Leishmanolysin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

metallo-peptidase, Clan MA(M), Family M8

Species:

Leishmania braziliensis

UniProt:

A4H628_LEIBR

TriTrypDb:

LbrM.10.0490 , LBRM2903_100011300

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 12, no: 4
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4H628

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H628

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0007155	cell adhesion	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0019538	protein metabolic process	3	17
GO:0043170	macromolecule metabolic process	3	17
GO:0044238	primary metabolic process	2	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004175	endopeptidase activity	4	17
GO:0004222	metalloendopeptidase activity	5	17
GO:0005488	binding	1	17
GO:0008233	peptidase activity	3	17
GO:0008237	metallopeptidase activity	4	17
GO:0016787	hydrolase activity	2	17
GO:0043167	ion binding	2	17
GO:0043169	cation binding	3	17
GO:0046872	metal ion binding	4	17
GO:0140096	catalytic activity, acting on a protein	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	115	121	PF00089	0.599
CLV_NRD_NRD_1	11	13	PF00675	0.685
CLV_NRD_NRD_1	64	66	PF00675	0.514
CLV_PCSK_KEX2_1	10	12	PF00082	0.705
CLV_PCSK_KEX2_1	139	141	PF00082	0.587
CLV_PCSK_KEX2_1	64	66	PF00082	0.588
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.595
CLV_PCSK_SKI1_1	140	144	PF00082	0.538
DOC_PP4_FxxP_1	181	184	PF00568	0.308
DOC_USP7_MATH_1	2	6	PF00917	0.710
DOC_WW_Pin1_4	41	46	PF00397	0.590
LIG_14-3-3_CanoR_1	10	15	PF00244	0.635
LIG_14-3-3_CanoR_1	97	105	PF00244	0.350
LIG_APCC_ABBA_1	152	157	PF00400	0.297
LIG_FHA_1	100	106	PF00498	0.304
LIG_FHA_1	143	149	PF00498	0.399
LIG_FHA_1	154	160	PF00498	0.350
LIG_FHA_1	172	178	PF00498	0.372
LIG_FHA_1	93	99	PF00498	0.344
LIG_FHA_2	104	110	PF00498	0.368
LIG_FHA_2	128	134	PF00498	0.395
LIG_LIR_Apic_2	145	149	PF02991	0.404
LIG_LIR_Apic_2	180	184	PF02991	0.367
LIG_LIR_Nem_3	92	96	PF02991	0.295
LIG_SH2_PTP2	78	81	PF00017	0.309
LIG_SH2_SRC	146	149	PF00017	0.412
LIG_SH2_STAT5	146	149	PF00017	0.368
LIG_SH2_STAT5	78	81	PF00017	0.393
LIG_SH3_3	71	77	PF00018	0.376
LIG_TYR_ITIM	76	81	PF00017	0.368
MOD_CDK_SPxK_1	41	47	PF00069	0.588
MOD_CK1_1	5	11	PF00069	0.687
MOD_CK1_1	69	75	PF00069	0.497
MOD_GlcNHglycan	59	62	PF01048	0.468
MOD_GlcNHglycan	68	71	PF01048	0.405
MOD_GSK3_1	164	171	PF00069	0.496
MOD_GSK3_1	99	106	PF00069	0.381
MOD_NEK2_1	3	8	PF00069	0.721
MOD_PK_1	10	16	PF00069	0.595
MOD_PKA_1	10	16	PF00069	0.704
MOD_PKA_2	10	16	PF00069	0.670
MOD_PKA_2	117	123	PF00069	0.493
MOD_PKA_2	57	63	PF00069	0.418
MOD_Plk_2-3	133	139	PF00069	0.473
MOD_Plk_4	142	148	PF00069	0.389
MOD_ProDKin_1	41	47	PF00069	0.588
MOD_SUMO_rev_2	176	184	PF00179	0.368
TRG_DiLeu_BaEn_3	137	143	PF01217	0.489
TRG_ENDOCYTIC_2	78	81	PF00928	0.368
TRG_ER_diArg_1	10	12	PF00400	0.704
TRG_ER_diArg_1	158	161	PF00400	0.447
TRG_ER_diArg_1	64	66	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY57	Leptomonas seymouri	46%	100%
A0A1X0NE39	Trypanosomatidae	29%	85%
A0A1X0NEZ4	Trypanosomatidae	32%	84%
A0A1X0NYP3	Trypanosomatidae	31%	100%
A0A1X0NYS3	Trypanosomatidae	30%	100%
A0A1X0NZ13	Trypanosomatidae	33%	100%
A0A1X0P096	Trypanosomatidae	33%	100%
A0A3R7KJI4	Trypanosoma rangeli	30%	100%
A0A3R7M020	Trypanosoma rangeli	30%	100%
A0A422MR05	Trypanosoma rangeli	31%	81%
A0A422MTC6	Trypanosoma rangeli	31%	100%
A0A422MYZ9	Trypanosoma rangeli	31%	95%
A4H6E6	Leishmania braziliensis	99%	100%
D0A7W3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	66%
V5B5E7	Trypanosoma cruzi	32%	68%