Leishmanolysin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

metallo-peptidase, Clan MA(M), Family M8

Species:

Leishmania braziliensis

UniProt:

A4H627_LEIBR

TriTrypDb:

LbrM.10.0480 , LBRM2903_100011100

Length:

584

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 51

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 41, no: 10
NetGPI	no	yes: 0, no: 51

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	52
GO:0110165	cellular anatomical entity	1	52
GO:0005737	cytoplasm	2	4
GO:0018995	host cellular component	2	4
GO:0033643	host cell part	3	4
GO:0033646	host intracellular part	4	4
GO:0033647	host intracellular organelle	5	4
GO:0033648	host intracellular membrane-bounded organelle	6	4
GO:0042025	host cell nucleus	7	4

Expansion

Sequence features

A4H627

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H627

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	52
GO:0006807	nitrogen compound metabolic process	2	52
GO:0007155	cell adhesion	2	52
GO:0008152	metabolic process	1	52
GO:0009987	cellular process	1	52
GO:0019538	protein metabolic process	3	52
GO:0043170	macromolecule metabolic process	3	52
GO:0044238	primary metabolic process	2	52
GO:0071704	organic substance metabolic process	2	52
GO:1901564	organonitrogen compound metabolic process	3	52
GO:0009966	regulation of signal transduction	4	4
GO:0010646	regulation of cell communication	4	4
GO:0010749	regulation of nitric oxide mediated signal transduction	6	4
GO:0023051	regulation of signaling	3	4
GO:0035821	modulation of process of another organism	2	4
GO:0044003	modulation by symbiont of host process	3	4
GO:0044068	modulation by symbiont of host cellular process	4	4
GO:0044081	modulation by symbiont of host nitric oxide-mediated signal transduction	5	4
GO:0044403	biological process involved in symbiotic interaction	2	4
GO:0044419	biological process involved in interspecies interaction between organisms	1	4
GO:0044501	modulation of signal transduction in another organism	3	4
GO:0048583	regulation of response to stimulus	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051701	biological process involved in interaction with host	3	4
GO:0052027	modulation by symbiont of host signal transduction pathway	4	4
GO:0065007	biological regulation	1	4
GO:0075130	modulation by symbiont of host protein kinase-mediated signal transduction	5	4
GO:1902531	regulation of intracellular signal transduction	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	52
GO:0004175	endopeptidase activity	4	52
GO:0004222	metalloendopeptidase activity	5	52
GO:0005488	binding	1	52
GO:0008233	peptidase activity	3	52
GO:0008237	metallopeptidase activity	4	52
GO:0016787	hydrolase activity	2	52
GO:0043167	ion binding	2	52
GO:0043169	cation binding	3	52
GO:0046872	metal ion binding	4	52
GO:0140096	catalytic activity, acting on a protein	2	52
GO:0008047	enzyme activator activity	3	4
GO:0008160	protein tyrosine phosphatase activator activity	6	4
GO:0019208	phosphatase regulator activity	3	4
GO:0019211	phosphatase activator activity	4	4
GO:0019888	protein phosphatase regulator activity	4	4
GO:0030234	enzyme regulator activity	2	4
GO:0072542	protein phosphatase activator activity	5	4
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.204
CLV_C14_Caspase3-7	544	548	PF00656	0.219
CLV_NRD_NRD_1	11	13	PF00675	0.580
CLV_NRD_NRD_1	427	429	PF00675	0.393
CLV_PCSK_KEX2_1	10	12	PF00082	0.598
CLV_PCSK_KEX2_1	150	152	PF00082	0.570
CLV_PCSK_KEX2_1	429	431	PF00082	0.389
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.559
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.389
CLV_PCSK_SKI1_1	143	147	PF00082	0.498
CLV_PCSK_SKI1_1	151	155	PF00082	0.544
CLV_PCSK_SKI1_1	272	276	PF00082	0.446
CLV_PCSK_SKI1_1	336	340	PF00082	0.493
CLV_PCSK_SKI1_1	394	398	PF00082	0.467
DEG_APCC_DBOX_1	150	158	PF00400	0.202
DEG_SCF_FBW7_1	532	539	PF00400	0.236
DEG_SPOP_SBC_1	91	95	PF00917	0.263
DOC_CKS1_1	297	302	PF01111	0.206
DOC_MAPK_gen_1	150	157	PF00069	0.204
DOC_MAPK_MEF2A_6	150	159	PF00069	0.202
DOC_PP1_RVXF_1	270	276	PF00149	0.189
DOC_PP2B_LxvP_1	70	73	PF13499	0.263
DOC_PP4_FxxP_1	192	195	PF00568	0.398
DOC_USP7_MATH_1	472	476	PF00917	0.250
DOC_USP7_MATH_1	536	540	PF00917	0.248
DOC_USP7_MATH_1	543	547	PF00917	0.233
DOC_USP7_MATH_1	73	77	PF00917	0.267
DOC_USP7_MATH_1	79	83	PF00917	0.245
DOC_WW_Pin1_4	247	252	PF00397	0.208
DOC_WW_Pin1_4	296	301	PF00397	0.258
DOC_WW_Pin1_4	445	450	PF00397	0.211
DOC_WW_Pin1_4	470	475	PF00397	0.254
DOC_WW_Pin1_4	532	537	PF00397	0.398
DOC_WW_Pin1_4	92	97	PF00397	0.281
LIG_14-3-3_CanoR_1	108	114	PF00244	0.380
LIG_14-3-3_CanoR_1	394	403	PF00244	0.217
LIG_14-3-3_CanoR_1	412	420	PF00244	0.286
LIG_14-3-3_CanoR_1	5	14	PF00244	0.602
LIG_14-3-3_CanoR_1	52	58	PF00244	0.371
LIG_14-3-3_CanoR_1	520	524	PF00244	0.372
LIG_AP2alpha_1	274	278	PF02296	0.204
LIG_AP2alpha_1	439	443	PF02296	0.204
LIG_APCC_ABBA_1	163	168	PF00400	0.398
LIG_APCC_ABBA_1	357	362	PF00400	0.373
LIG_APCC_ABBA_1	447	452	PF00400	0.235
LIG_APCC_ABBA_1	479	484	PF00400	0.398
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_BRCT_BRCA1_1	545	549	PF00533	0.398
LIG_FHA_1	104	110	PF00498	0.317
LIG_FHA_1	176	182	PF00498	0.304
LIG_FHA_1	280	286	PF00498	0.217
LIG_FHA_1	297	303	PF00498	0.204
LIG_FHA_1	354	360	PF00498	0.389
LIG_FHA_1	404	410	PF00498	0.285
LIG_FHA_1	413	419	PF00498	0.368
LIG_FHA_2	180	186	PF00498	0.234
LIG_FHA_2	457	463	PF00498	0.205
LIG_FHA_2	542	548	PF00498	0.245
LIG_LIR_Apic_2	191	195	PF02991	0.384
LIG_LIR_Apic_2	291	295	PF02991	0.299
LIG_LIR_Gen_1	112	121	PF02991	0.219
LIG_LIR_Gen_1	200	211	PF02991	0.213
LIG_LIR_Gen_1	225	232	PF02991	0.200
LIG_LIR_Gen_1	250	260	PF02991	0.352
LIG_LIR_Gen_1	316	322	PF02991	0.378
LIG_LIR_Gen_1	434	444	PF02991	0.281
LIG_LIR_Gen_1	478	486	PF02991	0.275
LIG_LIR_Nem_3	112	116	PF02991	0.259
LIG_LIR_Nem_3	120	125	PF02991	0.208
LIG_LIR_Nem_3	200	206	PF02991	0.341
LIG_LIR_Nem_3	207	211	PF02991	0.369
LIG_LIR_Nem_3	225	230	PF02991	0.191
LIG_LIR_Nem_3	250	255	PF02991	0.352
LIG_LIR_Nem_3	276	281	PF02991	0.251
LIG_LIR_Nem_3	291	296	PF02991	0.197
LIG_LIR_Nem_3	316	320	PF02991	0.346
LIG_LIR_Nem_3	434	439	PF02991	0.320
LIG_LIR_Nem_3	448	453	PF02991	0.285
LIG_LIR_Nem_3	478	482	PF02991	0.283
LIG_Pex14_1	399	403	PF04695	0.387
LIG_Pex14_2	227	231	PF04695	0.200
LIG_Pex14_2	270	274	PF04695	0.334
LIG_Pex14_2	439	443	PF04695	0.222
LIG_PTB_Apo_2	202	209	PF02174	0.387
LIG_SH2_CRK	252	256	PF00017	0.348
LIG_SH2_CRK	293	297	PF00017	0.196
LIG_SH2_CRK	352	356	PF00017	0.402
LIG_SH2_CRK	505	509	PF00017	0.361
LIG_SH2_PTP2	560	563	PF00017	0.395
LIG_SH2_SRC	293	296	PF00017	0.208
LIG_SH2_SRC	560	563	PF00017	0.395
LIG_SH2_STAP1	113	117	PF00017	0.200
LIG_SH2_STAP1	252	256	PF00017	0.356
LIG_SH2_STAP1	521	525	PF00017	0.398
LIG_SH2_STAT3	125	128	PF00017	0.256
LIG_SH2_STAT3	521	524	PF00017	0.384
LIG_SH2_STAT5	110	113	PF00017	0.233
LIG_SH2_STAT5	122	125	PF00017	0.239
LIG_SH2_STAT5	211	214	PF00017	0.380
LIG_SH2_STAT5	247	250	PF00017	0.211
LIG_SH2_STAT5	352	355	PF00017	0.326
LIG_SH2_STAT5	380	383	PF00017	0.202
LIG_SH2_STAT5	435	438	PF00017	0.383
LIG_SH2_STAT5	453	456	PF00017	0.214
LIG_SH2_STAT5	531	534	PF00017	0.332
LIG_SH2_STAT5	554	557	PF00017	0.395
LIG_SH2_STAT5	560	563	PF00017	0.329
LIG_SH2_STAT5	74	77	PF00017	0.369
LIG_SH3_3	489	495	PF00018	0.247
LIG_SH3_5	449	453	PF00018	0.211
LIG_TYR_ITIM	111	116	PF00017	0.228
LIG_WRC_WIRS_1	275	280	PF05994	0.194
LIG_WRC_WIRS_1	314	319	PF05994	0.194
MOD_CK1_1	328	334	PF00069	0.414
MOD_CK1_1	470	476	PF00069	0.352
MOD_CK1_1	82	88	PF00069	0.312
MOD_CK2_1	179	185	PF00069	0.251
MOD_CK2_1	313	319	PF00069	0.250
MOD_CK2_1	368	374	PF00069	0.492
MOD_CK2_1	472	478	PF00069	0.266
MOD_GlcNHglycan	100	103	PF01048	0.294
MOD_GlcNHglycan	224	227	PF01048	0.213
MOD_GlcNHglycan	528	531	PF01048	0.421
MOD_GlcNHglycan	67	70	PF01048	0.451
MOD_GlcNHglycan	75	78	PF01048	0.337
MOD_GlcNHglycan	81	84	PF01048	0.256
MOD_GSK3_1	175	182	PF00069	0.334
MOD_GSK3_1	197	204	PF00069	0.483
MOD_GSK3_1	412	419	PF00069	0.341
MOD_GSK3_1	532	539	PF00069	0.256
MOD_GSK3_1	78	85	PF00069	0.267
MOD_GSK3_1	90	97	PF00069	0.253
MOD_N-GLC_1	394	399	PF02516	0.394
MOD_N-GLC_1	404	409	PF02516	0.242
MOD_N-GLC_2	389	391	PF02516	0.295
MOD_NEK2_1	222	227	PF00069	0.219
MOD_NEK2_1	256	261	PF00069	0.369
MOD_NEK2_1	274	279	PF00069	0.328
MOD_NEK2_1	320	325	PF00069	0.257
MOD_NEK2_1	342	347	PF00069	0.204
MOD_NEK2_1	439	444	PF00069	0.305
MOD_PIKK_1	394	400	PF00454	0.373
MOD_PIKK_1	423	429	PF00454	0.202
MOD_PK_1	10	16	PF00069	0.597
MOD_PKA_1	10	16	PF00069	0.532
MOD_PKA_2	4	10	PF00069	0.547
MOD_PKA_2	411	417	PF00069	0.331
MOD_PKA_2	519	525	PF00069	0.278
MOD_PKB_1	3	11	PF00069	0.532
MOD_Plk_1	368	374	PF00069	0.244
MOD_Plk_1	394	400	PF00069	0.372
MOD_Plk_2-3	144	150	PF00069	0.386
MOD_Plk_4	121	127	PF00069	0.270
MOD_Plk_4	298	304	PF00069	0.317
MOD_Plk_4	310	316	PF00069	0.239
MOD_Plk_4	342	348	PF00069	0.194
MOD_Plk_4	431	437	PF00069	0.325
MOD_Plk_4	439	445	PF00069	0.264
MOD_Plk_4	472	478	PF00069	0.231
MOD_Plk_4	550	556	PF00069	0.327
MOD_ProDKin_1	247	253	PF00069	0.220
MOD_ProDKin_1	296	302	PF00069	0.290
MOD_ProDKin_1	445	451	PF00069	0.225
MOD_ProDKin_1	470	476	PF00069	0.285
MOD_ProDKin_1	532	538	PF00069	0.487
MOD_ProDKin_1	92	98	PF00069	0.323
MOD_SUMO_for_1	338	341	PF00179	0.339
MOD_SUMO_rev_2	138	145	PF00179	0.220
MOD_SUMO_rev_2	185	195	PF00179	0.339
TRG_DiLeu_BaEn_3	148	154	PF01217	0.264
TRG_ENDOCYTIC_2	113	116	PF00928	0.228
TRG_ENDOCYTIC_2	252	255	PF00928	0.433
TRG_ENDOCYTIC_2	293	296	PF00928	0.226
TRG_ENDOCYTIC_2	352	355	PF00928	0.492
TRG_ENDOCYTIC_2	505	508	PF00928	0.463
TRG_ENDOCYTIC_2	560	563	PF00928	0.482
TRG_ER_diArg_1	10	12	PF00400	0.597
TRG_ER_diArg_1	428	431	PF00400	0.211
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.225

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL11	Leptomonas seymouri	34%	89%
A0A0S4IP65	Bodo saltans	23%	72%
A0A0S4IUT6	Bodo saltans	28%	71%
A0A0S4IUU1	Bodo saltans	30%	89%
A0A0S4IYM3	Bodo saltans	28%	80%
A0A1B0GTW7	Homo sapiens	26%	74%
A0A1D5NSK0	Danio rerio	24%	94%
A0A1L8HYT7	Xenopus laevis	24%	81%
A0A1X0NDG7	Trypanosomatidae	30%	89%
A0A1X0NDJ3	Trypanosomatidae	30%	81%
A0A1X0NDK2	Trypanosomatidae	33%	100%
A0A1X0NDK7	Trypanosomatidae	31%	82%
A0A1X0NDM7	Trypanosomatidae	31%	91%
A0A1X0NDU8	Trypanosomatidae	31%	88%
A0A1X0NE71	Trypanosomatidae	31%	100%
A0A1X0NER9	Trypanosomatidae	34%	91%
A0A1X0NET7	Trypanosomatidae	33%	100%
A0A1X0NEX7	Trypanosomatidae	33%	89%
A0A1X0NEZ6	Trypanosomatidae	31%	89%
A0A1X0NF32	Trypanosomatidae	32%	100%
A0A1X0NF41	Trypanosomatidae	32%	95%
A0A1X0NFJ0	Trypanosomatidae	31%	100%
A0A1X0NFK3	Trypanosomatidae	30%	87%
A0A1X0NFS0	Trypanosomatidae	34%	67%
A0A1X0NFU4	Trypanosomatidae	32%	71%
A0A1X0NG20	Trypanosomatidae	32%	94%
A0A1X0NGP3	Trypanosomatidae	33%	68%
A0A1X0NGY3	Trypanosomatidae	30%	76%
A0A1X0NGZ3	Trypanosomatidae	33%	97%
A0A1X0NH86	Trypanosomatidae	31%	66%
A0A1X0NHP4	Trypanosomatidae	33%	100%
A0A1X0NHP6	Trypanosomatidae	31%	100%
A0A1X0NHQ6	Trypanosomatidae	32%	100%
A0A1X0NI38	Trypanosomatidae	30%	66%
A0A1X0NI74	Trypanosomatidae	32%	78%
A0A1X0NII4	Trypanosomatidae	31%	69%
A0A1X0NIZ3	Trypanosomatidae	33%	100%
A0A1X0NJU4	Trypanosomatidae	32%	68%
A0A1X0NK66	Trypanosomatidae	32%	88%
A0A1X0NKJ8	Trypanosomatidae	32%	78%
A0A1X0NKW9	Trypanosomatidae	29%	100%
A0A1X0NME2	Trypanosomatidae	33%	93%
A0A1X0NMK3	Trypanosomatidae	29%	100%
A0A1X0NMK7	Trypanosomatidae	37%	100%
A0A1X0NMV0	Trypanosomatidae	31%	79%
A0A1X0NN43	Trypanosomatidae	31%	81%
A0A1X0NNK8	Trypanosomatidae	33%	89%
A0A1X0NPW0	Trypanosomatidae	32%	91%
A0A1X0NQJ5	Trypanosomatidae	34%	100%
A0A1X0NQM4	Trypanosomatidae	34%	100%
A0A1X0NQN3	Trypanosomatidae	36%	100%
A0A1X0NQU4	Trypanosomatidae	33%	91%
A0A1X0NQW6	Trypanosomatidae	33%	100%
A0A1X0NRF3	Trypanosomatidae	33%	87%
A0A1X0NRY8	Trypanosomatidae	37%	100%
A0A1X0NU16	Trypanosomatidae	36%	97%
A0A1X0NUR2	Trypanosomatidae	34%	79%
A0A1X0NV28	Trypanosomatidae	37%	99%
A0A1X0NVC3	Trypanosomatidae	30%	86%
A0A1X0NVE0	Trypanosomatidae	30%	75%
A0A1X0NW07	Trypanosomatidae	30%	93%
A0A1X0NX94	Trypanosomatidae	33%	90%
A0A1X0NX98	Trypanosomatidae	32%	73%
A0A1X0NXB6	Trypanosomatidae	31%	83%
A0A1X0NXH6	Trypanosomatidae	33%	80%
A0A1X0NXQ4	Trypanosomatidae	32%	86%
A0A1X0NXR7	Trypanosomatidae	33%	78%
A0A1X0NYE3	Trypanosomatidae	33%	93%
A0A1X0NYE7	Trypanosomatidae	32%	100%
A0A1X0NYN2	Trypanosomatidae	33%	100%
A0A1X0NYN4	Trypanosomatidae	28%	82%
A0A1X0NYS5	Trypanosomatidae	34%	97%
A0A1X0NYZ2	Trypanosomatidae	37%	100%
A0A1X0NZ46	Trypanosomatidae	29%	100%
A0A1X0NZ63	Trypanosomatidae	32%	92%
A0A1X0NZN6	Trypanosomatidae	28%	90%
A0A1X0P055	Trypanosomatidae	36%	99%
A0A1X0P0C4	Trypanosomatidae	31%	100%
A0A1X0P154	Trypanosomatidae	30%	97%
A0A1X0P331	Trypanosomatidae	33%	100%
A0A1X0P3K0	Trypanosomatidae	31%	80%
A0A1X0P3S2	Trypanosomatidae	29%	100%
A0A1X0P4L8	Trypanosomatidae	32%	100%
A0A1X0P4Y5	Trypanosomatidae	29%	91%
A0A1X0P544	Trypanosomatidae	32%	91%
A0A1X0P5J0	Trypanosomatidae	33%	85%
A0A1X0P7R3	Trypanosomatidae	34%	100%
A0A1X0P8B4	Trypanosomatidae	34%	100%
A0A1X0P9Z4	Trypanosomatidae	33%	100%
A0A1X0PB04	Trypanosomatidae	33%	100%
A0A3Q8I8N3	Leishmania donovani	57%	98%
A0A3Q8I8P8	Leishmania donovani	58%	97%
A0A3Q8I8S6	Leishmania donovani	58%	91%
A0A3Q8I8S9	Leishmania donovani	58%	97%
A0A3Q8IAZ8	Leishmania donovani	57%	98%
A0A3Q8IC35	Leishmania donovani	57%	98%
A0A3Q8IC44	Leishmania donovani	57%	99%
A0A3Q8IH61	Leishmania donovani	57%	99%
A0A3Q8IIN4	Leishmania donovani	33%	92%
A0A3R7JT49	Trypanosoma rangeli	35%	69%
A0A3R7JTB6	Trypanosoma rangeli	33%	83%
A0A3R7JV87	Trypanosoma rangeli	33%	100%
A0A3R7K7T9	Trypanosoma rangeli	35%	97%
A0A3R7K9S1	Trypanosoma rangeli	33%	100%
A0A3R7KB14	Trypanosoma rangeli	32%	67%
A0A3R7KLR6	Trypanosoma rangeli	32%	91%
A0A3R7KMY2	Trypanosoma rangeli	36%	87%
A0A3R7LFC4	Trypanosoma rangeli	34%	87%
A0A3R7LFZ4	Trypanosoma rangeli	37%	100%
A0A3R7LWG1	Trypanosoma rangeli	32%	100%
A0A3R7LX11	Trypanosoma rangeli	36%	100%
A0A3R7M1R8	Trypanosoma rangeli	34%	100%
A0A3R7M574	Trypanosoma rangeli	35%	91%
A0A3R7M7N6	Trypanosoma rangeli	34%	85%
A0A3R7MTS2	Trypanosoma rangeli	39%	100%
A0A3R7MW36	Trypanosoma rangeli	32%	100%
A0A3R7MXF4	Trypanosoma rangeli	35%	95%
A0A3R7N1W7	Trypanosoma rangeli	34%	100%
A0A3R7N289	Trypanosoma rangeli	34%	81%
A0A3R7N7I3	Trypanosoma rangeli	40%	100%
A0A3R7NTI8	Trypanosoma rangeli	34%	100%
A0A3R7R2J4	Trypanosoma rangeli	34%	90%
A0A3R7R5R1	Trypanosoma rangeli	36%	97%
A0A3R7R818	Trypanosoma rangeli	32%	100%
A0A3S5H6G0	Leishmania donovani	58%	97%
A0A3S5IQY2	Trypanosoma rangeli	37%	100%
A0A3S7WR43	Leishmania donovani	57%	98%
A0A3S7WR46	Leishmania donovani	58%	97%
A0A3S7WR60	Leishmania donovani	57%	97%
A0A3S7X192	Leishmania donovani	38%	100%
A0A422MRQ6	Trypanosoma rangeli	35%	78%
A0A422MU95	Trypanosoma rangeli	33%	100%
A0A422MVF5	Trypanosoma rangeli	32%	100%
A0A422MVS3	Trypanosoma rangeli	37%	100%
A0A422MW99	Trypanosoma rangeli	33%	78%
A0A422MZ47	Trypanosoma rangeli	39%	100%
A0A422MZG4	Trypanosoma rangeli	36%	99%
A0A422N361	Trypanosoma rangeli	35%	100%
A0A422N7Q6	Trypanosoma rangeli	33%	90%
A0A422NDS2	Trypanosoma rangeli	31%	100%
A0A422NDT3	Trypanosoma rangeli	32%	100%
A0A422NP82	Trypanosoma rangeli	38%	100%
A4H626	Leishmania braziliensis	75%	99%
A4H630	Leishmania braziliensis	70%	94%
A4H631	Leishmania braziliensis	72%	100%
A4H632	Leishmania braziliensis	67%	100%
A4H633	Leishmania braziliensis	70%	100%
A4H634	Leishmania braziliensis	72%	95%
A4H635	Leishmania braziliensis	71%	94%
A4H636	Leishmania braziliensis	97%	100%
A4H637	Leishmania braziliensis	72%	94%
A4H638	Leishmania braziliensis	61%	99%
A4H639	Leishmania braziliensis	64%	96%
A4H640	Leishmania braziliensis	71%	94%
A4H6D1	Leishmania braziliensis	72%	100%
A4H6D3	Leishmania braziliensis	82%	100%
A4H6D5	Leishmania braziliensis	82%	83%
A4H6D7	Leishmania braziliensis	98%	100%
A4H6D8	Leishmania braziliensis	77%	100%
A4H6D9	Leishmania braziliensis	77%	100%
A4H6E0	Leishmania braziliensis	79%	82%
A4H6E1	Leishmania braziliensis	82%	100%
A4H6E2	Leishmania braziliensis	81%	100%
A4H6E3	Leishmania braziliensis	73%	100%
A4H6E4	Leishmania braziliensis	72%	100%
A4H6E5	Leishmania braziliensis	65%	100%
A4HJI2	Leishmania braziliensis	33%	90%
A4HUF6	Leishmania infantum	58%	98%
A4HUF8	Leishmania infantum	58%	97%
A4HUF9	Leishmania infantum	59%	91%
A4HUG0	Leishmania infantum	57%	77%
A4I6X5	Leishmania infantum	34%	92%
C9ZUT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A1R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
D0A7S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	87%
D0A855	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	95%
E9AHH5	Leishmania infantum	38%	100%
E9AN53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	89%
E9AN54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	97%
E9AN55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	91%
E9AN56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	90%
E9AN57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	97%
E9AZL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B1Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	92%
O62446	Caenorhabditis elegans	24%	88%
P08148	Leishmania major	58%	97%
P15706	Leishmania chagasi	58%	97%
P23223	Leishmania donovani	56%	99%
P43150	Leishmania mexicana	58%	90%
Q00689	Leishmania guyanensis	69%	94%
Q06031	Crithidia fasciculata	50%	89%
Q27673	Leishmania amazonensis	57%	98%
Q29AK2	Drosophila pseudoobscura pseudoobscura	23%	85%
Q4Q662	Leishmania major	33%	100%
Q4Q8L3	Leishmania major	39%	100%
Q4QHG9	Leishmania major	59%	100%
Q4QHH0	Leishmania major	59%	100%
Q4QHH1	Leishmania major	59%	100%
Q4QHH2	Leishmania major	59%	100%
Q61YG1	Caenorhabditis briggsae	23%	88%
Q6LA77	Leishmania infantum	58%	97%
Q8BMN4	Mus musculus	26%	86%
Q8MNZ1	Leishmania tropica	59%	89%
Q96KR4	Homo sapiens	24%	89%
Q9VH19	Drosophila melanogaster	23%	86%
V5A303	Trypanosoma cruzi	39%	100%
V5A359	Trypanosoma cruzi	37%	100%
V5A488	Trypanosoma cruzi	33%	72%
V5AII7	Trypanosoma cruzi	37%	100%
V5AN34	Trypanosoma cruzi	38%	100%
V5APQ4	Trypanosoma cruzi	33%	74%
V5AX72	Trypanosoma cruzi	35%	79%
V5B5M0	Trypanosoma cruzi	35%	79%
V5BAN1	Trypanosoma cruzi	33%	74%
V5BD39	Trypanosoma cruzi	39%	100%
V5BLT3	Trypanosoma cruzi	32%	93%
V5CI97	Trypanosoma cruzi	31%	92%
V5D358	Trypanosoma cruzi	33%	69%