LeishMANIAdb
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Zf-met2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Zf-met2 domain-containing protein
Gene product:
4F5 protein family/Zinc-binding, putative
Species:
Leishmania braziliensis
UniProt:
A4H625_LEIBR
TriTrypDb:
LbrM.10.0460 , LBRM2903_100010400
Length:
83

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H625
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H625

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 12 14 PF00675 0.259
CLV_NRD_NRD_1 56 58 PF00675 0.469
CLV_PCSK_KEX2_1 12 14 PF00082 0.259
CLV_PCSK_KEX2_1 56 58 PF00082 0.469
CLV_PCSK_PC7_1 8 14 PF00082 0.283
CLV_PCSK_SKI1_1 15 19 PF00082 0.325
LIG_FHA_1 43 49 PF00498 0.339
LIG_FHA_2 26 32 PF00498 0.459
LIG_LIR_Gen_1 73 81 PF02991 0.407
LIG_LIR_Nem_3 73 77 PF02991 0.440
LIG_PDZ_Class_2 78 83 PF00595 0.374
LIG_Pex14_2 74 78 PF04695 0.460
LIG_SH3_3 52 58 PF00018 0.574
LIG_TRAF2_1 28 31 PF00917 0.399
LIG_TRAF2_1 73 76 PF00917 0.426
MOD_CK2_1 25 31 PF00069 0.442
MOD_CK2_1 70 76 PF00069 0.396
MOD_GlcNHglycan 2 5 PF01048 0.297
MOD_GlcNHglycan 21 24 PF01048 0.336
MOD_N-GLC_2 5 7 PF02516 0.259
MOD_NEK2_1 17 22 PF00069 0.506
MOD_PIKK_1 17 23 PF00454 0.436
MOD_PKA_2 65 71 PF00069 0.410
MOD_SUMO_rev_2 14 20 PF00179 0.525
TRG_ER_diArg_1 55 57 PF00400 0.448

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HR95 Leptomonas seymouri 81% 100%
A0A0S4JSJ0 Bodo saltans 60% 79%
A0A1X0NRV9 Trypanosomatidae 66% 78%
A0A3S7WR26 Leishmania donovani 85% 100%
A4HUF3 Leishmania infantum 85% 100%
E9AN52 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4QHH3 Leishmania major 83% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS