Dihydroxyacetone kinase 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydroxyacetone kinase 1-like protein

Species:

Leishmania braziliensis

UniProt:

A4H621_LEIBR

TriTrypDb:

LbrM.10.0420 , LBRM2903_100009700 , LBRM2903_100009800

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H621

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H621

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0006066	alcohol metabolic process	3	11
GO:0006071	glycerol metabolic process	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019400	alditol metabolic process	4	11
GO:0019751	polyol metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044262	obsolete cellular carbohydrate metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:0009056	catabolic process	2	1
GO:0016052	carbohydrate catabolic process	4	1
GO:0019405	alditol catabolic process	5	1
GO:0019563	glycerol catabolic process	6	1
GO:0044248	cellular catabolic process	3	1
GO:0044275	obsolete cellular carbohydrate catabolic process	4	1
GO:0044282	small molecule catabolic process	3	1
GO:0046164	alcohol catabolic process	4	1
GO:0046174	polyol catabolic process	5	1
GO:1901575	organic substance catabolic process	3	1
GO:1901616	organic hydroxy compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	11
GO:0004371	glycerone kinase activity	5	11
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	476	480	PF00656	0.506
CLV_C14_Caspase3-7	548	552	PF00656	0.374
CLV_MEL_PAP_1	248	254	PF00089	0.370
CLV_NRD_NRD_1	219	221	PF00675	0.247
CLV_NRD_NRD_1	434	436	PF00675	0.279
CLV_NRD_NRD_1	441	443	PF00675	0.317
CLV_NRD_NRD_1	507	509	PF00675	0.260
CLV_PCSK_KEX2_1	218	220	PF00082	0.249
CLV_PCSK_KEX2_1	434	436	PF00082	0.279
CLV_PCSK_KEX2_1	441	443	PF00082	0.513
CLV_PCSK_KEX2_1	507	509	PF00082	0.260
CLV_PCSK_KEX2_1	96	98	PF00082	0.242
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.379
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.242
CLV_PCSK_SKI1_1	113	117	PF00082	0.292
CLV_PCSK_SKI1_1	15	19	PF00082	0.376
CLV_PCSK_SKI1_1	292	296	PF00082	0.352
CLV_PCSK_SKI1_1	333	337	PF00082	0.295
CLV_PCSK_SKI1_1	374	378	PF00082	0.272
CLV_PCSK_SKI1_1	508	512	PF00082	0.299
CLV_PCSK_SKI1_1	53	57	PF00082	0.369
DEG_MDM2_SWIB_1	18	26	PF02201	0.371
DEG_SPOP_SBC_1	10	14	PF00917	0.377
DOC_CDC14_PxL_1	494	502	PF14671	0.432
DOC_CYCLIN_RxL_1	110	118	PF00134	0.159
DOC_CYCLIN_RxL_1	235	243	PF00134	0.231
DOC_MAPK_gen_1	191	200	PF00069	0.302
DOC_MAPK_MEF2A_6	24	32	PF00069	0.365
DOC_MAPK_MEF2A_6	292	299	PF00069	0.344
DOC_MAPK_MEF2A_6	53	61	PF00069	0.370
DOC_PP1_RVXF_1	13	19	PF00149	0.376
DOC_PP2B_LxvP_1	295	298	PF13499	0.370
DOC_PP2B_LxvP_1	59	62	PF13499	0.372
DOC_PP2B_PxIxI_1	169	175	PF00149	0.290
DOC_PP4_FxxP_1	146	149	PF00568	0.247
DOC_PP4_FxxP_1	413	416	PF00568	0.368
DOC_USP7_MATH_1	11	15	PF00917	0.380
DOC_USP7_MATH_1	272	276	PF00917	0.428
DOC_USP7_MATH_1	522	526	PF00917	0.467
DOC_USP7_MATH_1	558	562	PF00917	0.397
DOC_USP7_MATH_1	64	68	PF00917	0.492
DOC_USP7_MATH_1	650	654	PF00917	0.486
DOC_USP7_UBL2_3	630	634	PF12436	0.506
DOC_WW_Pin1_4	145	150	PF00397	0.247
DOC_WW_Pin1_4	443	448	PF00397	0.489
LIG_14-3-3_CanoR_1	238	243	PF00244	0.323
LIG_14-3-3_CanoR_1	31	35	PF00244	0.375
LIG_14-3-3_CanoR_1	374	380	PF00244	0.247
LIG_14-3-3_CanoR_1	507	513	PF00244	0.568
LIG_APCC_ABBA_1	286	291	PF00400	0.247
LIG_CaM_IQ_9	427	443	PF13499	0.277
LIG_Clathr_ClatBox_1	388	392	PF01394	0.316
LIG_DLG_GKlike_1	238	245	PF00625	0.379
LIG_EH1_1	307	315	PF00400	0.352
LIG_FHA_1	11	17	PF00498	0.399
LIG_FHA_1	110	116	PF00498	0.247
LIG_FHA_1	149	155	PF00498	0.313
LIG_FHA_1	211	217	PF00498	0.311
LIG_FHA_1	279	285	PF00498	0.358
LIG_FHA_1	304	310	PF00498	0.208
LIG_FHA_1	342	348	PF00498	0.242
LIG_FHA_1	385	391	PF00498	0.386
LIG_FHA_1	401	407	PF00498	0.477
LIG_FHA_1	454	460	PF00498	0.207
LIG_FHA_1	507	513	PF00498	0.482
LIG_FHA_1	612	618	PF00498	0.411
LIG_FHA_1	66	72	PF00498	0.324
LIG_FHA_1	99	105	PF00498	0.247
LIG_FHA_2	343	349	PF00498	0.266
LIG_FHA_2	375	381	PF00498	0.247
LIG_FHA_2	574	580	PF00498	0.419
LIG_FHA_2	593	599	PF00498	0.485
LIG_LIR_Apic_2	144	149	PF02991	0.290
LIG_LIR_Gen_1	509	518	PF02991	0.450
LIG_LIR_LC3C_4	640	643	PF02991	0.425
LIG_LIR_Nem_3	467	473	PF02991	0.372
LIG_LYPXL_SIV_4	278	286	PF13949	0.159
LIG_Pex14_2	18	22	PF04695	0.376
LIG_Pex14_2	460	464	PF04695	0.210
LIG_PTB_Apo_2	182	189	PF02174	0.266
LIG_PTB_Phospho_1	182	188	PF10480	0.316
LIG_RPA_C_Fungi	429	441	PF08784	0.273
LIG_SH2_CRK	229	233	PF00017	0.275
LIG_SH2_CRK	529	533	PF00017	0.379
LIG_SH2_GRB2like	469	472	PF00017	0.311
LIG_SH2_STAT5	160	163	PF00017	0.291
LIG_SH2_STAT5	453	456	PF00017	0.352
LIG_SH2_STAT5	469	472	PF00017	0.299
LIG_SH2_STAT5	499	502	PF00017	0.336
LIG_SH3_3	164	170	PF00018	0.290
LIG_SH3_3	266	272	PF00018	0.379
LIG_SH3_3	316	322	PF00018	0.255
LIG_SH3_3	495	501	PF00018	0.266
LIG_SH3_3	71	77	PF00018	0.273
LIG_SUMO_SIM_anti_2	112	118	PF11976	0.346
LIG_SUMO_SIM_anti_2	363	369	PF11976	0.246
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.334
LIG_SUMO_SIM_anti_2	489	495	PF11976	0.219
LIG_SUMO_SIM_anti_2	576	582	PF11976	0.247
LIG_SUMO_SIM_par_1	112	118	PF11976	0.159
LIG_SUMO_SIM_par_1	385	396	PF11976	0.379
LIG_SUMO_SIM_par_1	55	60	PF11976	0.372
LIG_SUMO_SIM_par_1	576	582	PF11976	0.247
LIG_TRAF2_1	33	36	PF00917	0.369
LIG_TRAF2_1	563	566	PF00917	0.229
LIG_TYR_ITIM	227	232	PF00017	0.266
LIG_TYR_ITIM	277	282	PF00017	0.165
LIG_UBA3_1	172	177	PF00899	0.353
LIG_UBA3_1	309	316	PF00899	0.275
MOD_CK1_1	148	154	PF00069	0.297
MOD_CK1_1	262	268	PF00069	0.247
MOD_CK1_1	419	425	PF00069	0.540
MOD_CK2_1	153	159	PF00069	0.159
MOD_CK2_1	30	36	PF00069	0.368
MOD_CK2_1	342	348	PF00069	0.266
MOD_CK2_1	560	566	PF00069	0.186
MOD_CK2_1	592	598	PF00069	0.300
MOD_Cter_Amidation	632	635	PF01082	0.389
MOD_GlcNHglycan	117	120	PF01048	0.329
MOD_GlcNHglycan	137	140	PF01048	0.233
MOD_GlcNHglycan	155	158	PF01048	0.414
MOD_GlcNHglycan	371	374	PF01048	0.379
MOD_GlcNHglycan	483	486	PF01048	0.276
MOD_GlcNHglycan	488	491	PF01048	0.286
MOD_GlcNHglycan	524	527	PF01048	0.247
MOD_GlcNHglycan	547	550	PF01048	0.370
MOD_GSK3_1	105	112	PF00069	0.159
MOD_GSK3_1	141	148	PF00069	0.314
MOD_GSK3_1	149	156	PF00069	0.316
MOD_GSK3_1	22	29	PF00069	0.366
MOD_GSK3_1	255	262	PF00069	0.261
MOD_GSK3_1	443	450	PF00069	0.572
MOD_GSK3_1	5	12	PF00069	0.478
MOD_GSK3_1	517	524	PF00069	0.242
MOD_NEK2_1	115	120	PF00069	0.446
MOD_NEK2_1	240	245	PF00069	0.375
MOD_NEK2_1	347	352	PF00069	0.404
MOD_NEK2_1	384	389	PF00069	0.303
MOD_NEK2_1	400	405	PF00069	0.490
MOD_NEK2_1	521	526	PF00069	0.318
MOD_NEK2_1	57	62	PF00069	0.411
MOD_NEK2_1	621	626	PF00069	0.337
MOD_NEK2_2	453	458	PF00069	0.216
MOD_PIKK_1	240	246	PF00454	0.291
MOD_PK_1	5	11	PF00069	0.393
MOD_PKA_2	250	256	PF00069	0.266
MOD_PKA_2	30	36	PF00069	0.368
MOD_PKA_2	506	512	PF00069	0.460
MOD_Plk_1	347	353	PF00069	0.433
MOD_Plk_1	573	579	PF00069	0.247
MOD_Plk_1	611	617	PF00069	0.291
MOD_Plk_1	64	70	PF00069	0.346
MOD_Plk_4	141	147	PF00069	0.394
MOD_Plk_4	199	205	PF00069	0.394
MOD_Plk_4	272	278	PF00069	0.340
MOD_Plk_4	363	369	PF00069	0.382
MOD_Plk_4	384	390	PF00069	0.405
MOD_Plk_4	611	617	PF00069	0.159
MOD_Plk_4	65	71	PF00069	0.572
MOD_ProDKin_1	145	151	PF00069	0.247
MOD_ProDKin_1	443	449	PF00069	0.489
MOD_SUMO_rev_2	624	632	PF00179	0.373
TRG_ENDOCYTIC_2	229	232	PF00928	0.275
TRG_ENDOCYTIC_2	279	282	PF00928	0.291
TRG_ENDOCYTIC_2	529	532	PF00928	0.282
TRG_ER_diArg_1	506	508	PF00400	0.316
TRG_ER_diArg_1	623	626	PF00400	0.266
TRG_NES_CRM1_1	380	394	PF08389	0.316
TRG_NLS_MonoCore_2	216	221	PF00514	0.159
TRG_NLS_MonoExtN_4	217	222	PF00514	0.159
TRG_Pf-PMV_PEXEL_1	358	363	PF00026	0.159

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Z1	Leptomonas seymouri	75%	100%
A0A0S4IPA3	Bodo saltans	42%	100%
A0A1X0P659	Trypanosomatidae	54%	100%
A0A3S5H6F7	Leishmania donovani	85%	100%
A0A422NR38	Trypanosoma rangeli	55%	100%
A0QXE4	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	30%	100%
A0R758	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	32%	100%
A4HUE9	Leishmania infantum	85%	100%
E9AN48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
F1RKQ4	Sus scrofa	35%	100%
O04059	Solanum lycopersicum	34%	100%
O13902	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O60017	Pichia angusta	32%	100%
O74192	Komagataella pastoris	31%	100%
O74215	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P43550	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P45510	Citrobacter freundii	32%	100%
P54838	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q3LXA3	Homo sapiens	33%	100%
Q4KLZ6	Rattus norvegicus	34%	100%
Q4QHH6	Leishmania major	83%	100%
Q55EE0	Dictyostelium discoideum	27%	100%
Q58DK4	Bos taurus	33%	100%
Q6D8V6	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	32%	100%
Q8VC30	Mus musculus	35%	100%
V5C2U9	Trypanosoma cruzi	53%	100%