Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4H620_LEIBR

TriTrypDb:

LbrM.10.0410 , LBRM2903_100008700

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H620

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H620

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	329	331	PF00675	0.187
CLV_PCSK_KEX2_1	151	153	PF00082	0.298
CLV_PCSK_KEX2_1	511	513	PF00082	0.212
CLV_PCSK_KEX2_1	537	539	PF00082	0.523
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.298
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.212
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.523
CLV_PCSK_SKI1_1	134	138	PF00082	0.355
CLV_PCSK_SKI1_1	293	297	PF00082	0.266
CLV_PCSK_SKI1_1	662	666	PF00082	0.249
DEG_APCC_DBOX_1	292	300	PF00400	0.426
DEG_Nend_UBRbox_2	1	3	PF02207	0.616
DOC_CDC14_PxL_1	623	631	PF14671	0.332
DOC_CYCLIN_yCln2_LP_2	640	646	PF00134	0.379
DOC_MAPK_gen_1	151	157	PF00069	0.507
DOC_MAPK_gen_1	291	298	PF00069	0.540
DOC_MAPK_gen_1	511	518	PF00069	0.443
DOC_MAPK_gen_1	537	545	PF00069	0.324
DOC_MAPK_gen_1	61	70	PF00069	0.481
DOC_MAPK_gen_1	650	659	PF00069	0.588
DOC_MAPK_MEF2A_6	245	252	PF00069	0.330
DOC_MAPK_MEF2A_6	291	298	PF00069	0.406
DOC_MAPK_MEF2A_6	537	545	PF00069	0.358
DOC_MAPK_MEF2A_6	81	88	PF00069	0.547
DOC_PP1_RVXF_1	513	519	PF00149	0.520
DOC_PP2B_LxvP_1	458	461	PF13499	0.375
DOC_PP2B_LxvP_1	640	643	PF13499	0.365
DOC_PP2B_LxvP_1	646	649	PF13499	0.331
DOC_PP4_FxxP_1	50	53	PF00568	0.592
DOC_PP4_MxPP_1	1	4	PF00568	0.600
DOC_USP7_MATH_1	217	221	PF00917	0.323
DOC_USP7_MATH_1	316	320	PF00917	0.547
DOC_USP7_MATH_1	463	467	PF00917	0.326
DOC_USP7_MATH_1	500	504	PF00917	0.378
DOC_USP7_MATH_1	579	583	PF00917	0.487
DOC_USP7_MATH_1	663	667	PF00917	0.412
DOC_USP7_MATH_1	82	86	PF00917	0.521
DOC_WW_Pin1_4	15	20	PF00397	0.676
DOC_WW_Pin1_4	368	373	PF00397	0.408
DOC_WW_Pin1_4	39	44	PF00397	0.796
DOC_WW_Pin1_4	615	620	PF00397	0.350
LIG_14-3-3_CanoR_1	330	339	PF00244	0.578
LIG_14-3-3_CanoR_1	515	519	PF00244	0.492
LIG_APCC_ABBA_1	20	25	PF00400	0.610
LIG_APCC_ABBA_1	68	73	PF00400	0.643
LIG_BRCT_BRCA1_1	481	485	PF00533	0.318
LIG_CSL_BTD_1	566	569	PF09270	0.399
LIG_EVH1_2	619	623	PF00568	0.361
LIG_FHA_1	135	141	PF00498	0.571
LIG_FHA_1	302	308	PF00498	0.439
LIG_FHA_1	400	406	PF00498	0.357
LIG_FHA_1	515	521	PF00498	0.493
LIG_FHA_1	643	649	PF00498	0.417
LIG_FHA_1	690	696	PF00498	0.592
LIG_LIR_Apic_2	434	440	PF02991	0.419
LIG_LIR_Apic_2	47	53	PF02991	0.649
LIG_LIR_Gen_1	142	149	PF02991	0.521
LIG_LIR_Gen_1	163	173	PF02991	0.338
LIG_LIR_Gen_1	201	212	PF02991	0.530
LIG_LIR_Gen_1	484	493	PF02991	0.331
LIG_LIR_Gen_1	503	509	PF02991	0.395
LIG_LIR_Gen_1	529	536	PF02991	0.335
LIG_LIR_Gen_1	584	593	PF02991	0.517
LIG_LIR_Gen_1	622	631	PF02991	0.271
LIG_LIR_Nem_3	142	147	PF02991	0.496
LIG_LIR_Nem_3	150	156	PF02991	0.496
LIG_LIR_Nem_3	163	168	PF02991	0.331
LIG_LIR_Nem_3	201	207	PF02991	0.537
LIG_LIR_Nem_3	220	226	PF02991	0.293
LIG_LIR_Nem_3	260	266	PF02991	0.345
LIG_LIR_Nem_3	362	368	PF02991	0.559
LIG_LIR_Nem_3	434	439	PF02991	0.382
LIG_LIR_Nem_3	482	486	PF02991	0.301
LIG_LIR_Nem_3	503	508	PF02991	0.343
LIG_LIR_Nem_3	529	534	PF02991	0.337
LIG_LIR_Nem_3	622	626	PF02991	0.266
LIG_Pex14_1	221	225	PF04695	0.375
LIG_Pex14_2	264	268	PF04695	0.287
LIG_Pex14_2	481	485	PF04695	0.312
LIG_Pex14_2	505	509	PF04695	0.373
LIG_Rb_pABgroove_1	525	533	PF01858	0.335
LIG_SH2_CRK	120	124	PF00017	0.513
LIG_SH2_CRK	154	158	PF00017	0.376
LIG_SH2_CRK	169	173	PF00017	0.328
LIG_SH2_CRK	204	208	PF00017	0.516
LIG_SH2_CRK	397	401	PF00017	0.347
LIG_SH2_CRK	486	490	PF00017	0.304
LIG_SH2_NCK_1	486	490	PF00017	0.302
LIG_SH2_STAP1	149	153	PF00017	0.502
LIG_SH2_STAP1	204	208	PF00017	0.491
LIG_SH2_STAP1	397	401	PF00017	0.395
LIG_SH2_STAP1	587	591	PF00017	0.494
LIG_SH2_STAT3	103	106	PF00017	0.417
LIG_SH2_STAT3	451	454	PF00017	0.209
LIG_SH2_STAT5	149	152	PF00017	0.503
LIG_SH2_STAT5	338	341	PF00017	0.381
LIG_SH2_STAT5	365	368	PF00017	0.582
LIG_SH2_STAT5	451	454	PF00017	0.356
LIG_SH2_STAT5	457	460	PF00017	0.348
LIG_SH2_STAT5	468	471	PF00017	0.288
LIG_SH2_STAT5	483	486	PF00017	0.264
LIG_SH2_STAT5	507	510	PF00017	0.452
LIG_SH2_STAT5	551	554	PF00017	0.295
LIG_SH2_STAT5	90	93	PF00017	0.526
LIG_SH3_1	37	43	PF00018	0.626
LIG_SH3_3	16	22	PF00018	0.698
LIG_SH3_3	170	176	PF00018	0.301
LIG_SH3_3	369	375	PF00018	0.597
LIG_SH3_3	37	43	PF00018	0.718
LIG_SH3_3	473	479	PF00018	0.286
LIG_SUMO_SIM_anti_2	310	319	PF11976	0.391
LIG_SUMO_SIM_par_1	310	319	PF11976	0.388
LIG_SUMO_SIM_par_1	569	575	PF11976	0.330
LIG_TRAF2_1	340	343	PF00917	0.391
LIG_TRFH_1	169	173	PF08558	0.363
LIG_TYR_ITIM	167	172	PF00017	0.382
LIG_TYR_ITIM	284	289	PF00017	0.197
LIG_TYR_ITSM	482	489	PF00017	0.405
LIG_UBA3_1	167	175	PF00899	0.360
LIG_UBA3_1	377	385	PF00899	0.387
LIG_UBA3_1	530	537	PF00899	0.324
LIG_Vh1_VBS_1	395	413	PF01044	0.409
LIG_WRC_WIRS_1	464	469	PF05994	0.336
MOD_CK1_1	178	184	PF00069	0.266
MOD_CK1_1	42	48	PF00069	0.558
MOD_CK1_1	510	516	PF00069	0.353
MOD_CK1_1	599	605	PF00069	0.359
MOD_CK1_1	666	672	PF00069	0.563
MOD_CK2_1	330	336	PF00069	0.384
MOD_CK2_1	337	343	PF00069	0.318
MOD_CMANNOS	221	224	PF00535	0.252
MOD_Cter_Amidation	328	331	PF01082	0.472
MOD_GlcNHglycan	15	18	PF01048	0.725
MOD_GlcNHglycan	162	165	PF01048	0.368
MOD_GlcNHglycan	177	180	PF01048	0.358
MOD_GlcNHglycan	252	255	PF01048	0.373
MOD_GlcNHglycan	318	321	PF01048	0.281
MOD_GlcNHglycan	322	325	PF01048	0.266
MOD_GlcNHglycan	4	7	PF01048	0.673
MOD_GlcNHglycan	502	505	PF01048	0.347
MOD_GlcNHglycan	665	668	PF01048	0.425
MOD_GSK3_1	11	18	PF00069	0.581
MOD_GSK3_1	125	132	PF00069	0.398
MOD_GSK3_1	316	323	PF00069	0.372
MOD_GSK3_1	395	402	PF00069	0.376
MOD_GSK3_1	481	488	PF00069	0.380
MOD_GSK3_1	510	517	PF00069	0.365
MOD_GSK3_1	596	603	PF00069	0.375
MOD_NEK2_1	108	113	PF00069	0.294
MOD_NEK2_1	129	134	PF00069	0.377
MOD_NEK2_1	13	18	PF00069	0.602
MOD_NEK2_1	147	152	PF00069	0.284
MOD_NEK2_1	155	160	PF00069	0.339
MOD_NEK2_1	187	192	PF00069	0.346
MOD_NEK2_1	256	261	PF00069	0.295
MOD_NEK2_1	395	400	PF00069	0.373
MOD_NEK2_1	414	419	PF00069	0.299
MOD_NEK2_1	481	486	PF00069	0.364
MOD_NEK2_1	518	523	PF00069	0.368
MOD_NEK2_1	596	601	PF00069	0.356
MOD_NEK2_1	683	688	PF00069	0.474
MOD_NEK2_2	301	306	PF00069	0.182
MOD_NEK2_2	463	468	PF00069	0.338
MOD_OFUCOSY	403	410	PF10250	0.399
MOD_PKA_1	330	336	PF00069	0.190
MOD_PKA_2	329	335	PF00069	0.196
MOD_PKA_2	514	520	PF00069	0.351
MOD_PKA_2	579	585	PF00069	0.336
MOD_Plk_2-3	359	365	PF00069	0.230
MOD_Plk_4	217	223	PF00069	0.346
MOD_Plk_4	395	401	PF00069	0.357
MOD_Plk_4	409	415	PF00069	0.312
MOD_Plk_4	432	438	PF00069	0.395
MOD_Plk_4	463	469	PF00069	0.340
MOD_Plk_4	481	487	PF00069	0.465
MOD_Plk_4	519	525	PF00069	0.320
MOD_Plk_4	526	532	PF00069	0.328
MOD_Plk_4	54	60	PF00069	0.523
MOD_Plk_4	581	587	PF00069	0.383
MOD_Plk_4	642	648	PF00069	0.382
MOD_Plk_4	683	689	PF00069	0.628
MOD_ProDKin_1	15	21	PF00069	0.593
MOD_ProDKin_1	368	374	PF00069	0.220
MOD_ProDKin_1	39	45	PF00069	0.759
MOD_ProDKin_1	615	621	PF00069	0.419
MOD_SUMO_for_1	307	310	PF00179	0.291
MOD_SUMO_rev_2	655	664	PF00179	0.409
TRG_DiLeu_BaEn_2	45	51	PF01217	0.444
TRG_DiLeu_BaLyEn_6	635	640	PF01217	0.322
TRG_ENDOCYTIC_2	120	123	PF00928	0.326
TRG_ENDOCYTIC_2	154	157	PF00928	0.354
TRG_ENDOCYTIC_2	169	172	PF00928	0.342
TRG_ENDOCYTIC_2	204	207	PF00928	0.346
TRG_ENDOCYTIC_2	286	289	PF00928	0.449
TRG_ENDOCYTIC_2	397	400	PF00928	0.348
TRG_ENDOCYTIC_2	457	460	PF00928	0.361
TRG_ENDOCYTIC_2	486	489	PF00928	0.357
TRG_ENDOCYTIC_2	587	590	PF00928	0.341
TRG_NES_CRM1_1	459	473	PF08389	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	52%	100%
A0A0N1HY49	Leptomonas seymouri	55%	100%
A0A0N1HZ06	Leptomonas seymouri	40%	100%
A0A0N1IHL1	Leptomonas seymouri	47%	99%
A0A0N1PAY4	Leptomonas seymouri	51%	80%
A0A0N1PB77	Leptomonas seymouri	39%	100%
A0A0N1PBZ2	Leptomonas seymouri	61%	100%
A0A0N1PCC1	Leptomonas seymouri	46%	100%
A0A381MBI0	Leishmania infantum	48%	100%
A0A3Q8I8X7	Leishmania donovani	48%	100%
A0A3Q8IAZ0	Leishmania donovani	58%	100%
A0A3Q8IH50	Leishmania donovani	82%	98%
A0A3Q8IVN0	Leishmania donovani	41%	100%
A0A3R7M4J1	Trypanosoma rangeli	47%	100%
A0A3S5H5P4	Leishmania donovani	50%	100%
A0A3S5H5V2	Leishmania donovani	47%	100%
A0A3S5H6F6	Leishmania donovani	57%	100%
A0A3S5H763	Leishmania donovani	62%	100%
A0A3S7WR10	Leishmania donovani	51%	95%
A0A3S7WR14	Leishmania donovani	59%	100%
A0A3S7WR15	Leishmania donovani	61%	83%
A0A3S7WR24	Leishmania donovani	58%	100%
A4H4T8	Leishmania braziliensis	44%	99%
A4H5Y4	Leishmania braziliensis	48%	100%
A4H617	Leishmania braziliensis	57%	100%
A4H618	Leishmania braziliensis	58%	100%
A4H619	Leishmania braziliensis	58%	100%
A4H6C3	Leishmania braziliensis	50%	100%
A4HNH7	Leishmania braziliensis	38%	100%
A4HSS2	Leishmania infantum	50%	100%
A4HUE4	Leishmania infantum	50%	95%
A4HUE5	Leishmania infantum	62%	100%
A4HUE6	Leishmania infantum	59%	100%
A4HUE7	Leishmania infantum	58%	100%
A4HUE8	Leishmania infantum	57%	100%
A4HUF4	Leishmania infantum	57%	100%
A4HUF5	Leishmania infantum	82%	100%
A4HYA9	Leishmania infantum	63%	100%
A4IC33	Leishmania infantum	40%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9AG72	Leishmania infantum	47%	100%
E9AI40	Leishmania braziliensis	62%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	95%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4QDC4	Leishmania major	60%	100%
Q4QH81	Leishmania major	49%	100%
Q4QHH7	Leishmania major	80%	100%
Q4QHH8	Leishmania major	55%	100%
Q4QHH9	Leishmania major	56%	100%
Q4QHI0	Leishmania major	57%	99%
Q4QHI1	Leishmania major	61%	100%
Q4QHI2	Leishmania major	62%	100%
Q4QIU9	Leishmania major	45%	100%
Q4QJ48	Leishmania major	50%	100%
Q7KIP2	Leishmania major	40%	98%