Leishmanolysin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

metallo-peptidase, Clan MA(M), Family M8

Species:

Leishmania braziliensis

UniProt:

A4H631_LEIBR

TriTrypDb:

LbrM.10.0520 , LBRM2903_100010600

Length:

575

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 51

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 41, no: 10
NetGPI	no	yes: 0, no: 51

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	52
GO:0110165	cellular anatomical entity	1	52
GO:0005737	cytoplasm	2	4
GO:0018995	host cellular component	2	4
GO:0033643	host cell part	3	4
GO:0033646	host intracellular part	4	4
GO:0033647	host intracellular organelle	5	4
GO:0033648	host intracellular membrane-bounded organelle	6	4
GO:0042025	host cell nucleus	7	4

Expansion

Sequence features

A4H631

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H631

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	52
GO:0006807	nitrogen compound metabolic process	2	52
GO:0007155	cell adhesion	2	52
GO:0008152	metabolic process	1	52
GO:0009987	cellular process	1	52
GO:0019538	protein metabolic process	3	52
GO:0043170	macromolecule metabolic process	3	52
GO:0044238	primary metabolic process	2	52
GO:0071704	organic substance metabolic process	2	52
GO:1901564	organonitrogen compound metabolic process	3	52
GO:0009966	regulation of signal transduction	4	4
GO:0010646	regulation of cell communication	4	4
GO:0010749	regulation of nitric oxide mediated signal transduction	6	4
GO:0023051	regulation of signaling	3	4
GO:0035821	modulation of process of another organism	2	4
GO:0044003	modulation by symbiont of host process	3	4
GO:0044068	modulation by symbiont of host cellular process	4	4
GO:0044081	modulation by symbiont of host nitric oxide-mediated signal transduction	5	4
GO:0044403	biological process involved in symbiotic interaction	2	4
GO:0044419	biological process involved in interspecies interaction between organisms	1	4
GO:0044501	modulation of signal transduction in another organism	3	4
GO:0048583	regulation of response to stimulus	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051701	biological process involved in interaction with host	3	4
GO:0052027	modulation by symbiont of host signal transduction pathway	4	4
GO:0065007	biological regulation	1	4
GO:0075130	modulation by symbiont of host protein kinase-mediated signal transduction	5	4
GO:1902531	regulation of intracellular signal transduction	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	52
GO:0004175	endopeptidase activity	4	52
GO:0004222	metalloendopeptidase activity	5	52
GO:0005488	binding	1	52
GO:0008233	peptidase activity	3	52
GO:0008237	metallopeptidase activity	4	52
GO:0016787	hydrolase activity	2	52
GO:0043167	ion binding	2	52
GO:0043169	cation binding	3	52
GO:0046872	metal ion binding	4	52
GO:0140096	catalytic activity, acting on a protein	2	52
GO:0008047	enzyme activator activity	3	4
GO:0008160	protein tyrosine phosphatase activator activity	6	4
GO:0019208	phosphatase regulator activity	3	4
GO:0019211	phosphatase activator activity	4	4
GO:0019888	protein phosphatase regulator activity	4	4
GO:0030234	enzyme regulator activity	2	4
GO:0072542	protein phosphatase activator activity	5	4
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.222
CLV_NRD_NRD_1	11	13	PF00675	0.589
CLV_PCSK_KEX2_1	10	12	PF00082	0.606
CLV_PCSK_KEX2_1	141	143	PF00082	0.562
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.552
CLV_PCSK_SKI1_1	327	331	PF00082	0.496
CLV_PCSK_SKI1_1	99	103	PF00082	0.405
DEG_APCC_DBOX_1	529	537	PF00400	0.318
DEG_SPOP_SBC_1	82	86	PF00917	0.258
DOC_CYCLIN_RxL_1	96	106	PF00134	0.189
DOC_MAPK_gen_1	184	194	PF00069	0.198
DOC_MAPK_gen_1	279	287	PF00069	0.325
DOC_MAPK_gen_1	408	417	PF00069	0.185
DOC_MAPK_MEF2A_6	187	194	PF00069	0.198
DOC_PP1_RVXF_1	436	442	PF00149	0.193
DOC_PP2B_LxvP_1	333	336	PF13499	0.379
DOC_PP2B_LxvP_1	70	73	PF13499	0.258
DOC_PP4_FxxP_1	183	186	PF00568	0.390
DOC_PP4_MxPP_1	547	550	PF00568	0.189
DOC_USP7_MATH_1	486	490	PF00917	0.287
DOC_USP7_MATH_1	73	77	PF00917	0.263
DOC_WW_Pin1_4	287	292	PF00397	0.252
DOC_WW_Pin1_4	523	528	PF00397	0.403
DOC_WW_Pin1_4	83	88	PF00397	0.275
LIG_14-3-3_CanoR_1	10	19	PF00244	0.608
LIG_14-3-3_CanoR_1	142	146	PF00244	0.216
LIG_14-3-3_CanoR_1	403	411	PF00244	0.271
LIG_14-3-3_CanoR_1	438	442	PF00244	0.207
LIG_14-3-3_CanoR_1	485	495	PF00244	0.286
LIG_14-3-3_CanoR_1	507	513	PF00244	0.368
LIG_14-3-3_CanoR_1	52	58	PF00244	0.363
LIG_14-3-3_CanoR_1	99	105	PF00244	0.372
LIG_APCC_ABBA_1	154	159	PF00400	0.390
LIG_APCC_ABBA_1	263	268	PF00400	0.225
LIG_APCC_ABBA_1	348	353	PF00400	0.377
LIG_APCC_ABBA_1	470	475	PF00400	0.403
LIG_BIR_II_1	1	5	PF00653	0.697
LIG_BRCT_BRCA1_1	373	377	PF00533	0.272
LIG_BRCT_BRCA1_1	476	480	PF00533	0.191
LIG_BRCT_BRCA1_1	536	540	PF00533	0.403
LIG_Clathr_ClatBox_1	101	105	PF01394	0.185
LIG_FHA_1	156	162	PF00498	0.312
LIG_FHA_1	174	180	PF00498	0.263
LIG_FHA_1	189	195	PF00498	0.281
LIG_FHA_1	213	219	PF00498	0.276
LIG_FHA_1	345	351	PF00498	0.394
LIG_FHA_1	396	402	PF00498	0.297
LIG_FHA_1	509	515	PF00498	0.385
LIG_FHA_1	536	542	PF00498	0.277
LIG_FHA_1	95	101	PF00498	0.311
LIG_FHA_2	219	225	PF00498	0.222
LIG_FHA_2	262	268	PF00498	0.247
LIG_FHA_2	305	311	PF00498	0.211
LIG_FHA_2	360	366	PF00498	0.238
LIG_FHA_2	416	422	PF00498	0.199
LIG_FHA_2	438	444	PF00498	0.192
LIG_FHA_2	452	458	PF00498	0.207
LIG_FHA_2	524	530	PF00498	0.259
LIG_FHA_2	537	543	PF00498	0.230
LIG_GBD_Chelix_1	255	263	PF00786	0.427
LIG_LIR_Apic_2	182	186	PF02991	0.376
LIG_LIR_Apic_2	282	286	PF02991	0.294
LIG_LIR_Gen_1	241	251	PF02991	0.345
LIG_LIR_Gen_1	264	272	PF02991	0.255
LIG_LIR_Gen_1	305	313	PF02991	0.397
LIG_LIR_Gen_1	425	435	PF02991	0.288
LIG_LIR_Gen_1	440	449	PF02991	0.204
LIG_LIR_Gen_1	469	475	PF02991	0.280
LIG_LIR_Nem_3	111	116	PF02991	0.208
LIG_LIR_Nem_3	196	202	PF02991	0.367
LIG_LIR_Nem_3	241	246	PF02991	0.345
LIG_LIR_Nem_3	264	269	PF02991	0.256
LIG_LIR_Nem_3	305	311	PF02991	0.362
LIG_LIR_Nem_3	353	359	PF02991	0.213
LIG_LIR_Nem_3	425	430	PF02991	0.326
LIG_LIR_Nem_3	440	444	PF02991	0.275
LIG_LIR_Nem_3	465	470	PF02991	0.275
LIG_LIR_Nem_3	92	98	PF02991	0.282
LIG_LYPXL_SIV_4	73	81	PF13949	0.191
LIG_NRBOX	97	103	PF00104	0.185
LIG_PCNA_yPIPBox_3	141	150	PF02747	0.182
LIG_PCNA_yPIPBox_3	556	567	PF02747	0.258
LIG_Pex14_1	390	394	PF04695	0.392
LIG_Pex14_2	466	470	PF04695	0.203
LIG_Pex14_2	480	484	PF04695	0.192
LIG_REV1ctd_RIR_1	464	472	PF16727	0.182
LIG_SH2_CRK	243	247	PF00017	0.341
LIG_SH2_CRK	343	347	PF00017	0.403
LIG_SH2_GRB2like	451	454	PF00017	0.220
LIG_SH2_PTP2	551	554	PF00017	0.399
LIG_SH2_SRC	551	554	PF00017	0.399
LIG_SH2_STAP1	243	247	PF00017	0.348
LIG_SH2_STAP1	451	455	PF00017	0.210
LIG_SH2_STAP1	512	516	PF00017	0.403
LIG_SH2_STAT3	116	119	PF00017	0.251
LIG_SH2_STAT3	512	515	PF00017	0.388
LIG_SH2_STAT5	113	116	PF00017	0.234
LIG_SH2_STAT5	202	205	PF00017	0.376
LIG_SH2_STAT5	238	241	PF00017	0.207
LIG_SH2_STAT5	308	311	PF00017	0.361
LIG_SH2_STAT5	343	346	PF00017	0.328
LIG_SH2_STAT5	371	374	PF00017	0.202
LIG_SH2_STAT5	426	429	PF00017	0.387
LIG_SH2_STAT5	522	525	PF00017	0.337
LIG_SH2_STAT5	545	548	PF00017	0.399
LIG_SH2_STAT5	551	554	PF00017	0.332
LIG_SH2_STAT5	74	77	PF00017	0.361
LIG_SH3_3	204	210	PF00018	0.252
LIG_SH3_3	489	495	PF00018	0.235
LIG_SUMO_SIM_par_1	100	106	PF11976	0.185
LIG_SxIP_EBH_1	142	156	PF03271	0.193
LIG_TRAF2_1	329	332	PF00917	0.182
LIG_TYR_ITIM	306	311	PF00017	0.387
MOD_CDK_SPxxK_3	523	530	PF00069	0.405
MOD_CK1_1	205	211	PF00069	0.473
MOD_CK1_1	289	295	PF00069	0.228
MOD_CK1_1	397	403	PF00069	0.245
MOD_CK1_1	471	477	PF00069	0.283
MOD_CK2_1	261	267	PF00069	0.240
MOD_CK2_1	304	310	PF00069	0.243
MOD_CK2_1	359	365	PF00069	0.493
MOD_CK2_1	523	529	PF00069	0.303
MOD_CK2_1	536	542	PF00069	0.299
MOD_GlcNHglycan	240	243	PF01048	0.240
MOD_GlcNHglycan	519	522	PF01048	0.424
MOD_GlcNHglycan	67	70	PF01048	0.440
MOD_GlcNHglycan	75	78	PF01048	0.331
MOD_GlcNHglycan	91	94	PF01048	0.286
MOD_GSK3_1	141	148	PF00069	0.199
MOD_GSK3_1	166	173	PF00069	0.326
MOD_GSK3_1	188	195	PF00069	0.471
MOD_GSK3_1	311	318	PF00069	0.232
MOD_GSK3_1	458	465	PF00069	0.277
MOD_GSK3_1	532	539	PF00069	0.343
MOD_GSK3_1	81	88	PF00069	0.246
MOD_N-GLC_1	385	390	PF02516	0.403
MOD_N-GLC_1	395	400	PF02516	0.331
MOD_NEK2_1	145	150	PF00069	0.199
MOD_NEK2_1	247	252	PF00069	0.365
MOD_NEK2_1	261	266	PF00069	0.396
MOD_NEK2_1	311	316	PF00069	0.255
MOD_NEK2_1	430	435	PF00069	0.305
MOD_NEK2_1	449	454	PF00069	0.193
MOD_NEK2_1	473	478	PF00069	0.231
MOD_NEK2_1	480	485	PF00069	0.215
MOD_NEK2_1	536	541	PF00069	0.219
MOD_NEK2_1	81	86	PF00069	0.243
MOD_PIKK_1	385	391	PF00454	0.382
MOD_PKA_1	10	16	PF00069	0.541
MOD_PKA_1	141	147	PF00069	0.242
MOD_PKA_2	141	147	PF00069	0.243
MOD_PKA_2	4	10	PF00069	0.567
MOD_PKA_2	402	408	PF00069	0.338
MOD_PKA_2	437	443	PF00069	0.224
MOD_PKA_2	516	522	PF00069	0.311
MOD_PKB_1	3	11	PF00069	0.551
MOD_Plk_1	261	267	PF00069	0.248
MOD_Plk_1	385	391	PF00069	0.407
MOD_Plk_1	431	437	PF00069	0.251
MOD_Plk_1	468	474	PF00069	0.242
MOD_Plk_4	112	118	PF00069	0.263
MOD_Plk_4	141	147	PF00069	0.289
MOD_Plk_4	261	267	PF00069	0.336
MOD_Plk_4	304	310	PF00069	0.221
MOD_Plk_4	397	403	PF00069	0.190
MOD_Plk_4	422	428	PF00069	0.335
MOD_Plk_4	437	443	PF00069	0.220
MOD_Plk_4	462	468	PF00069	0.229
MOD_Plk_4	536	542	PF00069	0.298
MOD_ProDKin_1	287	293	PF00069	0.283
MOD_ProDKin_1	523	529	PF00069	0.493
MOD_ProDKin_1	83	89	PF00069	0.315
MOD_SUMO_for_1	329	332	PF00179	0.344
TRG_ENDOCYTIC_2	243	246	PF00928	0.422
TRG_ENDOCYTIC_2	308	311	PF00928	0.434
TRG_ENDOCYTIC_2	343	346	PF00928	0.493
TRG_ENDOCYTIC_2	496	499	PF00928	0.467
TRG_ENDOCYTIC_2	551	554	PF00928	0.488
TRG_ER_diArg_1	10	12	PF00400	0.604
TRG_ER_diArg_1	160	163	PF00400	0.230
TRG_ER_diArg_1	278	281	PF00400	0.217
TRG_NES_CRM1_1	262	274	PF08389	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL11	Leptomonas seymouri	36%	88%
A0A0S4IP65	Bodo saltans	24%	71%
A0A0S4IUT6	Bodo saltans	29%	70%
A0A0S4IUU1	Bodo saltans	30%	87%
A0A0S4IYM3	Bodo saltans	29%	79%
A0A1B0GTW7	Homo sapiens	25%	73%
A0A1L8HYT7	Xenopus laevis	26%	80%
A0A1X0NDG7	Trypanosomatidae	31%	88%
A0A1X0NDJ3	Trypanosomatidae	29%	80%
A0A1X0NDK2	Trypanosomatidae	33%	100%
A0A1X0NDK7	Trypanosomatidae	31%	81%
A0A1X0NDK9	Trypanosomatidae	29%	100%
A0A1X0NDM7	Trypanosomatidae	30%	89%
A0A1X0NDU8	Trypanosomatidae	32%	86%
A0A1X0NE71	Trypanosomatidae	29%	100%
A0A1X0NER9	Trypanosomatidae	33%	90%
A0A1X0NET7	Trypanosomatidae	35%	100%
A0A1X0NEX7	Trypanosomatidae	34%	88%
A0A1X0NEZ6	Trypanosomatidae	31%	88%
A0A1X0NF32	Trypanosomatidae	31%	100%
A0A1X0NF41	Trypanosomatidae	32%	94%
A0A1X0NFJ0	Trypanosomatidae	29%	100%
A0A1X0NFK3	Trypanosomatidae	30%	86%
A0A1X0NFS0	Trypanosomatidae	32%	66%
A0A1X0NFU4	Trypanosomatidae	32%	70%
A0A1X0NFZ9	Trypanosomatidae	33%	100%
A0A1X0NG20	Trypanosomatidae	33%	93%
A0A1X0NGP3	Trypanosomatidae	32%	67%
A0A1X0NGY3	Trypanosomatidae	31%	75%
A0A1X0NGZ3	Trypanosomatidae	31%	95%
A0A1X0NHP6	Trypanosomatidae	32%	100%
A0A1X0NHQ6	Trypanosomatidae	30%	100%
A0A1X0NI74	Trypanosomatidae	32%	77%
A0A1X0NII4	Trypanosomatidae	28%	68%
A0A1X0NIZ3	Trypanosomatidae	32%	100%
A0A1X0NJS3	Trypanosomatidae	30%	88%
A0A1X0NJU4	Trypanosomatidae	30%	67%
A0A1X0NK66	Trypanosomatidae	34%	87%
A0A1X0NKJ8	Trypanosomatidae	28%	77%
A0A1X0NKW9	Trypanosomatidae	30%	100%
A0A1X0NME2	Trypanosomatidae	31%	92%
A0A1X0NMK3	Trypanosomatidae	27%	100%
A0A1X0NMK7	Trypanosomatidae	38%	100%
A0A1X0NMV0	Trypanosomatidae	31%	78%
A0A1X0NN43	Trypanosomatidae	29%	80%
A0A1X0NNK8	Trypanosomatidae	31%	87%
A0A1X0NPW0	Trypanosomatidae	30%	89%
A0A1X0NQJ5	Trypanosomatidae	36%	100%
A0A1X0NQM4	Trypanosomatidae	34%	100%
A0A1X0NQN3	Trypanosomatidae	35%	100%
A0A1X0NQU4	Trypanosomatidae	36%	89%
A0A1X0NQW6	Trypanosomatidae	33%	100%
A0A1X0NRF3	Trypanosomatidae	32%	86%
A0A1X0NRY8	Trypanosomatidae	38%	100%
A0A1X0NU16	Trypanosomatidae	35%	96%
A0A1X0NUR2	Trypanosomatidae	32%	78%
A0A1X0NV28	Trypanosomatidae	37%	97%
A0A1X0NVC3	Trypanosomatidae	33%	84%
A0A1X0NVE0	Trypanosomatidae	32%	73%
A0A1X0NW07	Trypanosomatidae	27%	92%
A0A1X0NX94	Trypanosomatidae	31%	89%
A0A1X0NX98	Trypanosomatidae	33%	72%
A0A1X0NXB6	Trypanosomatidae	29%	82%
A0A1X0NXH6	Trypanosomatidae	32%	79%
A0A1X0NXQ4	Trypanosomatidae	29%	85%
A0A1X0NXR7	Trypanosomatidae	34%	76%
A0A1X0NY94	Trypanosomatidae	39%	100%
A0A1X0NYE3	Trypanosomatidae	32%	92%
A0A1X0NYE7	Trypanosomatidae	31%	100%
A0A1X0NYN2	Trypanosomatidae	35%	100%
A0A1X0NYN4	Trypanosomatidae	27%	81%
A0A1X0NYS5	Trypanosomatidae	34%	96%
A0A1X0NYZ2	Trypanosomatidae	37%	100%
A0A1X0NZ46	Trypanosomatidae	29%	99%
A0A1X0NZ63	Trypanosomatidae	31%	90%
A0A1X0NZN6	Trypanosomatidae	28%	88%
A0A1X0P055	Trypanosomatidae	35%	97%
A0A1X0P0C4	Trypanosomatidae	30%	100%
A0A1X0P154	Trypanosomatidae	29%	96%
A0A1X0P331	Trypanosomatidae	34%	100%
A0A1X0P3K0	Trypanosomatidae	29%	79%
A0A1X0P3S2	Trypanosomatidae	28%	100%
A0A1X0P4L8	Trypanosomatidae	32%	100%
A0A1X0P4Y5	Trypanosomatidae	31%	90%
A0A1X0P544	Trypanosomatidae	33%	90%
A0A1X0P5J0	Trypanosomatidae	32%	84%
A0A1X0P7R3	Trypanosomatidae	36%	100%
A0A1X0P8B4	Trypanosomatidae	32%	100%
A0A1X0P9Z4	Trypanosomatidae	34%	100%
A0A1X0PB04	Trypanosomatidae	33%	100%
A0A3Q8I8N3	Leishmania donovani	57%	96%
A0A3Q8I8P8	Leishmania donovani	59%	96%
A0A3Q8I8S6	Leishmania donovani	60%	90%
A0A3Q8I8S9	Leishmania donovani	59%	96%
A0A3Q8IAZ8	Leishmania donovani	57%	96%
A0A3Q8IC35	Leishmania donovani	57%	96%
A0A3Q8IC44	Leishmania donovani	57%	98%
A0A3Q8IH61	Leishmania donovani	58%	98%
A0A3Q8IIN4	Leishmania donovani	37%	90%
A0A3R7JT49	Trypanosoma rangeli	34%	68%
A0A3R7JTB6	Trypanosoma rangeli	33%	82%
A0A3R7JUS0	Trypanosoma rangeli	34%	100%
A0A3R7JV87	Trypanosoma rangeli	34%	100%
A0A3R7K7T9	Trypanosoma rangeli	34%	96%
A0A3R7K9S1	Trypanosoma rangeli	34%	100%
A0A3R7KLR6	Trypanosoma rangeli	31%	90%
A0A3R7KMY2	Trypanosoma rangeli	34%	86%
A0A3R7LFC4	Trypanosoma rangeli	34%	85%
A0A3R7LFZ4	Trypanosoma rangeli	37%	100%
A0A3R7LWG1	Trypanosoma rangeli	33%	100%
A0A3R7LX11	Trypanosoma rangeli	34%	100%
A0A3R7M1R8	Trypanosoma rangeli	35%	100%
A0A3R7M574	Trypanosoma rangeli	33%	90%
A0A3R7M5K4	Trypanosoma rangeli	34%	100%
A0A3R7M7N6	Trypanosoma rangeli	33%	84%
A0A3R7MTS2	Trypanosoma rangeli	39%	100%
A0A3R7MW36	Trypanosoma rangeli	34%	100%
A0A3R7MXF4	Trypanosoma rangeli	35%	94%
A0A3R7N1W7	Trypanosoma rangeli	34%	98%
A0A3R7N289	Trypanosoma rangeli	33%	79%
A0A3R7N7I3	Trypanosoma rangeli	41%	100%
A0A3R7NTI8	Trypanosoma rangeli	34%	100%
A0A3R7R2J4	Trypanosoma rangeli	32%	89%
A0A3R7R5R1	Trypanosoma rangeli	36%	96%
A0A3R7R818	Trypanosoma rangeli	32%	100%
A0A3S5H6G0	Leishmania donovani	59%	96%
A0A3S5IQY2	Trypanosoma rangeli	38%	100%
A0A3S7WR43	Leishmania donovani	57%	96%
A0A3S7WR46	Leishmania donovani	59%	96%
A0A3S7WR60	Leishmania donovani	59%	96%
A0A3S7X192	Leishmania donovani	39%	100%
A0A422MRQ6	Trypanosoma rangeli	35%	77%
A0A422MU95	Trypanosoma rangeli	33%	100%
A0A422MVF5	Trypanosoma rangeli	32%	100%
A0A422MVS3	Trypanosoma rangeli	36%	100%
A0A422MW99	Trypanosoma rangeli	32%	77%
A0A422MZ47	Trypanosoma rangeli	39%	100%
A0A422MZG4	Trypanosoma rangeli	35%	98%
A0A422N361	Trypanosoma rangeli	32%	100%
A0A422N7Q6	Trypanosoma rangeli	33%	89%
A0A422NDS2	Trypanosoma rangeli	32%	99%
A0A422NDT3	Trypanosoma rangeli	31%	100%
A0A422NP82	Trypanosoma rangeli	38%	100%
A4H626	Leishmania braziliensis	78%	99%
A4H627	Leishmania braziliensis	72%	100%
A4H629	Leishmania braziliensis	70%	100%
A4H630	Leishmania braziliensis	71%	100%
A4H632	Leishmania braziliensis	69%	100%
A4H633	Leishmania braziliensis	83%	100%
A4H634	Leishmania braziliensis	73%	93%
A4H635	Leishmania braziliensis	72%	92%
A4H636	Leishmania braziliensis	68%	100%
A4H637	Leishmania braziliensis	72%	92%
A4H638	Leishmania braziliensis	64%	98%
A4H639	Leishmania braziliensis	70%	94%
A4H640	Leishmania braziliensis	72%	93%
A4H6D3	Leishmania braziliensis	76%	98%
A4H6D5	Leishmania braziliensis	78%	81%
A4H6D7	Leishmania braziliensis	70%	98%
A4H6D8	Leishmania braziliensis	81%	98%
A4H6D9	Leishmania braziliensis	80%	98%
A4H6E0	Leishmania braziliensis	79%	81%
A4H6E1	Leishmania braziliensis	74%	98%
A4H6E2	Leishmania braziliensis	74%	100%
A4H6E3	Leishmania braziliensis	78%	100%
A4H6E4	Leishmania braziliensis	79%	100%
A4H6E5	Leishmania braziliensis	67%	100%
A4HJI2	Leishmania braziliensis	38%	89%
A4HUF6	Leishmania infantum	58%	96%
A4HUF8	Leishmania infantum	59%	96%
A4HUF9	Leishmania infantum	61%	90%
A4HUG0	Leishmania infantum	59%	75%
A4I6X5	Leishmania infantum	37%	90%
C9ZUT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
D0A1R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
D0A7S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	85%
D0A855	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
E9AHH5	Leishmania infantum	39%	100%
E9AN53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	88%
E9AN54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	96%
E9AN55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	89%
E9AN56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	89%
E9AN57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	96%
E9AZL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B1Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	91%
O62446	Caenorhabditis elegans	25%	87%
P08148	Leishmania major	58%	96%
P15706	Leishmania chagasi	59%	96%
P23223	Leishmania donovani	57%	97%
P43150	Leishmania mexicana	58%	89%
Q00689	Leishmania guyanensis	70%	93%
Q06031	Crithidia fasciculata	49%	88%
Q27673	Leishmania amazonensis	57%	96%
Q29AK2	Drosophila pseudoobscura pseudoobscura	24%	84%
Q4Q662	Leishmania major	37%	100%
Q4Q8L3	Leishmania major	40%	100%
Q4QHG9	Leishmania major	58%	100%
Q4QHH0	Leishmania major	60%	100%
Q4QHH1	Leishmania major	58%	100%
Q4QHH2	Leishmania major	58%	100%
Q61YG1	Caenorhabditis briggsae	26%	87%
Q6LA77	Leishmania infantum	59%	96%
Q8MNZ1	Leishmania tropica	60%	88%
Q96KR4	Homo sapiens	23%	88%
Q9VH19	Drosophila melanogaster	24%	84%
V5A303	Trypanosoma cruzi	38%	100%
V5A359	Trypanosoma cruzi	38%	100%
V5A488	Trypanosoma cruzi	34%	71%
V5AII7	Trypanosoma cruzi	38%	100%
V5AN34	Trypanosoma cruzi	38%	100%
V5APQ4	Trypanosoma cruzi	34%	72%
V5AX72	Trypanosoma cruzi	35%	78%
V5B5M0	Trypanosoma cruzi	35%	78%
V5B9W5	Trypanosoma cruzi	31%	85%
V5BAN1	Trypanosoma cruzi	34%	73%
V5BD39	Trypanosoma cruzi	40%	100%
V5BLT3	Trypanosoma cruzi	30%	91%
V5CI97	Trypanosoma cruzi	32%	90%
V5D358	Trypanosoma cruzi	34%	68%