Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)
by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 2 |
| Forrest at al. (procyclic) | no | yes: 4 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 51 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | yes | yes: 41, no: 9 |
| NetGPI | no | yes: 0, no: 50 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 51 |
| GO:0110165 | cellular anatomical entity | 1 | 51 |
| GO:0005737 | cytoplasm | 2 | 4 |
| GO:0018995 | host cellular component | 2 | 4 |
| GO:0033643 | host cell part | 3 | 4 |
| GO:0033646 | host intracellular part | 4 | 4 |
| GO:0033647 | host intracellular organelle | 5 | 4 |
| GO:0033648 | host intracellular membrane-bounded organelle | 6 | 4 |
| GO:0042025 | host cell nucleus | 7 | 4 |
Related structures:
AlphaFold database: A4H630
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006508 | proteolysis | 4 | 51 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 51 |
| GO:0007155 | cell adhesion | 2 | 51 |
| GO:0008152 | metabolic process | 1 | 51 |
| GO:0009987 | cellular process | 1 | 51 |
| GO:0019538 | protein metabolic process | 3 | 51 |
| GO:0043170 | macromolecule metabolic process | 3 | 51 |
| GO:0044238 | primary metabolic process | 2 | 51 |
| GO:0071704 | organic substance metabolic process | 2 | 51 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 51 |
| GO:0009966 | regulation of signal transduction | 4 | 4 |
| GO:0010646 | regulation of cell communication | 4 | 4 |
| GO:0010749 | regulation of nitric oxide mediated signal transduction | 6 | 4 |
| GO:0023051 | regulation of signaling | 3 | 4 |
| GO:0035821 | modulation of process of another organism | 2 | 4 |
| GO:0044003 | modulation by symbiont of host process | 3 | 4 |
| GO:0044068 | modulation by symbiont of host cellular process | 4 | 4 |
| GO:0044081 | modulation by symbiont of host nitric oxide-mediated signal transduction | 5 | 4 |
| GO:0044403 | biological process involved in symbiotic interaction | 2 | 4 |
| GO:0044419 | biological process involved in interspecies interaction between organisms | 1 | 4 |
| GO:0044501 | modulation of signal transduction in another organism | 3 | 4 |
| GO:0048583 | regulation of response to stimulus | 3 | 4 |
| GO:0050789 | regulation of biological process | 2 | 4 |
| GO:0050794 | regulation of cellular process | 3 | 4 |
| GO:0051701 | biological process involved in interaction with host | 3 | 4 |
| GO:0052027 | modulation by symbiont of host signal transduction pathway | 4 | 4 |
| GO:0065007 | biological regulation | 1 | 4 |
| GO:0075130 | modulation by symbiont of host protein kinase-mediated signal transduction | 5 | 4 |
| GO:1902531 | regulation of intracellular signal transduction | 5 | 4 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 51 |
| GO:0004175 | endopeptidase activity | 4 | 51 |
| GO:0004222 | metalloendopeptidase activity | 5 | 51 |
| GO:0005488 | binding | 1 | 51 |
| GO:0008233 | peptidase activity | 3 | 51 |
| GO:0008237 | metallopeptidase activity | 4 | 51 |
| GO:0016787 | hydrolase activity | 2 | 51 |
| GO:0043167 | ion binding | 2 | 51 |
| GO:0043169 | cation binding | 3 | 51 |
| GO:0046872 | metal ion binding | 4 | 51 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 51 |
| GO:0008047 | enzyme activator activity | 3 | 4 |
| GO:0008160 | protein tyrosine phosphatase activator activity | 6 | 4 |
| GO:0019208 | phosphatase regulator activity | 3 | 4 |
| GO:0019211 | phosphatase activator activity | 4 | 4 |
| GO:0019888 | protein phosphatase regulator activity | 4 | 4 |
| GO:0030234 | enzyme regulator activity | 2 | 4 |
| GO:0072542 | protein phosphatase activator activity | 5 | 4 |
| GO:0098772 | molecular function regulator activity | 1 | 4 |
| GO:0140677 | molecular function activator activity | 2 | 4 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_MEL_PAP_1 | 126 | 132 | PF00089 | 0.413 |
| CLV_NRD_NRD_1 | 11 | 13 | PF00675 | 0.797 |
| CLV_NRD_NRD_1 | 409 | 411 | PF00675 | 0.423 |
| CLV_NRD_NRD_1 | 61 | 63 | PF00675 | 0.445 |
| CLV_PCSK_KEX2_1 | 10 | 12 | PF00082 | 0.788 |
| CLV_PCSK_KEX2_1 | 150 | 152 | PF00082 | 0.575 |
| CLV_PCSK_KEX2_1 | 409 | 411 | PF00082 | 0.421 |
| CLV_PCSK_KEX2_1 | 61 | 63 | PF00082 | 0.445 |
| CLV_PCSK_PC1ET2_1 | 150 | 152 | PF00082 | 0.564 |
| CLV_PCSK_SKI1_1 | 151 | 155 | PF00082 | 0.511 |
| CLV_PCSK_SKI1_1 | 258 | 262 | PF00082 | 0.556 |
| CLV_PCSK_SKI1_1 | 282 | 286 | PF00082 | 0.415 |
| CLV_PCSK_SKI1_1 | 336 | 340 | PF00082 | 0.457 |
| DEG_COP1_1 | 427 | 435 | PF00400 | 0.182 |
| DEG_SCF_FBW7_1 | 532 | 539 | PF00400 | 0.235 |
| DEG_SPOP_SBC_1 | 91 | 95 | PF00917 | 0.267 |
| DOC_CKS1_1 | 428 | 433 | PF01111 | 0.214 |
| DOC_CYCLIN_yCln2_LP_2 | 342 | 348 | PF00134 | 0.295 |
| DOC_PP2B_LxvP_1 | 342 | 345 | PF13499 | 0.379 |
| DOC_PP2B_LxvP_1 | 70 | 73 | PF13499 | 0.267 |
| DOC_PP4_FxxP_1 | 192 | 195 | PF00568 | 0.296 |
| DOC_PP4_FxxP_1 | 292 | 295 | PF00568 | 0.285 |
| DOC_USP7_MATH_1 | 2 | 6 | PF00917 | 0.549 |
| DOC_USP7_MATH_1 | 201 | 205 | PF00917 | 0.215 |
| DOC_USP7_MATH_1 | 495 | 499 | PF00917 | 0.291 |
| DOC_USP7_MATH_1 | 536 | 540 | PF00917 | 0.247 |
| DOC_USP7_MATH_1 | 73 | 77 | PF00917 | 0.270 |
| DOC_WW_Pin1_4 | 427 | 432 | PF00397 | 0.220 |
| DOC_WW_Pin1_4 | 497 | 502 | PF00397 | 0.224 |
| DOC_WW_Pin1_4 | 5 | 10 | PF00397 | 0.494 |
| DOC_WW_Pin1_4 | 532 | 537 | PF00397 | 0.400 |
| DOC_WW_Pin1_4 | 92 | 97 | PF00397 | 0.285 |
| LIG_14-3-3_CanoR_1 | 10 | 15 | PF00244 | 0.626 |
| LIG_14-3-3_CanoR_1 | 108 | 116 | PF00244 | 0.354 |
| LIG_14-3-3_CanoR_1 | 380 | 387 | PF00244 | 0.224 |
| LIG_14-3-3_CanoR_1 | 426 | 431 | PF00244 | 0.332 |
| LIG_14-3-3_CanoR_1 | 496 | 501 | PF00244 | 0.277 |
| LIG_14-3-3_CanoR_1 | 52 | 58 | PF00244 | 0.376 |
| LIG_14-3-3_CanoR_1 | 590 | 597 | PF00244 | 0.337 |
| LIG_AP2alpha_1 | 439 | 443 | PF02296 | 0.206 |
| LIG_APCC_ABBA_1 | 163 | 168 | PF00400 | 0.297 |
| LIG_APCC_ABBA_1 | 357 | 362 | PF00400 | 0.374 |
| LIG_APCC_ABBA_1 | 479 | 484 | PF00400 | 0.400 |
| LIG_BRCT_BRCA1_1 | 270 | 274 | PF00533 | 0.325 |
| LIG_BRCT_BRCA1_1 | 382 | 386 | PF00533 | 0.265 |
| LIG_BRCT_BRCA1_1 | 545 | 549 | PF00533 | 0.400 |
| LIG_Clathr_ClatBox_1 | 571 | 575 | PF01394 | 0.242 |
| LIG_FHA_1 | 104 | 110 | PF00498 | 0.306 |
| LIG_FHA_1 | 111 | 117 | PF00498 | 0.364 |
| LIG_FHA_1 | 183 | 189 | PF00498 | 0.373 |
| LIG_FHA_1 | 198 | 204 | PF00498 | 0.254 |
| LIG_FHA_1 | 225 | 231 | PF00498 | 0.295 |
| LIG_FHA_1 | 254 | 260 | PF00498 | 0.340 |
| LIG_FHA_1 | 276 | 282 | PF00498 | 0.277 |
| LIG_FHA_1 | 354 | 360 | PF00498 | 0.391 |
| LIG_FHA_1 | 413 | 419 | PF00498 | 0.372 |
| LIG_FHA_1 | 420 | 426 | PF00498 | 0.308 |
| LIG_FHA_1 | 49 | 55 | PF00498 | 0.236 |
| LIG_FHA_1 | 518 | 524 | PF00498 | 0.381 |
| LIG_FHA_1 | 545 | 551 | PF00498 | 0.275 |
| LIG_FHA_1 | 596 | 602 | PF00498 | 0.339 |
| LIG_FHA_2 | 139 | 145 | PF00498 | 0.325 |
| LIG_FHA_2 | 533 | 539 | PF00498 | 0.253 |
| LIG_GBD_Chelix_1 | 613 | 621 | PF00786 | 0.252 |
| LIG_IRF3_LxIS_1 | 613 | 620 | PF10401 | 0.207 |
| LIG_LIR_Apic_2 | 156 | 160 | PF02991 | 0.227 |
| LIG_LIR_Apic_2 | 191 | 195 | PF02991 | 0.295 |
| LIG_LIR_Apic_2 | 308 | 313 | PF02991 | 0.221 |
| LIG_LIR_Apic_2 | 408 | 414 | PF02991 | 0.231 |
| LIG_LIR_Apic_2 | 427 | 431 | PF02991 | 0.242 |
| LIG_LIR_Gen_1 | 314 | 322 | PF02991 | 0.398 |
| LIG_LIR_Gen_1 | 434 | 444 | PF02991 | 0.285 |
| LIG_LIR_Gen_1 | 478 | 486 | PF02991 | 0.275 |
| LIG_LIR_Gen_1 | 502 | 512 | PF02991 | 0.208 |
| LIG_LIR_Nem_3 | 103 | 107 | PF02991 | 0.259 |
| LIG_LIR_Nem_3 | 207 | 211 | PF02991 | 0.371 |
| LIG_LIR_Nem_3 | 314 | 320 | PF02991 | 0.362 |
| LIG_LIR_Nem_3 | 434 | 439 | PF02991 | 0.320 |
| LIG_LIR_Nem_3 | 448 | 453 | PF02991 | 0.317 |
| LIG_LIR_Nem_3 | 478 | 482 | PF02991 | 0.282 |
| LIG_LIR_Nem_3 | 502 | 508 | PF02991 | 0.265 |
| LIG_MLH1_MIPbox_1 | 271 | 275 | PF16413 | 0.212 |
| LIG_PCNA_yPIPBox_3 | 565 | 576 | PF02747 | 0.253 |
| LIG_Pex14_1 | 399 | 403 | PF04695 | 0.389 |
| LIG_Pex14_2 | 270 | 274 | PF04695 | 0.338 |
| LIG_Pex14_2 | 439 | 443 | PF04695 | 0.224 |
| LIG_PTB_Apo_2 | 202 | 209 | PF02174 | 0.389 |
| LIG_PTB_Apo_2 | 437 | 444 | PF02174 | 0.186 |
| LIG_PTB_Apo_2 | 548 | 555 | PF02174 | 0.203 |
| LIG_PTB_Phospho_1 | 548 | 554 | PF10480 | 0.203 |
| LIG_SH2_CRK | 310 | 314 | PF00017 | 0.215 |
| LIG_SH2_CRK | 352 | 356 | PF00017 | 0.404 |
| LIG_SH2_CRK | 411 | 415 | PF00017 | 0.234 |
| LIG_SH2_CRK | 428 | 432 | PF00017 | 0.274 |
| LIG_SH2_CRK | 505 | 509 | PF00017 | 0.362 |
| LIG_SH2_GRB2like | 352 | 355 | PF00017 | 0.210 |
| LIG_SH2_GRB2like | 438 | 441 | PF00017 | 0.199 |
| LIG_SH2_PTP2 | 560 | 563 | PF00017 | 0.396 |
| LIG_SH2_SRC | 157 | 160 | PF00017 | 0.244 |
| LIG_SH2_SRC | 317 | 320 | PF00017 | 0.287 |
| LIG_SH2_SRC | 560 | 563 | PF00017 | 0.295 |
| LIG_SH2_STAP1 | 447 | 451 | PF00017 | 0.197 |
| LIG_SH2_STAP1 | 521 | 525 | PF00017 | 0.400 |
| LIG_SH2_STAT5 | 157 | 160 | PF00017 | 0.269 |
| LIG_SH2_STAT5 | 211 | 214 | PF00017 | 0.290 |
| LIG_SH2_STAT5 | 317 | 320 | PF00017 | 0.361 |
| LIG_SH2_STAT5 | 352 | 355 | PF00017 | 0.327 |
| LIG_SH2_STAT5 | 435 | 438 | PF00017 | 0.354 |
| LIG_SH2_STAT5 | 453 | 456 | PF00017 | 0.273 |
| LIG_SH2_STAT5 | 531 | 534 | PF00017 | 0.332 |
| LIG_SH2_STAT5 | 554 | 557 | PF00017 | 0.396 |
| LIG_SH2_STAT5 | 560 | 563 | PF00017 | 0.331 |
| LIG_SH2_STAT5 | 74 | 77 | PF00017 | 0.413 |
| LIG_SH3_3 | 213 | 219 | PF00018 | 0.253 |
| LIG_SH3_3 | 489 | 495 | PF00018 | 0.250 |
| LIG_SUMO_SIM_par_1 | 615 | 620 | PF11976 | 0.238 |
| LIG_TYR_ITIM | 315 | 320 | PF00017 | 0.384 |
| MOD_CDK_SPK_2 | 499 | 504 | PF00069 | 0.235 |
| MOD_CDK_SPK_2 | 5 | 10 | PF00069 | 0.494 |
| MOD_CDK_SPxK_1 | 5 | 11 | PF00069 | 0.496 |
| MOD_CDK_SPxxK_3 | 497 | 504 | PF00069 | 0.205 |
| MOD_CDK_SPxxK_3 | 5 | 12 | PF00069 | 0.494 |
| MOD_CK1_1 | 214 | 220 | PF00069 | 0.355 |
| MOD_CK1_1 | 328 | 334 | PF00069 | 0.419 |
| MOD_CK1_1 | 480 | 486 | PF00069 | 0.275 |
| MOD_CK1_1 | 5 | 11 | PF00069 | 0.646 |
| MOD_CK1_1 | 553 | 559 | PF00069 | 0.312 |
| MOD_CK1_1 | 76 | 82 | PF00069 | 0.289 |
| MOD_CK2_1 | 368 | 374 | PF00069 | 0.494 |
| MOD_CK2_1 | 532 | 538 | PF00069 | 0.294 |
| MOD_GlcNHglycan | 325 | 328 | PF01048 | 0.336 |
| MOD_GlcNHglycan | 346 | 349 | PF01048 | 0.275 |
| MOD_GlcNHglycan | 447 | 450 | PF01048 | 0.395 |
| MOD_GlcNHglycan | 528 | 531 | PF01048 | 0.423 |
| MOD_GlcNHglycan | 67 | 70 | PF01048 | 0.457 |
| MOD_GlcNHglycan | 75 | 78 | PF01048 | 0.342 |
| MOD_GlcNHglycan | 81 | 84 | PF01048 | 0.260 |
| MOD_GSK3_1 | 110 | 117 | PF00069 | 0.314 |
| MOD_GSK3_1 | 175 | 182 | PF00069 | 0.355 |
| MOD_GSK3_1 | 197 | 204 | PF00069 | 0.361 |
| MOD_GSK3_1 | 254 | 261 | PF00069 | 0.377 |
| MOD_GSK3_1 | 427 | 434 | PF00069 | 0.273 |
| MOD_GSK3_1 | 495 | 502 | PF00069 | 0.276 |
| MOD_GSK3_1 | 532 | 539 | PF00069 | 0.254 |
| MOD_GSK3_1 | 589 | 596 | PF00069 | 0.325 |
| MOD_GSK3_1 | 78 | 85 | PF00069 | 0.271 |
| MOD_LATS_1 | 46 | 52 | PF00433 | 0.205 |
| MOD_N-GLC_1 | 297 | 302 | PF02516 | 0.317 |
| MOD_N-GLC_1 | 353 | 358 | PF02516 | 0.223 |
| MOD_N-GLC_1 | 380 | 385 | PF02516 | 0.263 |
| MOD_N-GLC_1 | 394 | 399 | PF02516 | 0.427 |
| MOD_N-GLC_1 | 404 | 409 | PF02516 | 0.244 |
| MOD_N-GLC_1 | 439 | 444 | PF02516 | 0.231 |
| MOD_N-GLC_1 | 496 | 501 | PF02516 | 0.220 |
| MOD_N-GLC_1 | 550 | 555 | PF02516 | 0.227 |
| MOD_N-GLC_2 | 389 | 391 | PF02516 | 0.265 |
| MOD_NEK2_1 | 184 | 189 | PF00069 | 0.184 |
| MOD_NEK2_1 | 268 | 273 | PF00069 | 0.421 |
| MOD_NEK2_1 | 275 | 280 | PF00069 | 0.317 |
| MOD_NEK2_1 | 3 | 8 | PF00069 | 0.520 |
| MOD_NEK2_1 | 439 | 444 | PF00069 | 0.271 |
| MOD_NEK2_1 | 617 | 622 | PF00069 | 0.385 |
| MOD_NEK2_2 | 269 | 274 | PF00069 | 0.226 |
| MOD_PIKK_1 | 394 | 400 | PF00454 | 0.373 |
| MOD_PK_1 | 10 | 16 | PF00069 | 0.618 |
| MOD_PK_1 | 477 | 483 | PF00069 | 0.220 |
| MOD_PKA_1 | 10 | 16 | PF00069 | 0.551 |
| MOD_PKA_2 | 10 | 16 | PF00069 | 0.519 |
| MOD_PKA_2 | 128 | 134 | PF00069 | 0.260 |
| MOD_PKA_2 | 495 | 501 | PF00069 | 0.227 |
| MOD_PKA_2 | 525 | 531 | PF00069 | 0.307 |
| MOD_PKA_2 | 589 | 595 | PF00069 | 0.341 |
| MOD_PKB_1 | 410 | 418 | PF00069 | 0.256 |
| MOD_Plk_1 | 190 | 196 | PF00069 | 0.194 |
| MOD_Plk_1 | 353 | 359 | PF00069 | 0.238 |
| MOD_Plk_1 | 368 | 374 | PF00069 | 0.247 |
| MOD_Plk_1 | 394 | 400 | PF00069 | 0.372 |
| MOD_Plk_1 | 439 | 445 | PF00069 | 0.245 |
| MOD_Plk_1 | 477 | 483 | PF00069 | 0.235 |
| MOD_Plk_2-3 | 144 | 150 | PF00069 | 0.392 |
| MOD_Plk_4 | 153 | 159 | PF00069 | 0.340 |
| MOD_Plk_4 | 269 | 275 | PF00069 | 0.337 |
| MOD_Plk_4 | 431 | 437 | PF00069 | 0.324 |
| MOD_Plk_4 | 439 | 445 | PF00069 | 0.264 |
| MOD_Plk_4 | 550 | 556 | PF00069 | 0.326 |
| MOD_ProDKin_1 | 427 | 433 | PF00069 | 0.237 |
| MOD_ProDKin_1 | 497 | 503 | PF00069 | 0.242 |
| MOD_ProDKin_1 | 5 | 11 | PF00069 | 0.496 |
| MOD_ProDKin_1 | 532 | 538 | PF00069 | 0.489 |
| MOD_ProDKin_1 | 92 | 98 | PF00069 | 0.328 |
| MOD_SUMO_for_1 | 338 | 341 | PF00179 | 0.339 |
| TRG_DiLeu_BaEn_3 | 148 | 154 | PF01217 | 0.268 |
| TRG_ENDOCYTIC_2 | 317 | 320 | PF00928 | 0.433 |
| TRG_ENDOCYTIC_2 | 352 | 355 | PF00928 | 0.344 |
| TRG_ENDOCYTIC_2 | 447 | 450 | PF00928 | 0.325 |
| TRG_ENDOCYTIC_2 | 453 | 456 | PF00928 | 0.372 |
| TRG_ENDOCYTIC_2 | 505 | 508 | PF00928 | 0.350 |
| TRG_ENDOCYTIC_2 | 560 | 563 | PF00928 | 0.341 |
| TRG_ER_diArg_1 | 169 | 172 | PF00400 | 0.233 |
| TRG_ER_diArg_1 | 409 | 411 | PF00400 | 0.259 |
| TRG_ER_diArg_1 | 417 | 420 | PF00400 | 0.254 |
| TRG_ER_diArg_1 | 61 | 63 | PF00400 | 0.264 |
| TRG_ER_diArg_1 | 9 | 12 | PF00400 | 0.606 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IL11 | Leptomonas seymouri | 35% | 95% |
| A0A0S4IN60 | Bodo saltans | 33% | 69% |
| A0A0S4IYM3 | Bodo saltans | 33% | 86% |
| A0A1L8HYT7 | Xenopus laevis | 22% | 86% |
| A0A1X0NDG7 | Trypanosomatidae | 30% | 95% |
| A0A1X0NDJ3 | Trypanosomatidae | 29% | 86% |
| A0A1X0NDK2 | Trypanosomatidae | 32% | 100% |
| A0A1X0NDK7 | Trypanosomatidae | 29% | 87% |
| A0A1X0NDK9 | Trypanosomatidae | 31% | 100% |
| A0A1X0NDM7 | Trypanosomatidae | 30% | 97% |
| A0A1X0NDU8 | Trypanosomatidae | 27% | 93% |
| A0A1X0NE71 | Trypanosomatidae | 29% | 100% |
| A0A1X0NEE9 | Trypanosomatidae | 28% | 67% |
| A0A1X0NER9 | Trypanosomatidae | 33% | 97% |
| A0A1X0NET7 | Trypanosomatidae | 35% | 100% |
| A0A1X0NEX7 | Trypanosomatidae | 34% | 95% |
| A0A1X0NEZ6 | Trypanosomatidae | 30% | 95% |
| A0A1X0NF32 | Trypanosomatidae | 32% | 100% |
| A0A1X0NF41 | Trypanosomatidae | 32% | 100% |
| A0A1X0NFJ0 | Trypanosomatidae | 31% | 100% |
| A0A1X0NFK3 | Trypanosomatidae | 30% | 93% |
| A0A1X0NFS0 | Trypanosomatidae | 32% | 72% |
| A0A1X0NFT1 | Trypanosomatidae | 31% | 68% |
| A0A1X0NFU4 | Trypanosomatidae | 26% | 76% |
| A0A1X0NG20 | Trypanosomatidae | 30% | 100% |
| A0A1X0NGP3 | Trypanosomatidae | 28% | 73% |
| A0A1X0NGY3 | Trypanosomatidae | 30% | 81% |
| A0A1X0NGZ3 | Trypanosomatidae | 33% | 100% |
| A0A1X0NH86 | Trypanosomatidae | 31% | 71% |
| A0A1X0NHP6 | Trypanosomatidae | 29% | 100% |
| A0A1X0NHQ6 | Trypanosomatidae | 32% | 100% |
| A0A1X0NI38 | Trypanosomatidae | 27% | 71% |
| A0A1X0NI74 | Trypanosomatidae | 32% | 83% |
| A0A1X0NII4 | Trypanosomatidae | 29% | 74% |
| A0A1X0NIZ3 | Trypanosomatidae | 33% | 100% |
| A0A1X0NJS3 | Trypanosomatidae | 30% | 95% |
| A0A1X0NJU4 | Trypanosomatidae | 28% | 72% |
| A0A1X0NK29 | Trypanosomatidae | 30% | 67% |
| A0A1X0NK66 | Trypanosomatidae | 32% | 94% |
| A0A1X0NKJ8 | Trypanosomatidae | 29% | 83% |
| A0A1X0NKW9 | Trypanosomatidae | 30% | 100% |
| A0A1X0NME2 | Trypanosomatidae | 31% | 99% |
| A0A1X0NMK3 | Trypanosomatidae | 29% | 100% |
| A0A1X0NMK7 | Trypanosomatidae | 37% | 100% |
| A0A1X0NMV0 | Trypanosomatidae | 32% | 85% |
| A0A1X0NN43 | Trypanosomatidae | 30% | 87% |
| A0A1X0NNK8 | Trypanosomatidae | 31% | 94% |
| A0A1X0NP64 | Trypanosomatidae | 30% | 70% |
| A0A1X0NPW0 | Trypanosomatidae | 30% | 97% |
| A0A1X0NQM4 | Trypanosomatidae | 35% | 100% |
| A0A1X0NQN3 | Trypanosomatidae | 34% | 100% |
| A0A1X0NQU4 | Trypanosomatidae | 37% | 96% |
| A0A1X0NQW6 | Trypanosomatidae | 32% | 100% |
| A0A1X0NRF3 | Trypanosomatidae | 32% | 93% |
| A0A1X0NRY8 | Trypanosomatidae | 38% | 100% |
| A0A1X0NU16 | Trypanosomatidae | 34% | 100% |
| A0A1X0NUR2 | Trypanosomatidae | 32% | 84% |
| A0A1X0NV28 | Trypanosomatidae | 35% | 100% |
| A0A1X0NVE0 | Trypanosomatidae | 29% | 79% |
| A0A1X0NW07 | Trypanosomatidae | 27% | 99% |
| A0A1X0NX94 | Trypanosomatidae | 31% | 96% |
| A0A1X0NX98 | Trypanosomatidae | 30% | 78% |
| A0A1X0NXB6 | Trypanosomatidae | 29% | 88% |
| A0A1X0NXH6 | Trypanosomatidae | 34% | 85% |
| A0A1X0NXQ4 | Trypanosomatidae | 28% | 92% |
| A0A1X0NXR7 | Trypanosomatidae | 34% | 83% |
| A0A1X0NYE3 | Trypanosomatidae | 32% | 100% |
| A0A1X0NYE7 | Trypanosomatidae | 32% | 100% |
| A0A1X0NYN2 | Trypanosomatidae | 35% | 100% |
| A0A1X0NYN4 | Trypanosomatidae | 26% | 87% |
| A0A1X0NYS5 | Trypanosomatidae | 34% | 100% |
| A0A1X0NYZ2 | Trypanosomatidae | 36% | 100% |
| A0A1X0NZ46 | Trypanosomatidae | 26% | 100% |
| A0A1X0NZ63 | Trypanosomatidae | 31% | 97% |
| A0A1X0NZN6 | Trypanosomatidae | 28% | 96% |
| A0A1X0P055 | Trypanosomatidae | 35% | 100% |
| A0A1X0P154 | Trypanosomatidae | 28% | 100% |
| A0A1X0P331 | Trypanosomatidae | 32% | 100% |
| A0A1X0P3K0 | Trypanosomatidae | 27% | 85% |
| A0A1X0P3S2 | Trypanosomatidae | 27% | 100% |
| A0A1X0P4L8 | Trypanosomatidae | 31% | 100% |
| A0A1X0P4Y5 | Trypanosomatidae | 27% | 97% |
| A0A1X0P544 | Trypanosomatidae | 31% | 97% |
| A0A1X0P5J0 | Trypanosomatidae | 32% | 91% |
| A0A1X0P7K5 | Trypanosomatidae | 28% | 70% |
| A0A1X0P7R3 | Trypanosomatidae | 36% | 100% |
| A0A1X0P8B4 | Trypanosomatidae | 31% | 100% |
| A0A1X0P9Z4 | Trypanosomatidae | 32% | 100% |
| A0A1X0PB04 | Trypanosomatidae | 33% | 100% |
| A0A3Q8I8N3 | Leishmania donovani | 62% | 100% |
| A0A3Q8I8P8 | Leishmania donovani | 63% | 100% |
| A0A3Q8I8S6 | Leishmania donovani | 65% | 97% |
| A0A3Q8I8S9 | Leishmania donovani | 64% | 100% |
| A0A3Q8IAZ8 | Leishmania donovani | 62% | 100% |
| A0A3Q8IC35 | Leishmania donovani | 62% | 100% |
| A0A3Q8IC44 | Leishmania donovani | 62% | 100% |
| A0A3Q8IH61 | Leishmania donovani | 63% | 100% |
| A0A3Q8IIN4 | Leishmania donovani | 37% | 98% |
| A0A3R7JT49 | Trypanosoma rangeli | 37% | 74% |
| A0A3R7JTB6 | Trypanosoma rangeli | 34% | 88% |
| A0A3R7JV87 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7K7T9 | Trypanosoma rangeli | 33% | 100% |
| A0A3R7K9S1 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7KLR6 | Trypanosoma rangeli | 32% | 97% |
| A0A3R7KMY2 | Trypanosoma rangeli | 33% | 93% |
| A0A3R7LFC4 | Trypanosoma rangeli | 36% | 92% |
| A0A3R7LFZ4 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7LWG1 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7LX11 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7M1R8 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7M574 | Trypanosoma rangeli | 33% | 97% |
| A0A3R7M7N6 | Trypanosoma rangeli | 36% | 90% |
| A0A3R7MTS2 | Trypanosoma rangeli | 37% | 100% |
| A0A3R7MW36 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7MXF4 | Trypanosoma rangeli | 37% | 100% |
| A0A3R7N1W7 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7N289 | Trypanosoma rangeli | 35% | 86% |
| A0A3R7NTI8 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7R2J4 | Trypanosoma rangeli | 35% | 96% |
| A0A3R7R5R1 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7R818 | Trypanosoma rangeli | 32% | 100% |
| A0A3S5H6G0 | Leishmania donovani | 63% | 100% |
| A0A3S5IQY2 | Trypanosoma rangeli | 37% | 100% |
| A0A3S7WR43 | Leishmania donovani | 62% | 100% |
| A0A3S7WR46 | Leishmania donovani | 63% | 100% |
| A0A3S7WR60 | Leishmania donovani | 65% | 100% |
| A0A3S7X192 | Leishmania donovani | 39% | 100% |
| A0A422MRQ6 | Trypanosoma rangeli | 35% | 83% |
| A0A422MU95 | Trypanosoma rangeli | 36% | 100% |
| A0A422MVF5 | Trypanosoma rangeli | 33% | 100% |
| A0A422MVS3 | Trypanosoma rangeli | 34% | 100% |
| A0A422MW99 | Trypanosoma rangeli | 32% | 84% |
| A0A422MZ47 | Trypanosoma rangeli | 38% | 100% |
| A0A422MZG4 | Trypanosoma rangeli | 37% | 100% |
| A0A422N361 | Trypanosoma rangeli | 35% | 100% |
| A0A422N7Q6 | Trypanosoma rangeli | 34% | 96% |
| A0A422NDS2 | Trypanosoma rangeli | 34% | 100% |
| A0A422NDT3 | Trypanosoma rangeli | 32% | 100% |
| A0A422NP82 | Trypanosoma rangeli | 39% | 100% |
| A4H626 | Leishmania braziliensis | 74% | 100% |
| A4H627 | Leishmania braziliensis | 70% | 100% |
| A4H631 | Leishmania braziliensis | 71% | 100% |
| A4H632 | Leishmania braziliensis | 83% | 100% |
| A4H633 | Leishmania braziliensis | 72% | 100% |
| A4H634 | Leishmania braziliensis | 87% | 100% |
| A4H635 | Leishmania braziliensis | 89% | 100% |
| A4H636 | Leishmania braziliensis | 67% | 100% |
| A4H637 | Leishmania braziliensis | 88% | 100% |
| A4H638 | Leishmania braziliensis | 78% | 100% |
| A4H639 | Leishmania braziliensis | 87% | 100% |
| A4H640 | Leishmania braziliensis | 88% | 100% |
| A4H6D1 | Leishmania braziliensis | 72% | 100% |
| A4H6D3 | Leishmania braziliensis | 71% | 100% |
| A4H6D5 | Leishmania braziliensis | 73% | 88% |
| A4H6D7 | Leishmania braziliensis | 69% | 100% |
| A4H6D8 | Leishmania braziliensis | 72% | 100% |
| A4H6D9 | Leishmania braziliensis | 71% | 100% |
| A4H6E0 | Leishmania braziliensis | 73% | 87% |
| A4H6E1 | Leishmania braziliensis | 71% | 100% |
| A4H6E2 | Leishmania braziliensis | 72% | 100% |
| A4H6E3 | Leishmania braziliensis | 72% | 100% |
| A4H6E5 | Leishmania braziliensis | 88% | 100% |
| A4HJI2 | Leishmania braziliensis | 37% | 96% |
| A4HUF6 | Leishmania infantum | 62% | 100% |
| A4HUF8 | Leishmania infantum | 65% | 100% |
| A4HUF9 | Leishmania infantum | 65% | 97% |
| A4HUG0 | Leishmania infantum | 63% | 82% |
| A4I6X5 | Leishmania infantum | 38% | 98% |
| C9ZUT5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 34% | 100% |
| D0A1R8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 100% |
| D0A7S8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 29% | 92% |
| D0A855 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 100% |
| E9AHH5 | Leishmania infantum | 39% | 100% |
| E9AN53 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 65% | 95% |
| E9AN54 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 64% | 100% |
| E9AN55 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 64% | 97% |
| E9AN56 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 64% | 96% |
| E9AN57 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 63% | 100% |
| E9AZL8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 40% | 100% |
| E9B1Z9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 38% | 98% |
| O62446 | Caenorhabditis elegans | 25% | 94% |
| P08148 | Leishmania major | 64% | 100% |
| P15706 | Leishmania chagasi | 64% | 100% |
| P23223 | Leishmania donovani | 63% | 100% |
| P43150 | Leishmania mexicana | 65% | 96% |
| Q00689 | Leishmania guyanensis | 88% | 100% |
| Q06031 | Crithidia fasciculata | 53% | 95% |
| Q27673 | Leishmania amazonensis | 63% | 100% |
| Q29AK2 | Drosophila pseudoobscura pseudoobscura | 24% | 91% |
| Q4Q662 | Leishmania major | 37% | 100% |
| Q4Q8L3 | Leishmania major | 39% | 100% |
| Q4QHG9 | Leishmania major | 63% | 98% |
| Q4QHH0 | Leishmania major | 65% | 100% |
| Q4QHH1 | Leishmania major | 64% | 98% |
| Q4QHH2 | Leishmania major | 64% | 98% |
| Q61YG1 | Caenorhabditis briggsae | 26% | 94% |
| Q6LA77 | Leishmania infantum | 64% | 100% |
| Q8BMN4 | Mus musculus | 25% | 91% |
| Q8MNZ1 | Leishmania tropica | 66% | 95% |
| Q96KR4 | Homo sapiens | 21% | 95% |
| Q9VH19 | Drosophila melanogaster | 23% | 91% |
| V5A359 | Trypanosoma cruzi | 37% | 100% |
| V5A488 | Trypanosoma cruzi | 34% | 77% |
| V5AII7 | Trypanosoma cruzi | 37% | 100% |
| V5APQ4 | Trypanosoma cruzi | 34% | 78% |
| V5AX72 | Trypanosoma cruzi | 36% | 84% |
| V5B5M0 | Trypanosoma cruzi | 35% | 84% |
| V5BAN1 | Trypanosoma cruzi | 35% | 79% |
| V5BD39 | Trypanosoma cruzi | 39% | 100% |
| V5BLT3 | Trypanosoma cruzi | 31% | 99% |
| V5CI97 | Trypanosoma cruzi | 32% | 97% |
| V5D358 | Trypanosoma cruzi | 34% | 73% |