RING-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H624_LEIBR

TriTrypDb:

LbrM.10.0450 , LBRM2903_100010100

Length:

296

Annotations

LeishMANIAdb annotations

Related to divere Eukaryotic membrane-associated ubiquitin ligases (animal RNF180 or plant SPL1). If it has similar function, this protein is likely anchored to the ER. The topology must be in-out due to the RING finger being redox sensitive. The genes have duplicated in Leishmaniids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H624

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H624

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.642
CLV_NRD_NRD_1	108	110	PF00675	0.671
CLV_PCSK_KEX2_1	108	110	PF00082	0.671
DOC_PP2B_LxvP_1	79	82	PF13499	0.796
DOC_PP4_FxxP_1	273	276	PF00568	0.549
DOC_PP4_FxxP_1	73	76	PF00568	0.781
DOC_PP4_FxxP_1	89	92	PF00568	0.637
DOC_PP4_MxPP_1	95	98	PF00568	0.855
DOC_USP7_MATH_1	145	149	PF00917	0.549
DOC_USP7_MATH_1	182	186	PF00917	0.627
DOC_USP7_MATH_1	190	194	PF00917	0.537
DOC_USP7_MATH_1	82	86	PF00917	0.819
DOC_WW_Pin1_4	204	209	PF00397	0.643
LIG_14-3-3_CanoR_1	16	24	PF00244	0.616
LIG_14-3-3_CanoR_1	186	190	PF00244	0.635
LIG_14-3-3_CanoR_1	238	243	PF00244	0.486
LIG_BRCT_BRCA1_1	240	244	PF00533	0.471
LIG_BRCT_BRCA1_1	28	32	PF00533	0.549
LIG_EVH1_1	73	77	PF00568	0.781
LIG_FHA_1	62	68	PF00498	0.794
LIG_FHA_2	157	163	PF00498	0.590
LIG_FHA_2	266	272	PF00498	0.560
LIG_LIR_Apic_2	271	276	PF02991	0.561
LIG_LIR_Apic_2	86	92	PF02991	0.833
LIG_LIR_Gen_1	241	250	PF02991	0.484
LIG_LIR_Nem_3	162	168	PF02991	0.570
LIG_LIR_Nem_3	241	245	PF02991	0.474
LIG_LIR_Nem_3	29	35	PF02991	0.549
LIG_LIR_Nem_3	65	71	PF02991	0.794
LIG_Pex14_2	30	34	PF04695	0.549
LIG_Pex14_2	89	93	PF04695	0.839
LIG_SH2_PTP2	71	74	PF00017	0.788
LIG_SH2_SRC	264	267	PF00017	0.521
LIG_SH2_STAP1	63	67	PF00017	0.792
LIG_SH2_STAT5	166	169	PF00017	0.556
LIG_SH2_STAT5	289	292	PF00017	0.481
LIG_SH2_STAT5	63	66	PF00017	0.792
LIG_SH2_STAT5	71	74	PF00017	0.688
LIG_SH3_1	71	77	PF00018	0.784
LIG_SH3_3	274	280	PF00018	0.517
LIG_SH3_3	71	77	PF00018	0.784
LIG_TRAF2_1	159	162	PF00917	0.588
LIG_TRFH_1	166	170	PF08558	0.561
LIG_WRC_WIRS_1	291	296	PF05994	0.534
LIG_WW_3	96	100	PF00397	0.856
MOD_CK1_1	152	158	PF00069	0.583
MOD_CK1_1	185	191	PF00069	0.633
MOD_CK2_1	156	162	PF00069	0.587
MOD_Cter_Amidation	110	113	PF01082	0.662
MOD_Cter_Amidation	120	123	PF01082	0.534
MOD_GlcNHglycan	147	150	PF01048	0.549
MOD_GlcNHglycan	193	196	PF01048	0.836
MOD_GlcNHglycan	209	212	PF01048	0.632
MOD_GlcNHglycan	222	225	PF01048	0.633
MOD_GlcNHglycan	38	41	PF01048	0.549
MOD_GSK3_1	145	152	PF00069	0.549
MOD_GSK3_1	16	23	PF00069	0.616
MOD_GSK3_1	181	188	PF00069	0.630
MOD_NEK2_1	35	40	PF00069	0.549
MOD_NEK2_1	46	51	PF00069	0.679
MOD_NEK2_2	63	68	PF00069	0.792
MOD_OFUCOSY	20	27	PF10250	0.650
MOD_PIKK_1	152	158	PF00454	0.583
MOD_PKA_1	55	61	PF00069	0.801
MOD_PKA_2	185	191	PF00069	0.633
MOD_PKA_2	20	26	PF00069	0.449
MOD_PKB_1	14	22	PF00069	0.623
MOD_Plk_1	161	167	PF00069	0.577
MOD_Plk_1	218	224	PF00069	0.611
MOD_Plk_1	265	271	PF00069	0.548
MOD_Plk_2-3	212	218	PF00069	0.629
MOD_Plk_2-3	265	271	PF00069	0.548
MOD_Plk_4	161	167	PF00069	0.577
MOD_Plk_4	238	244	PF00069	0.482
MOD_Plk_4	26	32	PF00069	0.549
MOD_Plk_4	63	69	PF00069	0.793
MOD_ProDKin_1	204	210	PF00069	0.641
MOD_SUMO_rev_2	193	203	PF00179	0.641
TRG_ENDOCYTIC_2	165	168	PF00928	0.550
TRG_ER_diArg_1	108	110	PF00400	0.871
TRG_NLS_MonoCore_2	52	57	PF00514	0.806
TRG_NLS_MonoExtN_4	51	58	PF00514	0.807