LeishMANIAdb
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Leishmanolysin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leishmanolysin
Gene product:
metallo-peptidase, Clan MA(M), Family M8
Species:
Leishmania braziliensis
UniProt:
A4H632_LEIBR
TriTrypDb:
LbrM.10.0530 , LBRM2903_100013100
Length:
501

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 48
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 41, no: 9
NetGPI no yes: 0, no: 50
Cellular components
Term Name Level Count
GO:0016020 membrane 2 51
GO:0110165 cellular anatomical entity 1 51
GO:0005737 cytoplasm 2 4
GO:0018995 host cellular component 2 4
GO:0033643 host cell part 3 4
GO:0033646 host intracellular part 4 4
GO:0033647 host intracellular organelle 5 4
GO:0033648 host intracellular membrane-bounded organelle 6 4
GO:0042025 host cell nucleus 7 4

Expansion

Sequence features

A4H632
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H632

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 51
GO:0006807 nitrogen compound metabolic process 2 51
GO:0007155 cell adhesion 2 51
GO:0008152 metabolic process 1 51
GO:0009987 cellular process 1 51
GO:0019538 protein metabolic process 3 51
GO:0043170 macromolecule metabolic process 3 51
GO:0044238 primary metabolic process 2 51
GO:0071704 organic substance metabolic process 2 51
GO:1901564 organonitrogen compound metabolic process 3 51
GO:0009966 regulation of signal transduction 4 4
GO:0010646 regulation of cell communication 4 4
GO:0010749 regulation of nitric oxide mediated signal transduction 6 4
GO:0023051 regulation of signaling 3 4
GO:0035821 modulation of process of another organism 2 4
GO:0044003 modulation by symbiont of host process 3 4
GO:0044068 modulation by symbiont of host cellular process 4 4
GO:0044081 modulation by symbiont of host nitric oxide-mediated signal transduction 5 4
GO:0044403 biological process involved in symbiotic interaction 2 4
GO:0044419 biological process involved in interspecies interaction between organisms 1 4
GO:0044501 modulation of signal transduction in another organism 3 4
GO:0048583 regulation of response to stimulus 3 4
GO:0050789 regulation of biological process 2 4
GO:0050794 regulation of cellular process 3 4
GO:0051701 biological process involved in interaction with host 3 4
GO:0052027 modulation by symbiont of host signal transduction pathway 4 4
GO:0065007 biological regulation 1 4
GO:0075130 modulation by symbiont of host protein kinase-mediated signal transduction 5 4
GO:1902531 regulation of intracellular signal transduction 5 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 51
GO:0004175 endopeptidase activity 4 51
GO:0004222 metalloendopeptidase activity 5 51
GO:0005488 binding 1 51
GO:0008233 peptidase activity 3 51
GO:0008237 metallopeptidase activity 4 51
GO:0016787 hydrolase activity 2 51
GO:0043167 ion binding 2 51
GO:0043169 cation binding 3 51
GO:0046872 metal ion binding 4 51
GO:0140096 catalytic activity, acting on a protein 2 51
GO:0008047 enzyme activator activity 3 4
GO:0008160 protein tyrosine phosphatase activator activity 6 4
GO:0019208 phosphatase regulator activity 3 4
GO:0019211 phosphatase activator activity 4 4
GO:0019888 protein phosphatase regulator activity 4 4
GO:0030234 enzyme regulator activity 2 4
GO:0072542 protein phosphatase activator activity 5 4
GO:0098772 molecular function regulator activity 1 4
GO:0140677 molecular function activator activity 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 464 466 PF00675 0.584
CLV_NRD_NRD_1 5 7 PF00675 0.598
CLV_PCSK_KEX2_1 29 31 PF00082 0.613
CLV_PCSK_KEX2_1 464 466 PF00082 0.584
CLV_PCSK_KEX2_1 5 7 PF00082 0.599
CLV_PCSK_PC1ET2_1 29 31 PF00082 0.602
CLV_PCSK_SKI1_1 151 155 PF00082 0.497
CLV_PCSK_SKI1_1 215 219 PF00082 0.547
CLV_PCSK_SKI1_1 30 34 PF00082 0.591
DEG_APCC_DBOX_1 417 425 PF00400 0.368
DEG_Nend_UBRbox_2 1 2 PF02207 0.439
DOC_CDC14_PxL_1 170 178 PF14671 0.231
DOC_CYCLIN_yCln2_LP_2 221 227 PF00134 0.351
DOC_MAPK_gen_1 167 175 PF00069 0.375
DOC_MAPK_gen_1 296 305 PF00069 0.236
DOC_PP2B_LxvP_1 221 224 PF13499 0.430
DOC_PP4_FxxP_1 171 174 PF00568 0.340
DOC_USP7_MATH_1 374 378 PF00917 0.336
DOC_USP7_MATH_1 80 84 PF00917 0.242
DOC_WW_Pin1_4 324 329 PF00397 0.264
DOC_WW_Pin1_4 349 354 PF00397 0.309
DOC_WW_Pin1_4 376 381 PF00397 0.272
DOC_WW_Pin1_4 411 416 PF00397 0.453
LIG_14-3-3_CanoR_1 169 174 PF00244 0.252
LIG_14-3-3_CanoR_1 259 266 PF00244 0.281
LIG_14-3-3_CanoR_1 375 380 PF00244 0.327
LIG_14-3-3_CanoR_1 469 476 PF00244 0.299
LIG_APCC_ABBA_1 236 241 PF00400 0.428
LIG_APCC_ABBA_1 326 331 PF00400 0.285
LIG_APCC_ABBA_1 358 363 PF00400 0.453
LIG_APCC_ABBA_1 42 47 PF00400 0.441
LIG_BRCT_BRCA1_1 149 153 PF00533 0.377
LIG_BRCT_BRCA1_1 261 265 PF00533 0.324
LIG_BRCT_BRCA1_1 424 428 PF00533 0.453
LIG_FHA_1 134 140 PF00498 0.401
LIG_FHA_1 233 239 PF00498 0.444
LIG_FHA_1 284 290 PF00498 0.347
LIG_FHA_1 292 298 PF00498 0.420
LIG_FHA_1 299 305 PF00498 0.357
LIG_FHA_1 397 403 PF00498 0.435
LIG_FHA_1 475 481 PF00498 0.341
LIG_FHA_1 73 79 PF00498 0.327
LIG_FHA_2 18 24 PF00498 0.368
LIG_FHA_2 193 199 PF00498 0.262
LIG_FHA_2 412 418 PF00498 0.310
LIG_IRF3_LxIS_1 299 306 PF10401 0.231
LIG_IRF3_LxIS_1 493 499 PF10401 0.256
LIG_LIR_Apic_2 70 74 PF02991 0.427
LIG_LIR_Gen_1 195 201 PF02991 0.429
LIG_LIR_Gen_1 381 391 PF02991 0.259
LIG_LIR_Nem_3 195 199 PF02991 0.397
LIG_LIR_Nem_3 381 387 PF02991 0.357
LIG_LIR_Nem_3 86 90 PF02991 0.416
LIG_Pex14_1 278 282 PF04695 0.442
LIG_Pex14_2 149 153 PF04695 0.389
LIG_Pex14_2 354 358 PF04695 0.253
LIG_Pex14_2 368 372 PF04695 0.243
LIG_PTB_Apo_2 427 434 PF02174 0.254
LIG_PTB_Apo_2 81 88 PF02174 0.433
LIG_PTB_Phospho_1 427 433 PF10480 0.254
LIG_SH2_CRK 231 235 PF00017 0.453
LIG_SH2_CRK 384 388 PF00017 0.409
LIG_SH2_GRB2like 231 234 PF00017 0.265
LIG_SH2_GRB2like 317 320 PF00017 0.247
LIG_SH2_PTP2 439 442 PF00017 0.450
LIG_SH2_PTP2 71 74 PF00017 0.231
LIG_SH2_SRC 36 39 PF00017 0.291
LIG_SH2_SRC 439 442 PF00017 0.450
LIG_SH2_STAP1 400 404 PF00017 0.453
LIG_SH2_STAT3 400 403 PF00017 0.439
LIG_SH2_STAT5 196 199 PF00017 0.411
LIG_SH2_STAT5 231 234 PF00017 0.380
LIG_SH2_STAT5 317 320 PF00017 0.435
LIG_SH2_STAT5 36 39 PF00017 0.315
LIG_SH2_STAT5 410 413 PF00017 0.389
LIG_SH2_STAT5 433 436 PF00017 0.450
LIG_SH2_STAT5 439 442 PF00017 0.383
LIG_SH2_STAT5 71 74 PF00017 0.258
LIG_SH2_STAT5 90 93 PF00017 0.426
LIG_SH3_3 307 313 PF00018 0.291
LIG_SH3_3 368 374 PF00018 0.300
LIG_SH3_3 92 98 PF00018 0.304
LIG_SUMO_SIM_par_1 333 341 PF11976 0.245
LIG_SUMO_SIM_par_1 494 499 PF11976 0.288
LIG_TYR_ITIM 194 199 PF00017 0.437
MOD_CDK_SPK_2 378 383 PF00069 0.284
MOD_CDK_SPxxK_3 376 383 PF00069 0.253
MOD_CDK_SPxxK_3 411 418 PF00069 0.454
MOD_CK1_1 349 355 PF00069 0.411
MOD_CK1_1 432 438 PF00069 0.357
MOD_CK1_1 93 99 PF00069 0.523
MOD_CK2_1 192 198 PF00069 0.294
MOD_CK2_1 247 253 PF00069 0.544
MOD_CK2_1 411 417 PF00069 0.354
MOD_GlcNHglycan 225 228 PF01048 0.328
MOD_GlcNHglycan 407 410 PF01048 0.474
MOD_GlcNHglycan 424 427 PF01048 0.279
MOD_GSK3_1 199 206 PF00069 0.283
MOD_GSK3_1 283 290 PF00069 0.333
MOD_GSK3_1 374 381 PF00069 0.325
MOD_GSK3_1 468 475 PF00069 0.249
MOD_GSK3_1 54 61 PF00069 0.378
MOD_GSK3_1 72 79 PF00069 0.363
MOD_N-GLC_1 161 166 PF02516 0.315
MOD_N-GLC_1 176 181 PF02516 0.373
MOD_N-GLC_1 192 197 PF02516 0.261
MOD_N-GLC_1 232 237 PF02516 0.281
MOD_N-GLC_1 259 264 PF02516 0.344
MOD_N-GLC_1 273 278 PF02516 0.453
MOD_N-GLC_1 283 288 PF02516 0.382
MOD_N-GLC_1 318 323 PF02516 0.283
MOD_N-GLC_1 375 380 PF02516 0.268
MOD_N-GLC_1 429 434 PF02516 0.280
MOD_N-GLC_2 268 270 PF02516 0.350
MOD_NEK2_1 147 152 PF00069 0.473
MOD_NEK2_1 153 158 PF00069 0.384
MOD_NEK2_1 161 166 PF00069 0.331
MOD_NEK2_1 176 181 PF00069 0.244
MOD_NEK2_1 199 204 PF00069 0.306
MOD_NEK2_1 282 287 PF00069 0.245
MOD_NEK2_1 318 323 PF00069 0.357
MOD_NEK2_1 496 501 PF00069 0.427
MOD_PIKK_1 273 279 PF00454 0.434
MOD_PIKK_1 287 293 PF00454 0.289
MOD_PK_1 169 175 PF00069 0.233
MOD_PKA_2 374 380 PF00069 0.284
MOD_PKA_2 404 410 PF00069 0.362
MOD_PKA_2 468 474 PF00069 0.262
MOD_PKB_1 167 175 PF00069 0.232
MOD_PKB_1 296 304 PF00069 0.296
MOD_Plk_1 192 198 PF00069 0.238
MOD_Plk_1 232 238 PF00069 0.295
MOD_Plk_1 247 253 PF00069 0.297
MOD_Plk_1 273 279 PF00069 0.459
MOD_Plk_1 318 324 PF00069 0.301
MOD_Plk_2-3 23 29 PF00069 0.431
MOD_Plk_4 192 198 PF00069 0.272
MOD_Plk_4 429 435 PF00069 0.389
MOD_ProDKin_1 324 330 PF00069 0.279
MOD_ProDKin_1 349 355 PF00069 0.342
MOD_ProDKin_1 376 382 PF00069 0.291
MOD_ProDKin_1 411 417 PF00069 0.544
MOD_SUMO_for_1 217 220 PF00179 0.396
TRG_DiLeu_BaEn_3 27 33 PF01217 0.314
TRG_ENDOCYTIC_2 196 199 PF00928 0.484
TRG_ENDOCYTIC_2 231 234 PF00928 0.544
TRG_ENDOCYTIC_2 315 318 PF00928 0.287
TRG_ENDOCYTIC_2 384 387 PF00928 0.517
TRG_ENDOCYTIC_2 439 442 PF00928 0.539
TRG_ER_diArg_1 166 169 PF00400 0.265
TRG_ER_diArg_1 296 299 PF00400 0.310
TRG_ER_diArg_1 463 465 PF00400 0.405
TRG_ER_diArg_1 48 51 PF00400 0.281
TRG_ER_diArg_1 5 8 PF00400 0.453

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL11 Leptomonas seymouri 36% 76%
A0A0S4IS53 Bodo saltans 36% 100%
A0A0S4IUU1 Bodo saltans 30% 76%
A0A0S4IYM3 Bodo saltans 35% 69%
A0A1L8HYT7 Xenopus laevis 22% 70%
A0A1X0NDG7 Trypanosomatidae 29% 77%
A0A1X0NDJ3 Trypanosomatidae 29% 69%
A0A1X0NDK2 Trypanosomatidae 33% 87%
A0A1X0NDK7 Trypanosomatidae 31% 70%
A0A1X0NDM7 Trypanosomatidae 30% 78%
A0A1X0NDU8 Trypanosomatidae 30% 75%
A0A1X0NE71 Trypanosomatidae 29% 98%
A0A1X0NER9 Trypanosomatidae 32% 78%
A0A1X0NET7 Trypanosomatidae 34% 97%
A0A1X0NEX7 Trypanosomatidae 31% 76%
A0A1X0NEZ6 Trypanosomatidae 29% 77%
A0A1X0NF32 Trypanosomatidae 31% 100%
A0A1X0NF41 Trypanosomatidae 30% 82%
A0A1X0NFJ0 Trypanosomatidae 31% 95%
A0A1X0NFK3 Trypanosomatidae 30% 75%
A0A1X0NFZ9 Trypanosomatidae 34% 100%
A0A1X0NG20 Trypanosomatidae 31% 81%
A0A1X0NGN3 Trypanosomatidae 34% 100%
A0A1X0NGZ3 Trypanosomatidae 33% 83%
A0A1X0NHD0 Trypanosomatidae 31% 67%
A0A1X0NHP6 Trypanosomatidae 32% 95%
A0A1X0NHQ6 Trypanosomatidae 34% 97%
A0A1X0NI74 Trypanosomatidae 33% 67%
A0A1X0NIZ3 Trypanosomatidae 32% 89%
A0A1X0NJC6 Trypanosomatidae 34% 100%
A0A1X0NJS3 Trypanosomatidae 28% 77%
A0A1X0NK66 Trypanosomatidae 31% 76%
A0A1X0NKJ8 Trypanosomatidae 30% 67%
A0A1X0NKW9 Trypanosomatidae 29% 98%
A0A1X0NME2 Trypanosomatidae 31% 80%
A0A1X0NMK3 Trypanosomatidae 29% 97%
A0A1X0NMK7 Trypanosomatidae 38% 96%
A0A1X0NMV0 Trypanosomatidae 32% 68%
A0A1X0NN43 Trypanosomatidae 32% 70%
A0A1X0NPW0 Trypanosomatidae 32% 78%
A0A1X0NQJ5 Trypanosomatidae 35% 100%
A0A1X0NQM4 Trypanosomatidae 35% 100%
A0A1X0NQN3 Trypanosomatidae 35% 100%
A0A1X0NQU4 Trypanosomatidae 35% 78%
A0A1X0NQW6 Trypanosomatidae 31% 88%
A0A1X0NRF3 Trypanosomatidae 33% 75%
A0A1X0NRY8 Trypanosomatidae 37% 92%
A0A1X0NU16 Trypanosomatidae 36% 84%
A0A1X0NUR2 Trypanosomatidae 32% 68%
A0A1X0NV28 Trypanosomatidae 37% 85%
A0A1X0NVC3 Trypanosomatidae 31% 73%
A0A1X0NW07 Trypanosomatidae 28% 80%
A0A1X0NX94 Trypanosomatidae 33% 77%
A0A1X0NXB6 Trypanosomatidae 31% 71%
A0A1X0NXH6 Trypanosomatidae 35% 69%
A0A1X0NXQ4 Trypanosomatidae 30% 74%
A0A1X0NXR7 Trypanosomatidae 35% 67%
A0A1X0NY94 Trypanosomatidae 36% 100%
A0A1X0NYE3 Trypanosomatidae 31% 80%
A0A1X0NYE7 Trypanosomatidae 32% 98%
A0A1X0NYN2 Trypanosomatidae 34% 95%
A0A1X0NYN4 Trypanosomatidae 29% 70%
A0A1X0NYS5 Trypanosomatidae 36% 83%
A0A1X0NYZ2 Trypanosomatidae 40% 89%
A0A1X0NZ46 Trypanosomatidae 28% 86%
A0A1X0NZ63 Trypanosomatidae 32% 79%
A0A1X0NZN6 Trypanosomatidae 28% 77%
A0A1X0P055 Trypanosomatidae 35% 85%
A0A1X0P0C4 Trypanosomatidae 30% 98%
A0A1X0P154 Trypanosomatidae 29% 84%
A0A1X0P331 Trypanosomatidae 33% 88%
A0A1X0P3K0 Trypanosomatidae 29% 69%
A0A1X0P3S2 Trypanosomatidae 28% 90%
A0A1X0P4L8 Trypanosomatidae 32% 97%
A0A1X0P4Y5 Trypanosomatidae 29% 78%
A0A1X0P544 Trypanosomatidae 30% 78%
A0A1X0P5J0 Trypanosomatidae 33% 73%
A0A1X0P7R3 Trypanosomatidae 37% 89%
A0A1X0P8B4 Trypanosomatidae 34% 100%
A0A1X0P9Z4 Trypanosomatidae 32% 91%
A0A1X0PB04 Trypanosomatidae 33% 98%
A0A3Q8I8N3 Leishmania donovani 62% 84%
A0A3Q8I8P8 Leishmania donovani 62% 84%
A0A3Q8I8S6 Leishmania donovani 65% 78%
A0A3Q8I8S9 Leishmania donovani 62% 84%
A0A3Q8IAZ8 Leishmania donovani 62% 84%
A0A3Q8IC35 Leishmania donovani 62% 84%
A0A3Q8IC44 Leishmania donovani 62% 85%
A0A3Q8IH61 Leishmania donovani 62% 85%
A0A3Q8IIN4 Leishmania donovani 37% 79%
A0A3R7JTB6 Trypanosoma rangeli 33% 71%
A0A3R7JUH9 Trypanosoma rangeli 38% 100%
A0A3R7JUS0 Trypanosoma rangeli 33% 100%
A0A3R7JV87 Trypanosoma rangeli 34% 94%
A0A3R7K7T9 Trypanosoma rangeli 34% 84%
A0A3R7K9S1 Trypanosoma rangeli 34% 97%
A0A3R7KLR6 Trypanosoma rangeli 33% 78%
A0A3R7KMY2 Trypanosoma rangeli 36% 75%
A0A3R7LFC4 Trypanosoma rangeli 36% 74%
A0A3R7LFZ4 Trypanosoma rangeli 37% 92%
A0A3R7LWG1 Trypanosoma rangeli 33% 88%
A0A3R7LX11 Trypanosoma rangeli 36% 89%
A0A3R7M1R8 Trypanosoma rangeli 34% 87%
A0A3R7M574 Trypanosoma rangeli 34% 78%
A0A3R7M7N6 Trypanosoma rangeli 34% 73%
A0A3R7MTS2 Trypanosoma rangeli 39% 100%
A0A3R7MW36 Trypanosoma rangeli 34% 94%
A0A3R7MXF4 Trypanosoma rangeli 37% 82%
A0A3R7N1W7 Trypanosoma rangeli 33% 86%
A0A3R7N289 Trypanosoma rangeli 33% 69%
A0A3R7NTI8 Trypanosoma rangeli 35% 87%
A0A3R7R2J4 Trypanosoma rangeli 35% 78%
A0A3R7R5R1 Trypanosoma rangeli 35% 83%
A0A3R7R818 Trypanosoma rangeli 32% 95%
A0A3S5H6G0 Leishmania donovani 62% 84%
A0A3S5IQY2 Trypanosoma rangeli 37% 97%
A0A3S7WR43 Leishmania donovani 62% 84%
A0A3S7WR46 Leishmania donovani 62% 84%
A0A3S7WR60 Leishmania donovani 63% 84%
A0A3S7X192 Leishmania donovani 38% 89%
A0A422MP17 Trypanosoma rangeli 37% 100%
A0A422MQ49 Trypanosoma rangeli 32% 72%
A0A422MRQ6 Trypanosoma rangeli 35% 67%
A0A422MTE4 Trypanosoma rangeli 31% 100%
A0A422MU95 Trypanosoma rangeli 34% 88%
A0A422MUP1 Trypanosoma rangeli 38% 100%
A0A422MVF5 Trypanosoma rangeli 33% 89%
A0A422MVS3 Trypanosoma rangeli 33% 97%
A0A422MW99 Trypanosoma rangeli 30% 67%
A0A422MZ47 Trypanosoma rangeli 39% 89%
A0A422MZG4 Trypanosoma rangeli 36% 85%
A0A422N361 Trypanosoma rangeli 35% 90%
A0A422N7Q6 Trypanosoma rangeli 34% 77%
A0A422NDS2 Trypanosoma rangeli 33% 86%
A0A422NP82 Trypanosoma rangeli 39% 87%
A4H626 Leishmania braziliensis 69% 100%
A4H627 Leishmania braziliensis 67% 100%
A4H629 Leishmania braziliensis 77% 100%
A4H630 Leishmania braziliensis 83% 100%
A4H631 Leishmania braziliensis 69% 100%
A4H633 Leishmania braziliensis 69% 90%
A4H634 Leishmania braziliensis 80% 81%
A4H635 Leishmania braziliensis 80% 80%
A4H636 Leishmania braziliensis 68% 100%
A4H637 Leishmania braziliensis 81% 81%
A4H638 Leishmania braziliensis 74% 85%
A4H639 Leishmania braziliensis 82% 82%
A4H640 Leishmania braziliensis 81% 81%
A4H6D3 Leishmania braziliensis 70% 86%
A4H6D5 Leishmania braziliensis 69% 71%
A4H6D7 Leishmania braziliensis 67% 86%
A4H6D8 Leishmania braziliensis 68% 86%
A4H6D9 Leishmania braziliensis 67% 86%
A4H6E0 Leishmania braziliensis 70% 70%
A4H6E1 Leishmania braziliensis 69% 86%
A4H6E2 Leishmania braziliensis 70% 87%
A4H6E3 Leishmania braziliensis 66% 87%
A4H6E4 Leishmania braziliensis 68% 100%
A4H6E5 Leishmania braziliensis 76% 98%
A4HJI2 Leishmania braziliensis 36% 77%
A4HUF6 Leishmania infantum 62% 84%
A4HUF8 Leishmania infantum 62% 84%
A4HUF9 Leishmania infantum 65% 78%
A4I6X5 Leishmania infantum 37% 79%
C9ZUT5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 86%
D0A1R8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 85%
D0A7S8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 74%
D0A7W4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A855 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 81%
E9AHH5 Leishmania infantum 38% 89%
E9AN53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 76%
E9AN54 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 83%
E9AN55 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 78%
E9AN56 Leishmania mexicana (strain MHOM/GT/2001/U1103) 63% 78%
E9AN57 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 83%
E9AZL8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 89%
E9B1Z9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 79%
O62446 Caenorhabditis elegans 27% 76%
P08148 Leishmania major 65% 83%
P15706 Leishmania chagasi 62% 84%
P23223 Leishmania donovani 62% 85%
P43150 Leishmania mexicana 63% 78%
Q00689 Leishmania guyanensis 79% 81%
Q06031 Crithidia fasciculata 55% 77%
Q27673 Leishmania amazonensis 63% 84%
Q29AK2 Drosophila pseudoobscura pseudoobscura 24% 73%
Q4Q662 Leishmania major 35% 100%
Q4Q8L3 Leishmania major 37% 100%
Q4QHG9 Leishmania major 63% 100%
Q4QHH0 Leishmania major 65% 100%
Q4QHH1 Leishmania major 64% 100%
Q4QHH2 Leishmania major 64% 100%
Q61YG1 Caenorhabditis briggsae 28% 76%
Q6LA77 Leishmania infantum 62% 84%
Q8BMN4 Mus musculus 25% 74%
Q8MNZ1 Leishmania tropica 65% 76%
Q9VH19 Drosophila melanogaster 24% 73%
V5A303 Trypanosoma cruzi 37% 100%
V5A359 Trypanosoma cruzi 38% 92%
V5AII7 Trypanosoma cruzi 40% 93%
V5AJE7 Trypanosoma cruzi 33% 96%
V5AMH8 Trypanosoma cruzi 33% 100%
V5AN34 Trypanosoma cruzi 38% 100%
V5AX72 Trypanosoma cruzi 35% 68%
V5B5M0 Trypanosoma cruzi 35% 68%
V5B9W5 Trypanosoma cruzi 32% 74%
V5BAL3 Trypanosoma cruzi 43% 99%
V5BLT3 Trypanosoma cruzi 32% 80%
V5CI97 Trypanosoma cruzi 33% 79%
V5CIA7 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS