Leishmanolysin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

metallo-peptidase, Clan MA(M), Family M8

Species:

Leishmania braziliensis

UniProt:

A4H629_LEIBR

TriTrypDb:

LbrM.10.0500 , LBRM2903_100013100

Length:

385

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 41, no: 64
NetGPI	no	yes: 0, no: 105

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	106
GO:0110165	cellular anatomical entity	1	106
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H629

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H629

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	106
GO:0006807	nitrogen compound metabolic process	2	106
GO:0007155	cell adhesion	2	106
GO:0008152	metabolic process	1	106
GO:0009987	cellular process	1	106
GO:0019538	protein metabolic process	3	106
GO:0043170	macromolecule metabolic process	3	106
GO:0044238	primary metabolic process	2	106
GO:0071704	organic substance metabolic process	2	106
GO:1901564	organonitrogen compound metabolic process	3	106

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	106
GO:0004175	endopeptidase activity	4	106
GO:0004222	metalloendopeptidase activity	5	106
GO:0005488	binding	1	106
GO:0008233	peptidase activity	3	106
GO:0008237	metallopeptidase activity	4	106
GO:0016787	hydrolase activity	2	106
GO:0043167	ion binding	2	106
GO:0043169	cation binding	3	106
GO:0046872	metal ion binding	4	106
GO:0140096	catalytic activity, acting on a protein	2	106

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	137	141	PF00082	0.457
CLV_PCSK_SKI1_1	59	63	PF00082	0.529
CLV_PCSK_SKI1_1	83	87	PF00082	0.441
DEG_Nend_UBRbox_2	1	3	PF02207	0.137
DEG_SCF_FBW7_1	333	340	PF00400	0.335
DOC_CKS1_1	230	235	PF01111	0.360
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.325
DOC_PP2B_LxvP_1	143	146	PF13499	0.325
DOC_PP4_FxxP_1	93	96	PF00568	0.354
DOC_USP7_MATH_1	337	341	PF00917	0.265
DOC_WW_Pin1_4	229	234	PF00397	0.261
DOC_WW_Pin1_4	272	277	PF00397	0.346
DOC_WW_Pin1_4	333	338	PF00397	0.307
LIG_14-3-3_CanoR_1	181	188	PF00244	0.306
LIG_14-3-3_CanoR_1	214	222	PF00244	0.242
LIG_14-3-3_CanoR_1	228	233	PF00244	0.272
LIG_14-3-3_CanoR_1	296	304	PF00244	0.322
LIG_14-3-3_CanoR_1	320	325	PF00244	0.337
LIG_APCC_ABBA_1	158	163	PF00400	0.284
LIG_APCC_ABBA_1	281	286	PF00400	0.363
LIG_BRCT_BRCA1_1	183	187	PF00533	0.358
LIG_BRCT_BRCA1_1	346	350	PF00533	0.322
LIG_BRCT_BRCA1_1	71	75	PF00533	0.345
LIG_FHA_1	155	161	PF00498	0.272
LIG_FHA_1	215	221	PF00498	0.282
LIG_FHA_1	222	228	PF00498	0.261
LIG_FHA_1	26	32	PF00498	0.243
LIG_FHA_1	319	325	PF00498	0.296
LIG_FHA_1	355	361	PF00498	0.323
LIG_FHA_1	56	62	PF00498	0.317
LIG_FHA_2	170	176	PF00498	0.315
LIG_FHA_2	205	211	PF00498	0.291
LIG_FHA_2	297	303	PF00498	0.270
LIG_FHA_2	334	340	PF00498	0.300
LIG_LIR_Apic_2	109	114	PF02991	0.296
LIG_LIR_Apic_2	229	233	PF02991	0.285
LIG_LIR_Gen_1	115	123	PF02991	0.347
LIG_LIR_Gen_1	236	246	PF02991	0.291
LIG_LIR_Gen_1	280	288	PF02991	0.353
LIG_LIR_Nem_3	115	121	PF02991	0.351
LIG_LIR_Nem_3	236	241	PF02991	0.295
LIG_LIR_Nem_3	250	255	PF02991	0.232
LIG_LIR_Nem_3	280	284	PF02991	0.354
LIG_LIR_Nem_3	300	306	PF02991	0.168
LIG_LIR_Nem_3	8	12	PF02991	0.281
LIG_MLH1_MIPbox_1	72	76	PF16413	0.151
LIG_PCNA_yPIPBox_3	366	377	PF02747	0.403
LIG_Pex14_1	200	204	PF04695	0.270
LIG_Pex14_2	241	245	PF04695	0.333
LIG_Pex14_2	71	75	PF04695	0.354
LIG_PTB_Apo_2	3	10	PF02174	0.298
LIG_SH2_CRK	111	115	PF00017	0.289
LIG_SH2_CRK	153	157	PF00017	0.249
LIG_SH2_CRK	230	234	PF00017	0.245
LIG_SH2_GRB2like	153	156	PF00017	0.293
LIG_SH2_GRB2like	262	265	PF00017	0.311
LIG_SH2_PTP2	361	364	PF00017	0.360
LIG_SH2_SRC	118	121	PF00017	0.343
LIG_SH2_SRC	361	364	PF00017	0.275
LIG_SH2_STAP1	322	326	PF00017	0.287
LIG_SH2_STAT3	322	325	PF00017	0.254
LIG_SH2_STAT5	118	121	PF00017	0.357
LIG_SH2_STAT5	12	15	PF00017	0.250
LIG_SH2_STAT5	153	156	PF00017	0.228
LIG_SH2_STAT5	237	240	PF00017	0.287
LIG_SH2_STAT5	255	258	PF00017	0.131
LIG_SH2_STAT5	303	306	PF00017	0.250
LIG_SH2_STAT5	332	335	PF00017	0.315
LIG_SH2_STAT5	355	358	PF00017	0.345
LIG_SH2_STAT5	361	364	PF00017	0.329
LIG_SH3_3	14	20	PF00018	0.349
LIG_TYR_ITIM	116	121	PF00017	0.360
MOD_CK1_1	129	135	PF00069	0.294
MOD_CK1_1	15	21	PF00069	0.336
MOD_CK1_1	272	278	PF00069	0.296
MOD_CK2_1	169	175	PF00069	0.271
MOD_CK2_1	204	210	PF00069	0.242
MOD_CK2_1	296	302	PF00069	0.291
MOD_CK2_1	333	339	PF00069	0.298
MOD_GlcNHglycan	126	129	PF01048	0.487
MOD_GlcNHglycan	147	150	PF01048	0.481
MOD_GlcNHglycan	346	349	PF01048	0.399
MOD_GSK3_1	229	236	PF00069	0.292
MOD_GSK3_1	314	321	PF00069	0.246
MOD_GSK3_1	333	340	PF00069	0.282
MOD_GSK3_1	55	62	PF00069	0.286
MOD_N-GLC_1	154	159	PF02516	0.468
MOD_N-GLC_1	181	186	PF02516	0.417
MOD_N-GLC_1	195	200	PF02516	0.501
MOD_N-GLC_1	205	210	PF02516	0.508
MOD_N-GLC_1	98	103	PF02516	0.424
MOD_NEK2_1	314	319	PF00069	0.258
MOD_NEK2_1	69	74	PF00069	0.285
MOD_NEK2_1	76	81	PF00069	0.240
MOD_NEK2_2	70	75	PF00069	0.354
MOD_PIKK_1	195	201	PF00454	0.342
MOD_PK_1	320	326	PF00069	0.272
MOD_PKA_2	213	219	PF00069	0.233
MOD_PKA_2	295	301	PF00069	0.298
MOD_PKA_2	326	332	PF00069	0.327
MOD_PKB_1	219	227	PF00069	0.347
MOD_Plk_1	154	160	PF00069	0.270
MOD_Plk_1	195	201	PF00069	0.351
MOD_Plk_1	98	104	PF00069	0.253
MOD_Plk_4	233	239	PF00069	0.335
MOD_Plk_4	351	357	PF00069	0.318
MOD_Plk_4	70	76	PF00069	0.303
MOD_Plk_4	99	105	PF00069	0.312
MOD_ProDKin_1	229	235	PF00069	0.261
MOD_ProDKin_1	272	278	PF00069	0.346
MOD_ProDKin_1	333	339	PF00069	0.307
MOD_SUMO_for_1	139	142	PF00179	0.259
TRG_ENDOCYTIC_2	118	121	PF00928	0.351
TRG_ENDOCYTIC_2	153	156	PF00928	0.242
TRG_ENDOCYTIC_2	255	258	PF00928	0.294
TRG_ENDOCYTIC_2	306	309	PF00928	0.335
TRG_ENDOCYTIC_2	361	364	PF00928	0.258
TRG_ER_diArg_1	219	222	PF00400	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IS53	Bodo saltans	38%	80%
A0A1X0NDK2	Trypanosomatidae	32%	67%
A0A1X0NDK9	Trypanosomatidae	30%	79%
A0A1X0NE71	Trypanosomatidae	31%	76%
A0A1X0NES0	Trypanosomatidae	32%	100%
A0A1X0NET7	Trypanosomatidae	35%	75%
A0A1X0NF32	Trypanosomatidae	31%	82%
A0A1X0NFJ0	Trypanosomatidae	32%	73%
A0A1X0NFZ9	Trypanosomatidae	34%	84%
A0A1X0NGN3	Trypanosomatidae	35%	93%
A0A1X0NGS6	Trypanosomatidae	37%	87%
A0A1X0NHP4	Trypanosomatidae	32%	96%
A0A1X0NHP6	Trypanosomatidae	33%	73%
A0A1X0NHQ6	Trypanosomatidae	32%	75%
A0A1X0NIJ6	Trypanosomatidae	35%	93%
A0A1X0NIZ3	Trypanosomatidae	32%	69%
A0A1X0NJC6	Trypanosomatidae	34%	90%
A0A1X0NKW9	Trypanosomatidae	29%	75%
A0A1X0NMK3	Trypanosomatidae	29%	74%
A0A1X0NMK7	Trypanosomatidae	37%	74%
A0A1X0NQ02	Trypanosomatidae	32%	100%
A0A1X0NQJ5	Trypanosomatidae	37%	84%
A0A1X0NQM4	Trypanosomatidae	35%	84%
A0A1X0NQN3	Trypanosomatidae	35%	89%
A0A1X0NQU3	Trypanosomatidae	41%	100%
A0A1X0NQW6	Trypanosomatidae	33%	67%
A0A1X0NR02	Trypanosomatidae	39%	100%
A0A1X0NRY8	Trypanosomatidae	40%	71%
A0A1X0NTJ1	Trypanosomatidae	34%	95%
A0A1X0NWK7	Trypanosomatidae	36%	96%
A0A1X0NY94	Trypanosomatidae	40%	91%
A0A1X0NYE7	Trypanosomatidae	33%	76%
A0A1X0NYN2	Trypanosomatidae	35%	73%
A0A1X0NYZ2	Trypanosomatidae	39%	69%
A0A1X0NZ46	Trypanosomatidae	27%	66%
A0A1X0P0C4	Trypanosomatidae	33%	75%
A0A1X0P331	Trypanosomatidae	36%	68%
A0A1X0P3S2	Trypanosomatidae	28%	69%
A0A1X0P4L8	Trypanosomatidae	33%	75%
A0A1X0P5K2	Trypanosomatidae	38%	87%
A0A1X0P7R3	Trypanosomatidae	36%	68%
A0A1X0P8B4	Trypanosomatidae	36%	77%
A0A1X0P9Z4	Trypanosomatidae	30%	70%
A0A1X0PB04	Trypanosomatidae	32%	75%
A0A3R7JUH9	Trypanosoma rangeli	38%	100%
A0A3R7JUS0	Trypanosoma rangeli	31%	83%
A0A3R7JV87	Trypanosoma rangeli	34%	72%
A0A3R7K9S1	Trypanosoma rangeli	35%	74%
A0A3R7KFR4	Trypanosoma rangeli	33%	100%
A0A3R7KJC7	Trypanosoma rangeli	37%	94%
A0A3R7LFZ4	Trypanosoma rangeli	37%	70%
A0A3R7LWG1	Trypanosoma rangeli	34%	68%
A0A3R7LX11	Trypanosoma rangeli	37%	69%
A0A3R7M1R8	Trypanosoma rangeli	36%	67%
A0A3R7MTS2	Trypanosoma rangeli	39%	85%
A0A3R7MW36	Trypanosoma rangeli	35%	72%
A0A3R7NTI8	Trypanosoma rangeli	36%	67%
A0A3R7R818	Trypanosoma rangeli	32%	73%
A0A3S5IQY2	Trypanosoma rangeli	41%	75%
A0A3S7X192	Leishmania donovani	39%	68%
A0A422MQQ6	Trypanosoma rangeli	32%	100%
A0A422MR94	Trypanosoma rangeli	43%	100%
A0A422MTE4	Trypanosoma rangeli	34%	83%
A0A422MU95	Trypanosoma rangeli	37%	67%
A0A422MUP1	Trypanosoma rangeli	39%	100%
A0A422MVF5	Trypanosoma rangeli	33%	69%
A0A422MVS3	Trypanosoma rangeli	36%	74%
A0A422MXE4	Trypanosoma rangeli	39%	100%
A0A422MZ47	Trypanosoma rangeli	40%	68%
A0A422N361	Trypanosoma rangeli	36%	69%
A0A422NDS2	Trypanosoma rangeli	33%	66%
A0A422NDT3	Trypanosoma rangeli	34%	67%
A0A422NP82	Trypanosoma rangeli	38%	67%
A4H626	Leishmania braziliensis	72%	67%
A4H631	Leishmania braziliensis	70%	67%
A4H632	Leishmania braziliensis	77%	77%
A4H633	Leishmania braziliensis	72%	69%
A4H636	Leishmania braziliensis	68%	86%
A4H6E2	Leishmania braziliensis	71%	67%
A4H6E3	Leishmania braziliensis	70%	67%
A4H6E4	Leishmania braziliensis	71%	96%
A4H6E5	Leishmania braziliensis	91%	75%
A4H6E7	Leishmania braziliensis	91%	100%
A4HJI1	Leishmania braziliensis	37%	100%
C9ZUT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	66%
D0A7W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	87%
E9AHH5	Leishmania infantum	39%	68%
E9AZL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	68%
Q4Q8L3	Leishmania major	40%	68%
V5A2X8	Trypanosoma cruzi	36%	80%
V5A303	Trypanosoma cruzi	42%	92%
V5A359	Trypanosoma cruzi	42%	71%
V5AII7	Trypanosoma cruzi	43%	71%
V5AJE7	Trypanosoma cruzi	35%	73%
V5AMH8	Trypanosoma cruzi	36%	81%
V5AN34	Trypanosoma cruzi	39%	92%
V5ANT4	Trypanosoma cruzi	41%	100%
V5AZG8	Trypanosoma cruzi	35%	81%
V5B7J8	Trypanosoma cruzi	35%	80%
V5BAB0	Trypanosoma cruzi	34%	100%
V5BAL3	Trypanosoma cruzi	43%	76%
V5BD39	Trypanosoma cruzi	46%	87%
V5CHU5	Trypanosoma cruzi	42%	100%
V5CIA7	Trypanosoma cruzi	35%	80%