 3 | 51 |
| GO:0046872 | metal ion binding | 4 | 51 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 51 |
| GO:0008047 | enzyme activator activity | 3 | 4 |
| GO:0008160 | protein tyrosine phosphatase activator activity | 6 | 4 |
| GO:0019208 | phosphatase regulator activity | 3 | 4 |
| GO:0019211 | phosphatase activator activity | 4 | 4 |
| GO:0019888 | protein phosphatase regulator activity | 4 | 4 |
| GO:0030234 | enzyme regulator activity | 2 | 4 |
| GO:0072542 | protein phosphatase activator activity | 5 | 4 |
| GO:0098772 | molecular function regulator activity | 1 | 4 |
| GO:0140677 | molecular function activator activity | 2 | 4 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_MEL_PAP_1 | 125 | 131 | PF00089 | 0.412 |
| CLV_NRD_NRD_1 | 11 | 13 | PF00675 | 0.690 |
| CLV_PCSK_KEX2_1 | 10 | 12 | PF00082 | 0.693 |
| CLV_PCSK_KEX2_1 | 149 | 151 | PF00082 | 0.574 |
| CLV_PCSK_PC1ET2_1 | 149 | 151 | PF00082 | 0.563 |
| CLV_PCSK_SKI1_1 | 150 | 154 | PF00082 | 0.548 |
| CLV_PCSK_SKI1_1 | 257 | 261 | PF00082 | 0.555 |
| CLV_PCSK_SKI1_1 | 281 | 285 | PF00082 | 0.414 |
| CLV_PCSK_SKI1_1 | 335 | 339 | PF00082 | 0.492 |
| DEG_SCF_FBW7_1 | 532 | 539 | PF00400 | 0.234 |
| DEG_SPOP_SBC_1 | 90 | 94 | PF00917 | 0.266 |
| DOC_CKS1_1 | 428 | 433 | PF01111 | 0.213 |
| DOC_CYCLIN_yCln2_LP_2 | 341 | 347 | PF00134 | 0.294 |
| DOC_MAPK_gen_1 | 192 | 202 | PF00069 | 0.200 |
| DOC_MAPK_MEF2A_6 | 195 | 202 | PF00069 | 0.200 |
| DOC_PP2B_LxvP_1 | 341 | 344 | PF13499 | 0.378 |
| DOC_PP2B_LxvP_1 | 69 | 72 | PF13499 | 0.266 |
| DOC_PP4_FxxP_1 | 191 | 194 | PF00568 | 0.399 |
| DOC_PP4_FxxP_1 | 291 | 294 | PF00568 | 0.284 |
| DOC_PP4_MxPP_1 | 556 | 559 | PF00568 | 0.190 |
| DOC_USP7_MATH_1 | 2 | 6 | PF00917 | 0.549 |
| DOC_USP7_MATH_1 | 472 | 476 | PF00917 | 0.252 |
| DOC_USP7_MATH_1 | 495 | 499 | PF00917 | 0.290 |
| DOC_USP7_MATH_1 | 536 | 540 | PF00917 | 0.246 |
| DOC_USP7_MATH_1 | 72 | 76 | PF00917 | 0.269 |
| DOC_WW_Pin1_4 | 427 | 432 | PF00397 | 0.219 |
| DOC_WW_Pin1_4 | 470 | 475 | PF00397 | 0.252 |
| DOC_WW_Pin1_4 | 532 | 537 | PF00397 | 0.399 |
| DOC_WW_Pin1_4 | 91 | 96 | PF00397 | 0.284 |
| LIG_14-3-3_CanoR_1 | 10 | 19 | PF00244 | 0.635 |
| LIG_14-3-3_CanoR_1 | 107 | 115 | PF00244 | 0.384 |
| LIG_14-3-3_CanoR_1 | 379 | 386 | PF00244 | 0.223 |
| LIG_14-3-3_CanoR_1 | 412 | 420 | PF00244 | 0.284 |
| LIG_14-3-3_CanoR_1 | 426 | 431 | PF00244 | 0.258 |
| LIG_14-3-3_CanoR_1 | 51 | 57 | PF00244 | 0.375 |
| LIG_14-3-3_CanoR_1 | 519 | 524 | PF00244 | 0.382 |
| LIG_14-3-3_CanoR_1 | 585 | 594 | PF00244 | 0.362 |
| LIG_APCC_ABBA_1 | 162 | 167 | PF00400 | 0.403 |
| LIG_APCC_ABBA_1 | 356 | 361 | PF00400 | 0.373 |
| LIG_APCC_ABBA_1 | 479 | 484 | PF00400 | 0.399 |
| LIG_BRCT_BRCA1_1 | 269 | 273 | PF00533 | 0.324 |
| LIG_BRCT_BRCA1_1 | 381 | 385 | PF00533 | 0.264 |
| LIG_BRCT_BRCA1_1 | 545 | 549 | PF00533 | 0.399 |
| LIG_FHA_1 | 103 | 109 | PF00498 | 0.320 |
| LIG_FHA_1 | 110 | 116 | PF00498 | 0.322 |
| LIG_FHA_1 | 153 | 159 | PF00498 | 0.261 |
| LIG_FHA_1 | 182 | 188 | PF00498 | 0.265 |
| LIG_FHA_1 | 197 | 203 | PF00498 | 0.285 |
| LIG_FHA_1 | 254 | 260 | PF00498 | 0.346 |
| LIG_FHA_1 | 353 | 359 | PF00498 | 0.390 |
| LIG_FHA_1 | 413 | 419 | PF00498 | 0.372 |
| LIG_FHA_1 | 420 | 426 | PF00498 | 0.309 |
| LIG_FHA_1 | 48 | 54 | PF00498 | 0.196 |
| LIG_FHA_1 | 518 | 524 | PF00498 | 0.380 |
| LIG_FHA_1 | 596 | 602 | PF00498 | 0.290 |
| LIG_FHA_2 | 114 | 120 | PF00498 | 0.232 |
| LIG_FHA_2 | 138 | 144 | PF00498 | 0.324 |
| LIG_FHA_2 | 403 | 409 | PF00498 | 0.189 |
| LIG_FHA_2 | 533 | 539 | PF00498 | 0.252 |
| LIG_LIR_Apic_2 | 155 | 159 | PF02991 | 0.226 |
| LIG_LIR_Apic_2 | 190 | 194 | PF02991 | 0.385 |
| LIG_LIR_Apic_2 | 307 | 312 | PF02991 | 0.220 |
| LIG_LIR_Apic_2 | 427 | 431 | PF02991 | 0.200 |
| LIG_LIR_Gen_1 | 313 | 321 | PF02991 | 0.397 |
| LIG_LIR_Gen_1 | 434 | 444 | PF02991 | 0.284 |
| LIG_LIR_Gen_1 | 448 | 458 | PF02991 | 0.209 |
| LIG_LIR_Gen_1 | 478 | 486 | PF02991 | 0.274 |
| LIG_LIR_Nem_3 | 102 | 106 | PF02991 | 0.291 |
| LIG_LIR_Nem_3 | 206 | 210 | PF02991 | 0.370 |
| LIG_LIR_Nem_3 | 313 | 319 | PF02991 | 0.361 |
| LIG_LIR_Nem_3 | 434 | 439 | PF02991 | 0.319 |
| LIG_LIR_Nem_3 | 448 | 453 | PF02991 | 0.286 |
| LIG_LIR_Nem_3 | 478 | 482 | PF02991 | 0.281 |
| LIG_MLH1_MIPbox_1 | 270 | 274 | PF16413 | 0.211 |
| LIG_PCNA_yPIPBox_3 | 565 | 576 | PF02747 | 0.252 |
| LIG_PDZ_Class_2 | 610 | 615 | PF00595 | 0.266 |
| LIG_Pex14_1 | 398 | 402 | PF04695 | 0.388 |
| LIG_Pex14_2 | 269 | 273 | PF04695 | 0.337 |
| LIG_PTB_Apo_2 | 201 | 208 | PF02174 | 0.388 |
| LIG_SH2_CRK | 309 | 313 | PF00017 | 0.221 |
| LIG_SH2_CRK | 351 | 355 | PF00017 | 0.403 |
| LIG_SH2_CRK | 428 | 432 | PF00017 | 0.231 |
| LIG_SH2_GRB2like | 460 | 463 | PF00017 | 0.215 |
| LIG_SH2_PTP2 | 560 | 563 | PF00017 | 0.395 |
| LIG_SH2_SRC | 156 | 159 | PF00017 | 0.243 |
| LIG_SH2_SRC | 316 | 319 | PF00017 | 0.286 |
| LIG_SH2_SRC | 560 | 563 | PF00017 | 0.395 |
| LIG_SH2_STAP1 | 521 | 525 | PF00017 | 0.399 |
| LIG_SH2_STAT3 | 521 | 524 | PF00017 | 0.384 |
| LIG_SH2_STAT5 | 121 | 124 | PF00017 | 0.241 |
| LIG_SH2_STAT5 | 156 | 159 | PF00017 | 0.268 |
| LIG_SH2_STAT5 | 210 | 213 | PF00017 | 0.380 |
| LIG_SH2_STAT5 | 316 | 319 | PF00017 | 0.360 |
| LIG_SH2_STAT5 | 351 | 354 | PF00017 | 0.326 |
| LIG_SH2_STAT5 | 435 | 438 | PF00017 | 0.383 |
| LIG_SH2_STAT5 | 531 | 534 | PF00017 | 0.331 |
| LIG_SH2_STAT5 | 554 | 557 | PF00017 | 0.395 |
| LIG_SH2_STAT5 | 560 | 563 | PF00017 | 0.330 |
| LIG_SH2_STAT5 | 592 | 595 | PF00017 | 0.190 |
| LIG_SH2_STAT5 | 73 | 76 | PF00017 | 0.373 |
| LIG_SH3_3 | 212 | 218 | PF00018 | 0.252 |
| LIG_SH3_3 | 489 | 495 | PF00018 | 0.249 |
| LIG_TYR_ITIM | 314 | 319 | PF00017 | 0.383 |
| MOD_CDK_SPxxK_3 | 470 | 477 | PF00069 | 0.217 |
| MOD_CK1_1 | 213 | 219 | PF00069 | 0.480 |
| MOD_CK1_1 | 327 | 333 | PF00069 | 0.418 |
| MOD_CK1_1 | 470 | 476 | PF00069 | 0.351 |
| MOD_CK1_1 | 5 | 11 | PF00069 | 0.652 |
| MOD_CK1_1 | 75 | 81 | PF00069 | 0.288 |
| MOD_CK2_1 | 367 | 373 | PF00069 | 0.493 |
| MOD_CK2_1 | 402 | 408 | PF00069 | 0.193 |
| MOD_CK2_1 | 472 | 478 | PF00069 | 0.263 |
| MOD_CK2_1 | 532 | 538 | PF00069 | 0.293 |
| MOD_GlcNHglycan | 324 | 327 | PF01048 | 0.406 |
| MOD_GlcNHglycan | 345 | 348 | PF01048 | 0.271 |
| MOD_GlcNHglycan | 447 | 450 | PF01048 | 0.349 |
| MOD_GlcNHglycan | 528 | 531 | PF01048 | 0.420 |
| MOD_GlcNHglycan | 545 | 548 | PF01048 | 0.224 |
| MOD_GlcNHglycan | 66 | 69 | PF01048 | 0.456 |
| MOD_GlcNHglycan | 74 | 77 | PF01048 | 0.341 |
| MOD_GlcNHglycan | 80 | 83 | PF01048 | 0.259 |
| MOD_GSK3_1 | 109 | 116 | PF00069 | 0.321 |
| MOD_GSK3_1 | 174 | 181 | PF00069 | 0.338 |
| MOD_GSK3_1 | 196 | 203 | PF00069 | 0.483 |
| MOD_GSK3_1 | 253 | 260 | PF00069 | 0.376 |
| MOD_GSK3_1 | 427 | 434 | PF00069 | 0.272 |
| MOD_GSK3_1 | 468 | 475 | PF00069 | 0.273 |
| MOD_GSK3_1 | 495 | 502 | PF00069 | 0.275 |
| MOD_GSK3_1 | 513 | 520 | PF00069 | 0.335 |
| MOD_GSK3_1 | 532 | 539 | PF00069 | 0.253 |
| MOD_GSK3_1 | 77 | 84 | PF00069 | 0.270 |
| MOD_GSK3_1 | 89 | 96 | PF00069 | 0.255 |
| MOD_LATS_1 | 45 | 51 | PF00433 | 0.204 |
| MOD_N-GLC_1 | 296 | 301 | PF02516 | 0.316 |
| MOD_N-GLC_1 | 393 | 398 | PF02516 | 0.393 |
| MOD_N-GLC_1 | 403 | 408 | PF02516 | 0.243 |
| MOD_N-GLC_1 | 440 | 445 | PF02516 | 0.230 |
| MOD_N-GLC_2 | 388 | 390 | PF02516 | 0.293 |
| MOD_NEK2_1 | 267 | 272 | PF00069 | 0.420 |
| MOD_NEK2_1 | 3 | 8 | PF00069 | 0.525 |
| MOD_NEK2_1 | 513 | 518 | PF00069 | 0.203 |
| MOD_NEK2_1 | 89 | 94 | PF00069 | 0.252 |
| MOD_NEK2_2 | 268 | 273 | PF00069 | 0.225 |
| MOD_PIKK_1 | 393 | 399 | PF00454 | 0.372 |
| MOD_PK_1 | 519 | 525 | PF00069 | 0.367 |
| MOD_PKA_1 | 10 | 16 | PF00069 | 0.568 |
| MOD_PKA_2 | 10 | 16 | PF00069 | 0.536 |
| MOD_PKA_2 | 127 | 133 | PF00069 | 0.259 |
| MOD_PKA_2 | 178 | 184 | PF00069 | 0.205 |
| MOD_PKA_2 | 411 | 417 | PF00069 | 0.329 |
| MOD_PKA_2 | 495 | 501 | PF00069 | 0.226 |
| MOD_PKA_2 | 525 | 531 | PF00069 | 0.306 |
| MOD_Plk_1 | 367 | 373 | PF00069 | 0.246 |
| MOD_Plk_1 | 393 | 399 | PF00069 | 0.371 |
| MOD_Plk_1 | 440 | 446 | PF00069 | 0.244 |
| MOD_Plk_2-3 | 143 | 149 | PF00069 | 0.391 |
| MOD_Plk_4 | 152 | 158 | PF00069 | 0.298 |
| MOD_Plk_4 | 268 | 274 | PF00069 | 0.323 |
| MOD_Plk_4 | 431 | 437 | PF00069 | 0.323 |
| MOD_Plk_4 | 550 | 556 | PF00069 | 0.325 |
| MOD_Plk_4 | 93 | 99 | PF00069 | 0.290 |
| MOD_ProDKin_1 | 427 | 433 | PF00069 | 0.236 |
| MOD_ProDKin_1 | 470 | 476 | PF00069 | 0.282 |
| MOD_ProDKin_1 | 532 | 538 | PF00069 | 0.488 |
| MOD_ProDKin_1 | 91 | 97 | PF00069 | 0.327 |
| MOD_SUMO_for_1 | 337 | 340 | PF00179 | 0.338 |
| TRG_DiLeu_BaEn_3 | 147 | 153 | PF01217 | 0.267 |
| TRG_ENDOCYTIC_2 | 316 | 319 | PF00928 | 0.432 |
| TRG_ENDOCYTIC_2 | 351 | 354 | PF00928 | 0.493 |
| TRG_ENDOCYTIC_2 | 560 | 563 | PF00928 | 0.483 |
| TRG_ER_diArg_1 | 10 | 12 | PF00400 | 0.619 |
| TRG_ER_diArg_1 | 168 | 171 | PF00400 | 0.232 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IL11 | Leptomonas seymouri | 36% | 94% |
| A0A0S4IN60 | Bodo saltans | 33% | 68% |
| A0A0S4IUT6 | Bodo saltans | 30% | 75% |
| A0A0S4IYM3 | Bodo saltans | 32% | 85% |
| A0A1L8HYT7 | Xenopus laevis | 22% | 85% |
| A0A1X0NDG7 | Trypanosomatidae | 30% | 94% |
| A0A1X0NDJ3 | Trypanosomatidae | 27% | 85% |
| A0A1X0NDK2 | Trypanosomatidae | 34% | 100% |
| A0A1X0NDK7 | Trypanosomatidae | 30% | 86% |
| A0A1X0NDK9 | Trypanosomatidae | 30% | 100% |
| A0A1X0NDM7 | Trypanosomatidae | 29% | 95% |
| A0A1X0NDU8 | Trypanosomatidae | 29% | 92% |
| A0A1X0NE71 | Trypanosomatidae | 31% | 100% |
| A0A1X0NEE9 | Trypanosomatidae | 29% | 66% |
| A0A1X0NER9 | Trypanosomatidae | 34% | 96% |
| A0A1X0NET7 | Trypanosomatidae | 35% | 100% |
| A0A1X0NEX7 | Trypanosomatidae | 33% | 94% |
| A0A1X0NEZ6 | Trypanosomatidae | 30% | 94% |
| A0A1X0NF32 | Trypanosomatidae | 32% | 100% |
| A0A1X0NF41 | Trypanosomatidae | 31% | 100% |
| A0A1X0NFJ0 | Trypanosomatidae | 31% | 100% |
| A0A1X0NFK3 | Trypanosomatidae | 30% | 92% |
| A0A1X0NFS0 | Trypanosomatidae | 32% | 71% |
| A0A1X0NFT1 | Trypanosomatidae | 32% | 67% |
| A0A1X0NFU4 | Trypanosomatidae | 30% | 75% |
| A0A1X0NFZ9 | Trypanosomatidae | 33% | 100% |
| A0A1X0NG20 | Trypanosomatidae | 32% | 99% |
| A0A1X0NGP3 | Trypanosomatidae | 28% | 72% |
| A0A1X0NGY3 | Trypanosomatidae | 30% | 80% |
| A0A1X0NGZ3 | Trypanosomatidae | 32% | 100% |
| A0A1X0NH86 | Trypanosomatidae | 32% | 70% |
| A0A1X0NHP6 | Trypanosomatidae | 32% | 100% |
| A0A1X0NHQ6 | Trypanosomatidae | 32% | 100% |
| A0A1X0NI38 | Trypanosomatidae | 29% | 70% |
| A0A1X0NI74 | Trypanosomatidae | 31% | 82% |
| A0A1X0NII4 | Trypanosomatidae | 30% | 73% |
| A0A1X0NIZ3 | Trypanosomatidae | 33% | 100% |
| A0A1X0NJS3 | Trypanosomatidae | 30% | 94% |
| A0A1X0NJU4 | Trypanosomatidae | 29% | 71% |
| A0A1X0NK29 | Trypanosomatidae | 31% | 67% |
| A0A1X0NK66 | Trypanosomatidae | 32% | 93% |
| A0A1X0NKJ8 | Trypanosomatidae | 30% | 82% |
| A0A1X0NKW9 | Trypanosomatidae | 30% | 100% |
| A0A1X0NME2 | Trypanosomatidae | 30% | 98% |
| A0A1X0NMK3 | Trypanosomatidae | 28% | 100% |
| A0A1X0NMK7 | Trypanosomatidae | 38% | 100% |
| A0A1X0NMV0 | Trypanosomatidae | 32% | 84% |
| A0A1X0NN43 | Trypanosomatidae | 30% | 86% |
| A0A1X0NNK8 | Trypanosomatidae | 30% | 93% |
| A0A1X0NP64 | Trypanosomatidae | 29% | 69% |
| A0A1X0NPW0 | Trypanosomatidae | 31% | 96% |
| A0A1X0NQM4 | Trypanosomatidae | 35% | 100% |
| A0A1X0NQN3 | Trypanosomatidae | 37% | 100% |
| A0A1X0NQU4 | Trypanosomatidae | 37% | 95% |
| A0A1X0NQW6 | Trypanosomatidae | 34% | 100% |
| A0A1X0NRF3 | Trypanosomatidae | 33% | 92% |
| A0A1X0NRY8 | Trypanosomatidae | 39% | 100% |
| A0A1X0NU16 | Trypanosomatidae | 34% | 100% |
| A0A1X0NUR2 | Trypanosomatidae | 31% | 83% |
| A0A1X0NV28 | Trypanosomatidae | 35% | 100% |
| A0A1X0NVE0 | Trypanosomatidae | 29% | 79% |
| A0A1X0NW07 | Trypanosomatidae | 27% | 98% |
| A0A1X0NX94 | Trypanosomatidae | 30% | 95% |
| A0A1X0NX98 | Trypanosomatidae | 30% | 77% |
| A0A1X0NXB6 | Trypanosomatidae | 30% | 87% |
| A0A1X0NXH6 | Trypanosomatidae | 33% | 84% |
| A0A1X0NXQ4 | Trypanosomatidae | 29% | 91% |
| A0A1X0NXR7 | Trypanosomatidae | 33% | 82% |
| A0A1X0NYE3 | Trypanosomatidae | 33% | 98% |
| A0A1X0NYE7 | Trypanosomatidae | 33% | 100% |
| A0A1X0NYN2 | Trypanosomatidae | 35% | 100% |
| A0A1X0NYN4 | Trypanosomatidae | 29% | 86% |
| A0A1X0NYS5 | Trypanosomatidae | 35% | 100% |
| A0A1X0NYZ2 | Trypanosomatidae | 39% | 100% |
| A0A1X0NZ46 | Trypanosomatidae | 27% | 100% |
| A0A1X0NZ63 | Trypanosomatidae | 30% | 96% |
| A0A1X0NZN6 | Trypanosomatidae | 28% | 94% |
| A0A1X0P055 | Trypanosomatidae | 37% | 100% |
| A0A1X0P154 | Trypanosomatidae | 29% | 100% |
| A0A1X0P331 | Trypanosomatidae | 33% | 100% |
| A0A1X0P3K0 | Trypanosomatidae | 28% | 84% |
| A0A1X0P3S2 | Trypanosomatidae | 27% | 100% |
| A0A1X0P4L8 | Trypanosomatidae | 32% | 100% |
| A0A1X0P4Y5 | Trypanosomatidae | 28% | 96% |
| A0A1X0P5J0 | Trypanosomatidae | 31% | 90% |
| A0A1X0P7K5 | Trypanosomatidae | 29% | 69% |
| A0A1X0P7R3 | Trypanosomatidae | 38% | 100% |
| A0A1X0P8B4 | Trypanosomatidae | 34% | 100% |
| A0A1X0P9Z4 | Trypanosomatidae | 32% | 100% |
| A0A1X0PB04 | Trypanosomatidae | 33% | 100% |
| A0A3Q8I8N3 | Leishmania donovani | 62% | 100% |
| A0A3Q8I8P8 | Leishmania donovani | 63% | 100% |
| A0A3Q8I8S6 | Leishmania donovani | 65% | 96% |
| A0A3Q8I8S9 | Leishmania donovani | 63% | 100% |
| A0A3Q8IAZ8 | Leishmania donovani | 62% | 100% |
| A0A3Q8IC35 | Leishmania donovani | 62% | 100% |
| A0A3Q8IC44 | Leishmania donovani | 62% | 100% |
| A0A3Q8IH61 | Leishmania donovani | 63% | 100% |
| A0A3Q8IIN4 | Leishmania donovani | 39% | 97% |
| A0A3R7JT49 | Trypanosoma rangeli | 36% | 73% |
| A0A3R7JTB6 | Trypanosoma rangeli | 33% | 87% |
| A0A3R7JV87 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7K7T9 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7K9S1 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7KB14 | Trypanosoma rangeli | 36% | 70% |
| A0A3R7KLR6 | Trypanosoma rangeli | 34% | 96% |
| A0A3R7KMY2 | Trypanosoma rangeli | 34% | 92% |
| A0A3R7LFC4 | Trypanosoma rangeli | 34% | 91% |
| A0A3R7LFZ4 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7LWG1 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7LX11 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7M1R8 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7M574 | Trypanosoma rangeli | 35% | 96% |
| A0A3R7M5K4 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7M7N6 | Trypanosoma rangeli | 36% | 89% |
| A0A3R7MTS2 | Trypanosoma rangeli | 37% | 100% |
| A0A3R7MW36 | Trypanosoma rangeli | 33% | 100% |
| A0A3R7MXF4 | Trypanosoma rangeli | 38% | 100% |
| A0A3R7N1W7 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7N289 | Trypanosoma rangeli | 35% | 85% |
| A0A3R7NTI8 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7R2J4 | Trypanosoma rangeli | 34% | 95% |
| A0A3R7R5R1 | Trypanosoma rangeli | 33% | 100% |
| A0A3R7R818 | Trypanosoma rangeli | 34% | 100% |
| A0A3S5H6G0 | Leishmania donovani | 63% | 100% |
| A0A3S5IQY2 | Trypanosoma rangeli | 38% | 100% |
| A0A3S7WR43 | Leishmania donovani | 62% | 100% |
| A0A3S7WR46 | Leishmania donovani | 63% | 100% |
| A0A3S7WR60 | Leishmania donovani | 64% | 100% |
| A0A3S7X192 | Leishmania donovani | 39% | 100% |
| A0A422MRQ6 | Trypanosoma rangeli | 36% | 82% |
| A0A422MTA9 | Trypanosoma rangeli | 35% | 85% |
| A0A422MU95 | Trypanosoma rangeli | 35% | 100% |
| A0A422MVF5 | Trypanosoma rangeli | 34% | 100% |
| A0A422MVS3 | Trypanosoma rangeli | 35% | 100% |
| A0A422MW99 | Trypanosoma rangeli | 32% | 83% |
| A0A422MZ47 | Trypanosoma rangeli | 38% | 100% |
| A0A422MZG4 | Trypanosoma rangeli | 37% | 100% |
| A0A422N361 | Trypanosoma rangeli | 33% | 100% |
| A0A422N7Q6 | Trypanosoma rangeli | 35% | 95% |
| A0A422NDS2 | Trypanosoma rangeli | 33% | 100% |
| A0A422NDT3 | Trypanosoma rangeli | 33% | 100% |
| A0A422NP82 | Trypanosoma rangeli | 38% | 100% |
| A4H626 | Leishmania braziliensis | 73% | 100% |
| A4H627 | Leishmania braziliensis | 72% | 100% |
| A4H630 | Leishmania braziliensis | 87% | 100% |
| A4H631 | Leishmania braziliensis | 73% | 98% |
| A4H632 | Leishmania braziliensis | 80% | 100% |
| A4H633 | Leishmania braziliensis | 73% | 99% |
| A4H635 | Leishmania braziliensis | 95% | 99% |
| A4H636 | Leishmania braziliensis | 69% | 100% |
| A4H637 | Leishmania braziliensis | 94% | 99% |
| A4H638 | Leishmania braziliensis | 77% | 100% |
| A4H639 | Leishmania braziliensis | 82% | 100% |
| A4H640 | Leishmania braziliensis | 95% | 99% |
| A4H6D1 | Leishmania braziliensis | 74% | 100% |
| A4H6D3 | Leishmania braziliensis | 73% | 100% |
| A4H6D5 | Leishmania braziliensis | 73% | 87% |
| A4H6D7 | Leishmania braziliensis | 71% | 100% |
| A4H6D8 | Leishmania braziliensis | 73% | 100% |
| A4H6D9 | Leishmania braziliensis | 72% | 100% |
| A4H6E0 | Leishmania braziliensis | 75% | 86% |
| A4H6E1 | Leishmania braziliensis | 72% | 100% |
| A4H6E2 | Leishmania braziliensis | 73% | 100% |
| A4H6E3 | Leishmania braziliensis | 72% | 100% |
| A4H6E5 | Leishmania braziliensis | 87% | 100% |
| A4HJI2 | Leishmania braziliensis | 38% | 95% |
| A4HUF6 | Leishmania infantum | 62% | 100% |
| A4HUF8 | Leishmania infantum | 63% | 100% |
| A4HUF9 | Leishmania infantum | 66% | 96% |
| A4HUG0 | Leishmania infantum | 62% | 81% |
| A4I6X5 | Leishmania infantum | 39% | 97% |
| C9ZUT5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 37% | 100% |
| D0A1R8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 34% | 100% |
| D0A7S8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 30% | 91% |
| D0A855 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 35% | 100% |
| E9AHH5 | Leishmania infantum | 39% | 100% |
| E9AN53 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 65% | 94% |
| E9AN54 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 62% | 100% |
| E9AN55 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 63% | 95% |
| E9AN56 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 64% | 95% |
| E9AN57 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 62% | 100% |
| E9AZL8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 41% | 100% |
| E9B1Z9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 97% |
| O62446 | Caenorhabditis elegans | 26% | 93% |
| P08148 | Leishmania major | 65% | 100% |
| P15706 | Leishmania chagasi | 63% | 100% |
| P23223 | Leishmania donovani | 63% | 100% |
| P43150 | Leishmania mexicana | 65% | 95% |
| Q00689 | Leishmania guyanensis | 84% | 99% |
| Q06031 | Crithidia fasciculata | 54% | 94% |
| Q27673 | Leishmania amazonensis | 62% | 100% |
| Q29AK2 | Drosophila pseudoobscura pseudoobscura | 24% | 90% |
| Q4Q662 | Leishmania major | 38% | 100% |
| Q4Q8L3 | Leishmania major | 39% | 100% |
| Q4QHG9 | Leishmania major | 64% | 98% |
| Q4QHH0 | Leishmania major | 66% | 100% |
| Q4QHH1 | Leishmania major | 65% | 98% |
| Q4QHH2 | Leishmania major | 64% | 98% |
| Q61YG1 | Caenorhabditis briggsae | 26% | 93% |
| Q6LA77 | Leishmania infantum | 63% | 100% |
| Q8MNZ1 | Leishmania tropica | 67% | 94% |
| Q96KR4 | Homo sapiens | 23% | 94% |
| Q9VH19 | Drosophila melanogaster | 24% | 90% |
| V5A359 | Trypanosoma cruzi | 38% | 100% |
| V5A488 | Trypanosoma cruzi | 34% | 76% |
| V5AII7 | Trypanosoma cruzi | 39% | 100% |
| V5APQ4 | Trypanosoma cruzi | 35% | 77% |
| V5AX72 | Trypanosoma cruzi | 36% | 83% |
| V5B5M0 | Trypanosoma cruzi | 36% | 83% |
| V5BAN1 | Trypanosoma cruzi | 36% | 78% |
| V5BD39 | Trypanosoma cruzi | 40% | 100% |
| V5BLT3 | Trypanosoma cruzi | 32% | 98% |
| V5CI97 | Trypanosoma cruzi | 32% | 96% |
| V5D358 | Trypanosoma cruzi | 36% | 72% |