RING-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H623_LEIBR

TriTrypDb:

LbrM.10.0440 , LBRM2903_100010000

Length:

160

Annotations

LeishMANIAdb annotations

Related to divere Eukaryotic membrane-associated ubiquitin ligases (animal RNF180 or plant SPL1). If it has similar function, this protein is likely anchored to the ER. The topology must be in-out due to the RING finger being redox sensitive. The genes have duplicated in Leishmaniids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H623

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H623

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	147	153	PF00089	0.287
CLV_NRD_NRD_1	149	151	PF00675	0.378
CLV_NRD_NRD_1	92	94	PF00675	0.361
CLV_PCSK_FUR_1	90	94	PF00082	0.424
CLV_PCSK_KEX2_1	102	104	PF00082	0.304
CLV_PCSK_KEX2_1	149	151	PF00082	0.302
CLV_PCSK_KEX2_1	92	94	PF00082	0.359
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.260
CLV_PCSK_SKI1_1	105	109	PF00082	0.297
DOC_MAPK_gen_1	102	109	PF00069	0.458
DOC_MAPK_gen_1	149	157	PF00069	0.558
DOC_MAPK_gen_1	90	97	PF00069	0.592
DOC_MAPK_HePTP_8	147	159	PF00069	0.473
DOC_MAPK_MEF2A_6	150	159	PF00069	0.471
DOC_PP2B_LxvP_1	50	53	PF13499	0.578
DOC_PP4_FxxP_1	137	140	PF00568	0.568
LIG_eIF4E_1	128	134	PF01652	0.580
LIG_IRF3_LxIS_1	9	16	PF10401	0.370
LIG_LIR_Apic_2	45	51	PF02991	0.598
LIG_LIR_Nem_3	131	137	PF02991	0.574
LIG_LIR_Nem_3	26	32	PF02991	0.523
LIG_LIR_Nem_3	44	50	PF02991	0.601
LIG_Pex14_2	23	27	PF04695	0.343
LIG_Rb_pABgroove_1	131	139	PF01858	0.495
LIG_SH2_CRK	48	52	PF00017	0.648
LIG_SH2_GRB2like	85	88	PF00017	0.585
LIG_SH2_STAP1	128	132	PF00017	0.573
LIG_SH2_STAT5	153	156	PF00017	0.635
LIG_SH2_STAT5	32	35	PF00017	0.698
LIG_SH3_3	138	144	PF00018	0.651
LIG_SH3_3	76	82	PF00018	0.596
LIG_SUMO_SIM_par_1	11	16	PF11976	0.245
LIG_TRAF2_1	63	66	PF00917	0.582
LIG_TRFH_1	48	52	PF08558	0.664
MOD_CK1_1	16	22	PF00069	0.370
MOD_CK1_1	88	94	PF00069	0.554
MOD_NEK2_1	13	18	PF00069	0.515
MOD_NEK2_1	23	28	PF00069	0.241
MOD_NEK2_2	75	80	PF00069	0.576
MOD_PIKK_1	30	36	PF00454	0.695
MOD_Plk_1	128	134	PF00069	0.539
MOD_Plk_1	54	60	PF00069	0.487
MOD_Plk_1	69	75	PF00069	0.559
MOD_Plk_4	128	134	PF00069	0.580
MOD_Plk_4	16	22	PF00069	0.356
MOD_Plk_4	23	29	PF00069	0.361
TRG_ENDOCYTIC_2	47	50	PF00928	0.568
TRG_ER_diArg_1	103	106	PF00400	0.487
TRG_ER_diArg_1	149	151	PF00400	0.502
TRG_ER_diArg_1	90	93	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT25	Leptomonas seymouri	44%	98%
A0A3Q8I8R6	Leishmania donovani	43%	97%
A0A3S7WR53	Leishmania donovani	75%	99%
A4HUF1	Leishmania infantum	76%	99%
A4HUF2	Leishmania infantum	43%	97%
E9AN50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
E9AN51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	97%
Q4QHH4	Leishmania major	43%	98%
Q4QHH5	Leishmania major	78%	100%