Leishmanolysin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

metallo-peptidase, Clan MA(M), Family M8

Species:

Leishmania braziliensis

UniProt:

A4H633_LEIBR

TriTrypDb:

LbrM.10.0540 , LBRM2903_100012500

Length:

557

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 51

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 41, no: 10
NetGPI	no	yes: 0, no: 51

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	52
GO:0110165	cellular anatomical entity	1	52
GO:0005737	cytoplasm	2	4
GO:0018995	host cellular component	2	4
GO:0033643	host cell part	3	4
GO:0033646	host intracellular part	4	4
GO:0033647	host intracellular organelle	5	4
GO:0033648	host intracellular membrane-bounded organelle	6	4
GO:0042025	host cell nucleus	7	4

Expansion

Sequence features

A4H633

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H633

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	52
GO:0006807	nitrogen compound metabolic process	2	52
GO:0007155	cell adhesion	2	52
GO:0008152	metabolic process	1	52
GO:0009987	cellular process	1	52
GO:0019538	protein metabolic process	3	52
GO:0043170	macromolecule metabolic process	3	52
GO:0044238	primary metabolic process	2	52
GO:0071704	organic substance metabolic process	2	52
GO:1901564	organonitrogen compound metabolic process	3	52
GO:0009966	regulation of signal transduction	4	4
GO:0010646	regulation of cell communication	4	4
GO:0010749	regulation of nitric oxide mediated signal transduction	6	4
GO:0023051	regulation of signaling	3	4
GO:0035821	modulation of process of another organism	2	4
GO:0044003	modulation by symbiont of host process	3	4
GO:0044068	modulation by symbiont of host cellular process	4	4
GO:0044081	modulation by symbiont of host nitric oxide-mediated signal transduction	5	4
GO:0044403	biological process involved in symbiotic interaction	2	4
GO:0044419	biological process involved in interspecies interaction between organisms	1	4
GO:0044501	modulation of signal transduction in another organism	3	4
GO:0048583	regulation of response to stimulus	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051701	biological process involved in interaction with host	3	4
GO:0052027	modulation by symbiont of host signal transduction pathway	4	4
GO:0065007	biological regulation	1	4
GO:0075130	modulation by symbiont of host protein kinase-mediated signal transduction	5	4
GO:1902531	regulation of intracellular signal transduction	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	52
GO:0004175	endopeptidase activity	4	52
GO:0004222	metalloendopeptidase activity	5	52
GO:0005488	binding	1	52
GO:0008233	peptidase activity	3	52
GO:0008237	metallopeptidase activity	4	52
GO:0016787	hydrolase activity	2	52
GO:0043167	ion binding	2	52
GO:0043169	cation binding	3	52
GO:0046872	metal ion binding	4	52
GO:0140096	catalytic activity, acting on a protein	2	52
GO:0008047	enzyme activator activity	3	4
GO:0008160	protein tyrosine phosphatase activator activity	6	4
GO:0019208	phosphatase regulator activity	3	4
GO:0019211	phosphatase activator activity	4	4
GO:0019888	protein phosphatase regulator activity	4	4
GO:0030234	enzyme regulator activity	2	4
GO:0072542	protein phosphatase activator activity	5	4
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.238
CLV_NRD_NRD_1	308	310	PF00675	0.434
CLV_PCSK_KEX2_1	123	125	PF00082	0.613
CLV_PCSK_KEX2_1	307	309	PF00082	0.434
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.602
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.434
CLV_PCSK_SKI1_1	231	235	PF00082	0.608
CLV_PCSK_SKI1_1	309	313	PF00082	0.547
CLV_PCSK_SKI1_1	81	85	PF00082	0.456
DEG_APCC_DBOX_1	511	519	PF00400	0.368
DEG_Nend_UBRbox_1	1	4	PF02207	0.482
DEG_SPOP_SBC_1	64	68	PF00917	0.309
DOC_MAPK_gen_1	261	269	PF00069	0.376
DOC_PP1_RVXF_1	338	344	PF00149	0.241
DOC_PP2B_LxvP_1	315	318	PF13499	0.430
DOC_PP2B_LxvP_1	52	55	PF13499	0.309
DOC_PP4_FxxP_1	165	168	PF00568	0.441
DOC_USP7_MATH_1	55	59	PF00917	0.314
DOC_WW_Pin1_4	269	274	PF00397	0.303
DOC_WW_Pin1_4	443	448	PF00397	0.308
DOC_WW_Pin1_4	464	469	PF00397	0.284
DOC_WW_Pin1_4	505	510	PF00397	0.453
DOC_WW_Pin1_4	65	70	PF00397	0.326
LIG_14-3-3_CanoR_1	124	128	PF00244	0.267
LIG_14-3-3_CanoR_1	34	40	PF00244	0.414
LIG_14-3-3_CanoR_1	489	495	PF00244	0.418
LIG_14-3-3_CanoR_1	81	87	PF00244	0.423
LIG_APCC_ABBA_1	136	141	PF00400	0.441
LIG_APCC_ABBA_1	245	250	PF00400	0.276
LIG_APCC_ABBA_1	452	457	PF00400	0.453
LIG_BRCT_BRCA1_1	355	359	PF00533	0.323
LIG_BRCT_BRCA1_1	419	423	PF00533	0.253
LIG_BRCT_BRCA1_1	458	462	PF00533	0.241
LIG_BRCT_BRCA1_1	518	522	PF00533	0.453
LIG_Clathr_ClatBox_1	245	249	PF01394	0.238
LIG_deltaCOP1_diTrp_1	76	83	PF00928	0.232
LIG_FHA_1	138	144	PF00498	0.363
LIG_FHA_1	156	162	PF00498	0.314
LIG_FHA_1	171	177	PF00498	0.332
LIG_FHA_1	31	37	PF00498	0.245
LIG_FHA_1	386	392	PF00498	0.421
LIG_FHA_1	491	497	PF00498	0.435
LIG_FHA_1	518	524	PF00498	0.328
LIG_FHA_1	77	83	PF00498	0.361
LIG_FHA_2	287	293	PF00498	0.262
LIG_FHA_2	330	336	PF00498	0.259
LIG_FHA_2	342	348	PF00498	0.289
LIG_FHA_2	398	404	PF00498	0.250
LIG_FHA_2	506	512	PF00498	0.310
LIG_FHA_2	82	88	PF00498	0.272
LIG_LIR_Apic_2	164	168	PF02991	0.427
LIG_LIR_Apic_2	264	268	PF02991	0.345
LIG_LIR_Apic_2	381	387	PF02991	0.278
LIG_LIR_Apic_2	400	404	PF02991	0.259
LIG_LIR_Gen_1	223	233	PF02991	0.395
LIG_LIR_Gen_1	287	295	PF02991	0.448
LIG_LIR_Gen_1	332	341	PF02991	0.236
LIG_LIR_Gen_1	407	417	PF02991	0.339
LIG_LIR_Gen_1	420	431	PF02991	0.265
LIG_LIR_Gen_1	451	457	PF02991	0.331
LIG_LIR_Gen_1	476	486	PF02991	0.259
LIG_LIR_Gen_1	84	94	PF02991	0.267
LIG_LIR_Nem_3	178	184	PF02991	0.418
LIG_LIR_Nem_3	223	228	PF02991	0.395
LIG_LIR_Nem_3	287	293	PF02991	0.413
LIG_LIR_Nem_3	332	336	PF02991	0.261
LIG_LIR_Nem_3	407	412	PF02991	0.377
LIG_LIR_Nem_3	420	426	PF02991	0.329
LIG_LIR_Nem_3	451	455	PF02991	0.338
LIG_LIR_Nem_3	472	478	PF02991	0.342
LIG_LIR_Nem_3	74	80	PF02991	0.333
LIG_LIR_Nem_3	84	89	PF02991	0.309
LIG_LIR_Nem_3	93	98	PF02991	0.258
LIG_LYPXL_SIV_4	55	63	PF13949	0.241
LIG_PCNA_yPIPBox_3	538	549	PF02747	0.306
LIG_Pex14_1	372	376	PF04695	0.443
LIG_REV1ctd_RIR_1	202	208	PF16727	0.234
LIG_SH2_CRK	325	329	PF00017	0.453
LIG_SH2_CRK	384	388	PF00017	0.283
LIG_SH2_CRK	433	437	PF00017	0.295
LIG_SH2_CRK	478	482	PF00017	0.409
LIG_SH2_GRB2like	433	436	PF00017	0.270
LIG_SH2_NCK_1	433	437	PF00017	0.256
LIG_SH2_PTP2	533	536	PF00017	0.450
LIG_SH2_SRC	401	404	PF00017	0.269
LIG_SH2_SRC	533	536	PF00017	0.450
LIG_SH2_STAP1	225	229	PF00017	0.399
LIG_SH2_STAP1	433	437	PF00017	0.260
LIG_SH2_STAP1	494	498	PF00017	0.453
LIG_SH2_STAT3	98	101	PF00017	0.301
LIG_SH2_STAT5	184	187	PF00017	0.426
LIG_SH2_STAT5	220	223	PF00017	0.258
LIG_SH2_STAT5	325	328	PF00017	0.379
LIG_SH2_STAT5	408	411	PF00017	0.438
LIG_SH2_STAT5	504	507	PF00017	0.388
LIG_SH2_STAT5	527	530	PF00017	0.450
LIG_SH2_STAT5	533	536	PF00017	0.383
LIG_SH2_STAT5	56	59	PF00017	0.412
LIG_SH2_STAT5	95	98	PF00017	0.285
LIG_SUMO_SIM_anti_2	249	255	PF11976	0.277
LIG_SUMO_SIM_par_1	252	258	PF11976	0.242
LIG_SxIP_EBH_1	124	138	PF03271	0.243
LIG_TYR_ITIM	431	436	PF00017	0.256
LIG_WRC_WIRS_1	330	335	PF05994	0.240
LIG_WRC_WIRS_1	83	88	PF05994	0.235
MOD_CDK_SPK_2	464	469	PF00069	0.305
MOD_CDK_SPxxK_3	505	512	PF00069	0.455
MOD_CK1_1	187	193	PF00069	0.524
MOD_CK1_1	379	385	PF00069	0.296
MOD_CK1_1	397	403	PF00069	0.321
MOD_CK1_1	443	449	PF00069	0.410
MOD_CK1_1	456	462	PF00069	0.305
MOD_CK1_1	526	532	PF00069	0.358
MOD_CK2_1	286	292	PF00069	0.294
MOD_CK2_1	341	347	PF00069	0.544
MOD_CK2_1	505	511	PF00069	0.354
MOD_CK2_1	81	87	PF00069	0.250
MOD_GlcNHglycan	222	225	PF01048	0.291
MOD_GlcNHglycan	49	52	PF01048	0.491
MOD_GlcNHglycan	501	504	PF01048	0.475
MOD_GlcNHglycan	57	60	PF01048	0.382
MOD_GlcNHglycan	73	76	PF01048	0.337
MOD_GSK3_1	123	130	PF00069	0.250
MOD_GSK3_1	148	155	PF00069	0.377
MOD_GSK3_1	170	177	PF00069	0.522
MOD_GSK3_1	293	300	PF00069	0.283
MOD_GSK3_1	376	383	PF00069	0.328
MOD_GSK3_1	413	420	PF00069	0.275
MOD_GSK3_1	513	520	PF00069	0.405
MOD_GSK3_1	63	70	PF00069	0.297
MOD_LATS_1	28	34	PF00433	0.252
MOD_N-GLC_1	367	372	PF02516	0.454
MOD_N-GLC_1	377	382	PF02516	0.382
MOD_N-GLC_2	362	364	PF02516	0.349
MOD_NEK2_1	127	132	PF00069	0.250
MOD_NEK2_1	229	234	PF00069	0.416
MOD_NEK2_1	412	417	PF00069	0.356
MOD_NEK2_1	455	460	PF00069	0.282
MOD_NEK2_1	462	467	PF00069	0.266
MOD_NEK2_1	63	68	PF00069	0.294
MOD_PIKK_1	367	373	PF00454	0.432
MOD_PIKK_1	385	391	PF00454	0.237
MOD_PKA_1	123	129	PF00069	0.293
MOD_PKA_2	123	129	PF00069	0.293
MOD_PKA_2	394	400	PF00069	0.366
MOD_PKA_2	498	504	PF00069	0.362
MOD_Plk_1	367	373	PF00069	0.458
MOD_Plk_1	380	386	PF00069	0.372
MOD_Plk_1	513	519	PF00069	0.387
MOD_Plk_4	123	129	PF00069	0.340
MOD_Plk_4	271	277	PF00069	0.369
MOD_Plk_4	286	292	PF00069	0.271
MOD_Plk_4	404	410	PF00069	0.385
MOD_Plk_4	523	529	PF00069	0.387
MOD_Plk_4	94	100	PF00069	0.313
MOD_ProDKin_1	269	275	PF00069	0.334
MOD_ProDKin_1	443	449	PF00069	0.341
MOD_ProDKin_1	464	470	PF00069	0.306
MOD_ProDKin_1	505	511	PF00069	0.544
MOD_ProDKin_1	65	71	PF00069	0.366
MOD_SUMO_for_1	311	314	PF00179	0.394
TRG_DiLeu_BaEn_1	249	254	PF01217	0.263
TRG_DiLeu_BaEn_4	249	255	PF01217	0.242
TRG_ENDOCYTIC_2	225	228	PF00928	0.473
TRG_ENDOCYTIC_2	325	328	PF00928	0.544
TRG_ENDOCYTIC_2	433	436	PF00928	0.361
TRG_ENDOCYTIC_2	478	481	PF00928	0.518
TRG_ENDOCYTIC_2	533	536	PF00928	0.539
TRG_NES_CRM1_1	236	250	PF08389	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL11	Leptomonas seymouri	37%	85%
A0A0S4IUT6	Bodo saltans	30%	68%
A0A0S4IUU1	Bodo saltans	30%	85%
A0A0S4IYM3	Bodo saltans	30%	77%
A0A1D5NSK0	Danio rerio	24%	89%
A0A1X0NDG7	Trypanosomatidae	30%	85%
A0A1X0NDJ3	Trypanosomatidae	29%	77%
A0A1X0NDK2	Trypanosomatidae	32%	97%
A0A1X0NDK7	Trypanosomatidae	29%	78%
A0A1X0NDM7	Trypanosomatidae	29%	86%
A0A1X0NDU8	Trypanosomatidae	30%	84%
A0A1X0NE71	Trypanosomatidae	29%	100%
A0A1X0NER9	Trypanosomatidae	32%	87%
A0A1X0NET7	Trypanosomatidae	32%	100%
A0A1X0NEX7	Trypanosomatidae	32%	85%
A0A1X0NEZ6	Trypanosomatidae	31%	85%
A0A1X0NF32	Trypanosomatidae	31%	100%
A0A1X0NF41	Trypanosomatidae	31%	91%
A0A1X0NFJ0	Trypanosomatidae	27%	100%
A0A1X0NFK3	Trypanosomatidae	30%	83%
A0A1X0NFU4	Trypanosomatidae	31%	68%
A0A1X0NFZ9	Trypanosomatidae	33%	100%
A0A1X0NG20	Trypanosomatidae	30%	90%
A0A1X0NGN3	Trypanosomatidae	36%	100%
A0A1X0NGY3	Trypanosomatidae	29%	73%
A0A1X0NGZ3	Trypanosomatidae	32%	92%
A0A1X0NHP4	Trypanosomatidae	32%	100%
A0A1X0NHP6	Trypanosomatidae	31%	100%
A0A1X0NHQ6	Trypanosomatidae	31%	100%
A0A1X0NI74	Trypanosomatidae	32%	74%
A0A1X0NII4	Trypanosomatidae	30%	66%
A0A1X0NIJ6	Trypanosomatidae	32%	100%
A0A1X0NIZ3	Trypanosomatidae	32%	99%
A0A1X0NK66	Trypanosomatidae	32%	84%
A0A1X0NKJ8	Trypanosomatidae	28%	75%
A0A1X0NKW9	Trypanosomatidae	31%	100%
A0A1X0NME2	Trypanosomatidae	30%	89%
A0A1X0NMK3	Trypanosomatidae	28%	100%
A0A1X0NMK7	Trypanosomatidae	38%	100%
A0A1X0NMV0	Trypanosomatidae	31%	76%
A0A1X0NN43	Trypanosomatidae	29%	78%
A0A1X0NNK8	Trypanosomatidae	30%	85%
A0A1X0NPW0	Trypanosomatidae	30%	87%
A0A1X0NQJ5	Trypanosomatidae	32%	100%
A0A1X0NQM4	Trypanosomatidae	33%	100%
A0A1X0NQN3	Trypanosomatidae	35%	100%
A0A1X0NQU4	Trypanosomatidae	35%	86%
A0A1X0NQW6	Trypanosomatidae	32%	97%
A0A1X0NRF3	Trypanosomatidae	32%	83%
A0A1X0NRY8	Trypanosomatidae	39%	100%
A0A1X0NU16	Trypanosomatidae	35%	93%
A0A1X0NUR2	Trypanosomatidae	30%	76%
A0A1X0NV28	Trypanosomatidae	35%	94%
A0A1X0NVC3	Trypanosomatidae	30%	82%
A0A1X0NVE0	Trypanosomatidae	28%	71%
A0A1X0NW07	Trypanosomatidae	28%	89%
A0A1X0NX94	Trypanosomatidae	29%	86%
A0A1X0NX98	Trypanosomatidae	31%	69%
A0A1X0NXB6	Trypanosomatidae	29%	79%
A0A1X0NXH6	Trypanosomatidae	30%	76%
A0A1X0NXQ4	Trypanosomatidae	29%	82%
A0A1X0NXR7	Trypanosomatidae	33%	74%
A0A1X0NY94	Trypanosomatidae	38%	100%
A0A1X0NYE3	Trypanosomatidae	30%	89%
A0A1X0NYE7	Trypanosomatidae	30%	100%
A0A1X0NYN2	Trypanosomatidae	35%	100%
A0A1X0NYN4	Trypanosomatidae	28%	78%
A0A1X0NYS5	Trypanosomatidae	33%	93%
A0A1X0NYZ2	Trypanosomatidae	38%	99%
A0A1X0NZ46	Trypanosomatidae	27%	96%
A0A1X0NZ63	Trypanosomatidae	30%	87%
A0A1X0NZN6	Trypanosomatidae	28%	86%
A0A1X0P055	Trypanosomatidae	34%	94%
A0A1X0P0C4	Trypanosomatidae	30%	100%
A0A1X0P154	Trypanosomatidae	29%	93%
A0A1X0P331	Trypanosomatidae	33%	98%
A0A1X0P3K0	Trypanosomatidae	29%	77%
A0A1X0P3S2	Trypanosomatidae	28%	100%
A0A1X0P4L8	Trypanosomatidae	30%	100%
A0A1X0P4Y5	Trypanosomatidae	29%	87%
A0A1X0P544	Trypanosomatidae	30%	87%
A0A1X0P5J0	Trypanosomatidae	32%	81%
A0A1X0P7R3	Trypanosomatidae	35%	98%
A0A1X0P8B4	Trypanosomatidae	31%	100%
A0A1X0P9Z4	Trypanosomatidae	31%	100%
A0A1X0PB04	Trypanosomatidae	32%	100%
A0A286YEC0	Mus musculus	25%	80%
A0A3Q8I8N3	Leishmania donovani	59%	93%
A0A3Q8I8P8	Leishmania donovani	60%	93%
A0A3Q8I8S6	Leishmania donovani	62%	87%
A0A3Q8I8S9	Leishmania donovani	60%	93%
A0A3Q8IAZ8	Leishmania donovani	59%	93%
A0A3Q8IC35	Leishmania donovani	59%	93%
A0A3Q8IC44	Leishmania donovani	58%	95%
A0A3Q8IH61	Leishmania donovani	59%	95%
A0A3Q8IIN4	Leishmania donovani	39%	88%
A0A3R7JTB6	Trypanosoma rangeli	32%	79%
A0A3R7JUS0	Trypanosoma rangeli	34%	100%
A0A3R7JV87	Trypanosoma rangeli	33%	100%
A0A3R7K7T9	Trypanosoma rangeli	34%	93%
A0A3R7K9S1	Trypanosoma rangeli	34%	100%
A0A3R7KLR6	Trypanosoma rangeli	29%	87%
A0A3R7KMY2	Trypanosoma rangeli	33%	83%
A0A3R7LFC4	Trypanosoma rangeli	34%	83%
A0A3R7LFZ4	Trypanosoma rangeli	36%	100%
A0A3R7LWG1	Trypanosoma rangeli	33%	98%
A0A3R7LX11	Trypanosoma rangeli	32%	99%
A0A3R7M1R8	Trypanosoma rangeli	33%	97%
A0A3R7M574	Trypanosoma rangeli	32%	87%
A0A3R7M5K4	Trypanosoma rangeli	34%	100%
A0A3R7M7N6	Trypanosoma rangeli	33%	81%
A0A3R7MTS2	Trypanosoma rangeli	38%	100%
A0A3R7MW36	Trypanosoma rangeli	31%	100%
A0A3R7MXF4	Trypanosoma rangeli	35%	91%
A0A3R7N1W7	Trypanosoma rangeli	35%	95%
A0A3R7N289	Trypanosoma rangeli	33%	77%
A0A3R7N7I3	Trypanosoma rangeli	41%	100%
A0A3R7NTI8	Trypanosoma rangeli	31%	97%
A0A3R7R2J4	Trypanosoma rangeli	32%	86%
A0A3R7R5R1	Trypanosoma rangeli	36%	93%
A0A3R7R818	Trypanosoma rangeli	32%	100%
A0A3S5H6G0	Leishmania donovani	60%	93%
A0A3S5IQY2	Trypanosoma rangeli	37%	100%
A0A3S7WR43	Leishmania donovani	59%	93%
A0A3S7WR46	Leishmania donovani	60%	93%
A0A3S7WR60	Leishmania donovani	60%	93%
A0A3S7X192	Leishmania donovani	38%	98%
A0A422MNW0	Trypanosoma rangeli	33%	100%
A0A422MRQ6	Trypanosoma rangeli	33%	74%
A0A422MU95	Trypanosoma rangeli	33%	98%
A0A422MVF5	Trypanosoma rangeli	32%	99%
A0A422MVS3	Trypanosoma rangeli	36%	100%
A0A422MW99	Trypanosoma rangeli	33%	75%
A0A422MZ47	Trypanosoma rangeli	37%	99%
A0A422MZG4	Trypanosoma rangeli	34%	95%
A0A422N361	Trypanosoma rangeli	32%	100%
A0A422N7Q6	Trypanosoma rangeli	33%	86%
A0A422NDS2	Trypanosoma rangeli	32%	96%
A0A422NDT3	Trypanosoma rangeli	30%	98%
A0A422NP82	Trypanosoma rangeli	36%	97%
A4H626	Leishmania braziliensis	80%	100%
A4H627	Leishmania braziliensis	70%	100%
A4H629	Leishmania braziliensis	72%	100%
A4H630	Leishmania braziliensis	72%	100%
A4H631	Leishmania braziliensis	83%	100%
A4H632	Leishmania braziliensis	69%	100%
A4H634	Leishmania braziliensis	73%	91%
A4H635	Leishmania braziliensis	72%	89%
A4H636	Leishmania braziliensis	67%	100%
A4H637	Leishmania braziliensis	74%	90%
A4H638	Leishmania braziliensis	65%	95%
A4H639	Leishmania braziliensis	69%	91%
A4H640	Leishmania braziliensis	73%	90%
A4H6D3	Leishmania braziliensis	74%	95%
A4H6D5	Leishmania braziliensis	77%	79%
A4H6D7	Leishmania braziliensis	68%	95%
A4H6D8	Leishmania braziliensis	78%	95%
A4H6D9	Leishmania braziliensis	78%	95%
A4H6E0	Leishmania braziliensis	79%	78%
A4H6E1	Leishmania braziliensis	73%	95%
A4H6E2	Leishmania braziliensis	74%	97%
A4H6E3	Leishmania braziliensis	76%	97%
A4H6E4	Leishmania braziliensis	79%	100%
A4H6E5	Leishmania braziliensis	65%	100%
A4HJI2	Leishmania braziliensis	39%	86%
A4HUF6	Leishmania infantum	60%	93%
A4HUF8	Leishmania infantum	60%	93%
A4HUF9	Leishmania infantum	62%	87%
A4HUG0	Leishmania infantum	59%	73%
A4I6X5	Leishmania infantum	40%	88%
C9ZUT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
D0A1R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
D0A7S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	83%
D0A855	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	90%
E9AHH5	Leishmania infantum	38%	98%
E9AN53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	85%
E9AN54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	93%
E9AN55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	86%
E9AN56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	86%
E9AN57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	93%
E9AZL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	98%
E9B1Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	88%
P08148	Leishmania major	59%	93%
P15706	Leishmania chagasi	60%	93%
P23223	Leishmania donovani	58%	94%
P43150	Leishmania mexicana	60%	86%
Q00689	Leishmania guyanensis	70%	90%
Q06031	Crithidia fasciculata	50%	85%
Q27673	Leishmania amazonensis	58%	93%
Q29AK2	Drosophila pseudoobscura pseudoobscura	23%	81%
Q4Q662	Leishmania major	40%	100%
Q4Q8L3	Leishmania major	40%	100%
Q4QHG9	Leishmania major	59%	100%
Q4QHH0	Leishmania major	59%	100%
Q4QHH1	Leishmania major	59%	100%
Q4QHH2	Leishmania major	59%	100%
Q6LA77	Leishmania infantum	60%	93%
Q8BMN4	Mus musculus	24%	82%
Q8MNZ1	Leishmania tropica	61%	85%
Q96KR4	Homo sapiens	23%	85%
Q9VH19	Drosophila melanogaster	22%	82%
V5A303	Trypanosoma cruzi	39%	100%
V5A359	Trypanosoma cruzi	39%	100%
V5A488	Trypanosoma cruzi	32%	69%
V5AII7	Trypanosoma cruzi	38%	100%
V5AMH8	Trypanosoma cruzi	34%	100%
V5AN34	Trypanosoma cruzi	38%	100%
V5APQ4	Trypanosoma cruzi	32%	70%
V5AX72	Trypanosoma cruzi	33%	76%
V5B5M0	Trypanosoma cruzi	33%	75%
V5B9W5	Trypanosoma cruzi	29%	82%
V5BAN1	Trypanosoma cruzi	34%	71%
V5BD39	Trypanosoma cruzi	41%	100%
V5BLT3	Trypanosoma cruzi	30%	88%
V5CI97	Trypanosoma cruzi	30%	87%